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List of works by Karen E Duff

A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology

scientific article published on 17 December 2018

APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice

scientific article published on 09 March 2020

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes ⬇️

scientific article published on January 1, 1998

Alzheimer transgenic mouse models come of age ⬇️

scientific article published on July 1, 1997

Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy

scientific article published on 16 October 2020

Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus

scientific article published on 21 August 2020

Global Axonal Transport Rates are Unaltered in Htau Mice in vivo ⬇️

scientific article published on January 1, 2013

Insertion of a pathogenic mutation into a yeast artificial chromosome containing the human amyloid precursor protein gene

scientific article published on January 1, 1994

Mechanisms of Protein Seeding in Neurodegenerative Diseases ⬇️

scientific article published on March 1, 2013

Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein

scientific article published on 23 July 2009

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo.

scientific article

Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

scientific article

Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology

scientific article published on 13 November 2017

Non-invasive, Focused Ultrasound-Facilitated Gene Delivery for Optogenetics.

scientific article

P62 accumulates through neuroanatomical circuits in response to tauopathy propagation

scientific article published on 02 November 2021

Selective vulnerability in neurodegenerative diseases

scientific article published on 24 September 2018

Targeting the 26S Proteasome To Protect Against Proteotoxic Diseases

scientific article published on 9 December 2017

Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease.

scientific article published on 13 January 2017

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

scientific article

The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo

scientific article published on 12 December 2017

Trans-Synaptic Spread of Tau Pathology In Vivo ⬇️

scientific article published on January 1, 2012

Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing

scientific article published on March 2008

Transgenic models for Alzheimer's disease ⬇️

scientific article published on April 1, 1998

Tunneling nanotubes: A possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases.

scientific article published on 7 October 2016

Unilateral Focused Ultrasound-Induced Blood-Brain Barrier Opening Reduces Phosphorylated Tau from The rTg4510 Mouse Model

scientific article published on 13 July 2019

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