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List of works by Michael J Holtzman

"Hit-and-run" effects of paramyxoviruses as a basis for chronic respiratory disease

scientific article

A New Electrospray Aerosol Generator with High Particle Transmission Efficiency ⬇️

scientific article published on May 18, 2011

A centennial history of research on asthma pathogenesis

scientific article

A transgenic FOXJ1-Cre system for gene inactivation in ciliated epithelial cells.

scientific article published on 25 January 2007

Acute and chronic airway responses to viral infection: implications for asthma and chronic obstructive pulmonary disease

scientific article

Airway epithelial versus immune cell Stat1 function for innate defense against respiratory viral infection

scientific article published on 01 March 2008

Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum.

scientific article published in May 2006

Alternatively activated macrophages and airway disease

scientific article

Alternatively activated macrophages as cause or effect in airway disease

scientific article published on 01 July 2010

An acoustofluidic sputum liquefier

scientific article published in July 2015

Antigen-nonspecific recruitment of Th2 cells to the lung as a mechanism for viral infection-induced allergic asthma

scientific article published in November 2002

Antiviral IFN-γ responses of monocytes at birth predict respiratory tract illness in the first year of life ⬇️

scientific article published on March 27, 2012

Apoptosis in the airways: another balancing act in the epithelial program.

scientific article

Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens ⬇️

scientific article published on August 1, 2012

Asthma exacerbations after glucocorticoid withdrawal reflects T cell recruitment to the airway

scientific article

Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia

scientific article published on 08 December 2021

Author Correction: The choroid plexus is an important circadian clock component

scientific article published on 20 November 2019

Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals.

scientific article

Buprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically active

scientific article

Chemokine complexity: the case for CCL5.

scientific article published in August 2006

Chemokine signaling regulates apoptosis as well as immune cell traffic in host defense

scientific article published on 15 February 2006

Chemosensory functions for pulmonary neuroendocrine cells

scientific article

Cigarette smoke induces nucleic-acid oxidation in lung fibroblasts

scientific article

Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate

scientific article published on 02 February 2022

Controls for lung dendritic cell maturation and migration during respiratory viral infection

scientific article published in August 2007

Correction: SH2 Modified STAT1 Induces HLA-I Expression and Improves IFN-γ Signaling in IFN-α Resistant HCV Replicon Cells.

scientific article published on 17 November 2010

Cutting Edge: CD49d+ Neutrophils Induce FcεRI Expression on Lung Dendritic Cells in a Mouse Model of Postviral Asthma ⬇️

scientific article published on September 27, 2010

Cutting edge: B and T lymphocyte attenuator and programmed death receptor-1 inhibitory receptors are required for termination of acute allergic airway inflammation

scientific article published in April 2006

Defining and adjusting divergent host responses to viral infection

scientific article

Dentate gyrus morphogenesis is regulated by β-CATENIN function in hem-derived fimbrial glia

scientific article published in 2022

Detection of respiratory viruses and the associated chemokine responses in serious acute respiratory illness

scientific article

Detection of severe human metapneumovirus infection by real-time polymerase chain reaction and histopathological assessment

scientific article published on 4 August 2005

Determinants of outcome for patients admitted to a long-term ventilator unit

scientific article published in March 2002

Developing the epithelial, viral, and allergic paradigm for asthma: Giles F. Filley lecture.

scientific article

Differential role of Janus family kinases (JAKs) in interferon-gamma-induced lung epithelial ICAM-1 expression: involving protein interactions between JAKs, phospholipase Cgamma, c-Src, and STAT1.

scientific article published in March 2004

Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to Sendai virus infection

scientific article published on March 2008

Does chloride channel accessory 3 have a role in arthritis pain? A study on murine antigen-induced arthritis

scientific article published on 04 June 2014

Drug development for asthma

scientific article

Emerging role of dendritic cells in respiratory viral infection

scientific article published on 22 May 2007

Epithelial Chloride Transport by CFTR Requires TMEM16A.

scientific article published on 29 September 2017

Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma.

scientific article

Epithelial cell proliferation contributes to airway remodeling in severe asthma

scientific article

Genetic segregation of airway disease traits despite redundancy of calcium-activated chloride channel family members.

scientific article published on 28 March 2006

Genetic variability of human metapneumovirus infection: evidence of a shift in viral genotype without a change in illness

scientific article published on 28 December 2005

Group 2 Innate Lymphoid Cells Must Partner with the Myeloid-Macrophage Lineage for Long-Term Postviral Lung Disease

scientific article published on 08 July 2020

Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain

scientific article

High throughput screening for small molecule enhancers of the interferon signaling pathway to drive next-generation antiviral drug discovery

scientific article

High-Throughput Screening Normalized to Biological Response: Application to Antiviral Drug Discovery ⬇️

scientific article published on July 16, 2013

Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis

scientific article

Host epithelial–viral interactions as cause and cure for asthma ⬇️

scientific article published on June 22, 2011

Hypersusceptibility to respiratory viruses as a shared mechanism for asthma, chronic obstructive pulmonary disease, and cystic fibrosis

scientific article published on 01 June 2011

IL-13-induced airway mucus production is attenuated by MAPK13 inhibition

scientific article

IL13 activates autophagy to regulate secretion in airway epithelial cells

scientific article published on 10 June 2015

Immune pathways for translating viral infection into chronic airway disease.

scientific article

Immunity, Inflammation, and Remodeling in the Airway Epithelial Barrier: Epithelial-Viral-Allergic Paradigm ⬇️

scientific article published on January 1, 2002

Immunogenetic programs for viral induction of mucous cell metaplasia

scientific article

Impaired CD8(+) T cell immunity after allogeneic bone marrow transplantation leads to persistent and severe respiratory viral infection

scientific article

Increased iron sequestration in alveolar macrophages in chronic obstructive pulmonary disease

scientific article

Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection

scientific article

Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia

scientific article

Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells

scientific article

Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma

scientific article

Interferon-gamma-induced epithelial ICAM-1 expression and monocyte adhesion. Involvement of protein kinase C-dependent c-Src tyrosine kinase activation pathway

scientific article published on 20 December 2001

Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node

scientific article (publication date: June 2003)

Involvement of the p38 MAPK pathway in IL-13-induced mucous cell metaplasia in mouse tracheal epithelial cells

scientific article

Linking acute infection to chronic lung disease. The role of IL-33-expressing epithelial progenitor cells

scientific article

Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease.

scientific article published on 15 August 2013

Long-term IL-33–producing epithelial progenitor cells in chronic obstructive lung disease.

scientific article published on 2 December 2013

Macrophage chitinase 1 stratifies chronic obstructive lung disease

scientific article published on 2 June 2009

Melanoma Differentiation-Associated Gene 5 (MDA5) Is Involved in the Innate Immune Response to Paramyxoviridae Infection In Vivo

scientific article

Modification of the Stat1 SH2 domain broadly improves interferon efficacy in proportion to p300/CREB-binding protein coactivator recruitment

scientific article published on 17 August 2005

Molecular heterogeneity in the choroid plexus epithelium: the 22-member γ-protocadherin family is differentially expressed, apically localized, and implicated in CSF regulation

scientific article published on 7 December 2011

Monitoring in vivo changes in lung microstructure with 3He MRI in Sendai virus-infected mice ⬇️

scientific article published on March 1, 2012

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

scientific article

New immune pathways from chronic post-viral lung disease

scientific article

Novel mode of ISG15-mediated protection against influenza A virus and Sendai virus in mice

scientific article

OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes

scientific article

Oxidative damage to nucleic acids in severe emphysema

scientific article published on 31 December 2008

P-glycoprotein is a major determinant of norbuprenorphine brain exposure and antinociception

scientific article

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

scientific article

PET-based Imaging of Chemokine Receptor 2 in Experimental and Disease-related Lung Inflammation

scientific article published on 3 January 2017

Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma

scientific article published on 21 September 2009

Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells

scientific article

Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

scientific article published on 18 May 2008

Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseases

scientific article published on 07 February 2014

Publisher Correction: SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

scientific article published on 02 September 2020

Reactive Oxygen Species Induce Antiviral Innate Immune Response through IFN-λ Regulation in Human Nasal Epithelial Cells ⬇️

scientific article published on November 1, 2013

Recurrent wheezing in children following human metapneumovirus infection.

scientific article

Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation

scientific article published on 14 October 2016

Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness

scientific article

Role of PKCdelta in IFN-gamma-inducible CIITA gene expression

scientific article published on 7 March 2007

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

scientific article published on 24 August 2020

STAT1 activation causes translocation of Bax to the endoplasmic reticulum during the resolution of airway mucous cell hyperplasia by IFN-gamma.

scientific article published in June 2007

STAT1 modification improves therapeutic effects of interferons on lung cancer cells

scientific article

Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation.

scientific article

Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma

scientific article

Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production.

scientific article

Specification of a Foxj1-Dependent Lineage in the Forebrain Is Required for Embryonic-to-Postnatal Transition of Neurogenesis in the Olfactory Bulb ⬇️

scientific article published on June 22, 2011

Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses.

scientific article published on 30 June 2017

TREM-2 promotes macrophage survival and lung disease after respiratory viral infection

scientific article published on 20 April 2015

The Induction of Pattern-Recognition Receptor Expression against Influenza A Virus through Duox2-Derived Reactive Oxygen Species in Nasal Mucosa

scientific article

The Red journal at 25 years. Looking back and looking ahead

scientific article published in May 2014

The choroid plexus is an important circadian clock component.

scientific article published on 14 March 2018

The crystal structure of phosphorylated MAPK13 reveals common structural features and differences in p38 MAPK family activation.

scientific article

The microbial metabolite desaminotyrosine protects from influenza through type I interferon.

scientific article

The role of CLCA proteins in inflammatory airway disease

scientific article (publication date: 2009)

The role of airway epithelial cells and innate immune cells in chronic respiratory disease

scientific article published on 19 September 2014

Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression

scientific article published on July 2016

Tracking cell lineage to rediscover (again) the switch from ciliated to mucous cells

scientific article published in March 2011

Transition, sunlight, and the art of journal maintenance

scientific article published on 01 July 2003

Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) expression tracks with M2-like macrophage activity and disease severity in COPD.

scientific article published on 7 October 2017

Viral and Host Strategies to Take Advantage of the Innate Immune Response ⬇️

scientific article published on 01 November 2010

Viral induction of a chronic asthma phenotype and genetic segregation from the acute response

scientific article

Where are the gaps in asthma research? A counter-perspective

scientific article published on 01 February 2003

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