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List of works by Claus Nerlov

A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair

scientific article

A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors.

scientific article

A transit-amplifying population underpins the efficient regenerative capacity of the testis.

scientific article

Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block

scientific article published on 3 September 2006

Acute multiple organ failure in adult mice deleted for the developmental regulator Wt1

scientific article (publication date: December 2011)

Bi-directional signaling by membrane-bound KitL induces proliferation and coordinates thymic endothelial cell and thymocyte expansion

scientific article published in Nature Communications

C/EBPalpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation

scientific article published on 13 September 2009

C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor

scientific article published on 14 April 2020

CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex

scientific article published on 24 January 2019

Canonical Notch signaling is dispensible for adult steady-state and stress myelo-erythropoiesis

scientific article published on 16 January 2018

Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction

scientific article

Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation

scientific article published on 11 April 2019

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

scientific article published on 25 April 2016

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.

scientific article published on 4 October 2009

DNMT1 Deficiency Impacts on Plasmacytoid Dendritic Cells in Homeostasis and Autoimmune Disease

scientific article

Dependence on Myb expression is attenuated in myeloid leukaemia with N-terminal CEBPA mutations

scientific article published on 15 March 2019

Dicer is selectively important for the earliest stages of erythroid development.

scientific article

Direct role of FLT3 in regulation of early lymphoid progenitors.

scientific article published on 14 September 2018

Disease evolution and outcomes in familial AML with germline CEBPA mutations

scientific article published on 10 July 2015

Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo

scientific journal article

Distinct myeloid progenitor-differentiation pathways identified through single-cell RNA sequencing.

scientific article published on 04 April 2016

E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

scientific journal article

Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios.

scientific article published on 13 July 2016

Ectopic expression of PAX5 promotes maintenance of biphenotypic myeloid progenitors coexpressing myeloid and B-cell lineage-associated genes

scientific article published on 11 January 2007

Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

scholarly article by Florian Grebien et al published October 2015 in Nature Chemical Biology

Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate

scientific article published on 3 February 2014

FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors

scientific article published on 30 May 2013

FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors

scientific article published on 8 November 2011

Haematopoiesis in the era of advanced single-cell technologies

scientific article published on 02 January 2019

Hematopoietic Lineage Diversification, Simplified

scientific article published in August 2016

Hematopoietic stem cell expansion precedes the generation of committed myeloid leukemia-initiating cells in C/EBPalpha mutant AML.

scientific article published on November 2009

Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells

scientific article

Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin

scientific article published on 01 July 2018

Identification of two distinct pathways of human myelopoiesis

scientific article published on 01 May 2019

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation

scientific journal article

Inflammatory signals directly instruct PU.1 in HSCs via TNF

scientific article published on 09 October 2018

Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors

scientific article published on 03 October 2016

Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis

scientific article published on 13 October 2016

Kit ligand has a critical role in mouse yolk sac and aorta-gonad-mesonephros hematopoiesis

scientific article published on 30 August 2018

Liver haploinsufficiency of RuvBL1 causes hepatic insulin resistance and enhances hepatocellular carcinoma progression

scientific article published on 12 November 2019

Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage

scientific article

Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing

scientific article published on 14 August 2020

Modeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating Cells

article

Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model

scientific article published on 9 February 2012

Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen

scientific article published on 22 January 2008

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo

scientific article published on 15 May 2014

Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion

scientific article

Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia

scientific article published on 29 November 2019

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

scientific article published on May 2008

Neurotrophin/Trk receptor signaling mediates C/EBPalpha, -beta and NeuroD recruitment to immediate-early gene promoters in neuronal cells and requires C/EBPs to induce immediate-early gene transcription.

scientific article

Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation.

scientific article

Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia

scientific article published on 29 October 2019

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

scientific article

Phosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency.

scientific article

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy.

scientific article published on 11 August 2013

Pontin is essential for murine hematopoietic stem cell survival

scientific article published on 27 February 2012

Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice

scientific article

Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells

scientific article published on 24 March 2016

Single-cell analysis of bone marrow-derived CD34+ cells from children with sickle cell disease and thalassemia

scientific article published on 01 December 2019

Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia

scientific article

The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells

scientific article published on 17 July 2003

The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential

scientific article published on 19 February 2012

The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes

scientific article published on 06 July 2007

The proline-histidine-rich CDK2/CDK4 interaction region of C/EBPalpha is dispensable for C/EBPalpha-mediated growth regulation in vivo

scientific article published on February 2006

Wnt/β-Catenin Signaling Induces Integrin α4β1 in T Cells and Promotes a Progressive Neuroinflammatory Disease in Mice.

scientific article

β-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL ⬇️

scientific article published on June 25, 2013

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