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List of works by Hitoshi Shimano

A Rare Coexistence of Pheochromocytoma and Parkinson's Disease With Diagnostic Challenges.

scientific article

A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C-FOS in hepatocytes.

scientific article published on 13 January 2018

A distinct function of the retinoblastoma protein in the control of lipid composition identified by lipidomic profiling

scientific article

A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes

scientific article published on 9 March 2017

A kindred of familial acromegaly without evidence for linkage to MEN-1 locus

scientific article

A novel processing system of sterol regulatory element-binding protein-1c regulated by polyunsaturated fatty acid

scientific article published on 11 April 2014

A transcription factor of lipid synthesis, sterol regulatory element-binding protein (SREBP)-1a causes G(1) cell-cycle arrest after accumulation of cyclin-dependent kinase (cdk) inhibitors.

scientific article published on 27 July 2007

Abdominal Irradiation Ameliorates Obesity in ob/ob Mice

scientific article

Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion

scientific article published on 02 June 2014

Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model

scientific article

Absence of hormone-sensitive lipase inhibits obesity and adipogenesis in Lep ob/ob mice

scientific article published on 28 January 2004

Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice

scientific article

Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status

scientific journal article

Adiponectin and adiponectin receptors in human pheochromocytoma.

scientific article published on 11 August 2009

Age-dependent changes in dynamic standing-balance ability evaluated quantitatively using a stabilometer

scientific article published on 27 January 2018

Antioxidants and an inhibitor of advanced glycation ameliorate death of retinal microvascular cells in diabetic retinopathy

scientific article published in January 2006

Association between Lysosomal Dysfunction and Obesity-Related Pathology: A Key Knowledge to Prevent Metabolic Syndrome

scientific article published on 27 July 2019

Association between all-cause mortality and severity of depressive symptoms in patients with type 2 diabetes: Analysis from the Japan Diabetes Complications Study (JDCS).

scientific article published on 31 May 2017

Association between physical activity and risk of all-cause mortality and cardiovascular disease in patients with diabetes: a meta-analysis.

scientific article published on February 2013

Association of Helicobacter pylori infection with glycemic control in patients with diabetes: a meta-analysis

scientific article

Association of eating three meals irregularly with changes in BMI and weight among young Japanese men and women: A 2-year follow-up

scientific article published on 25 April 2016

Bioactive TNIIIA2 Sequence in Tenascin-C Is Responsible for Macrophage Foam Cell Transformation; Potential of FNIII14 Peptide Derived from Fibronectin in Suppression of Atherosclerotic Plaque Formation

scholarly article

CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα.

scientific article published on 16 December 2016

CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms

scientific article published on 21 February 2020

Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis

scientific article

Carotid artery plaque and LDL-to-HDL cholesterol ratio predict atherosclerotic status in coronary arteries in asymptomatic patients with type 2 diabetes mellitus.

scientific article

Cerebral hemorrhagic infarction after radiation for pituitary adenoma.

scientific article published in October 2002

Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity

scientific article

Cide-a and Cide-c are induced in the progression of hepatic steatosis and inhibited by eicosapentaenoic acid

scientific article published on 12 June 2010

Circulating malondialdehyde-modified LDL-related variables and coronary artery stenosis in asymptomatic patients with type 2 diabetes

scientific article

Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.

scientific article

Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma

scientific article published in June 2005

Comparison of baseline characteristics and clinical course in Japanese patients with type 2 diabetes among whom different types of oral hypoglycemic agents were chosen by diabetes specialists as initial monotherapy (JDDM 42).

scientific article published on February 2017

Comparison of clinical characteristics in patients with type 2 diabetes among whom different antihyperglycemic agents were prescribed as monotherapy or combination therapy by diabetes specialists.

scientific article published on 26 July 2015

Comparison of the Framingham risk score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and maximum carotid intima-media thickness for predicting coronary artery ste

scientific article published on 8 April 2014

Comparisons of the strength of associations with future type 2 diabetes risk among anthropometric obesity indicators, including waist-to-height ratio: a meta-analysis.

scientific article published on 9 November 2012

Critical role of CREBH-mediated induction of TGF-β2 by HCV infection in fibrogenic responses in hepatic stellate cells

scientific article published on 16 June 2017

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of L

scientific article published in May 2003

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling

scientific article published on May 2003

Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice

scientific article

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.

scientific article published on 30 September 2007

Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance.

scientific article published on 29 April 2008

Deciphering genetic signatures by whole exome sequencing in a case of co-prevalence of severe renal hypouricemia and diabetes with impaired insulin secretion

scientific article published on 06 May 2020

Development of a screening score for undiagnosed diabetes and its application in estimating absolute risk of future type 2 diabetes in Japan: Toranomon Hospital Health Management Center Study 10 (TOPICS 10).

scientific article published on 7 February 2013

Diabetes and risk of hearing impairment in adults: a meta-analysis.

scientific article

Diabetes mellitus and risk of new-onset and recurrent heart failure: a systematic review and meta-analysis

scientific article published on 29 July 2020

Dicer has a crucial role in the early stage of adipocyte differentiation, but not in lipid synthesis, in 3T3-L1 cells

scientific article published on 26 March 2012

Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice

scientific article

Distinct regulation of plasma LDL cholesterol by eicosapentaenoic acid and docosahexaenoic acid in high fat diet-fed hamsters: participation of cholesterol ester transfer protein and LDL receptor.

scientific article published on 30 January 2013

Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha

scientific article published in January 2002

Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene

scientific journal article

Effect of postmenopausal status and age at menopause on type 2 diabetes and prediabetes in Japanese individuals: Toranomon Hospital Health Management Center Study 17 (TOPICS 17).

scientific article published on 29 October 2013

Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry.

scientific article published on 16 September 2017

Effect of thiazolidinediones and metformin on LDL oxidation and aortic endothelium relaxation in diabetic GK rats

scientific article

Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice

scientific article

Effects of atorvastatin on glucose metabolism and insulin resistance in KK/Ay mice

scientific article published in January 2005

Effects of pitavastatin (LIVALO Tablet) on high density lipoprotein cholesterol (HDL-C) in hypercholesterolemia

scientific article

Effects of pitavastatin (LIVALO tablet) on the estimated glomerular filtration rate (eGFR) in hypercholesterolemic patients with chronic kidney disease. Sub-analysis of the LIVALO Effectiveness and Safety (LIVES) Study

scientific article published on 7 May 2010

Efficacy and safety of pitavastatin in Japanese patients with hypercholesterolemia: LIVES study and subanalysis

scientific article published on May 2011

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene ⬇️

scientific article published on October 15, 1997

Elimination of cholesterol ester from macrophage foam cells by adenovirus-mediated gene transfer of hormone-sensitive lipase.

scientific article

Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity.

scientific article

Elovl6 promotes nonalcoholic steatohepatitis

scientific article published on 01 December 2012

Elovl6: a new player in fatty acid metabolism and insulin sensitivity

scientific article

Elucidation of Molecular Mechanism of a Selective PPARα Modulator, Pemafibrate, through Combinational Approaches of X-ray Crystallography, Thermodynamic Analysis, and First-Principle Calculations

scientific article published on 06 January 2020

Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition

scientific article published on 24 November 2020

Erratum: Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice

scientific article published in Nature Communications

Estimated Stearoyl-CoA-desaturase (SCD)-1 and Elongase of Very Long Chain Fatty Acids (Elovl) 6 Activities From Serum Fatty Acids Are Reciprocally Associated with Visceral Fat Area in Type 2 Diabetic Patients

scholarly article

Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice

scientific article published on 27 March 2014

Exercise training reduces ventricular arrhythmias through restoring calcium handling and sympathetic tone in myocardial infarction mice

scientific article published on 01 February 2019

Exploratory analysis using machine learning of predictive factors for falls in type 2 diabetes

scholarly article

FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products.

scientific article

Fasting and post-challenge glucose as quantitative cardiovascular risk factors: a meta-analysis.

scientific article published on 11 January 2012

GLUT12: a second insulin-responsive glucose transporters as an emerging target for type 2 diabetes

scientific article published on March 2012

Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex

scientific article published on 01 February 2019

Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization

scientific article published on January 2013

Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice

scientific journal article

Guidelines on the Clinical Evaluation of Medicinal Products for Treatment of Dyslipidemia

scientific article published on 28 August 2020

HMG-CoA reductase inhibitor decreases small dense low-density lipoprotein and remnant-like particle cholesterol in patients with type-2 diabetes

scientific article published in October 2002

HbA1c 5·7-6·4% and impaired fasting plasma glucose for diagnosis of prediabetes and risk of progression to diabetes in Japan (TOPICS 3): a longitudinal cohort study

scientific article published on 24 June 2011

Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement

scientific article published in December 2003

Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes.

scientific article published on 18 September 2014

Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice

scientific article published on 17 September 2019

High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding

scientific article

High risk of failing eradication of Helicobacter pylori in patients with diabetes: A meta-analysis

article

Higher pulse pressure predicts initiation of dialysis in Japanese patients with diabetes

scientific article published on 16 January 2019

Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep ob/ob mice.

scientific article published on 18 July 2009

Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis.

scientific article

Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system

scientific article published on 13 June 2016

Identification of ISG12b as a putative interferon-inducible adipocytokine which is highly expressed in white adipose tissue

scientific article published on 14 August 2007

Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: a potential role in adipocyte lipolysis

scientific journal article

Identification of human ELOVL5 enhancer regions controlled by SREBP

scientific article published on 28 August 2015

In Search of the Ideal Resistance Training Program to Improve Glycemic Control and its Indication for Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

scientific article

In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression

scientific article

Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver

scientific article (publication date: September 2006)

Induction of ABCA1 by overexpression of hormone-sensitive lipase in macrophages

scientific article published on 30 August 2008

Influence of fat and carbohydrate proportions on the metabolic profile in patients with type 2 diabetes: a meta-analysis.

scientific article published on May 2009

Inhibition of autophagy enhances sunitinib-induced cytotoxicity in rat pheochromocytoma PC12 cells

scientific article published on 26 December 2012

Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice

scientific article published on 12 September 2011

Insulin inhibits apoptosis of macrophage cell line, THP-1 cells, via phosphatidylinositol-3-kinase-dependent pathway

scientific article published on March 2002

Insulin-dependent and -independent regulation of sterol regulatory element-binding protein-1c

scientific article published on September 2013

Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice

scientific article published in March 2004

Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression.

scientific article published on 17 September 2016

Involvement of glomerular SREBP-1c in diabetic nephropathy

scientific article published on 16 October 2007

KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting.

scientific article published on 17 August 2016

Ligand-activated PPARα-dependent DNA demethylation regulates the fatty acid β-oxidation genes in the postnatal liver

scientific article published on 13 October 2014

Lipid synthetic transcription factor SREBP-1a activates p21WAF1/CIP1, a universal cyclin-dependent kinase inhibitor

scientific article published on October 2005

Lipolysis in the absence of hormone-sensitive lipase: evidence for a common mechanism regulating distinct lipases

scientific article published in December 2002

Logistic regression analysis for identifying the factors affecting development of non-invasive blood glucose calibration model by near-infrared spectroscopy

scientific article published in 2015

Longitudinal trajectories of HbA1c and fasting plasma glucose levels during the development of type 2 diabetes: the Toranomon Hospital Health Management Center Study 7 (TOPICS 7)

scientific article published on 28 March 2012

Loss of SDHB Elevates Catecholamine Synthesis and Secretion Depending on ROS Production and HIF Stabilization

scientific article published on 30 November 2015

Low lung function and risk of type 2 diabetes in Japanese men: the Toranomon Hospital Health Management Center Study 9 (TOPICS 9)

scientific article

Macrophage Elovl6 Deficiency Ameliorates Foam Cell Formation and Reduces Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

scientific article published on 04 August 2011

MafB promotes atherosclerosis by inhibiting foam-cell apoptosis

scientific article

MafK overexpression in pancreatic beta-cells caused impairment of glucose-stimulated insulin secretion

scientific article published on 8 June 2006

Malondialdehyde-modified LDL-related variables are associated with diabetic kidney disease in type 2 diabetes

scientific article published on 26 May 2018

Meta-analytic research on the relationship between cumulative risk alleles and risk of type 2 diabetes mellitus.

scientific article published on 12 August 2015

MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice. ⬇️

scientific article published on January 2013

MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo

scientific article

Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction

scientific article

Molecular mechanisms involved in hepatic steatosis and insulin resistance

scientific article

Mouse Elovl-6 promoter is an SREBP target

scientific article published on 28 January 2008

Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter

scientific journal article

New evidence on pitavastatin: efficacy and safety in clinical studies

scientific article published on April 2010

New liver-β-cell axis that controls insulin secretory capacity

scientific article published on 17 March 2014

Novel role for the CRTC2 in lipid homeostasis

scientific article published on 11 February 2016

Nuclear SREBP-1a causes loss of pancreatic beta-cells and impaired insulin secretion

scientific article

Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism

scientific article published on 26 March 2019

PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity

scientific journal article

PPAR gamma ligands, troglitazone and pioglitazone, up-regulate expression of HMG-CoA synthase and HMG-CoA reductase gene in THP-1 macrophages

scientific article

Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets

scientific article published on 5 May 2008

Physiological changes in circulating mannose levels in normal, glucose-intolerant, and diabetic subjects

scientific article published in August 2003

Plasma chloride concentration as a new diagnostic indicator of insulin insufficiency

scientific article published in February 2005

Plasma free metanephrines in the diagnosis of pheochromocytoma: diagnostic accuracy and strategies for Japanese patients

scientific article published on 28 May 2014

Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression

scientific article published on December 2003

Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit.

scientific article

Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements

scientific article

Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver

scientific article published on 12 February 2007

Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin.

scientific article

Quality and accuracy of Internet information concerning a healthy diet.

scientific article published on 18 July 2013

Quality of Internet information related to the Mediterranean diet

scientific article published on 19 September 2011

Quantitative Relationship Between Cumulative Risk Alleles Based on Genome-Wide Association Studies and Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis.

scientific article published on 25 October 2017

Quantitative assessment of genetic testing for type 2 diabetes mellitus based on findings of genome-wide association studies.

scientific article published on 22 September 2016

Rapid manipulation of mitochondrial morphology in a living cell with iCMM

scientific article published on 22 July 2021

Receptor-type protein tyrosine phosphatase epsilon (PTPepsilonM) is a negative regulator of insulin signaling in primary hepatocytes and liver

scientific journal article

Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis

scientific article published on 31 October 2006

Relationship between intake of fruit separately from vegetables and triglycerides - A meta-analysis

scientific article published on 13 July 2018

Relationships among cardiorespiratory fitness, muscular fitness, and cardiometabolic risk factors in Japanese adolescents: Niigata screening for and preventing the development of non-communicable disease study-Agano (NICE EVIDENCE Study-Agano) 2.

scientific article published on 19 December 2017

Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules

scientific article published on November 2002

Rho-associated, coiled-coil-containing protein kinase 1 as a new player in the regulation of hepatic lipogenesis

scientific article published on 19 April 2019

Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids

scientific article published in November 2023

Risk imparted by various parameters of smoking in Japanese men with type 2 diabetes on their development of microalbuminuria: analysis from the Tsukuba Kawai Diabetes Registry

scientific article published on 2 March 2007

Role of Apolipoprotein E in Lipoprotein Metabolism and in the Process of Atherosclerosis ⬇️

scientific article published on January 1, 1995

Role of Hormone-sensitive Lipase in Leptin-Promoted Fat Loss and Glucose Lowering

scientific article published on 12 April 2017

Role of alcohol drinking pattern in type 2 diabetes in Japanese men: the Toranomon Hospital Health Management Center Study 11 (TOPICS 11).

scientific article

SPARC is a major secretory gene expressed and involved in the development of proliferative diabetic retinopathy

scientific article

SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes.

scientific article

SREBP-1-independent regulation of lipogenic gene expression in adipocytes.

scientific article published on 24 April 2007

SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism

scientific article published on 21 December 2016

SREBPs suppress IRS-2-mediated insulin signalling in the liver

scientific article published on 14 March 2004

Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages.

scientific article published on 8 February 2018

Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide

scientific article

Selective peroxisome proliferator-activated receptor-α modulator K-877 efficiently activates the peroxisome proliferator-activated receptor-α pathway and improves lipid metabolism in mice.

scientific article published on 13 January 2017

Self-reported fast eating is a potent predictor of development of impaired glucose tolerance in Japanese men and women: Tsukuba Medical Center Study

scientific article

Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy

scientific article published on 14 September 2015

Skipping breakfast and prevalence of overweight and obesity in Asian and Pacific regions: a meta-analysis.

scientific article published on 27 August 2011

Srebp-1c/Fgf21/Pgc-1α Axis Regulated by Leptin Signaling in Adipocytes-Possible Mechanism of Caloric Restriction-Associated Metabolic Remodeling of White Adipose Tissue

scientific article published on 10 July 2020

Statins downregulate ATP-binding-cassette transporter A1 gene expression in macrophages

scientific article published on April 2004

Sterol Regulatory Element–Binding Protein-1 Determines Plasma Remnant Lipoproteins and Accelerates Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice

scientific article published on 05 May 2011

Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes

scientific article

Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47.

scientific article published on 29 July 2005

Subendocardial Systolic Dysfunction in Asymptomatic Normotensive Diabetic Patients

scientific article

Sunitinib induces apoptosis in pheochromocytoma tumor cells by inhibiting VEGFR2/Akt/mTOR/S6K1 pathways through modulation of Bcl-2 and BAD.

scientific article

Sunitinib inhibits catecholamine synthesis and secretion in pheochromocytoma tumor cells by blocking VEGF receptor 2 via PLC-γ-related pathways

scientific article published on 21 August 2012

Suppression of the pancreatic duodenal homeodomain transcription factor-1 (Pdx-1) promoter by sterol regulatory element-binding protein-1c (SREBP-1c).

scientific article published on 7 June 2011

TFE3 controls lipid metabolism in adipose tissue of male mice by suppressing lipolysis and thermogenesis

scientific article published on 24 July 2013

TFE3 inhibits myoblast differentiation in C2C12 cells via down-regulating gene expression of myogenin.

scientific article published on 2 December 2012

TFE3 regulates muscle metabolic gene expression, increases glycogen stores, and enhances insulin sensitivity in mice

scientific article

TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes

scientific article published on 4 December 2005

TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN

scientific article published on 21 June 2009

The Relationship between Diabetic Neuropathy and Sleep Apnea Syndrome: A Meta-Analysis

scientific article published on 07 December 2013

The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha.

scientific article published on 16 December 2009

The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction

scientific article published on 04 June 2019

The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice

scientific article published on 19 May 2009

Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes

scientific journal article

Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1

scientific article published on 19 December 2019

Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance

scientific article published on 01 June 2018

Transgenic mice overexpressing SREBP-1a under the control of the PEPCK promoter exhibit insulin resistance, but not diabetes

scientific article published on 16 December 2004

Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells

scientific article

Unstable bodyweight and incident type 2 diabetes mellitus: A meta-analysis.

scientific article

Use of high-normal levels of haemoglobin A(1C) and fasting plasma glucose for diabetes screening and for prediction: a meta-analysis

scientific article

Utility of nonblood-based risk assessment for predicting type 2 diabetes mellitus: A meta-analysis

scientific article

Utility of the triglyceride level for predicting incident diabetes mellitus according to the fasting status and body mass index category: the Ibaraki Prefectural Health Study.

scientific article published on 16 July 2014

WGEF is a novel RhoGEF expressed in intestine, liver, heart, and kidney.

scientific article

p53 Activation in Adipocytes of Obese Mice ⬇️

scientific article published on May 6, 2003

p53 involvement in the pathogenesis of fatty liver disease.

scientific article published on 25 February 2004

p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus

scientific article (publication date: 26 December 2003)

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