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List of works by Anthony Letai

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016

scientific article published oln 16 November 2016

A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

scientific article

ABT-199: Taking Dead Aim at BCL-2 ⬇️

scientific article published on February 11, 2013

Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1.

scientific article

Activation of <i>Notch</i> and <i>Myc</i> Signaling via B-cell-Restricted Depletion of <i>Dnmt3a</i> Generates a Consistent Murine Model of Chronic Lymphocytic Leukemia

scientific article published on 22 October 2021

Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia

scientific article published in July 2015

Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division

scientific article published on 17 November 2020

Antiapoptotic BCL-2 is required for maintenance of a model leukemia

scientific article published on 01 September 2004

Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia

scientific article published on 01 August 2020

BCL-2 Inhibition: Stemming the Tide of Myeloid Malignancies ⬇️

scientific article published on March 7, 2013

BCL-2 inhibition in AML: an unexpected bonus?

scientific article published on 23 July 2018

BCL-XL directly modulates RAS signalling to favour cancer cell stemness.

scientific article published on 24 October 2017

BCL2 suppresses PARP1 function and nonapoptotic cell death.

scientific article

BH3 profiling discriminates on-target small molecule BH3 mimetics from putative mimetics

scientific article published on 22 July 2019

BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

scientific article

BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response

scientific article

Biomarker-driven strategy for MCL1 inhibition in T-cell lymphomas

scientific article published on 29 November 2018

Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax.

scientific article published on 16 December 2016

Cell Line–Specific Network Models of ER+ Breast Cancer Identify Potential PI3Kα Inhibitor Resistance Mechanisms and Drug Combinations

scientific article published on 13 July 2021

Cell and molecular determinants of in vivo efficacy of the BH3 mimetic ABT-263 against pediatric acute lymphoblastic leukemia xenografts

scientific article

Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages

scientific article published on 8 March 2017

Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition

scientific article published on 20 May 2016

Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells

scientific article published on 15 April 2016

Control of mitochondrial apoptosis by the Bcl-2 family

scientific article published on February 2009

DNA methyltransferase inhibition overcomes diphthamide pathway deficiencies underlying CD123-targeted treatment resistance

scientific article published on 01 November 2019

Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia ⬇️

scientific article published on September 5, 2012

Defining specificity and on-target activity of BH3-mimetics using engineered B-ALL cell lines

scientific article published on 05 February 2016

Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.

scientific article published on 23 July 2014

Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies

scientific article published on 14 November 2019

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

scientific article

Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics

scientific article published on 13 December 2016

Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage.

scientific article published on 12 March 2018

Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma

scientific article

Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise.

scientific article published on 21 March 2016

Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors

scientific article published on 23 November 2016

Dynamic BH3 profiling identifies active BH3 mimetic combinations in non-small cell lung cancer

scientific article published on 27 July 2021

Dynamic BH3 profiling-poking cancer cells with a stick

scientific article

ER stress signaling promotes the survival of cancer 'persister cells' tolerant to EGFR tyrosine kinase inhibitors

scientific article published on 19 December 2017

ER+ Breast Cancer Strongly Depends on MCL-1 and BCL-xL Anti-Apoptotic Proteins

scientific article published on 2 July 2021

Efficacy and Biological Correlates of Response in a Phase II Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia

scientific article

Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1

scientific article

Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection

scientific article

Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers

scientific article published on 27 March 2014

Found in Translation: How Preclinical Research Is Guiding the Clinical Development of the BCL2-Selective Inhibitor Venetoclax

scientific article

Functionally identifiable apoptosis-insensitive subpopulations determine chemoresistance in acute myeloid leukemia.

scientific article

Genomic evolution and chemoresistance in germ-cell tumours.

scientific article

Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes.

scientific article

High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis.

scientific article

High-throughput dynamic BH3 profiling may quickly and accurately predict effective therapies in solid tumors

scientific article published on 16 June 2020

Increased mitochondrial apoptotic priming of human regulatory T cells after allogeneic hematopoietic stem cell transplantation.

scientific article

Increased mitochondrial apoptotic priming with targeted therapy predicts clinical response to re-induction chemotherapy

scientific article published on 22 December 2019

Inhibition of USP10 induces degradation of oncogenic FLT3.

scientific article

Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.

scientific article published on 16 January 2018

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.

scientific article published on 04 February 2013

Leukemia cell of origin influences apoptotic priming and sensitivity to LSD1 inhibition

scientific article published on 30 June 2020

MCL-1-dependent leukemia cells are more sensitive to chemotherapy than BCL-2-dependent counterparts

scientific article published on 26 October 2009

MCL1 and DEDD Promote Urothelial Carcinoma Progression

scientific article published on 18 February 2019

MEF2C phosphorylation is required for chemotherapy resistance in acute myeloid leukemia.

scientific article published on 5 February 2018

MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199.

scientific article

MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer

scientific article published on 02 August 2019

Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199

scientific article

Mitochondria-Judges and Executioners of Cell Death Sentences

scientific article published on March 2016

Mitochondria: gatekeepers of response to chemotherapy

scientific article published on 21 September 2013

Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration

scientific article published on 01 June 2021

Multifunctional barcoding with ClonMapper enables high-resolution study of clonal dynamics during tumor evolution and treatment

scientific article published on 12 July 2021

Overcoming stroma-mediated treatment resistance in chronic lymphocytic leukemia through BCL-2 inhibition ⬇️

scientific article published on May 29, 2013

P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment ⬇️

scientific article published on November 16, 2011

PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells

scientific article published on 28 June 2018

Patterns of substrate affinity, competition, and degradation kinetics underlie biological activity of thalidomide analogs

scientific article published on 01 May 2019

Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance.

scientific article

Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer

scientific article published on 28 August 2019

Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL.

scientific article

Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling

scientific article published on 29 July 2019

Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy ⬇️

scientific article published on October 27, 2011

Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion

scientific article published on December 2007

RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis

scientific article

Rapid Optimization of Mcl-1 Inhibitors using Stapled Peptide Libraries Including Non-Natural Side Chains.

scientific article published on 8 February 2016

Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.

scientific article

Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia

scientific article published on 18 November 2020

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

scientific article published on 01 March 2019

Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML

scientific article

Safety and preliminary efficacy of venetoclax with decitabine or azacitidine in elderly patients with previously untreated acute myeloid leukaemia: a non-randomised, open-label, phase 1b study

scientific article published on 12 January 2018

Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies

scientific article published on 04 October 2018

Statins enhance efficacy of venetoclax in blood cancers.

scientific article published in June 2018

Synergistic interactions with PI3K inhibition that induce apoptosis.

scientific article

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

scientific article published in December 2017

Targeted inhibition of PI3Kα/δ is synergistic with BCL-2 blockade in genetically defined subtypes of DLBCL

scientific article published on 15 October 2018

Targeting the B-Cell Lymphoma/Leukemia 2 Family in Cancer ⬇️

scientific article published on May 29, 2012

The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism.

scientific article published on 11 April 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

scientific article published on April 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

scientific article published on 11 July 2016

The landscape of somatic copy-number alteration across human cancers

scientific article

Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance

scientific article published in December 2016

Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia

scholarly article by Courtney D DiNardo et al published 25 October 2018 in Blood

Venetoclax with azacitidine or decitabine in patients with newly diagnosed acute myeloid leukemia: long term follow-up from a Phase 1b study

scientific article published on 29 October 2020

Who put the "A" in Atg12: autophagy or apoptosis? ⬇️

scientific article published on December 2011

iBH3: simple, fixable BH3 profiling to determine apoptotic priming in primary tissue by flow cytometry

scientific article published on 23 February 2016

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