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List of works by Nicole P Juffermans

A consensus redefinition of transfusion-related acute lung injury

scientific article published on 16 April 2019

A dose-finding study of methylene blue to inhibit nitric oxide actions in the hemodynamics of human septic shock

scientific article

A new twist on the legend of granulocyte colony-stimulating factor in acute lung injury?

scientific article published in April 2009

A randomized trial of remote ischemic preconditioning and control treatment for cardioprotection in sevoflurane-anesthetized CABG patients.

scientific article

A short course of infusion of a hydrogen sulfide-donor attenuates endotoxemia induced organ injury via stimulation of anti-inflammatory pathways, with no additional protection from prolonged infusion

scientific article

Accumulation of bioactive lipids during storage of blood products is not cell but plasma derived and temperature dependent

scientific article published on 16 May 2011

Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis

scientific article published on 07 April 2020

An update of the transfusion-related acute lung injury (TRALI) definition.

scientific article published on 12 June 2019

Anemia and blood transfusion and outcome on the intensive care unit

scientific article

Antiplatelet therapy in bleeding trauma patients: tales of the unexpected

scientific article

Are there any alternatives for transfusion of AB plasma as universal donor in an emergency release setting?

scientific article published on 25 February 2016

Association between Maturation and Aging and Pulmonary Responses in Animal Models of Lung Injury: A Systematic Review

scientific article published on August 2015

Association between tidal volume size, duration of ventilation, and sedation needs in patients without acute respiratory distress syndrome: an individual patient data meta-analysis.

scientific article

Association between viscoelastic tests-guided therapy with synthetic factor concentrates and allogenic blood transfusion in liver transplantation: a before-after study

scientific article published on 22 December 2018

Associations between bolus infusion of hydrocortisone, glycemic variability and insulin infusion rate variability in critically Ill patients under moderate glycemic control.

scientific article

Associations between dynamics of the blood glucose level after hypoglycemia and intensive care unit mortality: a retrospective multicenter study

scientific article published on 10 July 2015

Bench-to-bedside review: bacterial pneumonia with influenza - pathogenesis and clinical implications

scientific article

Biological mechanisms implicated in adverse outcomes of sex mismatched transfusions

scientific article published on 01 May 2019

Blood manufacturing methods affect red blood cell product characteristics and immunomodulatory activity

scientific article published on 01 September 2018

Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study.

scientific article published on 11 February 2011

Carbon dioxide dynamics in relation to neurological outcome in resuscitated out-of-hospital cardiac arrest patients: an exploratory Target Temperature Management Trial substudy

scientific article published on 18 August 2018

Cardiac arrest patients have an impaired immune response, which is not influenced by induced hypothermia

scientific article

Cerebral air embolism after arthrography of the ankle.

scientific article

Changes in the inflammatory response following cardiac arrest: a matter of ischemia/reperfusion or induced hypothermia?

scientific article published on 01 November 2012

Changes in ventilator settings and ventilation-induced lung injury in burn patients-A systematic review

scientific article published on 12 June 2019

Clearance and phenotype of extracellular vesicles after red blood cell transfusion in a human endotoxemia model

scientific article published on 22 June 2019

Clearance of stored red blood cells is not increased compared with fresh red blood cells in a human endotoxemia model

scientific article published on 04 April 2016

Clinical practice of respiratory virus diagnostics in critically ill patients with a suspected pneumonia: A prospective observational study.

scientific article published on 16 August 2016

Coagulopathy as a therapeutic target for TRALI: rationale and possible sites of action

scientific article published on January 2012

Comparison of three transfusion protocols prior to central venous catheterization in patients with cirrhosis: A randomized controlled trial

scientific article published on 02 December 2019

Continuous postoperative pericardial flushing method versus standard care for wound drainage after adult cardiac surgery: A randomized controlled trial

scientific article published on 25 April 2020

Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitis

scientific article published in January 2002

Contribution of damage-associated molecular patterns to transfusion-related acute lung injury in cardiac surgery

scientific article

CpG oligodeoxynucleotides enhance host defense during murine tuberculosis

scientific article

Data-driven Development of ROTEM and TEG Algorithms for the Management of Trauma Hemorrhage

scientific article published on 01 December 2019

Determinants of gentamicin concentrations in critically ill patients: a population pharmacokinetic analysis.

scientific article published on 16 December 2016

Determinants of transfusion decisions in a mixed medical-surgical intensive care unit: a prospective cohort study

scientific article published on April 2009

Developing specific therapeutic strategies for transfusion-related acute lung injury. An overview of potentially useful animal models

scientific article published on October 2007

Development and first evaluation of a novel multiplex real-time PCR on whole blood samples for rapid pathogen identification in critically ill patients with sepsis

scientific article published on 26 April 2018

Development of a model for anemia of inflammation that is relevant to critical care

scientific article published on 25 July 2019

Diabetes insipidus as a complication of cryptococcal meningitis in an HIV-infected patient

scientific article

Early increase in anti-inflammatory biomarkers is associated with the development of multiple organ dysfunction syndrome in severely injured trauma patients

scientific article published on 23 October 2019

Early intravenous unfractionated heparin and outcome in acute lung injury and acute respiratory distress syndrome – a retrospective propensity matched cohort study ⬇️

scientific article published on August 15, 2012

Effect of On-Demand vs Routine Nebulization of Acetylcysteine With Salbutamol on Ventilator-Free Days in Intensive Care Unit Patients Receiving Invasive Ventilation: A Randomized Clinical Trial

scientific article published on 01 March 2018

Effect of a Low vs Intermediate Tidal Volume Strategy on Ventilator-Free Days in Intensive Care Unit Patients Without ARDS: A Randomized Clinical Trial

scientific article published in The Journal of the American Medical Association

Effect of extracorporeal CO2 removal on right ventricular and hemodynamic parameters in a patient with acute respiratory distress syndrome

scientific article published on 6 December 2015

Effect of transfusion of fresh frozen plasma on parameters of endothelial condition and inflammatory status in non-bleeding critically ill patients: a prospective substudy of a randomized trial.

scientific article published on 15 April 2015

Effectiveness and Clinical Outcomes of a Two-Step Implementation of Conservative Oxygenation Targets in Critically Ill Patients: A Before and After Trial.

scientific article published on 11 November 2015

Effects of a hospital-wide introduction of a massive transfusion protocol on blood product ratio and blood product waste

scientific article published on October 2015

Endogenous microparticles drive the proinflammatory host immune response in severely injured trauma patients

scientific article published on 01 April 2015

Endotoxemia Results in Trapping of Transfused Red Blood Cells in Lungs with Associated Lung Injury

scientific article published in October 2017

Erratum

scholarly article published in Transfusion Medicine and Hemotherapy

Expression of human immunodeficiency virus coreceptors CXC chemokine receptor 4 and CC chemokine receptor 5 on monocytes is down-regulated during human endotoxemia

scientific article published on 19 March 2002

Extracellular Vesicles from Red Blood Cell Products Induce a Strong Pro-Inflammatory Host Response, Dependent on Both Numbers and Storage Duration

scientific article

Fill the critical care discovery pipeline with ICMx!

scientific article published on 09 November 2020

Fluid restriction reduces pulmonary edema in a model of acute lung injury in mechanically ventilated rats

scientific article published in PLoS ONE

From protective ventilation to super-protective ventilation for acute respiratory distress syndrome ⬇️

scientific article published on January 10, 2013

HEPBURN - investigating the efficacy and safety of nebulized heparin versus placebo in burn patients with inhalation trauma: study protocol for a multi-center randomized controlled trial.

scientific article published on 25 March 2014

Heliox Improves Carbon Dioxide Removal during Lung Protective Mechanical Ventilation

scientific article published on 7 December 2014

Heliox allows for lower minute volume ventilation in an animal model of ventilator-induced lung injury

scientific article

Helium ventilation for treatment of post-cardiac arrest syndrome: A safety and feasibility study.

scientific article published on 26 July 2016

Hemodynamic management of critically ill burn patients: an international survey

scientific article published on 17 August 2018

High levels of S100A8/A9 proteins aggravate ventilator-induced lung injury via TLR4 signaling

scientific article

High-dose acetylsalicylic acid is superior to low-dose as well as to clopidogrel in preventing lipopolysaccharide-induced lung injury in mice

scientific article published in October 2013

Hydrogen sulfide donor NaHS reduces organ injury in a rat model of pneumococcal pneumosepsis, associated with improved bio-energetic status

scientific article

Hydrogen sulfide: a hot molecule

scientific article published on 01 November 2011

Hyperoxia provokes a time- and dose-dependent inflammatory response in mechanically ventilated mice, irrespective of tidal volumes

scientific article published on 26 May 2017

Hypothermia as a predictor for mortality in trauma patients at admittance to the Intensive Care Unit

scientific article published on July 2016

Hypothermia in acute lung injury: reduction of barotrauma or biotrauma?

scientific article published on 01 November 2007

In the critically ill patient, diabetes predicts mortality independent of statin therapy but is not associated with acute lung injury: a cohort study

scientific article

Incidence, risk factors, and outcome of transfusion-related acute lung injury in critically ill children: a retrospective study

scientific article published on 8 October 2014

Induced Hypothermia in Patients with Septic Shock and Ventilator-demanding Respiratory Failure.

scientific article published on 4 October 2017

Induced hypothermia in patients with septic shock and respiratory failure (CASS): a randomised, controlled, open-label trial

scientific article

Induced hypothermia is associated with reduced circulating subunits of mitochondrial DNA in cardiac arrest patients

scientific article published on 13 April 2017

Induced hypothermia is protective in a rat model of pneumococcal pneumonia associated with increased adenosine triphosphate availability and turnover*.

scientific article published in March 2012

Infectious complications after out-of-hospital cardiac arrest-A comparison between two target temperatures.

scientific article published on 16 December 2016

Influenza and other respiratory viruses are underdiagnosed in critically ill patients

scientific article

Interaction between peri-operative blood transfusion, tidal volume, airway pressure and postoperative ARDS: an individual patient data meta-analysis

scientific article published in January 2018

Interhospital critical care transports: a safe trip indeed!

scientific article

Invasive aspergillosis in patients admitted to the intensive care unit with severe influenza: a retrospective cohort study

scientific article published on 31 July 2018

Iron metabolism in critically ill patients developing anemia of inflammation: a case control study.

scientific article published on 2 May 2018

Is fever control or improved survival the 'risk factor' for ventilator-associated pneumonia?

scientific article published on 30 April 2015

Maldistribution of interalveolar perfusion--one early step in the pathogenesis of lung injury?

scientific article published in February 2008

Mathematical model and calculation to predict the effect of prophylactic plasma transfusion on change in international normalized ratio in critically ill patients with coagulopathy

scientific article published on 31 December 2015

Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice

scientific article published on 19 January 2009

Mechanical ventilation with heliox in an animal model of acute respiratory distress syndrome

scientific article published on 6 February 2014

Mechanisms of red blood cell transfusion-related immunomodulation.

scientific article published on 30 January 2018

Methylprednisolone fails to attenuate lung injury in a mouse model of transfusion related acute lung injury

scientific article published on 27 August 2013

Microbiological profile of nosocomial infections following cardiac arrest: Insights from the targeted temperature management (TTM) trial

scientific article published on 04 February 2020

Microparticles: Still Far From Being the Ideal Biomarker for Ventilator-Associated Lung Injury

scientific article published on 01 December 2015

Mild hypothermia reduces ventilator-induced lung injury, irrespective of reducing respiratory rate

scientific article published on 10 November 2011

Mitochondrial DNA is Released in Urine of Sirs Patients with Acute Kidney Injury and Correlates with Severity of Renal Dysfunction

scientific article published on 23 August 2017

Moderate positive predictive value of a multiplex real-time PCR on whole blood for pathogen detection in critically ill patients with sepsis

scientific article published on 26 June 2019

Monocyte-mediated activation of endothelial cells occurs only after binding to extracellular vesicles from red blood cell products, a process mediated by β-integrin

scientific article published on 7 November 2016

Myocardial Function during Low versus Intermediate Tidal Volume Ventilation in Patients without Acute Respiratory Distress Syndrome

scientific article published on 11 February 2020

Nebulized C1-Esterase Inhibitor does not Reduce Pulmonary Complement Activation in Rats with Severe Streptococcus Pneumoniae Pneumonia.

scientific article published on 28 September 2016

Nebulized Heparin in Burn Patients with Inhalation Trauma-Safety and Feasibility

scientific article published on 25 March 2020

Nebulized anticoagulants for acute lung injury - a systematic review of preclinical and clinical investigations

scientific article published on 12 December 2012

Nebulized anticoagulants in lung injury in critically ill patients-an updated systematic review of preclinical and clinical studies

scientific article published in November 2017

New blood for old? High quality evidence that fresh red blood cells confer no benefit for critically ill patients.

scientific article published on 14 March 2018

Nlrp3 plays no role in acute cardiac infarction due to low cardiac expression.

scientific article published on 10 October 2014

No association between systemic complement activation and intensive care unit-acquired weakness.

scientific article

Nurses versus physician-led interhospital critical care transport: a randomized non-inferiority trial

scientific article published on 11 May 2016

Opinions and Management of Hypothermic Sepsis: Results from an Online Survey

scientific article published on 24 June 2019

Outcome of red blood cell transfusion: ladies first, but perhaps not in donation

scientific article published in February 2018

PReVENT--protective ventilation in patients without ARDS at start of ventilation: study protocol for a randomized controlled trial

scientific article published on 24 May 2015

Pathogenesis of non-antibody mediated transfusion-related acute lung injury from bench to bedside

scientific article published on 20 September 2014

Perioperative proADM-change is associated with the development of acute respiratory distress syndrome in critically ill cardiac surgery patients: a prospective cohort study

scientific article published on 23 September 2019

Plasminogen activator inhibitor-type I gene deficient mice show reduced influx of neutrophils in ventilator-induced lung injury

scientific article

Point accuracy and reliability of an interstitial continuous glucose-monitoring device in critically ill patients: a prospective study

scientific article

Population Pharmacokinetics of Ganciclovir in Critically Ill Patients

scientific article published on 01 April 2020

Possible TRALI is a real entity

scientific article published on 10 July 2017

Potential applications of hydrogen sulfide-induced suspended animation

scientific article published on January 2009

Potential diagnostic markers for disseminated intravascular coagulation of sepsis

scientific article

Potential of Parameters of Iron Metabolism for the Diagnosis of Anemia of Inflammation in the Critically Ill

scientific article published on 03 May 2019

Practice of mechanical ventilation in cardiac arrest patients and effects of targeted temperature management: A substudy of the targeted temperature management trial

scientific article published on 12 May 2018

Pre-treatment with allopurinol or uricase attenuates barrier dysfunction but not inflammation during murine ventilator-induced lung injury ⬇️

scientific article published on November 30, 2012

Predictive performance of a gentamicin population pharmacokinetic model in two western populations of critically ill patients

scientific article published on 26 April 2018

Prevalence, predictors and outcome of hypofibrinogenaemia in trauma: a multicentre observational study.

scientific article

Preventing TRALI: ladies first, what follows?

scientific article published on 01 December 2008

Prevention of VAP: "WHAP" should we do?

scientific article published on 01 February 2010

Preventive nebulization of mucolytic agents and bronchodilating drugs in invasively ventilated intensive care unit patients (NEBULAE): study protocol for a randomized controlled trial

scientific article

Pulmonary coagulopathy as a new target in lung injury--a review of available pre-clinical models

scientific article published on January 2008

RELAx - REstricted versus Liberal positive end-expiratory pressure in patients without ARDS: protocol for a randomized controlled trial.

scientific article published on 9 May 2018

Recognition and Management of Hemostatic Disorders in Critically ill Patients Needing to Undergo an Invasive Procedure

scientific article

Recombinant human soluble tumor necrosis factor-alpha receptor fusion protein partly attenuates ventilator-induced lung injury

scientific article published on 01 March 2009

Red blood cell clearance in inflammation

scientific article published on 06 September 2012

Red blood cell transfusion results in adhesion of neutrophils in human endotoxemia and in critically ill patients with sepsis

scientific article published on 05 December 2019

Red-blood-cell manufacturing methods and storage solutions differentially induce pulmonary cell activation

scientific article published on 12 March 2020

Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice.

scientific article

Reporting transfusion-related acute lung injury by clinical and preclinical disciplines

scientific article published on 05 April 2017

Respiratory Viruses in Invasively Ventilated Critically Ill Patients-A Prospective Multicenter Observational Study

scientific article published on 6 October 2017

Risk factors and outcome of transfusion-related acute lung injury in the critically ill: a nested case-control study

scientific article

Risk factors for trauma-induced coagulopathy- and transfusion-associated multiple organ failure in severely injured trauma patients

scientific article published on 24 April 2015

Risk factors, host response and outcome of hypothermic sepsis.

scientific article

Selective decontamination of the digestive tract halves the prevalence of ventilator-associated pneumonia compared to selective oral decontamination.

scientific article published on 11 May 2017

Self-reported attitudes versus actual practice of oxygen therapy by ICU physicians and nurses

scientific article

Severe murine typhus with pulmonary system involvement

scientific article

Short-Course Adjunctive Gentamicin as Empirical Therapy in Patients With Severe Sepsis and Septic Shock: A Prospective Observational Cohort Study

scientific article published on 28 February 2017

Sildenafil attenuates pulmonary arterial pressure but does not improve oxygenation during ARDS

scientific article

Soluble CD40 ligand, a mediator of sepsis or of transfusion-related adverse effects?

scientific article published on 31 May 2011

Soluble receptor for advanced glycation end products as an indicator of pulmonary vascular injury after cardiac surgery

scientific article

Supernatant of Aged Erythrocytes Causes Lung Inflammation and Coagulopathy in a “Two-Hit” In Vivo Syngeneic Transfusion Model

scientific article published on 01 July 2010

Supernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion model

scientific article published on 17 May 2010

Suspended animation inducer hydrogen sulfide is protective in an in vivo model of ventilator-induced lung injury

scientific article

Targeted temperature management at 33°C versus 36°C after cardiac arrest

scientific article published on 17 November 2013

The Ability of Extracellular Vesicles to Induce a Pro-Inflammatory Host Response

scientific article

The Area Under the Concentration-Time Curve Is a Better Estimate for Vancomycin Exposure Than Trough Levels.

scientific article published in September 2015

The S100A10 Pathway Mediates an Occult Hyperfibrinolytic Subtype in Trauma Patients

scientific article published on 19 March 2018

The age of red blood cells is associated with bacterial infections in critically ill trauma patients ⬇️

scientific article published on February 22, 2012

The aged erythrocyte: key player in cancer progression, but also in infectious and respiratory complications of blood transfusion?

scientific article published on 01 August 2009

The current status of viscoelastic testing in septic coagulopathy

scientific article published on 23 October 2019

The divergent clinical presentations of transfusion-related acute lung injury illustrated by two case reports

scientific article published on October 1, 2010

The effect of blood transfusion on pulmonary permeability in cardiac surgery patients: a prospective multicenter cohort study ⬇️

scientific article published on July 11, 2011

The effect of induced hypothermia on respiratory parameters in mechanically ventilated patients ⬇️

scientific article published on October 14, 2010

The effect of red blood cell transfusion on iron metabolism in critically ill patients

scientific article published on 31 December 2018

The effect of red blood cell transfusion on platelet function in critically ill patients

scientific article published on 01 November 2019

The effect of washing of stored red blood cell transfusion units on post transfusion recovery and outcome in a pneumosepsis animal model

scientific article published on 17 March 2020

The extent of ventilator-induced lung injury in mice partly depends on duration of mechanical ventilation.

scientific article published on 17 April 2013

The importance of discovery science in the development of therapies for the critically ill

scientific article published on 26 May 2020

The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study ⬇️

scientific article published on February 16, 2011

The potential of heliox as a therapy for acute respiratory distress syndrome in adults and children: a descriptive review

scientific article published on 31 January 2015

The practice of reporting transfusion-related acute lung injury: a national survey among clinical and preclinical disciplines

scientific article published on 5 October 2009

The research agenda for trauma critical care.

scientific article

The role of bronchoalveolar hemostasis in the pathogenesis of acute lung injury

scientific article published on July 2008

Therapeutic drug monitoring of gentamicin peak concentrations in critically ill patients.

scientific article

There is no place (yet) for routine administration of sildenafil to patients with ARDS

Thromboelastometry and organ failure in trauma patients: a prospective cohort study

scientific article

Thromboelastometry in critically ill patients with disseminated intravascular coagulation

scientific article published on 01 July 2019

Towards patient-specific management of trauma hemorrhage: the effect of resuscitation therapy on parameters of thromboelastometry

scientific article published on 17 February 2019

Transfusion in Critical Care

scientific article

Transfusion in myocardial infarction: bloodcurdling?

scientific article published in June 2013

Transfusion of 35-Day Stored RBCs in the Presence of Endotoxemia Does Not Result in Lung Injury in Humans.

scientific article

Transfusion of 35-day stored red blood cells does not result in increase of plasma non-transferrin bound iron in human endotoxemia

scientific article published on 3 October 2016

Transfusion of 35-day-stored red blood cells does not alter lipopolysaccharide tolerance during human endotoxemia.

scientific article published on 4 April 2017

Transfusion of autologous extracellular vesicles from stored red blood cells does not affect coagulation in a model of human endotoxemia

scientific article published on 25 March 2018

Transfusion of fresh frozen plasma in non-bleeding ICU patients--TOPIC trial: study protocol for a randomized controlled trial

scientific article published on 23 December 2011

Transfusion of fresh-frozen plasma in critically ill patients with a coagulopathy before invasive procedures: a randomized clinical trial (CME).

scientific article

Transfusion of platelets, but not of red blood cells, is independently associated with nosocomial infections in the critically ill. ⬇️

scientific article published on 19 July 2016

Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine

scientific article published on 7 January 2020

Transfusion-related acute lung injury

scientific article published in January 2013

Transfusion-related acute lung injury in cardiac surgery patients is characterized by pulmonary inflammation and coagulopathy: a prospective nested case-control study

scientific article published in October 2012

Transfusion-related acute lung injury: a clinical review

scientific article published on May 2013

Transfusion-related acute lung injury: a preventable syndrome? ⬇️

scientific article published on February 1, 2012

Transfusion-related acute lung injury: emerging importance of host factors and implications for management ⬇️

scientific article published on August 1, 2010

Transfusion-related risk of secondary bacterial infections in sepsis patients: a retrospective cohort study

scientific article published in April 2011

Traumatic brain injury in rats induces lung injury and systemic immune suppression

scientific article

Treatment with broadly neutralizing influenza antibodies reduces severity of secondary pneumococcal pneumonia in mice

scientific article published on 12 June 2018

Use of a high platelet-to-RBC ratio of 2:1 is more effective in correcting trauma-induced coagulopathy than a ratio of 1:1 in a rat multiple trauma transfusion model

scientific article published on 25 July 2019

Utility of thromboelastography and/or thromboelastometry in adults with sepsis: a systematic review

scientific article

Ventilator-associated pneumonia prevention: WHAP, positive end-expiratory pressure, or both?

scientific article published on 01 August 2008

Viscoelastic Testing in Trauma

scientific article published on April 2017

Volume incompliance and transfusion are essential for transfusion-associated circulatory overload: a novel animal model

scientific article published on 07 November 2019

Washing or filtering of blood products does not improve outcome in a rat model of trauma and multiple transfusion

scientific article published on 21 November 2018

Why translational research matters: proceedings of the third international symposium on acute lung injury translational research (INSPIRES III)

scientific article published on 25 July 2019

iTACTIC - implementing Treatment Algorithms for the Correction of Trauma-Induced Coagulopathy: study protocol for a multicentre, randomised controlled trial

scientific article published on 18 October 2017

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