List of works by Francois Villinger

3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope-specific plasma cells and humoral immunity in nonhuman primates

scientific article published on 01 June 2020

A DNA vaccine encoding the 42 kDa C-terminus of merozoite surface protein 1 of Plasmodium falciparum induces antibody, interferon-gamma and cytotoxic T cell responses in rhesus monkeys: immuno-stimulatory effects of granulocyte macrophage-colony sti

scientific article published in April 2002

A bivalent, spherical virus-like particle vaccine enhances breadth of immune responses against pathogenic Ebola viruses in rhesus macaques

scientific article published on 19 February 2020

A re-evaluation of the mechanisms leading to dengue hemorrhagic fever

scientific article published on September 2009

A two years longitudinal study of a transgenic Huntington disease monkey

scientific article

Adjuvanting a DNA vaccine with a TLR9 ligand plus Flt3 ligand results in enhanced cellular immunity against the simian immunodeficiency virus

scientific article

Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques

scientific article

Adoptive transfer of simian immunodeficiency virus (SIV) naïve autologous CD4(+) cells to macaques chronically infected with SIV is sufficient to induce long-term nonprogressor status

scientific article published in January 2002

Aerosol Delivery of Synthetic mRNA to Vaginal Mucosa Leads to Durable Expression of Broadly Neutralizing Antibodies against HIV

scientific article published on 10 January 2020

An anti-HIV-1 V3 loop antibody fully protects cross-clade and elicits T-cell immunity in macaques mucosally challenged with an R5 clade C SHIV

scientific article

Ancient co-speciation of simian foamy viruses and primates

scientific article (publication date: 17 March 2005)

Anti-HIV IgA isotypes: differential virion capture and inhibition of transcytosis are linked to prevention of mucosal R5 SHIV transmission

scientific article

Antiretroviral therapy induces a rapid increase in bone resorption that is positively associated with the magnitude of immune reconstitution in HIV infection

scientific article

Association of Cytokines With Exosomes in the Plasma of HIV-1-Seropositive Individuals

scientific article published on 15 December 2014

Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys

scientific article published on June 2008

Blocking of α4β7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques

scientific article published on 13 December 2010

CD4+ T cells from simian immunodeficiency virus disease-resistant sooty mangabeys produce more IL-2 than cells from disease-susceptible species: involvement of p300 and CREB at the proximal IL-2 promoter in IL-2 up-regulation

scientific article published in June 2007

CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection

scientific article published on 4 February 2015

CX3CL1 and IL-15 Promote CD8 T cell chemoattraction in HIV and in atherosclerosis

scientific article published on 25 September 2020

Can non-human primates serve as models for investigating dengue disease pathogenesis?

scientific article

Central memory CD4 T cells are the predominant cell subset resistant to anergy in SIV disease resistant sooty mangabeys.

scientific article published in January 2006

Characterization and Implementation of a Diverse Simian Immunodeficiency Virus SIVsm Envelope Panel in the Assessment of Neutralizing Antibody Breadth Elicited in Rhesus Macaques by Multimodal Vaccines Expressing the SIVmac239 Envelope.

scientific article published on 27 May 2015

Characterization of antibodies elicited by XMRV infection and development of immunoassays useful for epidemiologic studies

scientific article

Characterization of dengue virus 2 growth in megakaryocyte-erythrocyte progenitor cells

scientific article

Cigarette smoke and HIV synergistically affect lung pathology in cynomolgus macaques

article

Co-immunization with IL-15 enhances cellular immune responses induced by a vif-deleted simian immunodeficiency virus proviral DNA vaccine and confers partial protection against vaginal challenge with SIVmac251.

scientific article published on 3 February 2009

Codelivery of Envelope Protein in Alum with MVA Vaccine Induces CXCR3-Biased CXCR5+ and CXCR5- CD4 T Cell Responses in Rhesus Macaques

scientific article published on 26 June 2015

Comparison of the vaginal environment in rhesus and cynomolgus macaques pre- and post-lactobacillus colonization.

scientific article published on 09 May 2017

Compromised steady-state germinal center activity with age in nonhuman primates

scientific article published on 15 December 2019

Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine

scientific article

Critical role for Env as well as Gag-Pol in control of a simian-human immunodeficiency virus 89.6P challenge by a DNA prime/recombinant modified vaccinia virus Ankara vaccine

scientific article

Decreased NK cell frequency and function is associated with increased risk of KIR3DL allele polymorphism in simian immunodeficiency virus-infected rhesus macaques with high viral loads

scientific article

Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: complete protection of rhesus monkeys from mucosal SHIV challenge

scientific article published on 11 March 2015

Delayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques

scientific article published on 13 May 2019

Delipidated retroviruses as potential autologous therapeutic vaccines--a pilot experiment

scientific article published on 11 April 2008

Dengue virus infection induces expansion of a CD14(+)CD16(+) monocyte population that stimulates plasmablast differentiation

scientific article

Dengue virus-induced hemorrhage in a nonhuman primate model

scientific article

Development of rectal enema as microbicide (DREAM): Preclinical progressive selection of a tenofovir prodrug enema

scientific article published on 24 May 2018

Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates

scientific article published on November 2007

Different patterns of immune responses but similar control of a simian-human immunodeficiency virus 89.6P mucosal challenge by modified vaccinia virus Ankara (MVA) and DNA/MVA vaccines.

scientific article

Diminished viral control during simian immunodeficiency virus infection is associated with aberrant PD-1hi CD4 T cell enrichment in the lymphoid follicles of the rectal mucosa.

scientific article

Divergent HIV-1-Directed Immune Responses Generated by Systemic and Mucosal Immunization with Replicating Single-Cycle Adenoviruses in Rhesus Macaques

article

Dysregulation of the polo-like kinase pathway in CD4+ T cells is characteristic of pathogenic simian immunodeficiency virus infection

scientific article published on February 2004

ELISpot and ELISA analysis of spontaneous, mitogen-induced and antigen-specific cytokine production in cynomolgus and rhesus macaques

scientific article published on December 2002

Early initiation of antiretroviral treatment postSIV infection does not resolve lymphoid tissue activation

scientific article published on 7 July 2017

Early lymphoid responses and germinal center formation correlate with lower viral load set points and better prognosis of simian immunodeficiency virus infection

scientific article

Elevated expression levels of inhibitory receptor programmed death 1 on simian immunodeficiency virus-specific CD8 T cells during chronic infection but not after vaccination

scientific article published on 21 March 2007

Engineering of a Lectibody Targeting High-Mannose-Type Glycans of the HIV Envelope

scientific article published on 09 August 2019

Enhancement of cell mediated immune responses using lipid depleted lentivirus as immunogen: a novel approach for inducing recognition of new viral epitopes

scientific article published in September 2005

Erratum: Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy–treated macaques

scholarly article published in Nature Methods

Evidence for antibody-mediated enhancement of simian immunodeficiency virus (SIV) Gag antigen processing and cross presentation in SIV-infected rhesus macaques

scientific article

Expression of functional folate receptors by human parathyroid cells.

scientific article published on 25 October 2013

FDC:TFH Interactions within Cervical Lymph Nodes of SIV-Infected Rhesus Macaques

scientific article published on 29 December 2017

GM-CSF DNA: an adjuvant for higher avidity IgG, rectal IgA, and increased protection against the acute phase of a SHIV-89.6P challenge by a DNA/MVA immunodeficiency virus vaccine

scientific article

Gammadelta T cell immune manipulation during chronic phase of simian-human immunodeficiency virus infection [corrected] confers immunological benefits

scientific article

Genetic analysis of cytokine promoters in nonhuman primates: implications for Th1/Th2 profile characteristics and SIV disease pathogenesis

scientific article published on March 2004

Genetic characterization of HIV type 1 Nef-induced vesicle secretion

scientific article

Glycosylation of simian immunodeficiency virus influences immune-tissue targeting during primary infection, leading to immunodeficiency or viral control

scientific article

Hallmarks of HIV-1 pathogenesis are modulated by Nef's Secretion Modification Region

scientific article

Hypo-osmolar Formulation of Tenofovir (TFV) Enema Promotes Uptake and Metabolism of TFV in Tissues, Leading to Prevention of SHIV/SIV Infection

scientific article published on 30 October 2017

IL-15 delays suppression and fails to promote immune reconstitution in virally suppressed chronically SIV-infected macaques.

scientific article

IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates

scientific article

IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responses

scientific article published on January 2008

Idiopathic chronic diarrhea associated with dysbiosis in a captive cynomolgus macaque (Macaca fascicularis)

scientific article published on 23 October 2019

Immune Cell Dynamics in Rhesus Macaques Infected with a Brazilian Strain of Zika Virus

scientific article published on 30 June 2017

Immune Priming and Long-term Persistence of Memory B Cells After Inactivated Poliovirus Vaccine in Macaque Models: Support for at least 2 Doses

scientific article published on 01 October 2018

Immunohistological characterization of intercellular junction proteins in rhesus macaque intestine

scientific article

Impact of glycosylation on antigenicity of simian immunodeficiency virus SIV239: induction of rapid V1/V2-specific non-neutralizing antibody and delayed neutralizing antibody following infection with an attenuated deglycosylated mutant

scientific article published in February 2008

In vivo administration of a JAK3 inhibitor during acute SIV infection leads to significant increases in viral load during chronic infection

scientific article

In vivo administration of a JAK3 inhibitor to chronically siv infected rhesus macaques leads to NK cell depletion associated with transient modest increase in viral loads

scientific article

In vivo blockade of the programmed cell death-1 pathway using soluble recombinant PD-1-Fc enhances CD4+ and CD8+ T cell responses but has limited clinical benefit

scientific article

In vivo characterization of macrophage-tropic simian immunodeficiency virus molecular clones in rhesus macaques.

scientific article published on 28 March 2018

In vivo hypermutation of xenotropic murine leukemia virus-related virus DNA in peripheral blood mononuclear cells of rhesus macaque by APOBEC3 proteins

scientific article published on 6 October 2011

In-vivo use of SIVmac239 with a reversing stop codon in the SIV nef gene

scientific article published on 01 March 2020

Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses

scientific article

Increased IL-15 production is associated with higher susceptibility of memory CD4 T cells to simian immunodeficiency virus during acute infection

scientific article published on February 2009

Induction of Th1-Biased T Follicular Helper (Tfh) Cells in Lymphoid Tissues during Chronic Simian Immunodeficiency Virus Infection Defines Functionally Distinct Germinal Center Tfh Cells

scientific article published on August 2016

Infection of bone marrow cells by dengue virus in vivo

scientific article

Inhibition of pathogenic SHIV replication in macaques treated with antisense DNA of interleukin-4.

scientific article published on 23 December 2004

Innate differences between simian-human immunodeficiency virus (SHIV)(KU-2)-infected rhesus and pig-tailed macaques in development of neurological disease

scientific article published on March 2002

Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques

scientific article published in March 2007

Interleukin-15 increases effector memory CD8+ t cells and NK Cells in simian immunodeficiency virus-infected macaques

scientific article published on April 2005

Interleukin-21 administration to rhesus macaques chronically infected with simian immunodeficiency virus increases cytotoxic effector molecules in T cells and NK cells and enhances B cell function without increasing immune activation or viral replic

scientific article published on 11 October 2011

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques

scientific article

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals

scientific article published on 5 January 2016

Live attenuated Rev-independent Nef¯SIV enhances acquisition of heterologous SIVsmE660 in acutely vaccinated rhesus macaques

scientific article

MAdCAM costimulation through Integrin-α4β7 promotes HIV replication

scientific article published on 06 June 2018

Magnetic resonance imaging of activated proliferating rhesus macaque T cells labeled with superparamagnetic monocrystalline iron oxide nanoparticles

article

Magnitude of alloresponses to MHC class I/II expressing human cardiac myocytes is limited by their intrinsic ability to process and present antigenic peptides.

scientific article published on June 2003

Maintenance of intestinal Th17 cells and reduced microbial translocation in SIV-infected rhesus macaques treated with interleukin (IL)-21

scientific article (publication date: 2013)

Massive occlusive thrombosis of the pulmonary artery in pigtailed macaques chronically infected with R5-tropic simian-human immunodeficiency virus

scientific article

Melatonin and ulcerative colitis: evidence, biological mechanisms, and future research

scientific article

Microarray analysis of cytokine and chemokine genes in the brains of macaques with SHIV‐encephalitis ⬇️

scientific article published on August 1, 2003

Morphine Potentiates Dysbiotic Microbial and Metabolic Shifts in Acute SIV Infection

scientific article published on 21 September 2018

Multimodality vaccination against clade C SHIV: partial protection against mucosal challenges with a heterologous tier 2 virus

scientific article

Multiploid CD61+ cells are the pre-dominant cell lineage infected during acute dengue virus infection in bone marrow

scientific article

Neuropathogenesis of lentiviral infection in macaques: roles of CXCR4 and CCR5 viruses and interleukin-4 in enhancing monocyte chemoattractant protein-1 production in macrophages.

scientific article published on September 2002

PAS-positive extracellular deposits within germinal centers of hyperplastic follicles during SIV infection in a rhesus macaque

scientific article

Passive immunization of macaques with polyclonal anti-SHIV IgG against a heterologous tier 2 SHIV: outcome depends on IgG dose

scientific article published on 20 January 2014

Pathogenic and apathogenic courses of SIV infection are associated with distinct and characteristic regulatory patterns of G1/S and G2/M cell cycle checkpoints in CD4+ T cells

scientific article published in November 2006

Pathology of Sooty Mangabeys (Cercocebus atys)

scholarly article published 2014

Paucity of IL-21-producing CD4(+) T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques

scientific article

Pharmacokinetics and Preliminary Safety of Pod-Intravaginal Rings Delivering the Monoclonal Antibody VRC01-N for HIV Prophylaxis in a Macaque Model

scientific article published on 17 April 2017

Phenotypic and Functional Characterization of Monoclonal Antibodies with Specificity for Rhesus Macaque CD200, CD200R and Mincle

scientific article published on 15 October 2015

Preclinical studies of human immunodeficiency virus/AIDS vaccines: inverse correlation between avidity of anti-Env antibodies and peak postchallenge viremia.

scientific article

Prevalence and characterization of Clostridium perfringens isolated from feces of captive cynomolgus monkeys (Macaca fascicularis)

scientific article published on 02 July 2020

Prevention of infection by a granulocyte-macrophage colony-stimulating factor co-expressing DNA/modified vaccinia Ankara simian immunodeficiency virus vaccine

scientific article (publication date: July 2011)

Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis.

scientific article published on 22 June 2009

Programming the magnitude and persistence of antibody responses with innate immunity

scientific article

Prolonged Release and Functionality of Interleukin-10 Encapsulated within PLA-PEG Nanoparticles

scientific article published on 26 July 2019

Protection of macaques with diverse MHC genotypes against a heterologous SIV by vaccination with a deglycosylated live-attenuated SIV.

scientific article

Protective Immune Responses Elicited by Deglycosylated Live-Attenuated Simian Immunodeficiency Virus Vaccine Are Associated with IL-15 Effector Functions

scientific article published on 03 August 2020

Re-evaluation of PD-1 expression by T cells as a marker for immune exhaustion during SIV infection

scientific article

Relationship of menstrual cycle and vaginal infection in female rhesus macaques challenged with repeated, low doses of SIVmac251.

scientific article

Relationships between IL-17(+) subsets, Tregs and pDCs that distinguish among SIV infected elite controllers, low, medium and high viral load rhesus macaques.

scientific article

Reproducing SIVΔnef vaccine correlates of protection: trimeric gp41 antibody concentrated at mucosal front lines

scientific article

Role of CD61+ cells in thrombocytopenia of dengue patients

scientific article

SIV/SHIV Infection Triggers Vascular Inflammation, Diminished Expression of Krüppel-like Factor 2 and Endothelial Dysfunction.

scientific article published on 15 December 2015

Safety and Immunological Evaluation of Interleukin-21 Plus Anti-α4β7 mAb Combination Therapy in Rhesus Macaques

scientific article published on 17 July 2020

Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7

article

Signaling through Toll-like receptors triggers HIV-1 replication in latently infected mast cells

scientific article

Simian Immunodeficiency Virus Targeting of CXCR3+ CD4+ T Cells in Secondary Lymphoid Organs Is Associated with Robust CXCL10 Expression in Monocyte/Macrophage Subsets.

scientific article published on 19 April 2017

Simian human immunodeficiency virus-associated pneumonia correlates with increased expression of MCP-1, CXCL10, and viral RNA in the lungs of rhesus macaques

scientific article

Slowly declining levels of viral RNA and DNA in DNA/recombinant modified vaccinia virus Ankara-vaccinated macaques with controlled simian-human immunodeficiency virus SHIV-89.6P challenges

scientific article

Soluble PD-1 rescues the proliferative response of simian immunodeficiency virus-specific CD4 and CD8 T cells during chronic infection

scientific article

Spatial alterations between CD4(+) T follicular helper, B, and CD8(+) T cells during simian immunodeficiency virus infection: T/B cell homeostasis, activation, and potential mechanism for viral escape

scientific article published on 2 March 2012

Species-specific differences in the expression and regulation of α4β7 integrin in various nonhuman primates

scientific article

Stimulation of both humoral and cellular immune responses to HIV-1 gp120 by interleukin-12 in Rhesus macaques

scientific article published on May 2002

Strong TH1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacy

scientific article published on 01 November 2019

Studies on GM-CSF DNA as an adjuvant for neutralizing Ab elicited by a DNA/MVA immunodeficiency virus vaccine

scientific article published on 5 June 2006

Studies using a viral challenge and CD8 T cell depletions on the roles of cellular and humoral immunity in the control of an SHIV-89.6P challenge in DNA/MVA-vaccinated macaques.

scientific article published on 26 September 2005

Suppression of the Insulin Receptors in Adult Schistosoma japonicum Impacts on Parasite Growth and Development: Further Evidence of Vaccine Potential

scientific article published on 11 May 2015

Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy

scientific article

Systemic and topical use of monoclonal antibodies to prevent the sexual transmission of HIV.

scientific article published in July 2017

Target cell availability, rather than breast milk factors, dictates mother-to-infant transmission of SIV in sooty mangabeys and rhesus macaques

scientific article

Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

scientific article

The Dynamics of T and B Cells in Lymph Node during Chronic HIV Infection: TFH and HIV, Unhappy Dance Partners?

scientific article

The Role of Integrin α4β7 in HIV Pathogenesis and Treatment.

scientific article published on 24 February 2018

Therapeutic vaccination against the rhesus lymphocryptovirus EBNA-1 homologue, rhEBNA-1, elicits T cell responses to novel epitopes in rhesus macaques.

scientific article published on 02 October 2013

Therapy of ‘SHIV’ infected macaques with liposomes delivering antisense interleukin-4 DNA

scientific article published on 01 May 2006

Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation

scientific article

Up-regulation of Tim-3 on T cells during acute simian immunodeficiency virus infection and on antigen specific responders

scientific article

Use of recombinant cytokines for optimized induction of antiviral immunity against SIV in the nonhuman primate model of human AIDS.

scientific article published on January 2004

Vaccine-induced plasmablast responses in rhesus macaques: phenotypic characterization and a source for generating antigen-specific monoclonal antibodies

scientific article

Visualization of early events in mRNA vaccine delivery in non-human primates via PET-CT and near-infrared imaging

scientific article published on 01 April 2019

Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy-treated macaques

scientific article published on 9 March 2015

XMRV replicates preferentially in mucosal sites in vivo: Relevance to XMRV transmission?

scientific article

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