List of works - Viktor Magdolen

A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity

scientific article

A bioengineered 3D ovarian cancer model for the assessment of peptidase-mediated enhancement of spheroid growth and intraperitoneal spread

scientific article

Advanced high-grade serous ovarian cancer: inverse association of KLK13 and KLK14 mRNA levels in tumor tissue and patients' prognosis

scientific article published on 15 March 2018

Assessment of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in Breast Cancer Tissue: Historical Aspects and Future Prospects ⬇️

scientific article published on October 15, 2008

Assessment of kallikrein-related peptidase 5 (KLK5) protein expression in tumor tissue of advanced ovarian cancer patients by immunohistochemistry and ELISA: correlation with clinical outcome

scientific article published on 15 December 2015

Association of tissue mRNA and serum antigen levels of members of the urokinase-type plasminogen activator system with clinical and prognostic parameters in prostate cancer.

scientific article published on 29 April 2014

Characteristics of the level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1.

scientific article published on October 2010

Characterization of kallikrein-related peptidase 4 (KLK4) mRNA expression in tumor tissue of advanced high-grade serous ovarian cancer patients

scientific article published on 27 February 2019

Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7

scientific article

Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer.

scientific article published on 2 November 2017

Clinical utility of level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1.

scientific article

Combined expression of KLK4, KLK5, KLK6, and KLK7 by ovarian cancer cells leads to decreased adhesion and paclitaxel-induced chemoresistance

scientific article published on 8 September 2012

Combined mRNA expression levels of members of the urokinase plasminogen activator (uPA) system correlate with disease-associated survival of soft-tissue sarcoma patients

scientific article

Downregulation of serine protease HTRA1 is associated with poor survival in breast cancer

scientific article

Emerging clinical importance of the cancer biomarkers kallikrein-related peptidases (KLK) in female and male reproductive organ malignancies

scientific article

Function and clinical relevance of kallikrein-related peptidases and other serine proteases in gynecological cancers

scientific article published on 03 February 2014

Gene expression analysis of HUVEC in response to TF-binding ⬇️

scientific article published on December 24, 2010

Impact of expression of the uPA system in sarcomas

scientific article published on June 2013

In vitro evidence that KLK14 regulates the components of the HGF/Met axis, pro-HGF and HGF-activator inhibitor 1A and 1B.

scientific article

Inhibition of the tumor-associated urokinase-type plasminogen activation system: effects of high-level synthesis of soluble urokinase receptor in ovarian and breast cancer cells in vitro and in vivo

scientific article

KLK4 Induces Anti-Tumor Effects in Human Xenograft Mouse Models of Orthotopic and Metastatic Prostate Cancer

scientific article published on 24 November 2020

Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cells

scientific article

Molecular and functional interdependence of the urokinase-type plasminogen activator system with integrins

scientific article

Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs).

scientific article

Non-muscle alpha-actinin-4 interacts with plasminogen activator inhibitor type-1 (PAI-1).

scientific article

Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes ⬇️

scientific article published on December 1, 2012

Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer

scientific article published on 18 May 2017

Plasmin(ogen) serves as a favorable biomarker for prediction of survival in advanced high-grade serous ovarian cancer.

scientific article published on 24 November 2016

Preclinical evaluation of [111 In]MICA-401, an activity-based probe for SPECT imaging of in vivo uPA activity

scientific article

Prognostic impact of urokinase-type plasminogen activator system components in clear cell renal cell carcinoma patients without distant metastasis

scientific article

Prognostic relevance of uPAR-del4/5 and TIMP-3 mRNA expression levels in breast cancer.

scientific article

Prognostic value of kallikrein-related peptidase 12 (KLK12) mRNA expression in triple-negative breast cancer patients

scientific article published on 07 February 2020

Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer

scientific article published on 21 October 2020

Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G

scientific article

Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer

scientific article published on 15 July 2019

Quantitative reverse transcription-PCR assay for detection of mRNA encoding full-length human tissue kallikrein 7: prognostic relevance of KLK7 mRNA expression in breast cancer

scientific article published on 20 April 2006

Rab31 expression levels modulate tumor-relevant characteristics of breast cancer cells ⬇️

scientific article published on August 24, 2012

STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization.

scientific article published on 24 March 2015

Secreted uPAR isoform 2 (uPAR7b) is a novel direct target of miR-221.

scientific article published on April 2015

Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFβ-1 signaling in ovarian cancer cells

scientific article published on October 2013

Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences

scientific article (publication date: September 2006)

Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10

scientific article

Structural basis of the zinc inhibition of human tissue kallikrein 5

scientific article

Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity.

scientific article

Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7.

scientific article published on June 2008

Sweetened kallikrein-related peptidases (KLKs): glycan trees as potential regulators of activation and activity.

scientific article

The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation

scientific article

The human fibrinolytic system is a target for the staphylococcal metalloprotease aureolysin

scientific article published on February 2008

The solution structure of the kallikrein-related peptidases inhibitor SPINK6

scientific article

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.

scientific article published on September 2012

The urokinase receptor (uPAR, CD87) as a target for tumor therapy: uPA-silica particles (SP-uPA) as a new tool for assessing synthetic peptides to interfere with uPA/uPA-receptor interaction.

scientific article

Tissue kallikrein-related peptidase 4 (KLK4), a novel biomarker in triple-negative breast cancer

scientific article

Urokinase-type plasminogen activator (uPA) and its receptor (uPAR): development of antagonists of uPA/uPAR interaction and their effects in vitro and in vivo

scientific article

List of works by Viktor Magdolen

A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity

A bioengineered 3D ovarian cancer model for the assessment of peptidase-mediated enhancement of spheroid growth and intraperitoneal spread

Advanced high-grade serous ovarian cancer: inverse association of KLK13 and KLK14 mRNA levels in tumor tissue and patients' prognosis

Assessment of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in Breast Cancer Tissue: Historical Aspects and Future Prospects ⬇️

Assessment of kallikrein-related peptidase 5 (KLK5) protein expression in tumor tissue of advanced ovarian cancer patients by immunohistochemistry and ELISA: correlation with clinical outcome

Association of tissue mRNA and serum antigen levels of members of the urokinase-type plasminogen activator system with clinical and prognostic parameters in prostate cancer.

Characteristics of the level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1.

Characterization of kallikrein-related peptidase 4 (KLK4) mRNA expression in tumor tissue of advanced high-grade serous ovarian cancer patients

Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7

Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer.

Clinical utility of level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1.

Combined expression of KLK4, KLK5, KLK6, and KLK7 by ovarian cancer cells leads to decreased adhesion and paclitaxel-induced chemoresistance

Combined mRNA expression levels of members of the urokinase plasminogen activator (uPA) system correlate with disease-associated survival of soft-tissue sarcoma patients

Downregulation of serine protease HTRA1 is associated with poor survival in breast cancer

Emerging clinical importance of the cancer biomarkers kallikrein-related peptidases (KLK) in female and male reproductive organ malignancies

Function and clinical relevance of kallikrein-related peptidases and other serine proteases in gynecological cancers

Gene expression analysis of HUVEC in response to TF-binding ⬇️

Impact of expression of the uPA system in sarcomas

In vitro evidence that KLK14 regulates the components of the HGF/Met axis, pro-HGF and HGF-activator inhibitor 1A and 1B.

Inhibition of the tumor-associated urokinase-type plasminogen activation system: effects of high-level synthesis of soluble urokinase receptor in ovarian and breast cancer cells in vitro and in vivo

KLK4 Induces Anti-Tumor Effects in Human Xenograft Mouse Models of Orthotopic and Metastatic Prostate Cancer

Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cells

Molecular and functional interdependence of the urokinase-type plasminogen activator system with integrins

Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs).

Non-muscle alpha-actinin-4 interacts with plasminogen activator inhibitor type-1 (PAI-1).

Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes ⬇️

Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer

Plasmin(ogen) serves as a favorable biomarker for prediction of survival in advanced high-grade serous ovarian cancer.

Preclinical evaluation of [111 In]MICA-401, an activity-based probe for SPECT imaging of in vivo uPA activity

Prognostic impact of urokinase-type plasminogen activator system components in clear cell renal cell carcinoma patients without distant metastasis

Prognostic relevance of uPAR-del4/5 and TIMP-3 mRNA expression levels in breast cancer.

Prognostic value of kallikrein-related peptidase 12 (KLK12) mRNA expression in triple-negative breast cancer patients

Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer

Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G

Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer

Quantitative reverse transcription-PCR assay for detection of mRNA encoding full-length human tissue kallikrein 7: prognostic relevance of KLK7 mRNA expression in breast cancer

Rab31 expression levels modulate tumor-relevant characteristics of breast cancer cells ⬇️

STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization.

Secreted uPAR isoform 2 (uPAR7b) is a novel direct target of miR-221.

Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFβ-1 signaling in ovarian cancer cells

Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences

Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10

Structural basis of the zinc inhibition of human tissue kallikrein 5

Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity.

Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7.

Sweetened kallikrein-related peptidases (KLKs): glycan trees as potential regulators of activation and activity.

The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation

The human fibrinolytic system is a target for the staphylococcal metalloprotease aureolysin

The solution structure of the kallikrein-related peptidases inhibitor SPINK6

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.

The urokinase receptor (uPAR, CD87) as a target for tumor therapy: uPA-silica particles (SP-uPA) as a new tool for assessing synthetic peptides to interfere with uPA/uPA-receptor interaction.

Tissue kallikrein-related peptidase 4 (KLK4), a novel biomarker in triple-negative breast cancer

Urokinase-type plasminogen activator (uPA) and its receptor (uPAR): development of antagonists of uPA/uPAR interaction and their effects in vitro and in vivo