List of works by Akiyoshi Fukamizu

A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding

scientific article published on 19 September 2008

A mouse renin distal enhancer is essential for blood pressure homeostasis in BAC-rescued renin-null mutant mice

scientific article published on 15 April 2014

A nuclear receptor, hepatocyte nuclear factor 4, differently contributes to the human and mouse angiotensinogen promoter activities ⬇️

scientific article published on 04 August 2010

A randomly integrated transgenic H19 imprinting control region acquires methylation imprinting independently of its establishment in germ cells

scientific article published on 22 June 2009

A role for endothelial cells in promoting the maturation of astrocytes through the apelin/APJ system in mice.

scientific article published on 22 February 2012

A selective requirement for copper-dependent activation of cytochrome c oxidase by Cox17p.

scientific article

A single nucleotide mutation in the mouse renin promoter disrupts blood pressure regulation

scientific article

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

scientific journal article

APJ Regulates Parallel Alignment of Arteries and Veins in the Skin.

scientific article published on 23 April 2015

Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation

scientific article

Adult stage gamma-globin silencing is mediated by a promoter direct repeat element

scientific article

All of the human beta-type globin genes compete for LCR enhancer activity in embryonic erythroid cells of yeast artificial chromosome transgenic mice

scientific article

Alterations in renal endothelial nitric oxide synthase expression by salt diet in angiotensin type-1a receptor gene knockout mice

scientific article

An essential role for angiotensin II type 1a receptor in pregnancy-associated hypertension with intrauterine growth retardation

scientific article published on 19 December 2003

Androgen Contributes to Gender-Related Cardiac Hypertrophy and Fibrosis in Mice Lacking the Gene Encoding Guanylyl Cyclase-A ⬇️

scientific article published on October 30, 2003

Angiodysplasia in embryo lacking protein arginine methyltransferase 1 in vascular endothelial cells

scientific article published on 21 December 2016

Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2.

scientific article

Angiotensin II accelerates mammary gland development independently of high blood pressure in pregnancy-associated hypertensive mice

scientific article

Angiotensin type 1 receptor blockade prevents cardiac remodeling in mice with pregnancy-associated hypertension

scientific article published in December 2008

Angiotensin-converting enzyme 2 protects from severe acute lung failure

scientific article published in July 2005

Antithetic effects of MBD2a on gene regulation

scientific article

Apelin elevates blood pressure in ICR mice with L‑NAME‑induced endothelial dysfunction

scientific article published on 15 March 2013

Apelin is a positive regulator of ACE2 in failing hearts.

scientific article

Apelin stimulates myosin light chain phosphorylation in vascular smooth muscle cells

scientific journal article

Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt.

scientific article

Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.

scientific article

Aromatic residues are required for RNA helicase A mediated transactivation

scientific article

Asymmetric Arginine Dimethylation Modulates Mitochondrial Energy Metabolism and Homeostasis in Caenorhabditis elegans

scientific article published on 19 December 2016

Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16.

scientific article published in May 2011

Bile acid represses the peroxisome proliferator-activated receptor-gamma coactivator-1 promoter activity in a small heterodimer partner-dependent manner

scientific article

Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1.

scientific article published on 26 March 2004

CTCF binding is not the epigenetic mark that establishes post-fertilization methylation imprinting in the transgenic H19 ICR.

scientific article

CTF18 interacts with replication protein A in response to replication stress

scientific article

Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease.

scientific article published on 17 May 2018

Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.

scientific article

Characterization and identification of promoter elements in the mouse COX17 gene

scientific article

Cloning and characterization of a novel splicing isoform of USF1.

scientific article

Conserved SAMS function in regulating egg-laying in C. elegans

scientific article published on 15 January 2013

Cooperative action of APJ and α1A-adrenergic receptor in vascular smooth muscle cells induces vasoconstriction

scientific article published on 01 November 2019

Cooperative interaction of EWS with CREB-binding protein selectively activates hepatocyte nuclear factor 4-mediated transcription.

scientific article published on 28 November 2002

Corrigendum to ‘Molecular cloning and expression of human neurochondrin-1 and -2’

scholarly article published in Biochimica et Biophysica Acta. Gene Regulatory Mechanisms

Cytodifferentiation enhances Erk activation induced by endothelin-1 in primary cultured astrocytes

scientific article

Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'

scientific article

DNase I hypersensitivity and epsilon-globin transcriptional enhancement are separable in locus control region (LCR) HS1 mutant human beta-globin YAC transgenic mice

scientific article

De novo DNA methylation through the 5'-segment of the H19 ICR maintains its imprint during early embryogenesis

scientific article

Deficiency of Cardiac Natriuretic Peptide Signaling Promotes Peripartum Cardiomyopathy-Like Remodeling in the Mouse Heart

scientific article published on 31 October 2019

Detection of LacZ-Positive Cells in Living Tissue with Single-Cell Resolution.

scientific article published on 12 July 2016

Detection of choline and phosphatidic acid (PA) catalyzed by phospholipase D (PLD) using MALDI-QIT-TOF/MS with 9-aminoacridine matrix

scientific article

Detection of ethanolamine altering in fetuses of pregnancy-associated hypertensive mice treated with vasodepressors by using UPLC and MALDI-TOF/MS.

scientific article published on 27 October 2015

Deterioration of atherosclerosis in mice lacking angiotensin II type 1A receptor in bone marrow-derived cells

scientific article published on 19 May 2008

Differential roles of renin and angiotensinogen in the feto-maternal interface in the development of complications of pregnancy

scientific article published on 03 February 2005

Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ

scientific article

ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage.

scientific article published on 23 March 2017

EWS is a substrate of type I protein arginine methyltransferase, PRMT8.

scientific article

Effect of lactation on postpartum cardiac function of pregnancy-associated hypertensive mice

scientific article

Effect of peroxisome proliferator-activated receptor alpha on human angiotensinogen promoter

scientific journal article

Emerging impacts of biological methylation on genetic information

scientific article published on 01 January 2019

Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression

scientific article published on March 2004

Enhanced erythropoiesis mediated by activation of the renin-angiotensin system via angiotensin II type 1a receptor

scientific article

Enhanced histamine production through the induction of histidine decarboxylase expression by phorbol ester in Jurkat cells

scientific article

Erratum: Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ

scientific article published on 01 May 2017

Erythropoiesis and Blood Pressure Are Regulated via AT1 Receptor by Distinctive Pathways

scientific article published on 24 June 2015

Essential role of synoviolin in embryogenesis

scientific journal article

Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5.

scientific article published on 12 April 2011

Evaluation of novel cyclic analogues of apelin.

scientific article published on October 2008

Expression of cyclooxygenase-2 in the juxtaglomerular apparatus of angiotensinogen gene-knockout mice.

scientific article

Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene.

scientific article

Foxo1 increases pro-inflammatory gene expression by inducing C/EBPbeta in TNF-alpha-treated adipocytes

scientific article published on 21 November 2008

G protein-coupled APJ receptor signaling induces focal adhesion formation and cell motility.

scientific article published on November 2005

GCIP, Id like HLH protein, negatively regulates cell proliferation of rheumatoid synovial cells via interaction with CBP

GSK3β regulates gluconeogenic gene expression through HNF4α and FOXO1.

scientific article published on 5 March 2012

Genetic disruption of angiotensin II type 1a receptor improves long-term survival of mice with chronic severe aortic regurgitation

scientific article

Genomic imprinting recapitulated in the human beta-globin locus

scientific article

Gestational changes in PRMT1 expression of murine placentas

scientific article published on 07 April 2018

Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies.

scientific article published on 28 January 2016

Guanylyl cyclase-A inhibits angiotensin II type 1A receptor-mediated cardiac remodeling, an endogenous protective mechanism in the heart

scientific article published in September 2002

Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor

scientific article published on 07 January 2003

Histamine receptor agonist alleviates severe cardiorenal damages by eliciting anti-inflammatory programming

scientific article published on 28 January 2020

Homeostatic response of mouse renin gene transcription in a hypertensive environment is mediated by a novel 5' enhancer

scientific article published on 22 January 2018

Human beta-globin locus control region HS5 contains CTCF- and developmental stage-dependent enhancer-blocking activity in erythroid cells

scientific article

Hydralazine is involved in tele-methylhistamine metabolism by inhibiting monoamine oxidase B in pregnancy-associated hypertensive mice

scientific article

Identification and functional analysis of endothelial tip cell-enriched genes

scientific article

Identification of a crucial site for synoviolin expression

scientific article

Identification of a novel nucleolar protein complex required for mitotic chromosome segregation through centromeric accumulation of Aurora B

scientific article published on 01 June 2020

Identification of cis-regulatory sequences in the human angiotensinogen gene by transgene coplacement and site-specific recombination

scientific article

Identification of the mouse neurochondrin promoter region and the responsible region for cell type specific gene regulation

scientific article published on February 2004

Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine

scientific article

Impaired placental neovascularization in mice with pregnancy-associated hypertension

scientific article published on 11 February 2008

Inhibitory effect of the small heterodimer partner on hepatocyte nuclear factor-4 mediates bile acid-induced repression of the human angiotensinogen gene

scientific article published on 12 December 2003

Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation

scientific article

Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor

scientific article

Isolation and identification of novel neutrophil-activating cryptides hidden in mitochondrial cytochrome C.

scientific article

KDM5D-mediated H3K4 demethylation is required for sexually dimorphic gene expression in mouse embryonic fibroblasts

scientific article published on 01 April 2019

Lactation Is a Risk Factor of Postpartum Heart Failure in Mice with Cardiomyocyte-specific Apelin Receptor (APJ) Overexpression

scientific article published on 31 March 2016

Linear distance from the locus control region determines epsilon-globin transcriptional activity

scientific article

Long-Range Control of Renin Gene Expression in Tsukuba Hypertensive Mice

scientific article

Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives

scientific article published on August 2017

Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II.

scientific article

Mechanism for p38α-mediated experimental autoimmune encephalomyelitis

scientific article

Mitocryptide-2, a neutrophil-activating cryptide, is a specific endogenous agonist for formyl-peptide receptor-like 1.

scientific article

Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1.

scientific article published on 30 August 2006

Molecular characterization of the zinc finger transcription factor, Osterix.

scientific article published on March 2006

Mutation analysis of HNF-4 binding sites in the human glucose-6-phosphatase promoter.

scientific article published on March 2005

NML-mediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a p53-dependent manner

scientific article published on 05 May 2016

Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation.

scientific article published on October 2003

Neurochondrin negatively regulates CaMKII phosphorylation, and nervous system-specific gene disruption results in epileptic seizure

scientific article

Non-transcriptional Function of FOXO1/DAF-16 Contributes to Translesion DNA Synthesis

scientific article

Novel helical assembly in arginine methyltransferase 8

scientific article

Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress.

scientific article

Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes.

scientific article

Nucleomethylin deficiency impairs embryonic erythropoiesis

scientific article

Nutrient control of phosphorylation and translocation of Foxo1 in C57BL/6 and db/db mice.

scientific article published in September 2006

Orientation of mouse H19 ICR affects imprinted H19 gene expression through promoter methylation-dependent and -independent mechanisms

scientific article published on 17 December 2021

Oxidative stress-induced ubiquitination of RCAN1 mediated by SCFbeta-TrCP ubiquitin ligase.

scientific article

PCAF represses transactivation function of FOXO1 in an acetyltransferase-independent manner

scientific article published in February 2010

PRMT-5 converts monomethylarginines into symmetrical dimethylarginines in Caenorhabditis elegans

scientific article published in February 2017

PRMT-5 converts monomethylarginines into symmetrical dimethylarginines in Caenorhabditis elegans

scientific article published on 01 April 2018

PRMT1 Deficiency in Mouse Juvenile Heart Induces Dilated Cardiomyopathy and Reveals Cryptic Alternative Splicing Products

scientific article published on 02 October 2018

PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination

scientific article

Pathophysiology of placentation abnormalities in pregnancy-induced hypertension

scientific article

Phosphatidylinositol 3-kinase/Akt regulates angiotensin II-induced inhibition of apoptosis in microvascular endothelial cells by governing survivin expression and suppression of caspase-3 activity

scientific article published on 12 February 2004

Podocyte injury-driven lipid peroxidation accelerates the infiltration of glomerular foam cells in focal segmental glomerulosclerosis

scientific article

Possible involvement of downregulation of the apelin-APJ system in doxorubicin-induced cardiotoxicity

scientific article

Possible role of transcriptional coactivator P/CAF and nuclear acetylation in calcium-induced keratinocyte differentiation

scientific article

Possible roles of the transcription factor Nrf1 (NFE2L1) in neural homeostasis by regulating the gene expression of deubiquitinating enzymes.

scientific article published on 11 January 2017

Pregnancy-associated homeostasis and dysregulation: lessons from genetically modified animal models

scientific article published on 25 May 2011

Production of free methylarginines via the proteasome and autophagy pathways in cultured cells

scientific article published on 16 May 2011

Pterosin B has multiple targets in gluconeogenic programs, including coenzyme Q in RORα-SRC2 signaling

scientific article published on 09 March 2016

Regulation of FOXO1-mediated transcription and cell proliferation by PARP-1.

scientific article published on 10 March 2009

Regulation of FoxO transcription factors by acetylation and protein-protein interactions

scientific article published on 22 March 2011

Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR.

scientific article published on March 2003

Regulation of alkaline phosphatase promoter activity by forkhead transcription factor FKHR.

scientific article published on February 2002

Regulation of cellular functions by arginine methylation

scientific article published in August 2009

Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo

scientific article

Relevance of nuclear localization and functions of RNA helicase A

scientific article published on 01 April 2005

Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice

scientific article

Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis

scientific article

Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase.

scientific article published on November 2009

Role of natriuretic peptide receptor guanylyl cyclase-A in myocardial infarction evaluated using genetically engineered mice

scientific article published on 5 July 2005

Sequences in the H19 ICR that are transcribed as small RNA in oocytes are dispensable for methylation imprinting in YAC transgenic mice

scientific article published on 4 August 2012

Severe Hypomyelination and Developmental Defects Are Caused in Mice Lacking Protein Arginine Methyltransferase 1 (PRMT1) in the Central Nervous System

scientific article

Short-term suppression of the renin-angiotensin system in mice associated with hypertension during pregnancy

scientific article

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

scientific article

Simultaneous ablation of prmt-1 and prmt-5 abolishes asymmetric and symmetric arginine dimethylations in Caenorhabditis elegans

scientific article published on 2 February 2017

Sox-Oct motifs contribute to maintenance of the unmethylated H19 ICR in YAC transgenic mice

scientific article published on 2 July 2013

Structural organization of the mouse neurochondrin gene.

scientific article

Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy

scientific article

Synthetic DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic imprinting in transgenic mice.

scientific article published on 29 June 2018

TNFalpha induces acetylation of p53 but attenuates its transcriptional activation in rheumatoid synoviocytes

scientific article published on 01 September 2002

The C. elegans PRMT-3 possesses a type III protein arginine methyltransferase activity

scientific article published on 01 April 2011

The GATA transcription factor ELT-2 modulates both the expression and methyltransferase activity of PRMT-1 in Caenorhabditis elegans

scientific article published on 01 May 2018

The H19 imprinting control region mediates preimplantation imprinted methylation of nearby sequences in yeast artificial chromosome transgenic mice

scientific article published on 10 December 2012

The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity

scientific article published on 17 August 2006

The N-terminal sequence of murine PRMT5 variant 2 is required for Hsp70 interaction and CHIP ligase-mediated degradation

scientific article published on 16 May 2019

The chicken HS4 insulator element does not protect the H19 ICR from differential DNA methylation in yeast artificial chromosome transgenic mouse

scientific article

The nuclear import of RNA helicase A is mediated by importin-alpha3.

scientific article published in February 2006

The presence of both the amino- and carboxyl-terminal domains in the AR is essential for the completion of a transcriptionally active form with coactivators and intranuclear compartmentalization common to the steroid hormone receptors: a three-dimen

scientific article

The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

scientific journal article

Transcriptional down-regulation through nuclear exclusion of EWS methylated by PRMT1.

scientific article published on April 2005

Transcriptional regulation of energy metabolism in the liver ⬇️

scientific article published on August 24, 2010

Transcriptomic Evaluation of Pulmonary Fibrosis-Related Genes: Utilization of Transgenic Mice with Modifying p38 Signal in the Lungs

scientific article published on 14 September 2020

Transcriptomic changes involved in the dedifferentiation of myofibroblasts derived from the lung of a patient with idiopathic pulmonary fibrosis

scientific article published on 10 June 2020

Transvection-like interchromosomal interaction is not observed at the transcriptional level when tested in the Rosa26 locus in mouse

scientific article published on 14 February 2019

Tricarboxylic acid cycle activity suppresses acetylation of mitochondrial proteins during early embryonic development in Caenorhabditis elegans

scientific article published on 03 January 2019

Truncated Cables1 causes agenesis of the corpus callosum in mice

scientific article published on 16 December 2013

Unique pH dynamics in GABAergic synaptic vesicles illuminates the mechanism and kinetics of GABA loading

scientific article published on 06 September 2016

Urinary excretion of fatty acid-binding protein reflects stress overload on the proximal tubules

scientific article

[FOXO: the regulator of metabolism, longevity, and aging]

scientific article published on 01 May 2005

p38 Mitogen-activated protein kinase accelerates emphysema in mouse model of chronic obstructive pulmonary disease.

scientific article published on 5 March 2014

rRNA adenine methylation requires T07A9.8 gene as rram-1 in Caenorhabditis elegans

scientific article published on 27 January 2018

siRNA screening identifies METTL9 as a histidine Nπ-methyltransferase that targets the proinflammatory protein S100A9

scientific article published on 23 September 2021

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