List of works - Mikihiko Naito

APOLLON protein promotes early mitotic CYCLIN A degradation independent of the spindle assembly checkpoint

scientific article published on 03 December 2013

Binding of PDZ-RhoGEF to ATP-binding cassette transporter A1 (ABCA1) induces cholesterol efflux through RhoA activation and prevention of transporter degradation

scientific article

Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders

scientific article

Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation.

scientific article published on 15 March 2018

Design and synthesis of estrogen receptor ligands with a 4-heterocycle-4-phenylheptane skeleton

scientific article published on 09 February 2018

Design and synthesis of novel selective estrogen receptor degradation inducers based on the diphenylheptane skeleton

scientific article published on 08 December 2016

Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells

scientific article published on 12 March 2020

Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand.

scientific article published on 15 September 2016

Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands.

scientific article published on 8 June 2017

Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins

scientific article published on 16 October 2019

Development of a Cell-penetrating Peptide that Exhibits Responsive Changes in its Secondary Structure in the Cellular Environment.

scientific article published on 9 September 2016

Development of a Small Hybrid Molecule That Mediates Degradation of His-Tag Fused Proteins.

scientific article published in May 2017

Development of a peptide-based inducer of nuclear receptors degradation

scientific article published on 07 April 2016

Development of a peptide-based inducer of protein degradation targeting NOTCH1.

scientific article published on 7 October 2017

Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.

scientific article published on 11 October 2013

Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands.

scientific article

Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-dependent Protein Eraser (SNIPER)

scientific article published on 26 October 2018

Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton

scientific article

HNF4α Increases Liver-Specific Human ATP-Binding Cassette Transporter A1 Expression and Cholesterol Efflux to Apolipoprotein A-I in Response to Cholesterol Depletion ⬇️

scientific article published on January 26, 2012

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs).

scientific article

Modulation of RIP1 ubiquitylation and distribution by MeBS to sensitize cancer cells to tumor necrosis factor α‐induced apoptosis ⬇️

scientific article published on November 1, 2010

Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERα.

scientific article published in January 2016

Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase

scientific article published in Scientific Reports

Proteasome inhibitors prevent cell death and prolong survival of mice challenged by Shiga toxin

scientific article

Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy

scientific article

SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib.

scientific article

Simple and efficient knockdown of His-tagged proteins by ternary molecules consisting of a His-tag ligand, a ubiquitin ligase ligand, and a cell-penetrating peptide.

scientific article published on 2 August 2017

Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein.

scientific article published on 21 March 2011

Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules.

scientific article

Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety

scientific article published on 25 February 2020

Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation.

scientific article published on 14 September 2017

Tributyltin chloride induces ABCA1 expression and apolipoprotein A-I-mediated cellular cholesterol efflux by activating LXRα/RXR.

scientific article published on 8 January 2011

List of works by Mikihiko Naito

APOLLON protein promotes early mitotic CYCLIN A degradation independent of the spindle assembly checkpoint

Binding of PDZ-RhoGEF to ATP-binding cassette transporter A1 (ABCA1) induces cholesterol efflux through RhoA activation and prevention of transporter degradation

Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders

Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation.

Design and synthesis of estrogen receptor ligands with a 4-heterocycle-4-phenylheptane skeleton

Design and synthesis of novel selective estrogen receptor degradation inducers based on the diphenylheptane skeleton

Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells

Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand.

Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands.

Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins

Development of a Cell-penetrating Peptide that Exhibits Responsive Changes in its Secondary Structure in the Cellular Environment.

Development of a Small Hybrid Molecule That Mediates Degradation of His-Tag Fused Proteins.

Development of a peptide-based inducer of nuclear receptors degradation

Development of a peptide-based inducer of protein degradation targeting NOTCH1.

Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.

Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands.

Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-dependent Protein Eraser (SNIPER)

Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton

HNF4α Increases Liver-Specific Human ATP-Binding Cassette Transporter A1 Expression and Cholesterol Efflux to Apolipoprotein A-I in Response to Cholesterol Depletion ⬇️

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs).

Modulation of RIP1 ubiquitylation and distribution by MeBS to sensitize cancer cells to tumor necrosis factor α‐induced apoptosis ⬇️

Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERα.

Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase

Proteasome inhibitors prevent cell death and prolong survival of mice challenged by Shiga toxin

Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy

SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib.

Simple and efficient knockdown of His-tagged proteins by ternary molecules consisting of a His-tag ligand, a ubiquitin ligase ligand, and a cell-penetrating peptide.

Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein.

Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules.

Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety

Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation.

Tributyltin chloride induces ABCA1 expression and apolipoprotein A-I-mediated cellular cholesterol efflux by activating LXRα/RXR.