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List of works by Jayachandran N Kizhakkedathu

A Novel Functional Polymer with Tunable LCST

A Polymer Therapeutic Having Universal Heparin Reversal Activity: Molecular Design and Functional Mechanism.

scientific article published on 7 September 2017

A nanoparticle-preparation kit using ethylene glycol-based block copolymers with a common temperature-responsive block

A pH and thermosensitive choline phosphate-based delivery platform targeted to the acidic tumor microenvironment

scientific article published on 07 October 2013

A planar model of the vessel wall from cellularized-collagen scaffolds: focus on cell-matrix interactions in mono-, bi- and tri-culture models

scientific article published on 5 December 2016

A thermoreversible poly(choline phosphate) based universal biomembrane adhesive.

scientific article published on 11 November 2013

ATRP synthesis of poly(2-(methacryloyloxy)ethyl choline phosphate): a multivalent universal biomembrane adhesive.

scientific article

Abnormal blood clot formation induced by temperature responsive polymers by altered fibrin polymerization and platelet binding

scientific article published on 31 December 2013

Advantages of replacing hydroxyethyl starch in University of Wisconsin solution with hyperbranched polyglycerol for cold kidney perfusion.

scientific article

Affinity-based design of a synthetic universal reversal agent for heparin anticoagulants.

scientific article published on 29 October 2014

Alteration of blood clotting and lung damage by protamine are avoided using the heparin and polyphosphate inhibitor UHRA.

scientific article published on 29 December 2016

An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient

scientific article published on 28 January 2019

An enzymatic pathway in the human gut microbiome that converts A to universal O type blood

scientific article published on 10 June 2019

An investigation of vibration-induced protein desorption mechanism using a micromachined membrane and PZT plate

scientific article published on October 2008

Anti-adhesive antimicrobial peptide coating prevents catheter associated infection in a mouse urinary infection model

scientific article

Antibacterial Surfaces Based on Polymer Brushes: Investigation on the Influence of Brush Properties on Antimicrobial Peptide Immobilization and Antimicrobial Activity

article

Antibacterial properties of hLf1-11 peptide onto titanium surfaces: a comparison study between silanization and surface initiated polymerization

scientific article published on 15 January 2015

Antigens protected functional red blood cells by the membrane grafting of compact hyperbranched polyglycerols

scientific article published on 2 January 2013

Antimicrobial Peptide-Polymer Conjugates with High Activity: Influence of Polymer Molecular Weight and Peptide Sequence on Antimicrobial Activity, Proteolysis, and Biocompatibility

scientific article published on 11 October 2017

Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo

scientific article published on 19 January 2018

Approaches to prevent bleeding associated with anticoagulants: current status and recent developments

scientific article

Attractive bridging interactions in dense polymer brushes in good solvent measured by atomic force microscopy.

scientific article

Aurein-Derived Antimicrobial Peptides Formulated with Pegylated Phospholipid Micelles to Target Methicillin-Resistant Staphylococcus aureus Skin Infections

scientific article published on 02 January 2019

Barrier Capacity of Hydrophilic Polymer Brushes To Prevent Hydrophobic Interactions: Effect of Graft Density and Hydrophilicity

Bending and stretching actuation of soft materials through surface-initiated polymerization

scientific article published on 21 April 2011

Biodegradable polyglycerols with randomly distributed ketal groups as multi-functional drug delivery systems.

scientific article

Biomembrane Interactions Reveal the Mechanism of Action of Surface-Immobilized Host Defense IDR-1010 Peptide

article

Blood Components Interactions to Ionic and Nonionic Glyconanogels.

scientific article published on 17 August 2015

Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface

scientific article published on 16 June 2020

Blood compatibility of novel water soluble hyperbranched polyglycerol-based multivalent cationic polymers and their interaction with DNA

scientific article published on 18 July 2006

Branched multifunctional polyether polyketals: variation of ketal group structure enables unprecedented control over polymer degradation in solution and within cells

scientific article

Carbohydrate structure dependent hemocompatibility of biomimetic functional polymer brushes on surfaces

scientific article published in March 2012

Chain Length and Grafting Density Dependent Enhancement in the Hydrolysis of Ester-Linked Polymer Brushes.

scientific article published on 3 June 2015

Choline phosphate functionalized cellulose membrane: A potential hemostatic dressing based on a unique bioadhesion mechanism

scientific article published on 23 June 2016

Chronic periodontitis is associated with platelet factor 4 (PF4) secretion: A pilot study

scientific article

Clinically approved iron chelators influence zebrafish mortality, hatching morphology and cardiac function

scientific article

Cold preservation with hyperbranched polyglycerol-based solution improves kidney functional recovery with less injury at reperfusion in rats

scientific article published on 15 February 2017

Comparative Degradomics of Porcine and Human Wound Exudates Unravels Biomarker Candidates for Assessment of Wound Healing Progression in Trauma Patients

scientific article published on 9 September 2017

Comparison of reversal activity and mechanism of action of UHRA, andexanet, and PER977 on heparin and oral FXa inhibitors

Complexes of poly(ethylene glycol)-based cationic random copolymer and calf thymus DNA: a complete biophysical characterization

scientific article published in March 2004

Conjugation of aurein 2.2 to HPG yields an antimicrobial with better properties.

scientific article published on 20 February 2015

Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts ⬇️

scientific article published on November 1, 2011

Deep Profiling of the Cleavage Specificity and Human Substrates of Snake Venom Metalloprotease HF3 by Proteomic Identification of Cleavage Site Specificity (PICS) Using Proteome Derived Peptide Libraries and Terminal Amine Isotopic Labeling of Subst

scientific article published on 08 August 2019

Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome.

scientific article published on 10 December 2012

Design Considerations for Developing Hyperbranched Polyglycerol Nanoparticles as Systemic Drug Carriers.

scientific article published on May 2016

Design of Polyphosphate Inhibitors: A Molecular Dynamics Investigation on Polyethylene Glycol-Linked Cationic Binding Groups.

scientific article published on 14 March 2018

Design of Safe Nanotherapeutics for the Excretion of Excess Systemic Toxic Iron

article

Design of long circulating nontoxic dendritic polymers for the removal of iron in vivo

scientific article published on 25 November 2013

Development of Antifouling and Bactericidal Coatings for Platelet Storage Bags Using Dopamine Chemistry

scientific article published on 29 September 2017

Development of soluble ester-linked aldehyde polymers for proteomics.

scientific article

Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis.

scientific article published on 29 June 2013

Durable Surfaces from Film-Forming Silver Assemblies for Long-Term Zero Bacterial Adhesion without Toxicity

scientific article published on 27 April 2022

Effect of Extreme Wettability on Platelet Adhesion on Metallic Implants: From Superhydrophilicity to Superhydrophobicity

scientific article

Electric field and vibration-assisted nanomolecule desorption and anti-biofouling for biosensor applications

scientific article published on 24 April 2007

Engineering biomaterials surfaces to modulate the host response

scientific article published on 20 August 2014

Enhanced cell surface polymer grafting in concentrated and nonreactive aqueous polymer solutions.

scientific article published in March 2010

Enhancement of biological reactions on cell surfaces via macromolecular crowding

scientific article

Evaluation of an atomic force microscopy pull-off method for measuring molecular weight and polydispersity of polymer brushes: effect of grafting density.

scientific article published in July 2004

Evaluation of hyperbranched polyglycerol for cold perfusion and storage of donor kidneys in a pig model of kidney autotransplantation

scientific article published on 24 October 2020

Formalin-Fixed, Paraffin-Embedded Tissues (FFPE) as a Robust Source for the Profiling of Native and Protease-Generated Protein Amino Termini.

scientific article published on 17 April 2016

Global Profiling of Proteolysis from the Mitochondrial Amino Terminome during Early Intrinsic Apoptosis Prior to Caspase-3 Activation

scientific article published on 29 October 2018

Hemocompatibility of Degrading Polymeric Biomaterials: Degradable Polar Hydrophobic Ionic Polyurethane versus Poly(lactic-co-glycolic) Acid

scientific article published on 16 June 2017

Hemocompatibility studies on a degradable polar hydrophobic ionic polyurethane (D-PHI).

scientific article published on 3 November 2016

High molecular weight polyglycerol-based multivalent mannose conjugates.

scientific article published on October 2010

Hybrid polyglycerols with long blood circulation: synthesis, biocompatibility, and biodistribution

scientific article published on 11 July 2014

Hydrophobically derivatized hyperbranched polyglycerol as a human serum albumin substitute

scientific article

Hyperbranched Glycopolymers for Blood Biocompatibility ⬇️

scientific article published on April 24, 2012

Hyperbranched polyglycerol as a colloid in cold organ preservation solutions

scientific article

Hyperbranched polyglycerol is an efficacious and biocompatible novel osmotic agent in a rodent model of peritoneal dialysis

scientific article published on January 2013

Hyperbranched polyglycerol is superior to glucose for long-term preservation of peritoneal membrane in a rat model of chronic peritoneal dialysis.

scientific article published on 13 December 2016

Hyperbranched polyglycerols: recent advances in synthesis, biocompatibility and biomedical applications

scientific article published on 07 November 2017

Identification of proteolytic products and natural protein N-termini by Terminal Amine Isotopic Labeling of Substrates (TAILS)

scientific article published on 01 January 2011

Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates

scientific article

In Vivo Biological Evaluation of High Molecular Weight Multifunctional Acid-Degradable Polymeric Drug Carriers with Structurally Different Ketals

scientific article published on 17 October 2016

In vitro chelating, cytotoxicity, and blood compatibility of degradable poly(ethylene glycol)-based macromolecular iron chelators

scientific article

In vivo assessment of protease dynamics in cutaneous wound healing by degradomics analysis of porcine wound exudates

scientific article

Influence of architecture of high molecular weight linear and branched polyglycerols on their biocompatibility and biodistribution

scientific article published on 25 September 2012

Influence of dynamic flow conditions on adsorbed plasma protein corona and surface-induced thrombus generation on antifouling brushes

scientific article published on 08 March 2018

Influence of polymer architecture on antigens camouflage, CD47 protection and complement mediated lysis of surface grafted red blood cells.

scientific article published on 26 July 2012

Inhibitory effect of hydrophilic polymer brushes on surface-induced platelet activation and adhesion

scientific article published on 15 October 2010

Interaction of blood components with cathelicidins and their modified versions.

scientific article published on 6 August 2015

Intravenously injected human apolipoprotein A-I rapidly enters the central nervous system via the choroid plexus

scientific article published on 12 November 2014

Investigation of hydrophobically derivatized hyperbranched polyglycerol with PEGylated shell as a nanocarrier for systemic delivery of chemotherapeutics.

scientific article published on 13 May 2015

In vivo circulation, clearance, and biodistribution of polyglycerol grafted functional red blood cells

scientific article published on 18 January 2012

In vivo efficacy, toxicity and biodistribution of ultra-long circulating desferrioxamine based polymeric iron chelator.

scientific article

Iron Binding and Iron Removal Efficiency of Desferrioxamine Based Polymeric Iron Chelators: Influence of Molecular Size and Chelator Density

scientific article published on 28 September 2016

Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products

scientific article

Laser-Light-Scattering Study of Internal Motions of Polymer Chains Grafted on Spherical Latex Particles

article by Cheng Yang et al published December 2004 in Journal of Physical Chemistry

Lectin interactions on surface-grafted glycostructures: influence of the spatial distribution of carbohydrates on the binding kinetics and rupture forces

scientific article

Linear and hyperbranched phosphorylcholine based homopolymers for blood biocompatibility

MANTI: Automated Annotation of Protein N-Termini for Rapid Interpretation of N-Terminome Data Sets

scientific article published on 17 March 2021

Master Sculptor at Work: Enteropathogenic Escherichia coli Infection Uniquely Modifies Mitochondrial Proteolysis during Its Control of Human Cell Death

scientific article published on 02 June 2020

Matrix Metalloproteinase 10 Degradomics in Keratinocytes and Epidermal Tissue Identifies Bioactive Substrates With Pleiotropic Functions

scientific article published on 16 October 2015

Mega macromolecules as single molecule lubricants for hard and soft surfaces

scientific article published on 01 May 2020

Modulation of Multivalent Protein Binding on Surfaces by Glycopolymer Brush Chemistry

scientific article published on January 2016

Modulation of complement activation and amplification on nanoparticle surfaces by glycopolymer conformation and chemistry

scientific article published on 15 August 2014

Molecular Dynamics Simulations on Nucleic Acid Binding Polymers Designed To Arrest Thrombosis

scientific article published on 20 August 2018

Molecular weight and polydispersity estimation of adsorbing polymer brushes by atomic force microscopy.

scientific article

Monitoring matrix metalloproteinase activity at the epidermal-dermal interface by SILAC-iTRAQ-TAILS.

scientific article published on 15 May 2015

Mucin-Inspired, High Molecular Weight Virus Binding Inhibitors Show Biphasic Binding Behavior to Influenza A Viruses

scientific article published on 01 November 2020

Multilayered coating on titanium for controlled release of antimicrobial peptides for the prevention of implant-associated infections

scientific article published on 13 May 2013

N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton.

scientific article published on 19 July 2017

N-Terminomics TAILS identifies host cell substrates of poliovirus and coxsackievirus B3 3C proteinases that modulate virus infection.

scientific article published on 7 February 2018

N-Terminomics/TAILS Profiling of Proteases and Their Substrates in Ulcerative Colitis

scientific article published on 21 August 2019

Nonbiofouling polymer brush with latent aldehyde functionality as a template for protein micropatterning

scientific article published in January 2010

Nontoxic polyphosphate inhibitors reduce thrombosis while sparing hemostasis.

scientific article

Nontransformed and Cancer Cells Can Utilize Different Endocytic Pathways To Internalize Dendritic Nanoparticle Variants: Implications on Nanocarrier Design

scientific article

Oncotically Driven Control over Glycocalyx Dimension for Cell Surface Engineering and Protein Binding in the Longitudinal Direction.

scientific article published on 15 May 2018

Peritoneal and Systemic Responses of Obese Type II Diabetic Rats to Chronic Exposure to a Hyperbranched Polyglycerol-Based Dialysis Solution

scientific article published on 21 June 2018

Plasma protein adsorption to surfaces grafted with dense homopolymer and copolymer brushes containing poly(N-isopropylacrylamide)

scientific article published on 01 January 2004

Poly(oligo(ethylene glycol)acrylamide) brushes by surface initiated polymerization: effect of macromonomer chain length on brush growth and protein adsorption from blood plasma.

scientific article

Polyglycerol based Macromolecular Iron Chelator Adjuvants for Antibiotics to Treat Drug Resistant Bacteria

scientific article published on 08 July 2020

Polymer brush-based approaches for the development of infection-resistant surfaces

scientific article published on 30 June 2014

Polymer-Nanoparticle Interaction as a Design Principle in the Development of a Durable Ultra-Thin Universal Binary Anti-Biofilm Coating with Long-Term Activity

scientific article published on 29 October 2018

Polymeric nanocarriers for the treatment of systemic iron overload

scientific article published on 24 March 2015

Polyvalent choline phosphate as a universal biomembrane adhesive.

scientific article published on 18 March 2012

Profiling of Protein N-Termini and Their Modifications in Complex Samples.

scientific article

Proteomic and N-Terminomic TAILS Analyses of Human Alveolar Bone Proteins: Improved Protein Extraction Methodology and LysargiNase Digestion Strategies Increase Proteome Coverage and Missing Protein Identification

scientific article published on 25 October 2019

Rationalized approach to the determination of contact point in force-distance curves: application to polymer brushes in salt solutions and in water

scientific article

Red blood cell membrane grafting of multi-functional hyperbranched polyglycerols

scientific article published on 20 February 2010

Reversible hemostatic properties of sulfabetaine/quaternary ammonium modified hyperbranched polyglycerol

scientific article published on 2 February 2016

Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFβ-1 signaling in ovarian cancer cells

scientific article published on October 2013

Self-assembled monothiol-terminated hyperbranched polyglycerols on a gold surface: a comparative study on the structure, morphology, and protein adsorption characteristics with linear poly(ethylene glycol)s

scientific article published on 25 March 2008

Simplified high yield TAILS terminomics using a new HPG-ALD 800K-2000 polymer with precipitation

scientific article published on 13 August 2019

Skin Barrier Defects Caused by Keratinocyte-Specific Deletion of ADAM17 or EGFR Are Based on Highly Similar Proteome and Degradome Alterations.

scientific article published on 11 April 2016

Stimuli-responsive cationic terpolymers by RAFT polymerization: Synthesis, characterization, and protein interaction studies

Surface Modification of Polyvinyl Chloride Sheets via Growth of Hydrophilic Polymer Brushes

Surface modification approaches for prevention of implant associated infections

scientific article published on 12 May 2020

Synthesis and characterization of carboxylic acid conjugated, hydrophobically derivatized, hyperbranched polyglycerols as nanoparticulate drug carriers for cisplatin

scientific article published on 3 December 2010

Synthesis and characterization of well-defined hydrophilic block copolymer brushes by aqueous ATRP

article

Synthesis of Functional Polymer Brushes Containing Carbohydrate Residues in the Pyranose Form and Their Specific and Nonspecific Interactions with Proteins ⬇️

scientific article published on October 18, 2010

Synthesis of Thermoresponsive Mixed Arm Star Polymers by Combination of RAFT and ATRP from a Multifunctional Core and Its Self-Assembly in Water

Synthesis of Well-Defined Environmentally Responsive Polymer Brushes by Aqueous ATRP

Synthesis of novel size exclusion chromatography support by surface initiated aqueous atom transfer radical polymerization.

scientific article published on 9 October 2007

Synthesis, characterization, and biocompatibility of biodegradable hyperbranched polyglycerols from acid-cleavable ketal group functionalized initiators

scientific article published on 5 September 2012

Targeting Biological Polyanions in Blood: Strategies towards the Design of Therapeutics

scientific article published on 04 June 2020

The biocompatibility and biofilm resistance of implant coatings based on hydrophilic polymer brushes conjugated with antimicrobial peptides

scientific article published on 5 March 2011

The induction of thrombus generation on nanostructured neutral polymer brush surfaces

scientific article published on September 2010

The influence of grafted polymer architecture and fluid hydrodynamics on protein separation by entropic interaction chromatography

scientific article published on 01 June 2007

The influence of poly-N-[(2,2-dimethyl-1,3-dioxolane)methyl]acrylamide on fibrin polymerization, cross-linking and clot structure

scientific article published on 01 August 2010

The mechanism and modulation of complement activation on polymer grafted cells

scientific article published on 16 November 2015

The mouse heart mitochondria N terminome provides insights into ClpXP-mediated proteolysis

scientific article published on 28 May 2020

The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury

scientific article published on 03 December 2018

The size-dependent efficacy and biocompatibility of hyperbranched polyglycerol in peritoneal dialysis

scientific article published on 15 November 2013

Therapeutic cells via functional modification: influence of molecular properties of polymer grafts on in vivo circulation, clearance, immunogenicity, and antigen protection.

scientific article published on 28 May 2013

Thermal reversal of polyvalent choline phosphate, a multivalent universal biomembrane adhesive.

scientific article published on 5 July 2013

Time-resolved analysis of the matrix metalloproteinase 10 substrate degradome.

scientific article

Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution

scientific article

Toward Infection-Resistant Surfaces: Achieving High Antimicrobial Peptide Potency by Modulating the Functionality of Polymer Brush and Peptide

scientific article

Towards Robust Delivery of Antimicrobial Peptides to Combat Bacterial Resistance

scientific article published on 03 July 2020

Transcriptome analysis of signaling pathways of human peritoneal mesothelial cells in response to different osmotic agents in a peritoneal dialysis solution

scientific article published on 21 May 2019

Understanding the interaction of polyelectrolyte architectures with proteins and biosystems

scientific article published on 26 June 2020

Use of Molecular Dynamics for the Refinement of an Electrostatic Model for the In Silico Design of a Polymer Antidote for the Anticoagulant Fondaparinux.

scientific article published on 24 July 2013

Water soluble nanoparticles from PEG-based cationic hyperbranched polymer and RNA that protect RNA from enzymatic degradation

scientific article

Water-soluble complexes from random copolymer and oppositely charged surfactant. 2. Complexes of poly(ethylene glycol)-based cationic random copolymer and bile salts

scientific article published in September 2004

Water-soluble nanoparticles from random copolymer and oppositely charged surfactant, 3a. Nanoparticles of poly(ethylene glycol)-based cationic random copolymer and fatty acid salts

scientific article published in June 2005

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