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List of works by Charles N Serhan

15-epi-Lipoxin A4, Resolvin D2, and Resolvin D3 Induce NF-κB Regulators in Bacterial Pneumonia.

scientific article published on 9 March 2018

15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury

scientific article published on 29 May 2009

17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli

scientific article

A cluster of immunoresolvents links coagulation to innate host defense in human blood

scientific article

A molecular defect in intracellular lipid signaling in human neutrophils in localized aggressive periodontal tissue damage

scientific article (publication date: February 2004)

A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae

scientific article

A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation

scientific article

A novel rat lipoxin A4 receptor that is conserved in structure and function ⬇️

scientific article published on May 1, 2003

A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS

scientific article published on 06 December 2018

A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease

scientific article

A search for endogenous mechanisms of anti-inflammation uncovers novel chemical mediators: missing links to resolution

scientific article (publication date: October 2004)

A stable aspirin-triggered lipoxin A4 analog blocks phosphorylation of leukocyte-specific protein 1 in human neutrophils

scientific article

A synthetic eicosanoid LX-mimetic unravels host-donor interactions in allogeneic BMT-induced GvHD to reveal an early protective role for host neutrophils

scientific article

A tribute to Gerald Weissmann (1930-2019)

scientific article published on 01 November 2019

Addition of aspirin to a fish oil-rich diet decreases inflammation and atherosclerosis in ApoE-null mice

scientific article published on 19 June 2016

Adipocytes promote ovarian cancer chemoresistance

scientific article published on 16 September 2019

Aging delays resolution of acute inflammation in mice: reprogramming the host response with novel nano-proresolving medicines

scientific article

Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4.

scientific article published on 05 January 2009

Altered Fatty Acid Composition of Dopaminergic Neurons Expressing α-Synuclein and Human Brains with α-Synucleinopathies ⬇️

scientific article published on September 23, 2003

Anesthetics impact the resolution of inflammation

scientific article

Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediators

scientific article

Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent

scientific article (publication date: March 2006)

Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes.

scientific article

Anti-inflammatory and pro-resolving properties of benzo-lipoxin A(4) analogs

scientific article published on 22 October 2009

Anti-inflammatory and proresolving lipid mediators

scientific article published on January 2008

Anti-inflammatory circuitry: lipoxin, aspirin-triggered lipoxins and their receptor ALX

scientific article

Antimicrobial aspects of inflammatory resolution in the mucosa: a role for proresolving mediators

scientific article

Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression

scientific article published on October 2006

Aspirin has a gender-dependent impact on antiinflammatory 15-epi-lipoxin A4 formation: a randomized human trial

scientific article (publication date: February 2006)

Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial

scholarly article

Aspirin triggers formation of anti-inflammatory mediators: New mechanism for an old drug

scientific article published on December 2004

Aspirin-triggered 15-epi-lipoxin A4 biosynthesis in rat liver cells

scientific article (publication date: 2002)

Aspirin-triggered lipoxin A4 and B4 analogs block extracellular signal-regulated kinase-dependent TNF-alpha secretion from human T cells

scientific article (publication date: 15 June 2003)

Aspirin-triggered lipoxin and resolvin E1 modulate vascular smooth muscle phenotype and correlate with peripheral atherosclerosis

scientific article

Aspirin-triggered lipoxins override the apoptosis-delaying action of serum amyloid A in human neutrophils: a novel mechanism for resolution of inflammation

scientific article (publication date: July 2007)

Aspirin-triggered proresolving mediators stimulate resolution in cancer

scientific article published on 12 March 2019

Atherosclerosis, Periodontal Disease, and Treatment with Resolvins

scientific article published on 6 November 2017

Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators

scientific article published on 17 June 2008

Author Correction: Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson's disease

scientific article published on 14 October 2019

Author Correction: ERV1 Overexpression in Myeloid Cells Protects against High Fat Diet Induced Obesity and Glucose Intolerance.

scientific article published on 2 March 2018

Author Correction: Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation

scientific article published on 19 December 2019

Biosynthesis of D-Series Resolvins in Skin Provides Insights into their Role in Tissue Repair

scientific article published on 17 March 2018

Biosynthetic metabolomes of cysteinyl-containing immunoresolvents

scientific article published on 05 October 2019

Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson's disease

scientific article published on 02 September 2019

CORRIGENDUM: Novel n-3 Immunoresolvents: Structures and Actions.

scientific article published on 24 October 2014

COX-3 the enzyme and the concept: steps towards highly specialized pathways and precision therapeutics? ⬇️

scientific article published on November 1, 2003

Candida albicans modulates host defense by biosynthesizing the pro-resolving mediator resolvin E1

scientific article

Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators

scientific article published on 10 August 2016

Cell-cell interaction in the transcellular biosynthesis of novel omega-3-derived lipid mediators

scientific article (publication date: 2006)

Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1.

scientific article

Changes in phosphatidylinositol and phosphatidic acid in stimulated human neutrophils

Chemical Mediators of Inflammation and Resolution in Post-Operative Abdominal Aortic Aneurysm Patients ⬇️

scientific article published on February 1, 2012

Chiral lipidomics of E-series resolvins: Aspirin and the biosynthesis of novel mediators ⬇️

scientific article published on June 16, 2011

Clues for new therapeutics in osteoporosis

scientific article published in April 2004

Clues for new therapeutics in osteoporosis and periodontal disease: new roles for lipoxygenases?

scientific article

Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation

scientific article published on 28 February 2011

Contributions of the three CYP1 monooxygenases to pro-inflammatory and inflammation-resolution lipid mediator pathways

scientific article

Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators

scientific article published in August 2008

Correction for Diaz et al., "Specialized Proresolving Mediators Rescue Infant Mice from Lethal Citrobacter rodentium Infection and Promote Immunity against Reinfection"

scholarly article published by Charles N Serhan in 2018

Cutting Edge: Human Vagus Produces Specialized Proresolving Mediators of Inflammation with Electrical Stimulation Reducing Proinflammatory Eicosanoids

article

Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing

scientific article

Cutting edge: Parathyroid hormone facilitates macrophage efferocytosis in bone marrow via proresolving mediators resolvin D1 and resolvin D2.

scientific article

Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation

scientific article

Cysteinyl maresins regulate the prophlogistic lung actions of cysteinyl leukotrienes

scientific article published on 14 October 2019

Cytosolic phospholipase A(2) in hypoxic pulmonary vasoconstriction

scientific article

D-series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury

scientific article published on 13 February 2013

Decoding functional metabolomics with docosahexaenoyl ethanolamide (DHEA) identifies novel bioactive signals

scientific article published on 12 July 2011

Deficit of resolution receptor magnifies inflammatory leukocyte directed cardiorenal and endothelial dysfunction with signs of cardiomyopathy of obesity

scientific article published on 16 June 2020

Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties

scientific article published on 9 January 2008

Design and synthesis of novel prostaglandin E2 ethanolamide and glycerol ester probes for the putative prostamide receptor(s)

scientific article

Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins

scientific article

Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1 ⬇️

scientific article published on January 17, 2012

Discovery of specialized pro-resolving mediators marks the dawn of resolution physiology and pharmacology

scientific article published on 3 March 2017

Distal vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension

scientific article published on June 2016

Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice.

scientific article

Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases

scientific article (publication date: June 2006)

Diversity of lipid mediators in human adipose tissue depots.

scientific article published on 30 January 2013

Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates.

scientific article

ERV1 Overexpression in Myeloid Cells Protects against High Fat Diet Induced Obesity and Glucose Intolerance

scientific article published on 9 October 2017

Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections

scientific article

Emerging roles of resolvins in the resolution of inflammation and pain

scientific article

Endogenous Specialized Proresolving Mediator Profiles in a Novel Experimental Model of Lymphatic Obstruction and Intestinal Inflammation in African Green Monkeys

scientific article published on 01 October 2019

Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor

scientific article (publication date: November 2002)

Endogenous receptor agonists: resolving inflammation.

scientific article

Enduring prevention and transient reduction of postoperative pain by intrathecal resolvin D1 ⬇️

scientific article published on January 20, 2011

Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesis

scientific article

Exploring new approaches to the treatment of asthma: potential roles for lipoxins and aspirin-triggered lipid mediators

scientific article (publication date: May 2003)

Expression of 5-lipoxygenase in pulmonary artery endothelial cells

scientific article

Fibrinogen-like protein 2 controls sepsis catabasis by interacting with resolvin Dp5

scientific article published on 13 November 2019

Fish Oil Supplementation in Pregnancy

scientific article published on 01 December 2016

Functional Metabolomics Reveals Novel Active Products in the DHA Metabolome ⬇️

scientific article published on April 17, 2012

Gene Expression of Proresolving Lipid Mediator Pathways Is Associated With Clinical Outcomes in Trauma Patients

scientific article

Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 - Fields of Precision Nutrition

scientific article published on 12 May 2016

Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma.

scientific article published on 6 October 2017

Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production

scientific article

Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections

scientific article published on February 2012

Human ALX receptor regulates neutrophil recruitment in transgenic mice: roles in inflammation and host defense.

scientific article published on April 2003

Human Periodontal Stem Cells Release Specialized Proresolving Mediators and Carry Immunomodulatory and Prohealing Properties Regulated by Lipoxins

scientific article

Human Sepsis Eicosanoid and Proresolving Lipid Mediator Temporal Profiles: Correlations With Survival and Clinical Outcomes

scientific article

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

scientific article published on 4 January 2018

Human milk proresolving mediators stimulate resolution of acute inflammation

scientific article published on 14 October 2015

IMMU-13. A FAILURE TO RESOLVE INFLAMMATION: ROLE OF RESOLVINS IN THE TREATMENT OF PEDIATRIC CNS TUMORS.

scientific article published on 22 June 2018

Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3

scientific article

Identification and Actions of the Maresin 1 Metabolome in Infectious Inflammation.

scientific article

Identification and Complete Stereochemical Assignments of the New Resolvin Conjugates in Tissue Regeneration in Human Tissues that Stimulate Proresolving Phagocyte Functions and Tissue Regeneration.

scientific article published in April 2018

Identification and Profiling of Specialized Pro-Resolving Mediators in Human Tears by Lipid Mediator Metabolomics

scientific article published on 19 January 2017

Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue

scientific article

Identification and structure elucidation of the pro-resolving mediators provides novel leads for resolution pharmacology.

scientific article

Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection

scientific article

Identification of Chemotype Agonists for Human Resolvin D1 Receptor DRV1 with Pro-Resolving Functions

scientific article published on 13 December 2018

Identification of endogenous resolvin E1 and other lipid mediators derived from eicosapentaenoic acid via electrospray low-energy tandem mass spectrometry: spectra and fragmentation mechanisms

scientific article published in January 2007

Identification of inflammatory and proresolving lipid mediators in bone marrow and their lipidomic profiles with ovariectomy and omega-3 intake

scientific article published on June 2008

Identification of proresolving and inflammatory lipid mediators in human psoriasis

scientific article published in 2018

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

scientific article

Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation

scientific article published in Scientific Reports

Immune responsive resolvin D1 programs myocardial infarction-induced cardiorenal syndrome in heart failure

scientific article published on 13 February 2018

Immunoresolvent Resolvin D1 Maintains the Health of the Ocular Surface

scientific article published on 01 January 2019

Immunoresolvents signaling molecules at intersection between the brain and immune system

scientific article published on 16 November 2017

Impaired local production of proresolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation

scientific article published on 24 January 2013

Impaired phagocytosis in localized aggressive periodontitis: rescue by Resolvin E1

scientific article (publication date: 2011)

Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis

scientific article published on 24 June 2007

Infection regulates pro-resolving mediators that lower antibiotic requirements

scientific article published on 25 April 2012

Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?

scientific article published on 08 May 2020

Inhaled carbon monoxide accelerates resolution of inflammation via unique proresolving mediator-heme oxygenase-1 circuits

scientific article

Inhibition of allergen-induced eosinophil migration by lipoxin (LX)A4 and aspirin-triggered 15-epi-LXA4

scientific article (publication date: 2002)

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family

scientific article

International Union of Basic and Clinical Pharmacology. LXXXIV: leukotriene receptor nomenclature, distribution, and pathophysiological functions

scientific article

International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor

scientific article (publication date: March 2004)

International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors

scientific article (publication date: March 2003)

Is C-reactive protein an inflammation opsonin that signals colon cancer risk?

scientific article published on 01 February 2004

Lack of resolution sensor drives age-related cardiometabolic and cardiorenal defects and impedes inflammation-resolution in heart failure

scientific article published on 16 November 2019

Leukotriene B4 and lipoxin A4 are regulatory signals for neural stem cell proliferation and differentiation

scientific article published in September 2006

Leukotriene B4 is a complete secretagogue in human neutrophils: A kinetic analysis

article

Lipid Mediator Metabolomics Via LC-MS/MS Profiling and Analysis

scientific article published in January 2018

Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC-MS/MS

scientific article

Lipid mediator informatics and proteomics in inflammation resolution

scientific article published in June 2006

Lipid mediator informatics-lipidomics: novel pathways in mapping resolution

scientific article published on 28 April 2006

Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia

scientific article

Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death

scientific article published on 27 October 2008

Lipid mediators in the resolution of inflammation

scientific article

Lipid signatures of unstable atheromas: fossils or a step toward personalized lipidomics-metabolomics?

scientific article

Lipid-derived mediators in endogenous anti-inflammation and resolution: lipoxins and aspirin-triggered 15-epi-lipoxins

scientific article (publication date: 22 January 2002)

Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease

scientific article

Lipoxin A4 Counter-regulates Histamine-stimulated Glycoconjugate Secretion in Conjunctival Goblet Cells

scientific article

Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit human neutrophil migration: comparisons between synthetic 15 epimers in chemotaxis and transmigration with microvessel endothelial cells and epithelial cells

scientific article (publication date: March 2003)

Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes.

scientific article

Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 modulate adhesion molecule expression on human leukocytes in whole blood and inhibit neutrophil-endothelial cell adhesion

scientific article (publication date: 2002)

Lipoxin A4 stable analogs reduce allergic airway responses via mechanisms distinct from CysLT1 receptor antagonism

scientific article

Lipoxin A₄ modulates adaptive immunity by decreasing memory B-cell responses via an ALX/FPR2-dependent mechanism

scientific article published on February 2014

Lipoxins and Related Eicosanoids: Biosynthesis, Biological Properties, and Chemical Synthesis

article published in 1991

Lipoxins and aspirin-triggered 15-epi-lipoxin biosynthesis: an update and role in anti-inflammation and pro-resolution

scientific article (publication date: August 2002)

Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution

scientific article

Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing

scientific article

Lipoxins and aspirin-triggered lipoxins in airway responses

scientific article (publication date: 2003)

Lipoxins and new lipid mediators in the resolution of inflammation

scientific article (publication date: August 2006)

Lipoxins and novel 15-epi-lipoxin analogs display potent anti-inflammatory actions after oral administration

scientific article (publication date: September 2004)

Macrophage Proresolving Mediators-the When and Where

scientific article published on June 2016

Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain

scientific article

Maresin 1 Biosynthesis and Proresolving Anti-infective Functions with Human-Localized Aggressive Periodontitis Leukocytes

scientific article

Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions

scientific article published on 01 December 2019

Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective

scientific article

Maresin 1, a specialized proresolving mediator, stimulates intracellular [Ca2+ ] and secretion in conjunctival goblet cells

scientific article published on 08 June 2020

Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages ⬇️

scientific article

Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages ⬇️

scientific article published on 06 October 2016

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

scientific article

Mediator lipidomics

scientific article

Mediator lipidomics: search algorithms for eicosanoids, resolvins, and protectins

scientific article published on January 2007

Mediator-lipidomics: databases and search algorithms for PUFA-derived mediators

scientific article published on 01 February 2005

Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acids

scholarly article

Metabolic Inactivation of Resolvin E1 and Stabilization of Its Anti-inflammatory Actions

scientific article published in Journal of Biological Chemistry

Metabololipidomic profiling of functional immunoresolvent clusters and eicosanoids in mammalian tissues.

scientific article published on 7 March 2018

Metabolomics‐Lipidomics of Eicosanoids and Docosanoids Generated by Phagocytes ⬇️

scientific article published on November 1, 2011

MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits

scientific article

Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions

scientific article

Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

scientific article published on 01 December 2018

Microscale arrays for the profiling of start and stop signals coordinating human-neutrophil swarming

scientific article published on 30 June 2017

Molecular and Cellular Differences in Cardiac Repair of Male and Female Mice

scientific article published on 16 April 2020

Molecular circuits of resolution: formation and actions of resolvins and protectins

scientific article

Moving beyond "good fat, bad fat": the complex roles of dietary lipids in cellular function and health: session abstracts

scientific article published on 5 January 2012

Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4).

scientific article published on 12 August 2002

NLRP3 Inflammasome Deficiency Protects Against Microbial Sepsis via Increased Lipoxin B4 Synthesis

scientific article published on 28 February 2017

Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6

Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6

Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6.

scientific article published on 14 April 2008

Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils

scientific article

Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress

scientific article published in June 2004

Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma

scientific article published on 04 September 2013

Neuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes

scientific article

Neutrophil Resolvin E1 Receptor Expression and Function in Type 2 Diabetes

scientific article published on 19 December 2016

New Lives Given by Cell Death: Macrophage Differentiation Following Their Encounter with Apoptotic Leukocytes during the Resolution of Inflammation ⬇️

scientific article published on January 31, 2012

New endogenous anti-inflammatory and proresolving lipid mediators: implications for rheumatic diseases

scientific article (publication date: October 2007)

New maresin conjugates in tissue regeneration pathway counters leukotriene D4-stimulated vascular responses

scientific article published on 28 February 2018

New mechanism for an old drug: aspirin triggers anti-inflammatory lipid mediators with gender implications

scientific article (publication date: 2006)

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

scientific article published on 09 August 2017

Novel Anti-Inflammatory-Pro-Resolving Mediators and Their Receptors ⬇️

scientific article published on January 1, 2011

Novel Endogenous Proresolving Molecules:Essential Fatty Acid-Derived and Gaseous Mediators in the Resolution of Inflammation

scientific article

Novel Resolvin D2 Receptor Axis in Infectious Inflammation.

scientific article published on 19 December 2016

Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke

scientific article

Novel chemical mediators in the resolution of inflammation: resolvins and protectins

scientific article (publication date: June 2006)

Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression

scientific article (publication date: 31 October 2003)

Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation

scientific article (publication date: 25 April 2003)

Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectins

scientific article (publication date: March 2005)

Novel endogenous small molecules as the checkpoint controllers in inflammation and resolution: entrée for resoleomics

scientific article published on February 2004

Novel lipid mediator regulators of endothelial cell proliferation and migration: aspirin-triggered-15R-lipoxin A(4) and lipoxin A(4).

scientific article published in February 2002

Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not?

scientific article

Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins

scientific article

Novel n-3 immunoresolvents: structures and actions

scientific article

Novel omega -- 3-derived local mediators in anti-inflammation and resolution

scientific article

Novel pathways and endogenous mediators in anti-inflammation and resolution

scientific article (publication date: 2003)

Novel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo

scientific article published in October 2005

Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways

scientific article

Novel proresolving aspirin-triggered DHA pathway ⬇️

scientific article published on August 26, 2011

Novel tail and head group prostamide probes

scientific article published on 4 February 2015

Nutrigenetic Disruption of Inflammation-Resolution Homeostasis and Atherogenesis ⬇️

scientific article published on April 7, 2011

PCTR1 Enhances Repair and Bacterial Clearance in Skin Wounds

scientific article published on 06 March 2021

Parasite-induced lipoxin A4 is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infection

scientific article

Plasma lipoxin A4 and resolvin D1 are not associated with reduced adenoma risk in a randomized trial of aspirin to prevent colon adenomas

scientific article published on 20 February 2017

Plasma metabolomics in human pulmonary tuberculosis disease: a pilot study

scientific article

Plasticity of leukocytic exudates in resolving acute inflammation is regulated by MicroRNA and proresolving mediators

scientific article

Potent Anti-Inflammatory and Pro-Resolving Effects of Anabasum in a Human Model of Self-Resolving Acute Inflammation.

scientific article

Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases

scientific article published on 17 June 2019

Pro-Resolving Lipid Mediators (SPMs) and Their Actions in Regulating miRNA in Novel Resolution Circuits in Inflammation

scientific article (publication date: 2012)

Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis

scientific article published on 9 December 2015

Pro-Resolving Mediators in Regulating and Conferring Macrophage Function

scientific article published in November 2017

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

scientific article

Pro-resolving lipid mediators are leads for resolution physiology

scientific article

Pro-resolving mediators promote resolution in a human skin model of UV-killed Escherichia coli-driven acute inflammation

scientific article published on 22 March 2018

Proresolving actions of a new resolvin D1 analog mimetic qualifies as an immunoresolvent

scientific article

Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis

scientific article

Proresolving lipid mediators and mechanisms in the resolution of acute inflammation

scientific article

Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses

scientific article published on August 2016

Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness

scientific article

Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection

scientific article

Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome

scientific article

Protective actions of aspirin-triggered (17R) resolvin D1 and its analogue, 17R-hydroxy-19-para-fluorophenoxy-resolvin D1 methyl ester, in C5a-dependent IgG immune complex-induced inflammation and lung injury

scientific article published on 29 August 2014

Rainbow trout (Oncorhynchus mykiss) brain cells biosynthesize novel docosahexaenoic acid-derived resolvins and protectins-Mediator lipidomic analysis

scientific article (publication date: December 2005)

Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution.

scientific article

Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators

scientific article

Regulation of inflammation in cancer by eicosanoids ⬇️

scientific article published on August 16, 2011

Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1.

scientific article

Resolution metabolomes activated by hypoxic environment

scientific article published on 23 October 2019

Resolution of acute inflammation in the lung

scientific article

Resolution of inflammation in asthma

scientific article

Resolution of inflammation is altered in Alzheimer's disease

scientific article

Resolution of inflammation: state of the art, definitions and terms

scientific article

Resolution of sickle cell disease associated inflammation and tissue damage with 17R-Resolvin D1

scientific article published on 07 November 2018

Resolution phase lipid mediators of inflammation: agonists of resolution

scientific article

Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways

scientific article published on January 2007

Resolvin D series and protectin D1 mitigate acute kidney injury.

scientific article published in November 2006

Resolvin D1 Increases Mucin Secretion in Cultured Rat Conjunctival Goblet Cells via Multiple Signaling Pathways

scientific article published on September 2017

Resolvin D1 Reduces Emphysema and Chronic Inflammation.

scientific article published on 12 October 2015

Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function.

scientific article published on 11 April 2015

Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses.

scientific article published on 16 July 2012

Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation

scientific article (publication date: 30 March 2007)

Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat

scientific article

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

scientific article

Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions

scientific article

Resolvin D1 protects periodontal ligament

scientific article published on 17 July 2013

Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs

scientific article

Resolvin D1 treatment on goblet cell mucin and immune responses in the chronic allergic eye disease (AED) model

article

Resolvin D1, but not resolvin E1, transactivates the epidermal growth factor receptor to increase intracellular calcium and glycoconjugate secretion in rat and human conjunctival goblet cells

scientific article published on 01 December 2018

Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms

scientific article published on 19 October 2006

Resolvin D2 elevates cAMP to increase intracellular [Ca2+] and stimulate secretion from conjunctival goblet cells

scientific article published on 23 April 2019

Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1.

scientific article published on December 2011

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

scientific article

Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation

scientific article

Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia.

scientific article

Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents

scientific article published on February 2013

Resolvin D3 multi-level proresolving actions are host protective during infection

scientific article published on 22 January 2016

Resolvin D4 attenuates the severity of pathological thrombosis in mice

scientific article published on 01 October 2019

Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance

scientific article

Resolvin E1 Reduces Leukotriene B4-Induced Intracellular Calcium Increase and Mucin Secretion in Rat Conjunctival Goblet Cells

scientific article published on 16 June 2020

Resolvin E1 and chemokine-like receptor 1 mediate bone preservation

scientific article published on 14 December 2012

Resolvin E1 and protectin D1 activate inflammation-resolution programmes

scientific article (publication date: 14 June 2007)

Resolvin E1 metabolome in local inactivation during inflammation-resolution

scientific article

Resolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolution

scientific article published on 11 May 2007

Resolvin E1 receptor activation signals phosphorylation and phagocytosis

scientific article

Resolvin E1 regulates adenosine diphosphate activation of human platelets

scientific article

Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo.

scientific article published in November 2007

Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation

scientific article published on 22 June 2008

Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation

scientific article published in March 2007

Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets

scientific article

Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium-induced colitis

scientific article

Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis

scientific article

Resolvin E2 formation and impact in inflammation resolution

scientific article

Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis

scientific article published on 01 November 2006

Resolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1n-3 DPA

scientific article published on 20 December 2018

Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1.

scientific article

Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

scientific article

Resolvins and protectins in inflammation resolution.

scientific article

Resolvins and protectins in the termination program of acute inflammation

scientific article published on 6 March 2007

Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages

scientific article

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

scientific article published on 14 May 2018

Resolvins suppress tumor growth and enhance cancer therapy.

scientific article published on 30 November 2017

Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis

scientific article (publication date: April 2004)

Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers

scientific article (publication date: November 2004)

Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases

scientific article

Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals

scientific article

Role for Periodontitis in the Progression of Lipid Deposition in an Animal Model ⬇️

scientific article published on October 1, 2003

RvE1 uses the LTB4 receptor BLT1 to increase [Ca2+]i and stimulate mucin secretion in cultured rat and human conjunctival goblet cells

scientific article published on 29 April 2020

Saturated-efferocytosis generates pro-resolving CD11b low macrophages: modulation by resolvins and glucocorticoids

scientific article

Selective identification of specialized pro-resolving lipid mediators from their biosynthetic double di-oxygenation isomers

scientific article published on 04 March 2016

Self-Limited versus Delayed Resolution of Acute Inflammation: Temporal Regulation of Pro-Resolving Mediators and MicroRNA ⬇️

scientific article published on September 6, 2012

Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue

scientific article

Signaling pathways activated by resolvin E1 to stimulate mucin secretion and increase intracellular Ca2+ in cultured rat conjunctival goblet cells.

scientific article

Simultaneous lipidomic analysis of three families of bioactive lipid mediators leukotrienes, resolvins, protectins and related hydroxy-fatty acids by liquid chromatography/electrospray ionisation tandem mass spectrometry.

scientific article published on January 2008

Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis

scientific article

Specialized Pro-resolving Mediators (SPM) Rescue Infant Mice from Lethal Citrobacter rodentium Infection and Promote Immunity against Re-infection

scientific article published on 10 July 2017

Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction

scientific article published on 28 November 2019

Specialized pro-resolving lipid mediators in the inflammatory response: An update

scientific article

Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling

scientific article

Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution ⬇️

scientific article published on July 15, 2011

Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells

scientific article published on 18 June 2012

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators ⬇️

scientific article published on August 17, 2012

Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132

scientific article published on 23 August 2018

Splenic leukocytes define the resolution of inflammation in heart failure

scientific article published on 06 March 2018

Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1

scientific article

Stereocontrolled total synthesis of neuroprotectin D1 / protectin D1 and its aspirin-triggered stereoisomer

scientific article

Stereocontrolled total synthesis of the potent anti-inflammatory and pro-resolving lipid mediator resolvin D3 and its aspirin-triggered 17R-epimer

scientific article published on 19 March 2013

Stretching Impacts Inflammation Resolution in Connective Tissue

scientific article

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

scientific article published on 20 March 2017

Structural insights into Resolvin D4 actions and further metabolites via a new total organic synthesis and validation

scientific article published on 29 January 2018

Success of prostaglandin E2 in structure-function is a challenge for structure-based therapeutics

scientific article

Synthesis and anti-inflammatory and pro-resolving activities of 22-OH-PD1, a monohydroxylated metabolite of protectin D1.

scientific article

Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins

scientific article published on 05 October 2016

Synthesis of protectin D1 analogs: novel pro-resolution and radiotracer agents

scientific article published on 01 September 2018

Synthesis of the 16S,17S-Epoxyprotectin Intermediate in the Biosynthesis of Protectins by Human Macrophages

scientific article published on 18 November 2015

Systems approach with inflammatory exudates uncovers novel anti-inflammatory and pro-resolving mediators

scientific article

TLR11 activation of dendritic cells by a protozoan profilin-like protein.

scientific article

Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome

scientific article published on 08 February 2019

Targeting lipid mediators in cancer biology

scientific article published on 01 September 2018

The Protectin Family of Specialized Pro-resolving Mediators: Potent Immunoresolvents Enabling Innovative Approaches to Target Obesity and Diabetes

The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation

scientific article

The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide

scientific article

The allergy archives: pioneer and milestones. The discovery and characterization of the leukotrienes

scientific article

The contributions of aspirin and microbial oxygenase to the biosynthesis of anti-inflammatory resolvins: novel oxygenase products from omega-3 polyunsaturated fatty acids

scientific article (publication date: 9 December 2005)

The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering

scientific article

The endogenous pro-resolving mediators lipoxin A4 and resolvin E1 preserve organ function in allograft rejection ⬇️

scientific article published on September 24, 2010

The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo

scientific article (publication date: September 2006)

The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype

scientific article published on 15 March 2013

The novel lipid mediator PD1n-3 DPA: An overview of the structural elucidation, synthesis, biosynthesis and bioactions

scientific article

The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase

scholarly article

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

scientific article

The resolution of inflammation

scientific article published on 30 November 2012

The resolution of inflammation: the devil in the flask and in the details

scientific article

The resolvin D1 analogue controls maturation of dendritic cells and suppresses alloimmunity in corneal transplantation

scientific article

The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant?

scientific article

Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection

scientific article

Thromboxane A2is a key regulator of pathogenesis duringTrypanosoma cruziinfection

Toll-like receptor 7 stimulates production of specialized pro-resolving lipid mediators and promotes resolution of airway inflammation

scientific article published on 15 April 2013

Tonic inhibition of chemotaxis in human plasma

scientific article

Total synthesis of the lipid mediator PD1n-3 DPA: configurational assignments and anti-inflammatory and pro-resolving actions

scientific article published on 27 February 2014

Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis

scholarly article

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms ⬇️

scientific article published on 13 January 2017

Trypanosoma cruzi produces the specialized proresolving mediators Resolvin D1, Resolvin D5 and Resolvin E2.

scientific article

Unesterified docosahexaenoic acid is protective in neuroinflammation

scientific article

Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7

scientific article

Vacuolar (H+)-ATPase Critically Regulates Specialized Proresolving Mediator Pathways in Human M2-like Monocyte-Derived Macrophages and Has a Crucial Role in Resolution of Inflammation

scientific article published on 12 July 2019

Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution

scientific article published on 4 January 2017

Vagus nerve controls resolution and pro-resolving mediators of inflammation

scientific article

[Novel chemical mediators in the resolution of inflammation]

scientific article published on 01 April 2007

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