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List of works by David Zagzag

144 GPR133 Promotes Glioblastoma Growth in Hypoxia

scientific article published in August 2016

A Rare Case of Composite Dural Extranodal Marginal Zone Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.

scientific article

A clinical trial of bevacizumab, temozolomide, and radiation for newly diagnosed glioblastoma

scientific article published on 28 October 2011

ATIM-01. A PHASE II, OPEN-LABEL, SINGLE ARM, MULTICENTER STUDY OF AVELUMAB WITH HYPOFRACTIONATED RE-IRRADIATION IN ADULT SUBJECTS WITH TRANSFORMED MUTANT GLIOBLASTOMA

scientific article published on 6 November 2017

Abstract LB-172: Novel candidate oncogenic drivers in pineoblastoma

Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target

scientific article

Angiogenesis in gliomas: biology and molecular pathophysiology

scientific article

Angiogenesis in gliomas: imaging and experimental therapeutics

scientific article

Antiangiogenic effects of noscapine enhance radioresponse for GL261 tumors

scientific article published on August 2008

Antiangiogenic therapy using bevacizumab in recurrent high-grade glioma: impact on local control and patient survival

scientific article published in January 2009

Assessing global invasion of newly diagnosed glial tumors with whole-brain proton MR spectroscopy

scientific article

BRAF alteration status and the histone H3F3A gene K27M mutation segregate spinal cord astrocytoma histology

scientific article published on 20 October 2015

BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants.

scientific article

Brainstem corticospinal tract diffusion tensor imaging in patients with primary posterior fossa neoplasms stratified by tumor type: a study of association with motor weakness and outcome.

scientific article

CBIO-19. CHARACTERIZATION OF GPR133 EXPRESSION IN GLIOMA SUBTYPES

CBMT-21. ALTERATIONS OF CYSTEINE METABOLISM IN GENETIC VARIANTS OF HIGH GRADE GLIOMAS

CMET-46. EXPRESSION OF HYDROGEN SULFIDE (HS) PRODUCING ENZYMES IN METASTATIC BRAIN TUMORS

scientific article published on 6 November 2017

COVID-19-Induced Neurovascular Injury: a Case Series with Emphasis on Pathophysiological Mechanisms

scientific article published on 22 October 2020

CXCR7 is induced by hypoxia and mediates glioma cell migration towards SDF-1α

scientific article

Carotid web: an occult mechanism of embolic stroke

scientific article published on 01 October 2020

Cell surface Notch ligand DLL3 is a therapeutic target in isocitrate dehydrogenase mutant glioma

scientific article published on 05 November 2018

Change in Pattern of Relapse After Antiangiogenic Therapy in High-Grade Glioma ⬇️

scientific article published on December 14, 2010

Clinical response to bevacizumab in schwannomatosis

scientific article

Clonal selection drives genetic divergence of metastatic medulloblastoma

scientific article published on 15 February 2012

Cochlear Implantation of a Patient with Definitive Neurosarcoidosis

scientific article published on 01 October 2017

Comparison of cerebral blood volume and vascular permeability from dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma grade

scientific article published in May 2004

Conventional and perfusion MR imaging of parafalcine chondrosarcoma

scientific article published on February 2003

Cytological diagnosis of cystic brain tumors: a retrospective study of 88 cases

scientific article published on 01 October 2004

Decreased expression of cystathionine β-synthase promotes glioma tumorigenesis

scientific article

Delayed hemorrhage from the tissue of an occluded arteriovenous malformation after stereotactic radiosurgery: report of 3 cases

scientific article published on 10 June 2016

Differentiating surgical from non-surgical lesions using perfusion MR imaging and proton MR spectroscopic imaging.

scientific article

Diffusion-Tensor MR Imaging of Intracranial Neoplasia and Associated Peritumoral Edema: Introduction of the Tumor Infiltration Index

article

Downregulation of major histocompatibility complex antigens in invading glioma cells: stealth invasion of the brain

scientific article

Dynamic contrast enhanced perfusion MRI in mycosis fungoides

scientific article published in September 2003

Dynamic contrast-enhanced perfusion MR imaging measurements of endothelial permeability: differentiation between atypical and typical meningiomas.

scientific article

Dynamic susceptibility contrast-enhanced perfusion and conventional MR imaging findings for adult patients with cerebral primitive neuroectodermal tumors.

scientific article published in June 2004

Dynamic, contrast-enhanced perfusion MRI in mouse gliomas: correlation with histopathology

scientific article published on May 2003

EMBR-02. RECURRENT HOMOZYGOUS DELETION OF DROSHA AND MICRODUPLICATION OF PDE4DIP CONTAINING THE ANCESTRAL DUF1220 DOMAIN IN PINEOBLASTOMA

ERG is a novel and reliable marker for endothelial cells in central nervous system tumors

scientific article

ET-51COMBINED THERAPY WITH A NOVEL CXCR4 ANTAGONIST AND AN ANTI-VEGF ANTIBODY IMPAIRS THE GROWTH OF GLIOMAS.

scientific article published in November 2014

Endarterectomy for symptomatic internal carotid artery web

scientific article published on 28 August 2020

Endothelium-Independent Primitive Myxoid Vascularization Creates Invertebrate-Like Channels to Maintain Blood Supply in Optic Gliomas.

scientific article

Enhanced overexpression of an HIF-1/hypoxia-related protein in cancer cells.

scientific article

Epithelioid ependymoma: a new variant of ependymoma: report of three cases

scientific article

ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma

scientific article

Expression of hypoxia-inducible factor 1? in brain tumors

scientific article (publication date: June 2000)

Expression of p27KIP1 in human gliomas: relationship between tumor grade, proliferation index, and patient survival

scientific article published in January 2003

Expression profiling of the adhesion G protein-coupled receptor GPR133 (ADGRD1) in glioma subtypes

scientific article published on 01 January 2020

Extraventricular subependymal giant cell tumor in a child with tuberous sclerosis complex

scientific article

Feasibility of using bevacizumab with radiation therapy and temozolomide in newly diagnosed high-grade glioma

scientific article published in October 2008

Flavopiridol downregulates hypoxia-mediated hypoxia-inducible factor-1alpha expression in human glioma cells by a proteasome-independent pathway: implications for in vivo therapy

scientific article published on July 2005

Flavopiridol induces mitochondrial-mediated apoptosis in murine glioma GL261 cells via release of cytochrome c and apoptosis inducing factor

scientific article published on May 1, 2003

Flavopiridol inhibits the growth of GL261 gliomas in vivo: implications for malignant glioma therapy

scientific article published on February 2004

Functional and topographic effects on DNA methylation in IDH1/2 mutant cancers

scientific article published on 14 November 2019

GENE-02. PERIPHERAL BLOOD DNA METHYLATION PROFILES IDENTIFY IDH1/2 MUTATION STATUS IN ADULTS WITH DIFFUSE GLIOMA

GENE-14. DNA METHYLATION AND PROTEOMIC ALTERATIONS IDENTIFY HISTOLOGICALLY-DEFINED TUMOR CELL POPULATIONS AND CHARACTERIZE INTRATUMOR HETEROGENEITY IN GLIOBLASTOMA

GENE-62. IDENTIFICATION OF FGFR4 p.G388R VARIANT IN CEREBELLAR HEMANGIOBLASTOMAS ⬇️

scholarly article

GENO-20NOVEL CANDIDATE ONCOGENIC DRIVERS IN PINEOBLASTOMA.

scientific article

GPR133 Promotes Glioblastoma Growth in Hypoxia.

scientific article

Gamma Knife Radiosurgery and Immunotherapy as Primary Treatment for a Malignant Tumor of the Cranial Base Beginning as Lentigo Maligna: A Case Report

scientific article published on 23 May 2019

Geldanamycin induces G2 arrest in U87MG glioblastoma cells through downregulation of Cdc2 and cyclin B1.

scientific article published on 21 January 2007

Geldanamycin induces mitotic catastrophe and subsequent apoptosis in human glioma cells

scientific article published on December 2004

Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion

scientific article

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

scientific article (publication date: May 2014)

Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging

scientific article published in November 2003

Gliomas: predicting time to progression or survival with cerebral blood volume measurements at dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging

scientific article published on 18 March 2008

Green fluorescent protein immunohistochemistry as a novel experimental tool for the detection of glioma cell invasion in vivo.

scientific article

HGF upregulates CXCR4 expression in gliomas via NF-kappaB: implications for glioma cell migration

scientific article published on 16 February 2010

Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis

scientific article published on 2 February 2018

Hemorrhagic stroke and anticoagulation in COVID-19

scientific article published on 23 May 2020

High cerebral blood volume in human gliomas predicts deletion of chromosome 1p: Preliminary results of molecular studies in gliomas with elevated perfusion

scientific article

High-grade glioma before and after treatment with radiation and Avastin: initial observations

scientific article published on 12 August 2008

Hypoxia- and vascular endothelial growth factor-induced stromal cell-derived factor-1alpha/CXCR4 expression in glioblastomas: one plausible explanation of Scherer's structures.

scientific article published on 3 July 2008

Hypoxia-Mediated Mechanisms Associated with Antiangiogenic Treatment Resistance in Glioblastomas.

scientific article published on 8 March 2017

Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion

scientific article published on 30 October 2006

Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.

scientific article published in March 2006

Induction and Assessment of Hypoxia in Glioblastoma Cells In Vitro

scientific article published in January 2018

Induction of medulloblastomas in mice by sonic hedgehog, independent of Gli1.

scientific article published in November 2002

Intracranial lesions mimicking neoplasms

scientific article published on January 2009

Intracranial mass lesions: dynamic contrast-enhanced susceptibility-weighted echo-planar perfusion MR imaging

scientific article

Intraosseous Petrous Apex Schwannoma: Case Report and Review of Literature

scientific article published on 30 August 2019

Invasion is not an independent prognostic factor in high-grade glioma ⬇️

scientific article published on July 1, 2011

LGG-02. BIOCHEMICAL COMPOSITION AND BIOLOGICAL FUNCTION OF MYXOID MATRIX IN OPTIC GLIOMAS.

scientific article published on 31 May 2017

LGG-11. LOW-GRADE ASTROCYTOMA CORE MUTATIONS IN IDH1, P53 AND ATRX COOPERATE TO BLOCK DIFFERENTIATION OF HUMAN NEURAL STEM CELLS VIA EPIGENETIC REPRESSION OF SOX2.

scientific article

Leptomeningeal dissemination at diagnosis of pediatric low-grade neuroepithelial tumors

scientific article published in July 2003

Leptomeningeal dissemination in children with progressive low-grade neuroepithelial tumors

scientific article published in October 2002

Leptomeningeal dissemination in children with progressive low-grade neuroepithelial tumors

Levels of elevated circulating endothelial cell decline after tumor resection in patients with pancreatic ductal adenocarcinoma

scientific article published on 01 July 2010

Loss of histone H3K27me3 identifies a subset of meningiomas with increased risk of recurrence

scientific article published on 7 April 2018

Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2.

scientific article published in October 2017

Low-grade gliomas: dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging--prediction of patient clinical response

scientific article published on 5 January 2006

MB-17NOVEL CANDIDATE ONCOGENIC DRIVERS IN PINEOBLASTOMA.

scientific article

MNGI-14. LOSS OF HISTONE H3K27me3 IDENTIFIES A SUBSET OF MENINGIOMAS WITH INCREASED RISK OF RECURRENCE

MPTH-24. CYSTATHIONE β-SYNTHASE EXPRESSION IN ASTROCYTOMAS INCREASES WITH HISTOPATHOLOGICAL GRADE

MPTH-34. THE PROGNOSTIC VALUE OF POLYSOMY IN OLIGODENDROGLIAL TUMORS

MR imaging phenotype correlates with extent of genome-wide copy number abundance in IDH mutant gliomas

scientific article published on 27 May 2019

Medulloblastoma subgroups remain stable across primary and metastatic compartments

scientific article

Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus

scientific article

MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2.

scientific article published on 15 November 2012

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

scientific article

Multifaceted C-X-C Chemokine Receptor 4 (CXCR4) Inhibition Interferes with Anti-Vascular Endothelial Growth Factor Therapy-Induced Glioma Dissemination

scientific article published on 20 July 2017

Mutant IDH1 and thrombosis in gliomas.

scientific article published on 23 September 2016

NEXT-GENERATION NEUROPATHOLOGY - IMPROVING DIAGNOSTIC ACCURACY FOR BRAIN TUMORS USING DNA METHYLATION ARRAY-BASED MOLECULAR PROFILING.

scientific article published in July 2014

NIMG-33. CORRELATION BETWEEN IDH MUTATION STATUS, PATIENT SURVIVAL, AND BLOOD VOLUME ESTIMATES IN DIFFUSE GLIOMAS: A TCGA/TCIA PROJECT

article

NIMG-48. MR IMAGING PHENOTYPE CORRELATES WITH EXTENT OF GENOME-WIDE COPY NUMBER ABUNDANCE IN IDH MUTATED GLIOMAS

Noninvasive diagnosis and management of spontaneous intracranial hypotension in patients with marfan syndrome: Case Report and Review of the Literature

scientific article published on 21 January 2014

Noscapine induces apoptosis in human glioma cells by an apoptosis-inducing factor-dependent pathway

scientific article

Noscapine inhibits hypoxia-mediated HIF-1alpha expression andangiogenesis in vitro: a novel function for an old drug.

scientific article published on May 2006

Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells.

scientific article published on 23 May 2017

Overexpression and activation of epidermal growth factor receptor in hemangioblastomas ⬇️

scientific article published on February 22, 2010

PATH-42. DETECTION OF MUTATIONS IN CELL-FREE CIRCULATING TUMOR DNA (ctDNA) OF GLIOBLASTOMA PATIENTS USING DROPLET DIGITAL PCR

Patient-Specific Screening Using High-Grade Glioma Explants to Determine Potential Radiosensitization by a TGF-β Small Molecule Inhibitor.

scientific article published on December 2016

Pediatric midline H3K27M-mutant tumor with disseminated leptomeningeal disease and glioneuronal features: case report and literature review

scientific article published on 28 September 2020

Perfusion MR imaging and proton MR spectroscopic imaging in differentiating necrotizing cerebritis from glioblastoma multiforme

scientific article

Perfusion magnetic resonance imaging predicts patient outcome as an adjunct to histopathology: a second reference standard in the surgical and nonsurgical treatment of low-grade gliomas

scientific article published in June 2006

Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas.

scientific article

Pilocytic astrocytoma and glioneuronal tumor with histone H3 K27M mutation

scientific article published on 12 August 2016

Polysomy is associated with poor outcome in 1p19q co-deleted oligodendroglial tumors

scientific article published on 29 May 2019

Predicting Genotype and Survival in Glioma Using Standard Clinical MR Imaging Apparent Diffusion Coefficient Images: A Pilot Study from The Cancer Genome Atlas

scientific article published on 06 September 2018

Probing Glioblastoma Tissue Heterogeneity with Laser Capture Microdissection

scientific article published in January 2018

Prospective neuraxis MRI surveillance reveals a high risk of leptomeningeal dissemination in diffuse intrinsic pontine glioma.

scientific article published on 10 July 2010

Proton MR spectroscopy of tumefactive demyelinating lesions.

scientific article published in September 2002

R132H-mutation of isocitrate dehydrogenase-1 is not sufficient for HIF-1α upregulation in adult glioma.

scientific article published on 24 December 2010

Radiation sensitivity of GL261 murine glioma model and enhanced radiation response by flavopiridol

scientific article published on 25 January 2006

Radiologic response to MEK inhibition in a patient with a WNT-activated craniopharyngioma

scientific article published on 19 October 2020

Radiotherapy enhances antitumor effect of anti-CD137 therapy in a mouse Glioma model

scientific article published on April 2010

Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis

scientific article published on 17 October 2013

Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma

scientific article published in Nature Communications

Relative cerebral blood volume measurements of low-grade gliomas predict patient outcome in a multi-institution setting

scientific article published on 6 February 2009

Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.

scientific article published on 12 June 2012

SARS-CoV-2 Is Not Detected in the Cerebrospinal Fluid of Encephalopathic COVID-19 Patients

scientific article published on 11 December 2020

SC-04NON-UNIFORM NOTCH SIGNALING UNDERLIES HETEROGENEITY WITHIN THE GLIOBLASTOMA STEM CELL POPULATION

STEM-04DEFINING GLIOBLASTOMA STEM CELL HETEROGENEITY.

scientific article

STEM-05GPR133 IS ENRICHED IN GLIOBLASTOMA STEM CELLS AND REGULATES THE RESPONSE TO HYPOXIA.

scientific article

STMC-25. GPR133 PROMOTES HYPOXIA-DRIVEN TUMOR PROGRESSION IN GLIOBLASTOMA

Selective lentiviral gene delivery to CD133-expressing human glioblastoma stem cells

scientific article

Serial Imaging of Virus-Associated Necrotizing Disseminated Acute Leukoencephalopathy (VANDAL) in COVID-19

scientific article published on 22 October 2020

Somatic Focal Copy Number Gains of Noncoding Regions of Receptor Tyrosine Kinase Genes in Treatment-Resistant Epilepsy

scientific article published on 04 December 2020

Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor

scientific article published on July 2005

Synchronous mixed germ cell tumor of the pineal gland and suprasellar region with a predominant angiomatous component: a diagnostic challenge

scientific article published on 20 December 2008

TMIC-13MUTANT IDH1/2 SUPPRESSES LOCAL AND SYSTEMIC THROMBOSIS IN GLIOMA PATIENTS.

scientific article

TMIC-19HYPOXIA-INDUCIBLE GENE (HIG2) AND PERILIPIN 2 ARE SPECIFIC BIOMARKERS OF HYPOXIC TUMOR CELLS IN GLIOMA AND STROMAL CELLS IN CNS HEMANGIOBLASTOMA.

scientific article

Temporal bone histopathology case of the month: Malignant peripheral nerve sheath tumor arising within vestibular schwannoma

scientific article published in December 2012

Tenascin-C promotes microvascular cell migration and phosphorylation of focal adhesion kinase.

scientific article published in May 2002

The combination of ionizing radiation and peripheral vaccination produces long-term survival of mice bearing established invasive GL261 gliomas

scientific article published on August 2006

The geldanamycin analogue 17-allylamino-17-demethoxygeldanamycin inhibits the growth of GL261 glioma cells in vitro and in vivo

scientific article published on September 2007

The posterior nasoseptal flap: A novel technique for closure after endoscopic transsphenoidal resection of pituitary adenomas

scientific article published on 14 February 2018

The transcriptional landscape of Shh medulloblastoma

scientific article published on 19 March 2021

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis

scientific article published on 06 June 2016

Therapeutic targets in malignant glioblastoma microenvironment

scientific article published on July 2009

Transforming fusions of FGFR and TACC genes in human glioblastoma

scientific article

Tumor antigen precursor protein profiles of adult and pediatric brain tumors identify potential targets for immunotherapy

scientific article published on 08 February 2008

Tumoral Presentation of Homonymous Hemianopia and Prosopagnosia in Cerebral Amyloid Angiopathy-Related Inflammation

scientific article published in March 2017

Unique findings of subependymal giant cell astrocytoma within cortical tubers in patients with tuberous sclerosis complex: a histopathological evaluation

scientific article

Upregulation of cystathione β-synthase and p70S6K/S6 in neonatal hypoxic ischemic brain injury.

scientific article

Utility of MRI versus tumor markers for post-treatment surveillance of marker-positive CNS germ cell tumors.

scientific article published on 12 July 2016

Utility of positron emission tomography in schwannomatosis

scientific article published on 5 March 2016

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