List of works by Eric E Schadt

A Bayesian partition method for detecting pleiotropic and epistatic eQTL modules

scientific article

A Complete Genome Screening Program of Clinical Methicillin-Resistant Staphylococcus aureus Isolates Identifies the Origin and Progression of a Neonatal Intensive Care Unit Outbreak

scientific article published on 22 November 2019

A Cytosine Methyltransferase Modulates the Cell Envelope Stress Response in the Cholera Pathogen [corrected].

scientific article

A Model Selection Approach for Expression Quantitative Trait Loci (eQTL) Mapping ⬇️

scientific article published on November 29, 2010

A Nasal Brush-based Classifier of Asthma Identified by Machine Learning Analysis of Nasal RNA Sequence Data.

scientific article

A New Liver Expression Quantitative Trait Locus Map From 1,183 Individuals Provides Evidence for Novel Expression Quantitative Trait Loci of Drug Response, Metabolic, and Sex-Biased Phenotypes

scientific article published on 23 December 2019

A Next Generation Multiscale View of Inborn Errors of Metabolism

scientific article published on 16 December 2015

A comprehensive transcript index of the human genome generated using microarrays and computational approaches

scientific article

A family-based test for correlation between gene expression and trait values

scientific article

A functional genomics predictive network model identifies regulators of inflammatory bowel disease

scientific article published on 11 September 2017

A genome-wide set of congenic mouse strains derived from CAST/Ei on a C57BL/6 background

scientific article

A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background

scientific article published in September 2005

A hybrid approach for the automated finishing of bacterial genomes

scientific article

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

scientific article

A network view of disease and compound screening

scientific article published in April 2009

A new molecular signature method for prediction of driver cancer pathways from transcriptional data

scientific article

A next generation sequencing based approach to identify extracellular vesicle mediated mRNA transfers between cells

scientific article published on 22 December 2017

A noncoding variant near PPP1R3B promotes liver glycogen storage and MetS, but protects against myocardial infarction

scientific article published on 24 November 2020

A personalized platform identifies trametinib plus zoledronate for a patient with KRAS-mutant metastatic colorectal cancer

scientific article published on 22 May 2019

A robust blood gene expression-based prognostic model for castration-resistant prostate cancer

scientific article published on 21 August 2015

A role for noncoding variation in schizophrenia

scientific article

A survey of cancer cell lines reveals highly structured and hierarchical relationships within and between DNA and mRNA that may be the result of selection

scientific article

A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort

scientific article

A systematic approach to multifactorial cardiovascular disease: causal analysis

scientific article published on 18 October 2012

A systems biology approach to drug discovery

scientific article published on January 2008

A systems genetic analysis of high density lipoprotein metabolism and network preservation across mouse models

scientific article published on 23 July 2011

A window into third-generation sequencing ⬇️

scientific article published on September 21, 2010

AKI in hospitalized patients with COVID-19

journal article published in 2021

Aberrant methylation underlies insulin gene expression in human insulinoma

scientific article published on 15 October 2020

Accuracy of genome-wide imputation of untyped markers and impacts on statistical power for association studies

scientific article

Acute Kidney Injury in Hospitalized Patients with COVID-19

scientific article published on 08 May 2020

Advances in systems biology are enhancing our understanding of disease and moving us closer to novel disease treatments

scientific article published on 11 April 2009

Altering Sphingolipid Metabolism Attenuates Cell Death and Inflammatory Response After Myocardial Infarction

scientific article published on 29 January 2020

Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes

scientific article

An Integrative Multi-Network and Multi-Classifier Approach to Predict Genetic Interactions ⬇️

scientific article published on September 9, 2010

An inflammatory cytokine signature helps predict COVID-19 severity and death

scientific article published on 30 May 2020

An inflammatory cytokine signature predicts COVID-19 severity and survival

scientific article published on 24 August 2020

An integrated map of structural variation in 2,504 human genomes

scientific article

An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits

scientific article

An integrative genetics approach to identify candidate genes regulating BMD: combining linkage, gene expression, and association

scientific article

An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease

scientific article published on 22 January 2021

Analysis of 589,306 genomes identifies individuals resilient to severe Mendelian childhood diseases.

scientific article published on 11 April 2016

Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity

scientific article

Analysis of hospitalized COVID-19 patients in the Mount Sinai Health System using electronic medical records (EMR) reveals important prognostic factors for improved clinical outcomes

scientific article published on 04 May 2020

Analytical validation of whole exome and whole genome sequencing for clinical applications

scientific article

Applications of codon and rate variation models in molecular phylogeny

scientific article

Assembly and diploid architecture of an individual human genome via single-molecule technologies

scientific article published on 29 June 2015

Assessing the prospects of genome-wide association studies performed in inbred mice

scientific article published on 5 February 2010

Association analyses based on false discovery rate implicate new loci for coronary artery disease ⬇️

scientific article published on 17 July 2017

Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach

scientific article

Author Correction: Expression-based drug screening of neural progenitor cells from individuals with schizophrenia

scientific article published in Nature Communications

Author Correction: Sampling the host response to SARS-CoV-2 in hospitals under siege

scientific article published on 21 August 2020

Autotransporters but not pAA are critical for rabbit colonization by Shiga toxin-producing Escherichia coli O104:H4.

scientific article published on January 2014

B Cell Defects Observed in Nod2 Knockout Mice Are a Consequence of a Dock2 Mutation Frequently Found in Inbred Strains

scientific article published on 16 July 2018

Bayesian method to predict individual SNP genotypes from gene expression data

scientific article

Bayesian test for colocalisation between pairs of genetic association studies using summary statistics

scientific article (publication date: May 2014)

Biological, clinical and population relevance of 95 loci for blood lipids

scientific article

Biology and Bias in Cell Type-Specific RNAseq of Nucleus Accumbens Medium Spiny Neurons

scientific article published on 06 June 2019

Blood and Intestine eQTLs from an Anti-TNF-Resistant Crohn's Disease Cohort Inform IBD Genetic Association Loci

scientific article published on 23 June 2016

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

scientific article published on 20 July 2016

CDT2-controlled cell cycle reentry regulates the pathogenesis of Alzheimer's disease

scientific article published on 12 October 2018

COSINE: COndition-SpecIfic sub-NEtwork identification using a global optimization method

scientific article

CR1 and the "vanishing amyloid" hypothesis of Alzheimer's disease

scientific article

CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 N141I neurons

scientific article

Calibrating the performance of SNP arrays for whole-genome association studies

scientific article

Cancer gene profiling in non-small cell lung cancers reveals activating mutations in JAK2 and JAK3 with therapeutic implications

scientific article published on 30 October 2017

Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.

scientific article published on 6 September 2017

Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases.

scientific article published on August 2016

Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis

scientific article

Causal inference in biology networks with integrated belief propagation

scientific article

Characterization of the human ESC transcriptome by hybrid sequencing

scientific article

Characterizing dynamic changes in the human blood transcriptional network

scientific article

Characterizing the role of miRNAs within gene regulatory networks using integrative genomics techniques

scientific article

Cis-acting expression quantitative trait loci in mice

scientific article

Cis-regulatory variations: a study of SNPs around genes showing cis-linkage in segregating mouse populations

scientific article

Clinicopathologic and gene expression parameters predict liver cancer prognosis.

scientific article

Coanalysis of GWAS with eQTLs reveals disease-tissue associations

scientific article

Codon and rate variation models in molecular phylogeny

scientific article

Common body mass index-associated variants confer risk of extreme obesity

scientific article

Common body mass index-associated variants confer risk of extreme obesity

Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases

scientific article

Common variants at 30 loci contribute to polygenic dyslipidemia

scientific article

Comparative analyses of population-scale phenomic data in electronic medical records reveal race-specific disease networks

scientific article

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies

scientific article

Contribution of Gene Regulatory Networks to Heritability of Coronary Artery Disease

scientific article published on 01 June 2019

Correction to: Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits

scientific article published on 05 November 2019

Correction: A Cytosine Methytransferase Modulates the Cell Envelope Stress Response in the Cholera Pathogen

scientific article published on 11 December 2015

Correction: Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden

scientific article published on 01 March 2019

Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease

scientific article published on 3 March 2016

Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis

scientific article published on 17 February 2014

Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis

Cytotoxic lymphocytes are dysregulated in multisystem inflammatory syndrome in children

scientific article published on 02 September 2020

Dark matter in the genome: evidence of widespread transcription detected by microarray tiling experiments

scientific article

Deciphering bacterial epigenomes using modern sequencing technologies

scientific article published on 01 March 2019

Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.

scientific article published on 13 June 2017

Detecting DNA modifications from SMRT sequencing data by modeling sequence context dependence of polymerase kinetic

scientific article

Detecting and phasing minor single-nucleotide variants from long-read sequencing data

scientific article published on 24 May 2021

Detection of endometrial precancer by a targeted gynecologic cancer liquid biopsy

Development and clinical application of an integrative genomic approach to personalized cancer therapy

scientific article published on June 2016

Differential activity of transcribed enhancers in the prefrontal cortex of 537 cases with schizophrenia and controls

scientific article published on 08 May 2018

Directed Differentiation of Human Pluripotent Stem Cells to Microglia

scientific article published on 18 May 2017

Discover the network mechanisms underlying the connections between aging and age-related diseases

scientific article published on September 2016

Discovering genetic interactions bridging pathways in genome-wide association studies

scientific article published on 19 September 2019

Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus

scientific article

Disentangling molecular relationships with a causal inference test

scientific article (publication date: 27 May 2009)

Disruption of the aortic elastic lamina and medial calcification share genetic determinants in mice

scientific article

Dissecting cis regulation of gene expression in human metabolic tissues

scientific article (publication date: 2011)

Dissection of immune gene networks in primary melanoma tumors critical for antitumor surveillance of patients with stage II-III resectable disease

scientific article published on 12 February 2014

Diurnal variation of the human adipose transcriptome and the link to metabolic disease

scientific article

Dosage compensation is less effective in birds than in mammals

scientific article

Downregulation of carnitine acyl-carnitine translocase by miRNAs 132 and 212 amplifies glucose-stimulated insulin secretion

scientific article

Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children

scientific article published on 11 August 2021

Drug Discovery in a Multidimensional World: Systems, Patterns, and Networks

Dual transcriptomic and epigenomic study of reaction severity in peanut-allergic children

scientific article published on 12 December 2019

ERRATUM: Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

article by Matthew B. Lanktree et al published June 2012 in American Journal of Human Genetics

EXPLORING THE REPRODUCIBILITY OF PROBABILISTIC CAUSAL MOLECULAR NETWORK MODELS.

scientific article published on January 2016

Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes

scientific article

Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks

scientific article published on 30 October 2008

Embracing complexity, inching closer to reality

scientific article

Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis

scientific article published on 25 November 2019

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

scientific article

Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article published in November 2011

Evaluation of direct-to-consumer low-volume lab tests in healthy adults.

scientific article published on 28 March 2016

Evaluation of direct-to-consumer low-volume lab tests in healthy adults.

scientific article published on July 2016

Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants

article

Evidence for widespread adaptive evolution of gene expression in budding yeast

scientific article

Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders

scientific article

Exon and junction microarrays detect widespread mouse strain- and sex-bias expression differences

scientific article

Expression quantitative trait Loci acting across multiple tissues are enriched in inherited risk for coronary artery disease

scientific article

Expression quantitative trait loci: replication, tissue- and sex-specificity in mice

scientific article

Expression-based drug screening of neural progenitor cells from individuals with schizophrenia

scientific article published in Nature Communications

Extensive sequencing of seven human genomes to characterize benchmark reference materials

scientific article

Familial Hypercholesterolemia in a Healthy Elderly Population

scientific article published on 10 June 2020

Family-Based Approaches to Cardiovascular Health Promotion

scientific article published on April 2016

Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus

scientific article

FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation

scientific article

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

scientific article

From smartphone to EHR: a case report on integrating patient-generated health data

scientific article published on 20 June 2018

Functional interpretation of genetic variants using deep learning predicts impact on chromatin accessibility and histone modification

scientific article published on 01 November 2019

Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus

scientific article published on 16 November 2018

GJA1 (connexin43) is a key regulator of Alzheimer's disease pathogenesis

scientific article published on 21 December 2018

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

scientific article published in Nature Communications

Gaining comprehensive biological insight into the transcriptome by performing a broad-spectrum RNA-seq analysis

scientific article

Gene bionetwork analysis of ovarian primordial follicle development

scientific article

Gene expression elucidates functional impact of polygenic risk for schizophrenia

scientific article published on 26 September 2016

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci

scientific article published on 20 February 2014

Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity

scientific article

Genetic evidence of assortative mating in humans

article

Genetic loci for diet-induced atherosclerotic lesions and plasma lipids in mice

scientific article

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetic validation of whole-transcriptome sequencing for mapping expression affected by cis-regulatory variation

scientific article

Genetic variation at the phospholipid transfer protein locus affects its activity and high-density lipoprotein size and is a novel marker of cardiovascular disease susceptibility

scientific article published on 19 July 2010

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

scientific article published on 26 June 2011

Genetics of gene expression and its effect on disease

scientific article (publication date: 27 March 2008)

Genetics. A GPS for navigating DNA

scientific article published on 05 September 2012

Genome Plasticity of -Defective Staphylococcus aureus during Clinical Infection

scholarly article published by Deena R Altman in 2018

Genome scans for transmission ratio distortion regions in mice

scientific article

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits

scientific article

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

scientific article published on 16 October 2011

Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis

scientific article published on 26 October 2015

Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing

scientific article

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

scientific journal article

Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders

scientific article

Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays

scientific article (publication date: 19 December 2003)

Genomic analyses implicate noncoding de novo variants in congenital heart disease

scientific article published on 29 June 2020

Genomic analysis of metabolic pathway gene expression in mice

scientific article

Genomic and network patterns of schizophrenia genetic variation in human evolutionary accelerated regions

scientific article published on 12 February 2015

Genomic profiling reveals mutational landscape in parathyroid carcinomas

scientific article

Genomics and genome-wide association studies: an integrative approach to expression QTL mapping

scientific article published on 30 June 2008

Geospatial Resolution of Human and Bacterial Diversity with City-Scale Metagenomics

scientific article

Geospatial Resolution of Human and Bacterial Diversity with City-Scale Metagenomics

article

Germline deletion of Krüppel-like factor 14 does not increase risk of diet induced metabolic syndrome in male C57BL/6 mice

scientific article published on 26 September 2017

Global analysis of A-to-I RNA editing reveals association with common disease variants.

scientific article published on 6 March 2018

Gut microbiota density influences host physiology and is shaped by host and microbial factors

scientific article published on 22 January 2019

High-Throughput Characterization of Blood Serum Proteomics of IBD Patients with Respect to Aging and Genetic Factors.

scientific article

High-Throughput Identification of the Plasma Proteomic Signature of Inflammatory Bowel Disease

scientific article published on 01 March 2019

Hospitalised COVID-19 patients of the Mount Sinai Health System: a retrospective observational study using the electronic medical records

scientific article published on 26 October 2020

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

scientific article

How do students react to analyzing their own genomes in a whole-genome sequencing course?: outcomes of a longitudinal cohort study.

scientific article

Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks

scientific article published on 28 December 2016

Human geroprotector discovery by targeting the converging subnetworks of aging and age-related diseases

scientific article published on 21 October 2019

Hundreds of variants clustered in genomic loci and biological pathways affect human height

scientific article

IDENTIFY CANCER DRIVER GENES THROUGH SHARED MENDELIAN DISEASE PATHOGENIC VARIANTS AND CANCER SOMATIC MUTATIONS.

scientific article published on January 2016

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene

scientific article published on 23 March 2015

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene

scientific article published on 4 January 2016

Identification and validation of genes affecting aortic lesions in mice

scientific article

Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics

scholarly article

Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels

scientific article

Identification of a novel RASD1 somatic mutation in a USP8-mutated corticotroph adenoma.

scientific article

Identification of causal genes, networks, and transcriptional regulators of REM sleep and wake

scientific article

Identification of genes and networks driving cardiovascular and metabolic phenotypes in a mouse F2 intercross

scientific article (publication date: 14 December 2010)

Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data

scientific article

Impact of Genomic Counseling on Informed Decision-Making among ostensibly Healthy Individuals Seeking Personal Genome Sequencing: the HealthSeq Project

scientific article published on 22 February 2016

Impacts of incorporating personal genome sequencing into graduate genomics education: a longitudinal study over three course years

scientific article published on 30 January 2018

Improved integrative framework combining association data with gene expression features to prioritize Crohn's disease genes

scientific article

Improving breast cancer survival analysis through competition-based multidimensional modeling

scientific article

In the Absence of HCV Infection, Interferon Stimulated Gene Expression in Liver Is Not Associated With IL28B Genotype ⬇️

scientific article published on August 25, 2010

Increasing the power to detect causal associations by combining genotypic and expression data in segregating populations

scientific article

Inferred miRNA activity identifies miRNA-mediated regulatory networks underlying multiple cancers

scientific article published on 10 September 2015

Inferring causal genomic alterations in breast cancer using gene expression data

scientific article

Informed decision-making among students analyzing their personal genomes on a whole genome sequencing course: a longitudinal cohort study

scientific article published on 30 December 2013

Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas.

scientific article published on 3 October 2017

Institutional profile: translational pharmacogenomics at the Icahn School of Medicine at Mount Sinai

scientific article

Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models.

scientific article published on 29 March 2018

Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis

scientific article

Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease

scientific article published on April 2013

Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels

scientific article published on 29 August 2005

Integrating genetic and gene expression data to study the metabolic syndrome and diabetes in mice

scientific article

Integrating genetic and gene expression data: application to cardiovascular and metabolic traits in mice

scientific article

Integrating genetic and network analysis to characterize genes related to mouse weight

scientific article

Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits

scientific article

Integrating pathway analysis and genetics of gene expression for genome-wide association studies

scientific article

Integrating siRNA and protein-protein interaction data to identify an expanded insulin signaling network

scientific article

Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits

scientific article published on 25 July 2019

Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau

article

Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden

scientific article

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci

scientific article published on 08 July 2016

Integrative gene network analysis identifies key signatures, intrinsic networks and host factors for influenza virus A infections

scientific article published on 4 December 2017

Integrative genomics and drug development

scientific article published on February 2009

Integrative genomics identifies 7p11.2 as a novel locus for fever and clinical stress response in humans

scientific article

Integrative genomics strategies to elucidate the complexity of drug response

scientific article published on December 2011

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease

scientific article

Integrative study of the upper and lower airway microbiome and transcriptome in asthma

scientific article published on 12 March 2020

Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility

scientific article published on 08 October 2018

Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits

scientific article published on 23 August 2019

Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions.

scientific article published on 5 December 2017

Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease

scientific article published on 24 September 2020

Intratumoral heterogeneity and clonal evolution in liver cancer

scientific article published on 15 January 2020

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

scientific article

Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression

scientific article published on 22 May 2017

Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression

scientific article published on July 2017

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

scientific article

Large-scale association analysis identifies new risk loci for coronary artery disease

scientific article published on 02 December 2012

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci

scientific article

Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

scientific article published on 13 April 2020

Lessons learned from expanded reproductive carrier screening in self-reported Ashkenazi, Sephardi, and Mizrahi Jewish patients

scientific article published on 27 December 2019

Leveraging models of cell regulation and GWAS data in integrative network-based association studies

scientific article (publication date: 27 July 2012)

Lim domain binding 2: a key driver of transendothelial migration of leukocytes and atherosclerosis

scientific article

Linkage disequilibrium in wild mice

scientific article

List of Contributors

Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes

scientific article

Loci influencing blood pressure identified using a cardiovascular gene-centric array

scientific article published on 8 January 2013

Loci influencing blood pressure identified using a cardiovascular gene-centric array.

scientific article

Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation

scientific article

METHODS FOR CLUSTERING TIME SERIES DATA ACQUIRED FROM MOBILE HEALTH APPS.

scientific article

MODMatcher: multi-omics data matcher for integrative genomic analysis

scientific article

Magnitude of stratification in human populations and impacts on genome wide association studies

scientific article

Mapping and characterizing N6-methyladenine in eukaryotic genomes using single-molecule real-time sequencing

Mapping cis- and trans-regulatory effects across multiple tissues in twins

scientific article published on 02 September 2012

Mapping the genetic architecture of gene expression in human liver ⬇️

scientific article

Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma

scientific article

Medically actionable pathogenic variants in a population of 13,131 healthy elderly individuals

scientific article published on 01 July 2020

Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment

scientific article published on 01 July 2018

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci ⬇️

scientific article

Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models

scientific article published on 01 July 2020

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

scientific article

Meta-analysis of inter-species liver co-expression networks elucidates traits associated with common human diseases

scientific article

Meta-analysis of the human brain transcriptome identifies heterogeneity across human AD coexpression modules robust to sample collection and methodological approach

Metagenomic binning and association of plasmids with bacterial host genomes using DNA methylation.

scientific article

Microarray standard data set and figures of merit for comparing data processing methods and experiment designs

scientific article

Modeling kinetic rate variation in third generation DNA sequencing data to detect putative modifications to DNA bases

scientific article

Modern Methods for Delineating Metagenomic Complexity

scientific article

Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets

Motivations, concerns and preferences of personal genome sequencing research participants: Baseline findings from the HealthSeq project

scientific article

Motivations, concerns and preferences of personal genome sequencing research participants: Baseline findings from the HealthSeq project.

scientific article published on 28 October 2015

Moving toward a system genetics view of disease

scientific article

Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: the Stockholm Atherosclerosis Gene Expression (STAGE) study

scientific article

Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease

scientific article

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

scientific article published on 12 March 2018

Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus

article

Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease

scientific article published on 07 August 2020

Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer's disease

scientific article published on 6 November 2017

Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease.

scientific article

Network study of nasal transcriptome profiles reveals master regulator genes of asthma

scientific article published on 19 August 2020

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ⬇️

scientific article published on February 2016

Non-O1 Vibrio cholerae unlinked to cholera in Haiti

scientific article published on 3 October 2012

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Novel, compound heterozygous, single-nucleotide variants in MARS2 associated with developmental delay, poor growth, and sensorineural hearing loss

scientific article

On the adjustment for covariates in genetic association analysis: a novel, simple principle to infer direct causal effects

scientific article published on July 2009

On the replication of genetic associations: timing can be everything!

scientific article published on April 2008

Optimization of oligonucleotide arrays and RNA amplification protocols for analysis of transcript structure and alternative splicing ⬇️

scientific article published on September 19, 2003

Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany

scientific article

Personalized Circulating Tumor DNA Biomarkers Dynamically Predict Treatment Response and Survival In Gynecologic Cancers

scientific article published on 30 December 2015

Personalized ovarian cancer disease surveillance and detection of candidate therapeutic drug target in circulating tumor DNA.

scientific article published on January 2014

Pharmacogenetics of metformin response: a step in the path toward personalized medicine

scientific article published on May 2007

Phase 2 Trial of Gemcitabine, Cisplatin, plus Ipilimumab in Patients with Metastatic Urothelial Cancer and Impact of DNA Damage Response Gene Mutations on Outcomes

scientific article published on 13 December 2017

Ppargamma2 is a key driver of longevity in the mouse

scientific article

Prediction of Causal Candidate Genes in Coronary Artery Disease Loci

scientific article

Predictive genes in adjacent normal tissue are preferentially altered by sCNV during tumorigenesis in liver cancer and may rate limiting

scientific article (publication date: 2011)

Predictive network modeling in human induced pluripotent stem cells identifies key driver genes for insulin responsiveness

scientific article published on 23 December 2020

Predispositional genome sequencing in healthy adults: design, participant characteristics, and early outcomes of the PeopleSeq Consortium

article by Emilie S Zoltick et al published 27 February 2019 in Genome Medicine

Preparing the next generation of genomicists: a laboratory-style course in medical genomics

scientific article published on 12 August 2015

Prevalence and disease predisposition of p.A91V perforin in an aged population of European ancestry

scientific article published on 01 February 2020

Prothymosin α variants isolated from CD8+ T cells and cervicovaginal fluid suppress HIV-1 replication through type I interferon induction

scientific article published on 17 November 2014

Psychological and behavioural impact of returning personal results from whole-genome sequencing: the HealthSeq project

scientific article

Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

scientific article published on 01 July 2019

Rationale and Design of Family-Based Approach in a Minority Community Integrating Systems-Biology for Promotion of Health (FAMILIA).

scientific article published on 22 February 2017

STAR Chimeric Post For Rapid Detection of Circular RNA and Fusion Transcripts.

scientific article published on 20 February 2018

Sampling the host response to SARS-CoV-2 in hospitals under siege

scientific article published on 27 July 2020

Sequence variation in NPC1L1 and association with improved LDL-cholesterol lowering in response to ezetimibe treatment

scientific article

Seventy-five genetic loci influencing the human red blood cell

scientific article published on 5 December 2012

Sex differences in human adipose tissue gene expression and genetic regulation involve adipogenesis

scientific article published on 23 September 2020

Sex differences in viral entry protein expression, host responses to SARS-CoV-2, and in vitro responses to sex steroid hormone treatment in COVID-19

scientific article published on 04 November 2020

Simultaneous clustering of multiple gene expression and physical interaction datasets

scientific article

Single molecule-level detection and long read-based phasing of epigenetic variations in bacterial methylomes

scientific article published on 15 June 2015

Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy

scientific article published on 29 August 2019

Something wiki this way comes. Interview by Bryn Nelson

scientific article published in March 2009

Statistical power of phylo-HMM for evolutionarily conserved element detection

scientific article

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease ⬇️

scientific article published on February 2017

Systematic detection of polygenic cis-regulatory evolution

scientific article

Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver

scientific article

Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers

scientific article

Systems biology of asthma and allergic diseases: a multiscale approach

scientific article

Systems genetics of susceptibility to obesity-induced diabetes in mice

scientific article published on 18 October 2011

Systems modeling of white matter microstructural abnormalities in Alzheimer's disease

scientific article published on 04 February 2020

TGFβ receptor 1: an immune susceptibility gene in HPV-associated cancer

scientific article published in October 2014

THE HUMAN BRAINOME: HUMAN BRAIN GENOME, TRANSCRIPTOME, AND PROTEOME INTEGRATION

The C3a anaphylatoxin receptor is a key mediator of insulin resistance and functions by modulating adipose tissue macrophage infiltration and activation

scientific article published on 6 July 2009

The Collaborative Cross, a community resource for the genetic analysis of complex traits

article

The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease

scientific article published on 11 September 2018

The Pioglitazone Trek via Human PPAR Gamma: From Discovery to a Medicine at the FDA and Beyond

scholarly article by Pallavi R Devchand et al published 2018 in Frontiers in Pharmacology

The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface

scientific article

The arrestin domain-containing 3 protein regulates body mass and energy expenditure

scientific article

The asthma mobile health study, smartphone data collected using ResearchKit.

scientific article published on 22 May 2018

The effect of food intake on gene expression in human peripheral blood

scientific article

The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target

The origin of the Haitian cholera outbreak strain

scientific article

The origin, global distribution, and functional impact of the human 8p23 inversion polymorphism

scientific article

The quantitative genetics of phenotypic robustness

scientific article (publication date: 8 January 2010)

Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Reverse engineering gene networks to identify key drivers of complex disease phenotypes

scientific article published on October 2006

Tissue-specific expression and regulation of sexually dimorphic genes in mice

scientific article

Transcriptional dissection of melanoma identifies a high-risk subtype underlying TP53 family genes and epigenome deregulation

scientific article

Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer's Disease

scientific article published on 17 November 2020

Translational genomics. Clues from the resilient

scientific article

Tsc2, a positional candidate gene underlying a quantitative trait locus for hepatic steatosis

scientific article published on 23 May 2012

Ultrafine mapping of SNPs from mouse strains C57BL/6J, DBA/2J, and C57BLKS/J for loci contributing to diabetes and atherosclerosis susceptibility

scientific article published in April 2005

Uncovering the genetic landscape for multiple sleep-wake traits

scientific article

Unifying immunology with informatics and multiscale biology.

scientific article

VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice

scientific article published on 10 January 2020

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

scientific article

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks

scientific article

Variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease

scientific article published on 30 January 2016

Variations in DNA elucidate molecular networks that cause disease

scientific article

Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies

scientific article published on 03 December 2019

Whole-genome sequencing identifies emergence of a quinolone resistance mutation in a case of Stenotrophomonas maltophilia bacteremia.

scientific article

iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease

scientific article

lrgpr: interactive linear mixed model analysis of genome-wide association studies with composite hypothesis testing and regression diagnostics in R.

scientific article

variancePartition: interpreting drivers of variation in complex gene expression studies.

scientific article

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