Search filters

List of works by Shigehira Saji

A close association between alteration in growth kinetics by neoadjuvant chemotherapy and survival outcome in primary breast cancer

scientific article published on August 2004

A low number of tumor-infiltrating FOXP3-positive cells during primary systemic chemotherapy correlates with favorable anti-tumor response in patients with breast cancer

scientific article published on 01 August 2009

A nonfucosylated anti-HER2 antibody augments antibody-dependent cellular cytotoxicity in breast cancer patients

scientific article published on March 2007

A phase I study of infusional 5-fluorouracil, leucovorin, oxaliplatin and irinotecan in Japanese patients with advanced colorectal cancer who harbor UGT1A1*1/*1,*1/*6 or *1/*28

scientific article published on 12 April 2012

A phase I/II pharmacokinetics/pharmacodynamics study of irinotecan combined with S-1 for recurrent/metastatic breast cancer in patients with selected UGT1A1 genotypes (the JBCRG-M01 study).

scientific article published on 13 November 2017

A phase II study of lapatinib for brain metastases in patients with HER2-overexpressing breast cancer following trastuzumab based systemic therapy and cranial radiotherapy: subset analysis of Japanese patients

scientific article published on 19 July 2012

A randomized, open-label, Phase III trial of pertuzumab retreatment in HER2-positive locally advanced/metastatic breast cancer patients previously treated with pertuzumab, trastuzumab and chemotherapy: the Japan Breast Cancer Research Group-M05 PREC

scientific article published on 01 September 2018

A role for the androgen receptor in follicular atresia of estrogen receptor beta knockout mouse ovary

scientific article published in January 2002

Adjuvant S-1 plus endocrine therapy for oestrogen receptor-positive, HER2-negative, primary breast cancer: a multicentre, open-label, randomised, controlled, phase 3 trial

scientific article published on 01 January 2021

Alcohol and postmenopausal breast cancer risk defined by estrogen and progesterone receptor status: a prospective cohort study

scientific article published in November 2005

Alcohol intake and risk of breast cancer defined by estrogen and progesterone receptor status--a meta-analysis of epidemiological studies

scientific article published in April 2008

Alternation of estrogen receptor and progesterone receptor expression in primary breast cancer patients treated with neoadjuvant chemotherapy

scientific article published on 10 June 2010

Analysis of estrogen receptor expression in tissues

scientific article published in January 2003

Application of selective estrogen receptor modulators for breast cancer treatment according to their intrinsic nature

scientific article published on 25 July 2008

Association of ABCC2 Genotype with Efficacy of First-line FOLFIRI in Japanese Patients with Advanced Colorectal Cancer ⬇️

scientific article published on December 27, 2011

Association of Double-Positive FOXA1 and FOXP1 Immunoreactivities with Favorable Prognosis of Tamoxifen-Treated Breast Cancer Patients ⬇️

scientific article published on April 3, 2012

Association of positive EBAG9 immunoreactivity with unfavorable prognosis in breast cancer patients treated with tamoxifen.

scientific article

Associations among baseline variables, treatment-related factors and health-related quality of life 2 years after breast cancer surgery.

scientific article published on 17 June 2011

Body weight and incidence of breast cancer defined by estrogen and progesterone receptor status--a meta-analysis

scientific article published in February 2009

Body weight and postmenopausal breast cancer risk defined by estrogen and progesterone receptor status among Swedish women: A prospective cohort study

scientific article published in October 2006

Breast Cancer Provider Interval Length in Fukushima, Japan, After the 2011 Triple Disaster: A Long-Term Retrospective Study

scientific article published on 06 September 2019

Breast cancer patient delay in Fukushima, Japan following the 2011 triple disaster: a long-term retrospective study

scientific article

CYP2D6 Genotype-Guided Tamoxifen Dosing in Hormone Receptor-Positive Metastatic Breast Cancer (TARGET-1): A Randomized, Open-Label, Phase II Study

scientific article published on 10 December 2019

Changes in Recurrence Score by neoadjuvant endocrine therapy of breast cancer and their prognostic implication

scientific article published on 27 February 2019

Characteristics of adverse events of endocrine therapies among older patients with breast cancer

scientific article published on 07 February 2019

Circulating cell-free DNA-based epigenetic assay can detect early breast cancer.

scientific article published on 19 December 2016

Clinical impact of assay of estrogen receptor beta cx in breast cancer

scientific article published in January 2002

Clinical importance of androgen receptor in breast cancer patients treated with adjuvant tamoxifen monotherapy

scientific article published on 04 February 2012

Clinical importance of estrogen receptor-beta evaluation in breast cancer patients treated with adjuvant tamoxifen therapy

scientific article published on August 2008

Clinical significance of estrogen receptor beta in breast cancer

scientific article

Clinical significance of the expression of autophagy-associated marker, beclin 1, in breast cancer patients who received neoadjuvant endocrine therapy ⬇️

scientific article

Clinical usefulness of high-dose toremifene in patients relapsed on treatment with an aromatase inhibitor

scientific article published on 15 August 2009

Clinicopathological analysis of ten patients with metaplastic squamous cell carcinoma of the breast ⬇️

scientific article published on 02 March 2011

Clinicopathological characteristics of breast cancer and trends in the management of breast cancer patients in Japan: Based on the Breast Cancer Registry of the Japanese Breast Cancer Society between 2004 and 2011.

scientific article published on 11 March 2015

Clinicopathological characteristics, practical treatments, prognosis, and clinical issues of older breast cancer patients in Japan

scientific article published on 21 November 2020

Cluster of differentiation 8 and programmed cell death ligand 1 expression in triple-negative breast cancer combined with autosomal dominant polycystic kidney disease and tuberous sclerosis complex: a case report

scientific article published on 24 December 2019

Combination of molecular-targeted drugs with endocrine therapy for hormone-resistant breast cancer

scientific article

Comparison of immune microenvironments between primary tumors and brain metastases in patients with breast cancer

scientific article published on 27 October 2017

Concomitant polypharmacy is associated with irinotecan-related adverse drug reactions in patients with cancer

scientific article published on 26 May 2012

Controversies in endocrine therapy for breast cancer

scientific article published in February 2004

Correction to: Trastuzumab, pertuzumab, and eribulin mesylate versus trastuzumab, pertuzumab, and a taxane as a first-line or second-line treatment for HER2-positive, locally advanced or metastatic breast cancer: study protocol for a randomized cont

scientific article published on 08 June 2020

Current status of antibody therapy for breast cancer

scientific article published on January 2004

DFU, a selective COX-2 inhibitor, suppresses MCF-7 xenograft tumor growth in mice

scientific article published on August 2004

Decision tree and paradigms of primary breast cancer: changes elicited by preoperative therapy.

scientific article

Delayed elimination of SN-38 in cancer patients with severe renal failure ⬇️

scientific article published on October 27, 2010

Development of breast cancer therapy: biomarker-driven and response-guided approaches in a neoadjuvant setting

scientific article published in April 2015

Dietary fiber intake and risk of postmenopausal breast cancer defined by estrogen and progesterone receptor status--a prospective cohort study among Swedish women

scientific article published on 01 January 2008

Differences in clinical importance of Bcl-2 in breast cancer according to hormone receptors status or adjuvant endocrine therapy.

scientific article published on 15 October 2015

Differential Involvement of Autophagy and Apoptosis in Response to Chemoendocrine and Endocrine Therapy in Breast Cancer: JBCRG-07TR

scientific article published on 24 February 2019

Differential survival following trastuzumab treatment based on quantitative HER2 expression and HER2 homodimers in a clinic-based cohort of patients with metastatic breast cancer

scientific article

Distinct gene expression profiles between primary breast cancers and brain metastases from pair-matched samples

scientific article published on 16 September 2019

Distinct promoter usage of mdm2 gene in human breast cancer

scientific article published in May 2002

Dose-finding phase I and pharmacokinetic study of capecitabine (Xeloda) in combination with epirubicin and cyclophosphamide (CEX) in patients with inoperable or metastatic breast cancer

scientific article

Durable complete response in HER2-positive breast cancer: a multicenter retrospective analysis.

scientific article published on 11 September 2017

Early breast cancer

scientific article published on 01 April 2006

Effect of low-dose Paclitaxel and docetaxel on endothelial progenitor cells

scientific article

Efficacy of biweekly paclitaxel therapy in advanced or recurrent breast cancer

scientific article published in January 2002

Erratum to: Evolving Approaches to Metastatic Breast Cancer Patients Pre-treated with Anthracycline and Taxane

scientific article published on 27 August 2013

Estradiol promotes rapid degradation of HER3 in ER-positive breast cancer cell line MCF-7

Estradiol stabilizes p53 protein in breast cancer cell line, MCF-7.

scientific article published on August 2002

Estrogen-Related Factors in the Frontal Lobe of Alzheimer's Disease Patients and Importance of Body Mass Index

scientific article

Evaluating the 21-gene assay Recurrence Score® as a predictor of clinical response to 24 weeks of neoadjuvant exemestane in estrogen receptor-positive breast cancer

scientific article published on 8 October 2013

Evolving approaches to metastatic breast cancer patients pre-treated with anthracycline and taxane

scientific article published on October 2013

Expression of estrogen receptor (ER) (beta)cx protein in ER(alpha)-positive breast cancer: specific correlation with progesterone receptor.

scientific article

FOXP1, an Estrogen-Inducible Transcription Factor, Modulates Cell Proliferation in Breast Cancer Cells and 5-Year Recurrence-Free Survival of Patients with Tamoxifen-Treated Breast Cancer ⬇️

scientific article published on October 1, 2011

Factors associated with prolonged overall survival in patients with postmenopausal estrogen receptor-positive advanced breast cancer using real-world data: a follow-up analysis of the JBCRG-C06 Safari study

scientific article published on 06 December 2019

Factors associated with prolonged time to treatment failure with fulvestrant 500 mg in patients with post-menopausal estrogen receptor-positive advanced breast cancer: a sub-group analysis of the JBCRG-C06 Safari study.

scientific article published on 2 November 2017

Fuel, electricity, ER and HER2—a hybrid-car model of breast cancer ⬇️

scientific article published on June 5, 2012

Genomic tumor evolution of breast cancer

scientific article published on 22 May 2015

Germline mutation of the LKB1/STK11 gene with loss of the normal allele in an aggressive breast cancer of Peutz-Jeghers syndrome

scientific article published on 01 January 2004

Immunohistochemical Detection of Breast Cancer Stem Cells in Hormone Receptor-Positive Breast Cancer and Their Role in Response to Endocrine Therapy and Clinical Outcome ⬇️

scientific article published on March 15, 2012

Immunohistochemical analysis of estrone sulfatase and aromatase in human breast cancer tissues.

scientific article

Impact of body mass index on breast cancer in accordance with the life-stage of women ⬇️

scientific article published on October 4, 2012

Impact of clinical response to neoadjuvant endocrine therapy on patient outcomes: a follow-up study of JFMC34-0601 multicentre prospective neoadjuvant endocrine trial.

scientific article published on 14 February 2018

Impact of physiological hormonal fluctuations on 18F-fluorodeoxyglucose uptake in breast cancer

scientific article published on 8 February 2018

Impact of recent parity on histopathological tumor features and breast cancer outcome in premenopausal Japanese women

scientific article published on 4 April 2013

Impact of vasculogenesis on solid tumor growth in a rat model.

scientific article

Intensive vs. Standard Post-Operative Surveillance in High-Risk Breast Cancer Patients (INSPIRE): Japan Clinical Oncology Group Study JCOG1204.

scientific article published on 5 August 2015

Involvement of androgen receptor in 17beta-estradiol-induced cell proliferation in rat uterus

scientific article

Joint symptoms and health-related quality of life in postmenopausal women with breast cancer who completed 5 years of anastrozole

scientific article

Ki-67 evaluation at the hottest spot predicts clinical outcome of patients with hormone receptor-positive/HER2-negative breast cancer treated with adjuvant tamoxifen monotherapy.

scientific article published on 12 March 2013

Ki67 index changes, pathological response and clinical benefits in primary breast cancer patients treated with 24 weeks of aromatase inhibition

scientific article published on 10 February 2011

Long isoform of VEGF stimulates cell migration of breast cancer by filopodia formation via NRP1/ARHGAP17/Cdc42 regulatory network

scientific article published on 09 October 2018

MLH1 germline mutation associated with Lynch syndrome in a family followed for more than 45 years

scientific article published on 02 May 2019

Neoadjuvant atezolizumab in combination with sequential nab-paclitaxel and anthracycline-based chemotherapy versus placebo and chemotherapy in patients with early-stage triple-negative breast cancer (IMpassion031): a randomised, double-blind, phase

scientific article published on 18 September 2020

Neoadjuvant endocrine therapy with exemestane followed by response-guided combination therapy with low-dose cyclophosphamide in postmenopausal patients with estrogen receptor-positive breast cancer: A multicenter, open-label, phase II study

scientific article published on 14 June 2018

Neoadjuvant exemestane or exemestane plus docetaxel and cyclophosphamide tailored by clinicopathological response to 12 weeks' exemestane exposure in patients with estrogen receptor-positive breast cancer: A multicenter, open-label, phase II study

scientific article published on 30 July 2019

Novel sensitizing agents: potential contribution of COX-2 inhibitor for endocrine therapy of breast cancer

scientific article

Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human breast carcinoma.

scientific article

Oestrogen receptor-beta1 but not oestrogen receptor-betacx is of prognostic value in apocrine carcinoma of the breast

scientific article published in October 2008

Phase II study of gemcitabine monotherapy as a salvage treatment for Japanese metastatic breast cancer patients after anthracycline and taxane treatment

scientific article published on 22 September 2009

Poland syndrome accompanied by internal iliac artery supply disruption sequence: a case report

article

Possible available treatment option for early stage, small, node-negative, and HER2-overexpressing breast cancer

scientific article published on 24 August 2011

Potential clinical applications of matrix metalloproteinase inhibitors and their future prospects

scientific article published on April 2013

Prediction of prognosis of estrogen receptor-positive breast cancer with combination of selected estrogen-regulated genes

scientific article published in June 2004

Progesterone receptor expression in proliferating cancer cells of hormone-receptor-positive breast cancer

scientific article published on 01 November 2018

Prognostic factors of HER2-positive breast cancer patients who develop brain metastasis: a multicenter retrospective analysis

scientific article published on 21 December 2014

Proportion of estrogen or progesterone receptor expressing cells in breast cancers and response to endocrine therapy.

scientific article published on 29 August 2014

Protracted administration of weekly docetaxel in metastatic breast cancer.

scientific article published in September 2003

Randomized controlled trial of toremifene 120 mg compared with exemestane 25 mg after prior treatment with a non-steroidal aromatase inhibitor in postmenopausal women with hormone receptor-positive metastatic breast cancer

scientific article

Randomized phase II study of three doses of oral TAS‐108 in postmenopausal patients with metastatic breast cancer ⬇️

scientific article published on July 16, 2012

Recent progress of molecular target therapy for breast cancer

scientific article published on 01 October 2017

Refractory lung metastasis from breast cancer treated with multidisciplinary therapy including an immunological approach.

scientific article published on 31 March 2010

Regimen Selection for First-line FOLFIRI and FOLFOX Based on UGT1A1 Genotype and Physical Background is Feasible in Japanese Patients with Advanced Colorectal Cancer ⬇️

scientific article published on February 9, 2011

Relationship between body mass index and preoperative treatment response to aromatase inhibitor exemestane in postmenopausal patients with primary breast cancer ⬇️

scientific article published on August 19, 2011

Relationships between pathological factors and long-term outcomes in patients enrolled in two prospective randomized controlled trials comparing the efficacy of oral tegafur-uracil with CMF (N·SAS-BC 01 trial and CUBC trial)

scientific article published on 01 December 2020

Sex steroid hormones in pairs of tumor and serum from breast cancer patients and pathobiological role of androstene-3β, 17β-diol

scientific article published on August 10, 2011

Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer

scientific article published on June 2005

Social isolation and cancer management after the 2011 triple disaster in Fukushima, Japan: A case report of breast cancer with patient and provider delay.

scientific article published on June 2016

The Japanese Breast Cancer Society Clinical Practice Guideline for radiation treatment of breast cancer, 2018 edition

scientific article published on 28 October 2019

The Japanese Breast Cancer Society Clinical Practice Guidelines for Breast Cancer Screening and Diagnosis, 2018 Edition

scientific article published on 16 November 2019

The Japanese Breast Cancer Society Clinical Practice Guidelines for systemic treatment of breast cancer, 2018 edition ⬇️

scientific article published on 02 April 2020

The Japanese Breast Cancer Society Clinical Practice Guidelines, 2018 edition: the tool for shared decision making between doctor and patient

scientific article published on 22 November 2019

The Japanese Breast Cancer Society clinical practice guidelines for surgical treatment of breast cancer, 2018 edition

scientific article published on 12 December 2019

The long and winding road for overcoming resistance to hormone therapy in breast cancer

scientific article published on 01 July 2018

Trastuzumab, pertuzumab, and eribulin mesylate versus trastuzumab, pertuzumab, and a taxane as a first-line or second-line treatment for HER2-positive, locally advanced or metastatic breast cancer: study protocol for a randomized controlled, non-inf

scientific article published on 07 May 2020

Trastuzumab: updates and future issues

scientific article

Treatment outcomes and prognostic factors for patients with brain metastases from breast cancer of each subtype: a multicenter retrospective analysis

scientific article published on 9 August 2014

Trends in local therapy application for early breast cancer patients in the Japanese Breast Cancer Society Breast Cancer Registry during 2004-2009

scientific article published on 01 January 2012

UGT1A1*1/*28 and *1/*6 genotypes have no effects on the efficacy and toxicity of FOLFIRI in Japanese patients with advanced colorectal cancer ⬇️

scientific article published on October 19, 2010

Weekly schedule of docetaxel in breast cancer: evaluation of response and toxicity

scientific article

[Clinical pharmacology of targeted drug for breast cancer].

scientific article published in November 2012

[Combination Therapy of Molecular-Targeted Drugs for Breast Cancer -- Their Potential in the Future].

scientific article

[Current indications for mastectomy in patients with breast cancer]

scientific article published on 01 November 2002

[III. Novel Endocrine Therapy with Signal Transduction Inhibitors for Hormone Dependent Breast Cancer].

scientific article published in December 2016

[Leanness, obesity, and breast cancer risk-different impact of body weight on breast cancer risk according to women's life stages]

scientific article published in May 2015

[Mechanism and side effect of endocrine therapy]

[Predictors of axillary node metastasis at breast surgery after neoadjuvant chemotherapy in patients with pre- chemotherapy-sentinel node positive breast cancer]

scientific article published on 01 October 2011

[The differences of standard therapy for breast cancer between Europe/America and Japan--chemotherapy, operation,and radiotherapy]

scientific article published on 01 May 2007

[Trastuzumab treatment for breast cancer]

scientific article published on 01 July 2004

Paulina is supported by:

About Paulina

Help