Search filters

Authors whose works are in public domain in at least one jurisdiction

List of works by Thomas R Ioerger

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.

scientific article published on 9 March 2018

3-O-Methyl-Alkylgallates Inhibit Fatty Acid Desaturation in Mycobacterium tuberculosis

scientific article published on 23 August 2019

A Hidden Markov Model for identifying essential and growth-defect regions in bacterial genomes from transposon insertion sequencing data

scientific article

A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro

scientific article published on 3 July 2017

A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide.

scientific article published on 19 September 2017

A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis

scientific article published on 15 June 2016

A multifaceted secondary structure mimic based on piperidine-piperidinones

scientific article

A novel antimycobacterial compound acts as an intracellular iron chelator

scientific article

A statistical method to identify recombination in bacterial genomes based on SNP incompatibility

scientific article published on 22 November 2018

A vitamin B₁₂ transporter in Mycobacterium tuberculosis

scientific article published on 13 February 2013

Altered Mycobacterium tuberculosis Cell Wall Metabolism and Physiology Associated With RpoB Mutation H526D.

scientific article

Analysis of diversity of nucleotide and amino acid distributions in the VD and DJ joining regions in Ig heavy chains

scientific article published on 01 October 2000

Anion-π Interactions in Computer-Aided Drug Design: Modeling the Inhibition of Malate Synthase by Phenyl-Diketo Acids

scientific article published on 12 September 2018

Antibody-ligand interactions: computational modeling and correlation with biophysical measurements

scientific article

Automated structure determination with phenix

Automated structure solution with the PHENIX suite

scientific article (publication date: 2008)

Automatic modeling of protein backbones in electron-density maps via prediction of Calpha coordinates

scientific article published on 23 November 2002

Bayesian analysis of gene essentiality based on sequencing of transposon insertion libraries.

scientific article

Behavioral and transcriptomic profiling of mice null for Lphn3, a gene implicated in ADHD and addiction

scientific article published on 4 March 2016

Capturing Uncertainty by Modeling Local Transposon Insertion Frequencies Improves Discrimination of Essential Genes.

scientific article published on January 2015

Cell-Cycle-Associated Expression Patterns Predict Gene Function in Mycobacteria

scientific article published on 02 September 2020

Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis

scientific article

Chlorflavonin Targets Acetohydroxyacid Synthase Catalytic Subunit IlvB1 for Synergistic Killing of Mycobacterium tuberculosis

scientific article

Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase

scientific article published on 19 October 2015

Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis

scientific article

Comprehensive analysis of iron utilization by Mycobacterium tuberculosis

scientific article published on 18 February 2020

Conservation of cys-cys trp structural triads and their geometry in the protein domains of immunoglobulin superfamily members

scientific article published on 01 April 1999

Constructive induction and protein tertiary structure prediction

scientific article published on January 1, 1993

Correction: Global Assessment of Genomic Regions Required for Growth in Mycobacterium tuberculosis

scientific article published on 25 July 2013

Correction: TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities

scientific article published on 04 June 2019

Correlations between secondary structure- and protein-protein interface-mimicry: the interface mimicry hypothesis

scientific article published on 01 March 2019

Crystal Structure of Mycobacterium tuberculosis Polyketide Synthase 11 (PKS11) Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones ⬇️

scientific article published on April 24, 2013

Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response

scientific article

Crystal structure of circadian clock protein KaiA from Synechococcus elongatus

scientific article published on 8 March 2004

Crystal structures ofMycobacterium tuberculosisS-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors

scientific article

Crystallographic protein model-building on the web.

scientific article

Deletion of SenX3-RegX3, a key two-component regulatory system of Mycobacterium smegmatis, results in growth defects under phosphate-limiting conditions.

scientific article

Design criteria for minimalist mimics of protein-protein interface segments

scientific article published on 01 January 2019

Determining protein structure from electron-density maps using pattern matching.

scientific article

Determining relevant features to recognize electron density patterns in x-ray protein crystallography.

scientific article

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.

scientific article

Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32

scientific article

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase

scientific article

Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA

scientific article published on 01 June 2018

Discovery of antimicrobial lipodepsipeptides produced by a Serratia sp. within mosquito microbiomes.

scientific article published on 26 April 2018

Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening

scientific journal article

Distinct Bacterial Pathways Influence the Efficacy of Antibiotics against Mycobacterium tuberculosis

scientific article published on 04 August 2020

Erratum for Perkowski et al., "The EXIT Strategy: an Approach for Identifying Bacterial Proteins Exported during Host Infection".

scientific article published on 20 June 2017

Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis

scientific article

Evaluating minimalist mimics by exploring key orientations on secondary structures (EKOS)

scientific article published on 14 October 2013

Exploiting Homoplasy in Genome-Wide Association Studies to Enhance Identification of Antibiotic-Resistance Mutations in Bacterial Genomes

scientific article published on 27 July 2020

Exploring Key Orientations at Protein–Protein Interfaces with Small Molecule Probes ⬇️

scientific article published on December 27, 2012

FINDMOL: automated identification of macromolecules in electron-density maps

scientific article published on 19 October 2005

First Evaluation of GenoType MTBDRplus 2.0 Performed Directly on Respiratory Specimens in Central America

scientific article published on 20 July 2016

Functional genomics screening utilizing mutant mouse embryonic stem cells identifies novel radiation-response genes

scientific article published on 8 April 2015

GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions

article

Genetic Variation/Evolution and Differential Host Responses Resulting from In-Patient Adaptation of

article

Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa

scientific article

Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness

scientific article published on 06 August 2019

Global Assessment of Mycobacterium avium subsp. hominissuis Genetic Requirement for Growth and Virulence

scientific article published on 10 December 2019

Global assessment of genomic regions required for growth in Mycobacterium tuberculosis

scientific article

Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis

scientific article published on 6 March 2017

High throughput crystallography of TB drug targets.

scientific article published on June 2007

High-Throughput Differentiation and Screening of a Library of Mutant Stem Cell Clones Defines New Host-Based Genes Involved in Rabies Virus Infection.

scientific article published on 12 May 2015

High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism

scientific article published on 29 September 2011

High-throughput sequencing enhanced phage display identifies peptides that bind mycobacteria

scientific article

Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis.

scientific article published on 21 February 2018

Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis.

scientific article published on 28 June 2018

Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis

scientific article (publication date: 2013)

Identifying essential genes in Mycobacterium tuberculosis by global phenotypic profiling.

scientific article

Identifying non-crystallographic symmetry in protein electron-density maps: a feature-based approach

scientific article published on 19 August 2006

Impact of immunopathology on the antituberculous activity of pyrazinamide

scientific article published on 17 July 2018

Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB.

scientific article published on 16 October 2017

Improving amino-acid identification, fit and C(alpha) prediction using the Simplex method in automated model building

scientific article published on 18 October 2006

Inhibition of CorA-Dependent Magnesium Homeostasis Is Cidal in Mycobacterium tuberculosis

scientific article published on 23 September 2019

Introduction to selected papers from the 8th International Conference on Bioinformatics and Computational Biology (BICOB 2016).

scientific article published in June 2017

Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes

scientific article published on 19 June 2019

Leaderless Transcripts and Small Proteins Are Common Features of the Mycobacterial Translational Landscape.

scientific article published on 4 November 2015

MOPAC: motif finding by preprocessing and agglomerative clustering from microarrays.

scientific article

Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape.

scientific article

Metabolic Network for the Biosynthesis of Intra- and Extracellular α-Glucans Required for Virulence of Mycobacterium tuberculosis

scientific article

MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212

scientific article

Multidrug-Resistant Tuberculosis in Panama Is Driven by Clonal Expansion of a Multidrug-Resistant Mycobacterium tuberculosis Strain Related to the KZN Extensively Drug-Resistant M. tuberculosis Strain from South Africa ⬇️

scientific article published on July 24, 2013

Mutations in fbiD (Rv2983) as a novel determinant of resistance to pretomanid and delamanid in Mycobacterium tuberculosis

scientific article published on 19 October 2020

Mutations in pepQ Confer Low-Level Resistance to Bedaquiline and Clofazimine in Mycobacterium tuberculosis

scientific article published on 16 May 2016

Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis

scientific article published on 29 October 2019

Mycobacterium smegmatis HtrA Blocks the Toxic Activity of a Putative Cell Wall Amidase

article

Mycobacterium tuberculosis dihydrofolate reductase is not a target relevant to the antitubercular activity of isoniazid

scientific article published on 21 June 2010

N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.

scientific article published on 18 July 2016

Natural brominated phenoxyphenols kill persistent and biofilm-incorporated cells of MRSA and other pathogenic bacteria

scientific article published on 16 May 2020

Nature-Inspired (di)Azine-Bridged Bisindole Alkaloids with Potent Antibacterial In Vitro and In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus

scientific article published on 25 October 2020

Normalization of transposon-mutant library sequencing datasets to improve identification of conditionally essential genes

scientific article

Novel Pyrazole-Containing Compounds Active against Mycobacterium tuberculosis

scientific article published on 18 September 2019

Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition

scientific article published on 01 February 2019

PHENIX: building new software for automated crystallographic structure determination

scientific article (publication date: November 2002)

Peptidoglycan synthesis in Mycobacterium tuberculosis is organized into networks with varying drug susceptibility

scientific article

Perturbation of cytochrome c maturation reveals adaptability of the respiratory chain in Mycobacterium tuberculosis.

scientific article published on 17 September 2013

Polymorphism at the self-incompatibility locus in Solanaceae predates speciation

scientific article

Pyrrolinone-pyrrolidine oligomers as universal peptidomimetics

scientific article

RNA sequencing for transcript 5'-end mapping in mycobacteria

scientific article published on January 2015

Reannotation of translational start sites in the genome of Mycobacterium tuberculosis ⬇️

scientific article published on December 26, 2012

Recent developments in the PHENIX software for automated crystallographic structure determination

scientific article (publication date: 2004)

Reinforcement Learning using EEG signals for Therapeutic Use of Music in Emotion Management

scientific article published on 01 July 2020

Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment

scientific article published on 21 February 2017

Selective Inactivity of Pyrazinamide against Tuberculosis in C3HeB/FeJ Mice Is Best Explained by Neutral pH of Caseum

scientific article published on 16 November 2015

Statistical analysis of genetic interactions in Tn-Seq data

scientific article

Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression

scientific article published on 21 November 2019

Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing

scientific article published on 15 December 2013

Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2.

scientific article published on 14 December 2015

Structural genomics approach to drug discovery for Mycobacterium tuberculosis

scientific article published on 28 May 2009

Structure-Activity Relationships of Pyrazolo[1,5-<i>a</i>]pyrimidin-7(4<i>H</i>)-ones as Antitubercular Agents

scientific article published on 06 January 2021

Structure-Guided Discovery of Phenyl-diketo Acids as Potent Inhibitors of M. tuberculosis Malate Synthase ⬇️

scientific article published on December 21, 2012

Structures of Mycobacterium tuberculosis FadD10 Protein Reveal a New Type of Adenylate-forming Enzyme ⬇️

scientific article published on April 26, 2013

Structures of Mycobacterium tuberculosis FadD10 protein reveal a new type of adenylate-forming enzyme

scientific article published in August 2013

Susceptibility of Mycobacterium tuberculosis cytochrome bd oxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c.

scientific article

Synthesis and evaluation of the 2,4-diaminoquinazoline series as anti-tubercular agents

scientific article published on 22 October 2014

Synthesis, Structure Activity Relationship and Mechanistic Studies of Aminoquinazolinones Displaying Antimycobacterial Activity

scientific article published on 29 May 2020

TEXTAL system: artificial intelligence techniques for automated protein model building

scientific article published in January 2003

TEXTAL: a pattern recognition system for interpreting electron density maps

scientific article published in January 1999

TRANSIT--A Software Tool for Himar1 TnSeq Analysis.

scientific article published on 08 October 2015

Targeting protein biotinylation enhances tuberculosis chemotherapy.

scientific article

The 1.25 Å resolution structure of phosphoribosyl-ATP pyrophosphohydrolase fromMycobacterium tuberculosis

scientific article

The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis

scientific article published on 7 November 2017

The EXIT Strategy: an Approach for Identifying Bacterial Proteins Exported during Host Infection

scientific article

The conserved translation factor LepA is required for optimal synthesis of a porin family in <i>Mycobacterium smegmatis</i>

scientific article published on 23 December 2020

The context-dependence of amino acid properties

scientific article published on 01 January 1997

The copper-responsive RicR regulon contributes to Mycobacterium tuberculosis virulence

scientific article published on 18 February 2014

The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa

scientific article

The tuberculosis structural genomics consortium: a structural genomics approach to drug discovery

scientific article

TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities.

scientific article published on 5 March 2018

Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice

scientific article

Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing

scientific article published on December 2013

Use of multiplex allele-specific polymerase chain reaction (MAS-PCR) to detect multidrug-resistant tuberculosis in Panama

scientific article

Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection

scientific article

Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories

scientific article

Weighting features to recognize 3D patterns of electron density in X-ray protein crystallography

scientific article published in January 2004

Paulina is supported by:

About Paulina

Help