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List of works by Michael D. Taylor

A novel method for rapid molecular subgrouping of medulloblastoma.

scientific article

Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling

scientific article published on 01 September 2018

Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma.

scientific article published on 25 November 2012

Abstract 3094: Epigenetic classification of ependymal brain tumors across age groups

Adult medulloblastoma comprises three major molecular variants.

scientific article

An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate

scientific article published on 20 July 2020

An animal model of MYC-driven medulloblastoma

scientific article published on February 2012

Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

scientific article

Biological and clinical heterogeneity of MYCN-amplified medulloblastoma.

scientific article

Bmi1overexpression in the cerebellar granule cell lineage of mice affects cell proliferation and survival without initiating medulloblastoma formation ⬇️

scientific article published on October 12, 2012

CBMT-05. ROLE OF THE let7-eEF2K AXIS IN MYC-DRIVEN MEDULLOBLASTOMA ADAPTATION TO NUTRIENT DEPRIVATION

CS-16 * THE eEF2 KINASE IS CRITICAL FOR BRAIN TUMOURS ADAPTATION TO METABOLIC STRESS

CSIG-15. PROTEOMIC AND PHOSPHOPROTEOMIC ANALYSIS OF HUMAN MEDULLOBLASTOMA REVEALS DISTINCT ACTIVATED PATHWAYS BETWEEN SUBGROUPS

Challenges to curing primary brain tumours

scientific article published on 01 August 2019

Childhood cerebellar tumours mirror conserved fetal transcriptional programs

scientific article published on 01 May 2019

Clinical and neuroanatomical predictors of cerebellar mutism syndrome ⬇️

scientific article published on September 5, 2012

Clonal selection drives genetic divergence of metastatic medulloblastoma

scientific article published on 15 February 2012

Coverage bias and sensitivity of variant calling for four whole-genome sequencing technologies

scientific article

Cytogenetic prognostication within medulloblastoma subgroups

scientific article published on 03 February 2014

DNA methylation-based classification of central nervous system tumours

scientific article published on 14 March 2018

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

scientific article

Deep Learning for Pediatric Posterior Fossa Tumor Detection and Classification: A Multi-Institutional Study

scientific article published on 13 August 2020

Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma

scientific article

Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma

scientific article published on 11 September 2018

Dissecting the genomic complexity underlying medulloblastoma

scientific article

Divergent clonal selection dominates medulloblastoma at recurrence

scientific article published on 13 January 2016

Does thiopentone delay recovery in children premedicated with midazolam? ⬇️

scientific article published on January 1, 1997

EP-03MOLECULAR CLASSIFICATION OF EPENDYMAL TUMORS ACROSS ALL CNS COMPARTMENTS, HISTOPATHOLOGICAL GRADES AND AGE GROUPS.

scientific article published on 21 April 2015

EPEN-23. MOLECULAR HETEROGENEITY AMONG PEDIATRIC POSTERIOR FOSSA EPENDYMOMA

EPEN-28. HETEROGENEITY WITHIN THE PFB EPENDYMOMA SUBGROUP.

scientific article published on 22 June 2018

EPN-31MOLECULAR REFINEMENT OF PEDIATRIC POSTERIOR FOSSA EPENDYMOMA.

scientific article published on 30 May 2016

EPND-01. THE ACTIVE REGULATORY LANDSCAPE OF EPENDYMAL TUMORS.

scientific article published on 31 May 2017

EPND-07. MOLECULAR HETEROGENEITY AMONG PEDIATRIC POSTERIOR FOSSA EPENDYMOMA.

scientific article published on 31 May 2017

Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity

scientific article

Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis

scientific article published on 13 June 2019

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

scientific article

FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma

scientific article

FORETINIB IS EFFECTIVE THERAPY FOR METASTATIC SONIC HEDGEHOG MEDULLOBLASTOMA.

scientific article published in July 2014

FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma

scientific article

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy.

scientific article published on 30 August 2017

Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma.

scientific article

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

scientific article

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

scientific article

Genome-Wide Methylation Analysis ⬇️

scientific article published on January 1, 2012

HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma

scientific article published on March 2016

HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth

scientific article published on 22 April 2010

Heterogeneity within the PF-EPN-B ependymoma subgroup

article

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

scientific article published on 20 November 2020

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma

scientific article published in October 2012

Hyaluronate receptors mediating glioma cell migration and proliferation

scientific article (publication date: June 2001)

Hypermutation of the inactive X chromosome is a frequent event in cancer

scientific article published on 17 October 2013

ICGC PedBrain - dissecting the genomic complexity underlying medulloblastoma using whole-genome sequencing.

scientific article

Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration

scientific article published on 07 November 2019

Identification of CD24 as a marker of Patched1 deleted medulloblastoma-initiating neural progenitor cells

scientific article published in PLoS ONE

Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome

scientific article

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

scientific article

Integrated genomics elucidates relative spatial homogeneity of embryonal brain tumors.

scientific article

International network of cancer genome projects

scientific article

Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma

scientific article published on 27 April 2020

MB-21INTEGRATED GENOMICS ELUCIDATES RELATIVE SPATIAL HOMOGENEITY OF EMBRYONAL BRAIN TUMORS.

scientific article published on 21 April 2015

MB-44SUBGROUP-SPECIFIC QUANTITATIVE PROTEOMIC ANALYSIS OF MEDULLOBLASTOMA.

scientific article published on 30 May 2016

MB-53hTERT EXPRESSION AND REGULATION IN PEDIATRIC MEDULLOBLASTOMA (MB).

scientific article published on 30 May 2016

MBRS-57. TARGETING METABOLIC ADAPTATION IN MYC/MYCN AMPLIFIED PEDIATRIC MEDULLOBLASTOMA AND NEUROBLASTOMA

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin

scientific article published on 25 November 2015

MPTH-26MOLECULAR REFINEMENT OF PEDIATRIC POSTERIOR FOSSA EPENDYMOMA.

scientific article

MR Imaging-Based Radiomic Signatures of Distinct Molecular Subgroups of Medulloblastoma

scientific article published on 06 December 2018

MRI Characteristics of Primary Tumors and Metastatic Lesions in Molecular Subgroups of Pediatric Medulloblastoma: A Single-Center Study

scientific article published on 15 March 2018

Medulloblastoma

scientific article published on 14 February 2019

Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group.

scientific article published on 22 November 2013

Medulloblastoma comprises four distinct molecular variants

scientific article published on 07 September 2010

Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

scientific article (publication date: 22 July 2012)

Medulloblastoma subgroups remain stable across primary and metastatic compartments

scientific article

Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress

scientific article published on 05 April 2016

Medulloblastomics: the end of the beginning

scientific article published on December 2012

Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study.

scientific article

MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma

scientific article published on 2 December 2011

Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy

scientific article published on 14 April 2020

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

scientific article

Molecular diagnostics of CNS embryonal tumors

scientific article published on 30 September 2010

Molecular genetics of ependymoma ⬇️

scientific article published on October 1, 2011

Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas

scientific article published on 16 June 2018

Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis

scientific article

Molecular subgroups of medulloblastoma

scientific article

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

scientific article

Molecular subgroups of medulloblastoma: the current consensus

scientific article

Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression

scientific article published on 24 July 2013

Nestin expression identifies ependymoma patients with poor outcome

scientific article published on 30 May 2012

Neurosurgical management of extraaxial central nervous system infections in children ⬇️

scientific article published on May 1, 2011

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

scientific article

Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma

scientific article published on 9 March 2018

PATH-32. MOLECULAR HETEROGENEITY AMONG PEDIATRIC POSTERIOR FOSSA EPENDYMOMA

PCDH10 is a candidate tumour suppressor gene in medulloblastoma.

scientific article published on 20 May 2011

PDTM-23. THE ACTIVE REGULATORY LANDSCAPE OF EPENDYMAL TUMORS

PDTM-46. TARGETING METABOLIC ADAPTATION IN MYC DRIVEN PEDIATRIC NEURONAL TUMORS

scientific article published on 6 November 2017

PDTM-49. GLOBAL REDUCTION IN H3K27me3, SIMILAR TO H3K27M MUTANT GLIOMAS, IS A MOLECULAR SURROGATE FOR PEDIATRIC POSTERIOR FOSSA- GROUP A EPENDYMOMAS

scientific article published on 6 November 2017

PROGNOSTIC SIGNIFICANCE OF CLINICAL, HISTOPATHOLOGICAL, AND MOLECULAR CHARACTERISTICS OF MEDULLOBLASTOMAS IN THE PROSPECTIVE HIT2000 MULTICENTER CLINICAL TRIAL COHORT

Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma

scientific article published on 01 June 2020

Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct

scientific article

Pleiotropic role for MYCN in medulloblastoma.

scientific article published on May 2010

Posterior fossa ependymomas: new radiological classification with surgical correlation ⬇️

scientific article published on August 3, 2010

Preclinical target validation using patient-derived cells

scientific article

Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort

scientific article

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

scientific article published on 11 March 2016

Proteomic analysis of Medulloblastoma reveals functional biology with translational potential.

scientific article published on 7 June 2018

Proteomic profiling of high risk medulloblastoma reveals functional biology

scientific article published on June 2015

Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma

scientific article published on 19 June 2014

Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples

scientific article published on 6 November 2011

Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis

scientific article published on 17 October 2013

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

scientific article

Reply to 'Assembling the brain trust: the multidisciplinary imperative in neuro-oncology'

scientific article published on 01 August 2019

Reply to J.C. Lindsey et al

Risk stratification of childhood medulloblastoma in the molecular era: the current consensus

scientific article published on 4 April 2016

Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays

scientific article published on 14 May 2013

Role of LIM and SH3 protein 1 (LASP1) in the metastatic dissemination of medulloblastoma

scientific article

Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes

scientific article published on 10 May 2019

Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer

scientific article published on 02 September 2021

Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors

scientific article published on 23 January 2019

Somatostatin receptor subtype 2 (sst₂) is a potential prognostic marker and a therapeutic target in medulloblastoma

scientific article published on 16 May 2013

Spatial heterogeneity in medulloblastoma

scientific article published on 10 April 2017

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

scientific article

Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype.

scientific article

Stalled developmental programs at the root of pediatric brain tumors

scientific article published on 25 November 2019

Subgroup-specific alternative splicing in medulloblastoma

scientific article

Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma

scientific article published on 08 July 2013

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

scientific article

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

scientific article published on 31 October 2013

TMOD-11. HUMAN STEM CELL BASED MODEL OF MEDULLOBLASTOMA

TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma.

scientific article

The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma

scientific article

The RNA-binding protein Musashi1 affects medulloblastoma growth via a network of cancer-related genes and is an indicator of poor prognosis

scientific article

The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors

scientific article published on 25 September 2014

The clinical implications of medulloblastoma subgroups

scientific article published on 08 May 2012

The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants

scientific article

The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation

scientific article

The genetics of pediatric brain tumors

scientific article published on May 2010

The molecular landscape of ETMR at diagnosis and relapse

scientific article published on 04 December 2019

The transcriptional landscape of Shh medulloblastoma

scientific article published on 19 March 2021

The whole-genome landscape of medulloblastoma subtypes

scientific article published in July 2017

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis

scientific article published on 06 June 2016

Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas

scientific article

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

scientific article published on 20 December 2017

Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma

scientific article published on 18 May 2020

Ultra high-risk PFA ependymoma is characterized by loss of chromosome 6q

scientific article published on 01 August 2021

Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics

scientific article

WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma

scientific article

scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy

scientific article published on 20 December 2019

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