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List of works by Christian Grimm

A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease

scientific article published on 29 November 2018

A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV.

scientific article published on 14 August 2014

Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

scientific article published on 16 March 2020

Discovery of lipophilic two-pore channel agonists

scientific article published on 01 June 2020

Endolysosomal Cation Channels and Cancer-A Link with Great Potential.

scientific article published on 5 January 2018

Evolutionary Aspects of TRPMLs and TPCs

scientific article published on 11 June 2020

Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells

scientific article

From mucolipidosis type IV to Ebola: TRPML and two-pore channels at the crossroads of endo-lysosomal trafficking and disease.

scientific article

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

scientific article (publication date: 21 August 2014)

Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect

scientific article published on 19 January 2021

Identification of entry inhibitors of Ebola virus pseudotyped vectors from a myxobacterial compound library.

scientific article

Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice

scientific article published on 14 January 2022

Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells

scientific article published on 21 March 2022

Neurodegenerative Lysosomal Storage Disorders: TPC2 Comes to the Rescue!

scientific article published in 2022

Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes

scientific article

Recombinant tandem of pore-domains in a Weakly Inward rectifying K+ channel 2 (TWIK2) forms active lysosomal channels

scientific article

Remodeling of secretory lysosomes during education tunes functional potential in NK cells

scientific article published in Nature Communications

Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells

scientific article published on 27 November 2018

Small Molecules for Early Endosome-Specific Patch Clamping.

scientific article published in July 2017

TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity

scientific article published on 13 July 2020

TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms

scientific article published on 18 September 2017

TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organelles

scientific article published on 11 November 2020

TRPML3.

scientific article published on January 2014

The biophysical and molecular basis of TRPV1 proton gating ⬇️

scientific article published on March 16, 2011

The protein interaction networks of mucolipins and two-pore channels

scientific article published on 02 November 2018

The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes.

scientific article published on 30 August 2017

Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells.

scientific article published on 20 January 2017

Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function.

scientific article

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