List of works - Subhas S Karki

1-Arylmethyl-2,3-dioxo-2,3-dihydroindole thiosemicarbazones as leads for developing cytotoxins and anticonvulsants

2-(4-Chlorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazoles: synthesis, cytotoxic activity and mechanism of action

scientific article

3,5-Bis(3-alkylaminomethyl-4-hydroxybenzylidene)-4-piperidones: A Novel Class of Potent Tumor-Selective Cytotoxins

scientific article published on 4 January 2016

3,5-Bis(3-dimethylaminomethyl-4-hydroxybenzylidene)-4-piperidone and related compounds induce glutathione oxidation and mitochondria-mediated cell death in HCT-116 colon cancer cells

scientific article

A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells

scientific article published on 17 October 2016

A novel inhibitor of BCL2, Disarib abrogates tumor growth while sparing platelets, by activating intrinsic pathway of apoptosis.

scientific article published on 29 September 2016

An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression ⬇️

scientific article published on December 21, 2012

Autocyclized and oxidized forms of SCR7 induce cancer cell death by inhibiting nonhomologous DNA end joining in a Ligase IV dependent manner

scientific article published on 08 October 2018

Enhanced efficacy of pluronic copolymer micelle encapsulated SCR7 against cancer cell proliferation

scientific article published on 16 December 2014

Identification and characterization of novel ligase I inhibitors

scientific article published on 17 June 2016

Identification of a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain.

scientific article published on 22 July 2016

Novel BCL2 inhibitor, Disarib induces apoptosis by disruption of BCL2-BAK interaction

scientific article published on 18 February 2017

Novel Levamisole Derivative Induces Extrinsic Pathway of Apoptosis in Cancer Cells and Inhibits Tumor Progression in Mice ⬇️

scientific article published on September 10, 2012

ST09, A Novel Curcumin Derivative, Blocks Cell Migration by Inhibiting Matrix Metalloproteases in Breast Cancer Cells and Inhibits Tumor Progression in EAC Mouse Tumor Models

scientific article published on 30 September 2020

Synthesis, anticancer and cytostatic activity of some 6H-indolo[2,3-b]quinoxalines

scientific article

Synthesis, anticancer, and cytotoxic activities of some mononuclear Ru(II) compounds

scientific article published on 19 August 2007

Synthesis, antineoplastic and cytotoxic activities of some mononuclear Ru(II) complexes

scientific article

The crystal structure of 6-(4-chloro-phen-yl)-2-(4-methyl-benz-yl)imidazo[2,1-b][1,3,4]thia-diazole-5-carbaldehyde.

scientific article published on 23 September 2016

Three novel piperidones exhibit tumor-selective cytotoxicity on leukemia cells via protein degradation and stress-mediated mechanisms

scientific article published on 26 August 2021

List of works by Subhas S Karki

1-Arylmethyl-2,3-dioxo-2,3-dihydroindole thiosemicarbazones as leads for developing cytotoxins and anticonvulsants

2-(4-Chlorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazoles: synthesis, cytotoxic activity and mechanism of action

3,5-Bis(3-alkylaminomethyl-4-hydroxybenzylidene)-4-piperidones: A Novel Class of Potent Tumor-Selective Cytotoxins

3,5-Bis(3-dimethylaminomethyl-4-hydroxybenzylidene)-4-piperidone and related compounds induce glutathione oxidation and mitochondria-mediated cell death in HCT-116 colon cancer cells

A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells

A novel inhibitor of BCL2, Disarib abrogates tumor growth while sparing platelets, by activating intrinsic pathway of apoptosis.

An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression ⬇️

Autocyclized and oxidized forms of SCR7 induce cancer cell death by inhibiting nonhomologous DNA end joining in a Ligase IV dependent manner

Enhanced efficacy of pluronic copolymer micelle encapsulated SCR7 against cancer cell proliferation

Identification and characterization of novel ligase I inhibitors

Identification of a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain.

Novel BCL2 inhibitor, Disarib induces apoptosis by disruption of BCL2-BAK interaction

Novel Levamisole Derivative Induces Extrinsic Pathway of Apoptosis in Cancer Cells and Inhibits Tumor Progression in Mice ⬇️

ST09, A Novel Curcumin Derivative, Blocks Cell Migration by Inhibiting Matrix Metalloproteases in Breast Cancer Cells and Inhibits Tumor Progression in EAC Mouse Tumor Models

Synthesis, anticancer and cytostatic activity of some 6H-indolo[2,3-b]quinoxalines

Synthesis, anticancer, and cytotoxic activities of some mononuclear Ru(II) compounds

Synthesis, antineoplastic and cytotoxic activities of some mononuclear Ru(II) complexes

The crystal structure of 6-(4-chloro-phen-yl)-2-(4-methyl-benz-yl)imidazo[2,1-b][1,3,4]thia-diazole-5-carbaldehyde.

Three novel piperidones exhibit tumor-selective cytotoxicity on leukemia cells via protein degradation and stress-mediated mechanisms