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List of works by Hiroyuki Inuzuka

APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction

scientific article

Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function.

scientific article

Acetylation-dependent regulation of Skp2 function

scientific article

Acetylation-dependent regulation of essential iPS-inducing factors: a regulatory crossroad for pluripotency and tumorigenesis

scientific article

An Evolving Role for DEPTOR in Tumor Development and Progression ⬇️

scientific article published on May 1, 2012

Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

scientific article published on 01 May 2019

Author Correction: Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle

scientific article published on 28 August 2020

Cdc20: a potential novel therapeutic target for cancer treatment

scientific article

Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways

scientific article published on 28 May 2009

Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

scientific article published on December 2011

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

scientific article

Cyclin C is a haploinsufficient tumour suppressor

scientific article

DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction ⬇️

scientific article published on September 1, 2012

Degradation of the transcription factor Twist, an oncoprotein that promotes cancer metastasis.

scientific article

Emerging roles of the FBW7 tumour suppressor in stem cell differentiation ⬇️

scientific article published on December 23, 2011

Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets

scientific article (publication date: 21 August 2003)

FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC.

scientific article published in May 2015

Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells

scientific article

LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma

scientific article

Mcl-1 ubiquitination and destruction

scientific article published on March 2011

Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase ⬇️

scientific article published on May 17, 2012

Negative regulation of DAB2IP by Akt and SCFFbw7 pathways

scientific article

Novel insights into the molecular mechanisms governing Mdm2 ubiquitination and destruction

scientific article published on November 2010

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

scientific article

Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase

scientific article

Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins

scientific article

Rictor Forms a Complex with Cullin-1 to Promote SGK1 Ubiquitination and Destruction ⬇️

scientific article published on September 10, 2010

Roles of F-box proteins in cancer

scientific article

SCF β-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration

scientific article published on December 2013

SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

scientific article

SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.

scientific article

SCF(β-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradation

scientific article

SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2.

scientific article

SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway

scientific article

SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression.

scientific article published on 22 August 2013

SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination

scientific article

SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer

scientific article

SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation

scientific article

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.

scientific article published on 2 September 2015

STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase

scientific article

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

scientific article published on 27 October 2013

Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle

scientific article published on 15 July 2020

Skp2 is a promising therapeutic target in breast cancer

scientific article published on January 2012

Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors.

scientific article published on 13 March 2018

Skp2: A novel potential therapeutic target for prostate cancer ⬇️

scientific article published on September 22, 2011

Smurf1 regulation of DAB2IP controls cell proliferation and migration

scientific article published on 27 March 2016

The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function

scientific article published on 7 February 2017

The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.

scientific article published on 03 January 2017

The two faces of FBW7 in cancer drug resistance.

scientific article

Tumor suppressor functions of FBW7 in cancer development and progression ⬇️

scientific article published on March 21, 2012

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR

scientific article

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