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List of works by Kei Kawana

A Possible Coagulation‐Independent Mechanism for Pregnancy Loss Involving β2glycoprotein 1‐Dependent Antiphospholipid Antibodies and CD1d ⬇️

scientific article published on June 20, 2011

A case of lymphangioleiomyomatosis associated with endometrial cancer and severe systemic lupus erythematosus

scientific article

A case of successful detection of disseminated gastrointestinal stromal tumors by ascites smear cytology using cell block preparation with DOG1 immunostaining.

scientific article published on 9 December 2015

A novel interaction between hScrib and PP1γ downregulates ERK signaling and suppresses oncogene-induced cell transformation

scientific article

Activation of Nrf2 might reduce oxidative stress in human granulosa cells

scientific article

Adjuvant effect of Japanese herbal medicines on the mucosal type 1 immune responses to human papillomavirus (HPV) E7 in mice immunized orally with Lactobacillus-based therapeutic HPV vaccine in a synergistic manner

scientific article published on 21 June 2012

Advanced age is a significant determinant of poor prognosis in patients treated with surgery plus postoperative radiotherapy for endometrial cancer ⬇️

scientific article published on August 1, 2010

Anti-tumor activity of dual inhibition of phosphatidylinositol 3-kinase and MDM2 against clear cell ovarian carcinoma

scientific article published on 05 September 2019

Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells

scientific article

Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423.

scientific article published on 04 February 2014

Antitumor activity of a combination of dual PI3K/mTOR inhibitor SAR245409 and selective MEK1/2 inhibitor pimasertib in endometrial carcinomas.

scientific article published on 29 May 2015

Aromatase inhibitor anastrozole as a second-line hormonal treatment to a recurrent low-grade endometrial stromal sarcoma: a case report

scientific article published on 31 March 2010

Association between carotenoids and outcome of cervical intraepithelial neoplasia: a prospective cohort study ⬇️

scientific article published on October 25, 2012

Autophagy inhibition augments resveratrol-induced apoptosis in Ishikawa endometrial cancer cells.

scientific article published on 08 August 2016

CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase

scientific article

CD1d degradation in Chlamydia trachomatis-infected epithelial cells is the result of both cellular and chlamydial proteasomal activity

scientific article published on 10 January 2007

CD1d, a Sentinel Molecule Bridging Innate and Adaptive Immunity, Is Downregulated by the Human Papillomavirus (HPV) E5 Protein: a Possible Mechanism for Immune Evasion by HPV ⬇️

scientific article published on September 1, 2010

Cancer-associated fibroblast suppresses killing activity of natural killer cells through downregulation of poliovirus receptor (PVR/CD155), a ligand of activating NK receptor

scientific article published on 26 July 2016

Cervical Expression of Elafin and SLPI in Pregnancy and Their Association With Preterm Labor

scientific article published on 5 January 2015

Characterization of Gut-Derived Intraepithelial Lymphocyte (IEL) Residing in Human Papillomavirus (HPV)-Infected Intraepithelial Neoplastic Lesions ⬇️

scientific article published on July 12, 2011

Characterization of TP53 and PI3K signaling pathways as molecular targets in gynecologic malignancies

scientific article published on 20 April 2016

Characterization of human decidual mast cells and establishment of a culture system

scientific article published on 18 May 2018

Characterization of novel transcripts of human papillomavirus type 16 using cap analysis gene expression technology

scientific article

Claudin‐18 overexpression in intestinal‐type mucinous borderline tumour of the ovary ⬇️

scientific article published on July 26, 2013

Clinical significance of Gremlin 1 in cervical cancer and its effects on cancer stem cell maintenance.

scientific article published on 30 October 2015

Comparison between conventional surgery plus postoperative adjuvant radiotherapy and concurrent chemoradiation for FIGO stage IIB cervical carcinoma: a retrospective study

scientific article published on 01 December 2010

Comparison of survival between primary debulking surgery and neoadjuvant chemotherapy for stage III/IV ovarian, tubal and peritoneal cancers in phase III randomised trial

scientific article published on 13 March 2020

Comparison of treatment invasiveness between upfront debulking surgery versus interval debulking surgery following neoadjuvant chemotherapy for stage III/IV ovarian, tubal, and peritoneal cancers in a phase III randomised trial: Japan Clinical Oncol

scientific article published on 17 June 2016

Consensus statement from 17 relevant Japanese academic societies on the promotion of the human papillomavirus vaccine

scientific article published on 18 March 2017

Correction: Integrated Copy Number and Expression Analysis Identifies Profiles of Whole-Arm Chromosomal Alterations and Subgroups with Favorable Outcome in Ovarian Clear Cell Carcinomas

scientific article published on 6 July 2015

Cyclin D1 harboring the T286I mutation promotes oncogenic activation in endometrial cancer.

scientific article published on 3 June 2013

Decreased expression of the plasminogen activator inhibitor type 1 is involved in degradation of extracellular matrix surrounding cervical cancer stem cells.

scientific article published on 9 December 2015

Detachment from the primary site and suspension in ascites as the initial step in metabolic reprogramming and metastasis to the omentum in ovarian cancer

scientific article published on 9 November 2017

Development and evaluation of a cervical cancer screening system in Cambodia: A collaborative project of the Cambodian Society of Gynecology and Obstetrics and Japan Society of Obstetrics and Gynecology

scientific article published on 11 April 2019

Development of endometrioma after cervical conization

scientific article published on 26 October 2017

Development of new generation HPV vaccines: prophylactic and therapeutic

scientific article published on 01 June 2012

Development of ovarian cancer after excision of endometrioma.

scientific article published on 17 August 2016

Diagnostic usefulness of endometrial aspiration cytology for endometrial cancer cases with normal curettage findings

scientific article published on 01 September 2005

Differential clinical manifestations of congenital cytomegalovirus infection between dizygotic twins: a case report

scientific article published on 01 October 2004

Differential expression of human papillomavirus 16-, 18-, 52-, and 58-derived transcripts in cervical intraepithelial neoplasia

scientific article published on 06 March 2020

Distinct lymphatic spread of endometrial carcinoma in comparison with cervical and ovarian carcinomas

scientific article published on 01 June 2002

Do neutralizing antibody responses generated by human papillomavirus infections favor a better outcome of low-grade cervical lesions?

scientific article published in July 2012

Effect of progesterone on HLA-E gene expression in JEG-3 choriocarcinoma cell line

scientific article

Effective treatment of pelvic lymphocele by lymphaticovenular anastomosis ⬇️

scientific article published on November 16, 2012

Effectiveness and Tolerability of Oral Amoxicillin in Pregnant Women with Active Syphilis, Japan, 2010-2018

scientific article published on 01 June 2020

Elevated concentration of secretory leukocyte protease inhibitor in the cervical mucus before delivery

scientific article published on 14 January 2016

Emerging roles for lysophospholipid mediators in pregnancy

scientific article published on April 2014

Endometrial cytology in early diagnosis of adenocarcinoma arising from adenomyosis uteri

scientific article published on 01 May 2002

Enhanced efficacy against cervical carcinomas through polymeric micelles physically incorporating the proteasome inhibitor MG132

scientific article published on 14 March 2016

Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy

scientific article published on 15 November 2018

Evidence for the presence of neutralizing antibodies against human papillomavirus type 6 in infants born to mothers with condyloma acuminata.

scientific article

Expression of CD1d and ligand-induced cytokine production are tissue specific in mucosal epithelia of the human lower reproductive tract

scientific article published on 5 May 2008

Expression of Par3 polarity protein correlates with poor prognosis in ovarian cancer

scientific article

Expression of autotaxin, an ectoenzyme that produces lysophosphatidic acid, in human placenta.

scientific article published in August 2009

Expression of surface CD1d in the extravillous trophoblast cells of early gestational placenta is downregulated in a manner dependent on trophoblast differentiation

scientific article published on 21 April 2008

Female steroid hormones use signal transducers and activators of transcription protein-mediated pathways to modulate the expression of T-bet in epithelial cells: a mechanism for local immune regulation in the human reproductive tract

scientific article (publication date: August 2005)

Genome-wide single nucleotide polymorphism arrays as a diagnostic tool in patients with synchronous endometrial and ovarian cancer.

scientific article

Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas

scientific article

HAND2-mediated proteolysis negatively regulates the function of estrogen receptor α.

scientific article published on 9 July 2015

HPV-16 impairs the subcellular distribution and levels of expression of protein phosphatase 1γ in cervical malignancy

scientific article

High-risk human papillomavirus correlates with recurrence after laser ablation for treatment of patients with cervical intraepithelial neoplasia 3: a long-term follow-up retrospective study

scientific article

Huge pyogenic cervical cyst with endometriosis, developing 13 years after myomectomy at the lower uterine segment: a case report

scientific article

Human decidual macrophages suppress IFN-γ production by T cells through costimulatory B7-H1:PD-1 signaling in early pregnancy

scientific article published on 22 August 2013

Human leukocyte antigen class II DRB1*1302 allele protects against cervical cancer: At which step of multistage carcinogenesis?

scientific article

Human papillomavirus genotype distribution in cervical intraepithelial neoplasia grade 2/3 and invasive cervical cancer in Japanese women.

scientific article published on 24 August 2014

Human papillomavirus prophylactic vaccine ⬇️

scientific article published on 01 June 2012

Human papillomavirus vaccines: current issues & future

scientific article published on September 2009

IL-1β increases expression of tryptophan 2,3-dioxygenase and stimulates tryptophan catabolism in endometrioma stromal cells

scientific article published on 26 June 2014

Identification of nucleolin as a protein that binds to human papillomavirus type 16 DNA

scientific article published on 16 July 2009

IgG antibodies to human papillomavirus 16, 52, 58, and 6 L1 capsids: case-control study of cervical intraepithelial neoplasia in Japan

scientific article published on 01 March 2003

Impact of Th1/Th2 cytokine polarity induced by invariant NKT cells on the incidence of pregnancy loss in mice.

scientific article

Impact of additional risk factors on the incidence of preterm delivery among pregnant women diagnosed with short cervix

scientific article published on 01 March 2020

Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth

scientific article

Inhibition of endoplasmic reticulum (ER) stress sensors sensitizes cancer stem-like cells to ER stress-mediated apoptosis

scientific article published on 17 June 2016

Integrated copy number and expression analysis identifies profiles of whole-arm chromosomal alterations and subgroups with favorable outcome in ovarian clear cell carcinomas

scientific article published on 4 June 2015

Interleukin-17 is associated with expression of programmed cell death 1 ligand 1 in ovarian carcinoma

scientific article published on 24 September 2019

Interstitial pneumonitis induced by pegylated liposomal doxorubicin in a patient with recurrent ovarian cancer ⬇️

scientific article published on March 10, 2011

Intracellular signaling entropy can be a biomarker for predicting the development of cervical intraepithelial neoplasia

scientific article

Intraperitoneal neutrophils activated by KRAS-induced ovarian cancer exert antitumor effects by modulating adaptive immunity

scientific article published on 26 July 2018

Kaempferol, a natural dietary flavonoid, suppresses 17β-estradiol-induced survivin expression and causes apoptotic cell death in endometrial cancer

Labor prediction based on the expression patterns of multiple genes related to cervical maturation in human term pregnancy.

scientific article published on 30 May 2017

Low uptake of fluorodeoxyglucose in positron emission tomography/computed tomography in ovarian clear cell carcinoma may reflect glutaminolysis of its cancer stem cell-like properties.

scientific article published on 20 January 2017

Low‐grade endometrial stromal sarcoma developing in a postmenopausal woman under toremifene treatment for breast cancer ⬇️

scientific article published on June 13, 2012

MDM2 is a potential therapeutic target and prognostic factor for ovarian clear cell carcinomas with wild type TP53.

scientific article published on 21 September 2016

Matrix metalloproteinase (MMP)-9 in cancer-associated fibroblasts (CAFs) is suppressed by omega-3 polyunsaturated fatty acids in vitro and in vivo

scientific article

Measurement of endometrial thickness by transvaginal ultrasonography to predict pathological response to medroxyprogesterone acetate in patients with grade 1 endometrioid adenocarcinoma

scientific article published on 28 January 2016

Minimization of curative surgery for treatment of early cervical cancer: a review

scientific article published on 16 April 2015

Modification of the Tumor Microenvironment in KRAS or c-MYC-Induced Ovarian Cancer-Associated Peritonitis

scientific article

Multistate Markov Model to Predict the Prognosis of High-Risk Human Papillomavirus-Related Cervical Lesions

scientific article published on 22 January 2020

Myoepithelioma-like Tumors of the Vulvar Region: A Distinctive Group of SMARCB1-deficient Neoplasms

scientific article

Neoadjuvant Chemotherapy with Taxane and Platinum Followed by Radical Hysterectomy for Stage IB2-IIB Cervical Cancer: Impact of Histology Type on Survival

scientific article published on 30 January 2019

Neutralizing antibodies against oncogenic human papillomavirus as a possible determinant of the fate of low-grade cervical intraepithelial neoplasia

scientific article published on 01 August 2002

Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report

scientific article published on 5 June 2014

Omega-3 polyunsaturated Fatty acids suppress the cystic lesion formation of peritoneal endometriosis in transgenic mouse models

scientific article

Oncogenic histone methyltransferase EZH2: A novel prognostic marker with therapeutic potential in endometrial cancer

scientific article published on 17 March 2017

Optimization of human papillomavirus (HPV) type 16 E7-expressing lactobacillus-based vaccine for induction of mucosal E7-specific IFNγ-producing cells

scientific article published on 05 May 2018

Oral immunization with a Lactobacillus casei vaccine expressing human papillomavirus (HPV) type 16 E7 is an effective strategy to induce mucosal cytotoxic lymphocytes against HPV16 E7

scientific article published on 17 February 2010

Oral vaccination against HPV E7 for treatment of cervical intraepithelial neoplasia grade 3 (CIN3) elicits E7-specific mucosal immunity in the cervix of CIN3 patients

scientific article published on 22 September 2014

PDZ domains and viral infection: versatile potentials of HPV-PDZ interactions in relation to malignancy

scientific article published on 04 September 2013

PI3K/mTOR pathway inhibition overcomes radioresistance via suppression of the HIF1-α/VEGF pathway in endometrial cancer.

scientific article published on 22 April 2015

Placental autotaxin expression is diminished in women with pre-eclampsia.

scientific article

Poor prognosis of ovarian cancer with large cell neuroendocrine carcinoma: case report and review of published works

scientific article published on March 2014

Positive peritoneal cytology at interval surgery is a poor prognostic factor in patients with stage T3c advanced ovarian carcinoma: A retrospective study

scientific article published on 25 November 2014

Prognostic importance of CDK4/6-specific activity as a predictive marker for recurrence in patients with endometrial cancer, with or without adjuvant chemotherapy

scientific article published on 10 November 2015

Prolactin can modulate CD4+ T-cell response through receptor-mediated alterations in the expression of T-bet

scientific article

Putative tumor suppression function of SIRT6 in endometrial cancer

scientific article published on 13 July 2015

Radiation therapy for vaginal cancer in complete uterine prolapse with intrauterine adhesion: a case report

scientific article published on 23 May 2019

Radical hysterectomy with or without para-aortic lymphadenectomy for patients with stage IB2, IIA2, and IIB cervical cancer: outcomes for a series of 308 patients

scientific article published on 5 October 2015

Recent Progress in Therapeutics for Inflammation-Associated Preterm Birth: A Review

scientific article

Recombinant Thrombomodulin Attenuates Preeclamptic Symptoms by Inhibiting High Mobility Group Box 1 in Mice

scientific article published on 06 January 2021

Reconstructed uterine length is critical for the prevention of cervical stenosis following abdominal trachelectomy in cervical cancer patients

scientific article published on 20 January 2020

Regeneration of cervical reserve cell-like cells from human induced pluripotent stem cells (iPSCs): A new approach to finding targets for cervical cancer stem cell treatment.

scientific article published on 3 April 2017

Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression

scientific article

Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells.

scientific article published on 19 January 2016

Resveratrol Protects Against Pathological Preterm Birth by Suppression of Macrophage-Mediated Inflammation

scientific article published on 2 June 2015

Resveratrol suppresses inflammatory responses in endometrial stromal cells derived from endometriosis: a possible role of the sirtuin 1 pathway.

scientific article published on 10 December 2013

Retreatment with nedaplatin in patients with recurrent gynecological cancer after the development of hypersensitivity reaction to carboplatin ⬇️

scientific article published on June 13, 2012

SIRT3 positively regulates the expression of folliculogenesis- and luteinization-related genes and progesterone secretion by manipulating oxidative stress in human luteinized granulosa cells.

scientific article

STAT3 activity regulates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cervical cancer cells.

scientific article published on 06 September 2016

Safety and efficacy of mucosal immunotherapy using human papillomavirus (HPV) type 16 E7-expressing Lactobacillus-based vaccine for the treatment of high-grade squamous intraepithelial lesion (HSIL): the study protocol of a randomized placebo-contro

scientific article published on 01 September 2019

Safety and immunogenicity of a peptide containing the cross-neutralization epitope of HPV16 L2 administered nasally in healthy volunteers

scientific article published on 01 October 2003

Second-line chemotherapy with docetaxel and carboplatin in paclitaxel and platinum-pretreated ovarian, fallopian tube, and peritoneal cancer ⬇️

scientific article published on June 1, 2012

Secretory leukocyte protease inhibitor and progranulin as possible regulators of cervical remodeling in pregnancy

scientific article published on 01 November 2020

Sequential effects of the proteasome inhibitor bortezomib and chemotherapeutic agents in uterine cervical cancer cell lines

scientific article published on 5 October 2012

Significance of survivin as a prognostic factor and a therapeutic target in endometrial cancer.

scientific article published on 11 April 2016

Spheroid cancer stem cells display reprogrammed metabolism and obtain energy by actively running the tricarboxylic acid (TCA) cycle

scientific article published on 23 April 2016

Subsequent risks for cervical precancer and cancer in women with low-grade squamous intraepithelial lesions unconfirmed by colposcopy-directed biopsy: results from a multicenter, prospective, cohort study ⬇️

scientific article published on July 13, 2011

Successful surgical treatment of cardiac metastasis from uterine leiomyosarcoma: A case report and literature review

scientific article published on 12 March 2020

Survey on the use of personal protective equipment and COVID-19 testing of pregnant women in Japan

scientific article published on 10 August 2020

Synergistic antitumor effects of combination PI3K/mTOR and MEK inhibition (SAR245409 and pimasertib) in mucinous ovarian carcinoma cells by fluorescence resonance energy transfer imaging

scientific article published on 18 April 2016

Systemic delivery of siRNA by actively targeted polyion complex micelles for silencing the E6 and E7 human papillomavirus oncogenes

scientific article published on 12 March 2016

Targeting glutamine metabolism and the focal adhesion kinase additively inhibits the mammalian target of the rapamycin pathway in spheroid cancer stem-like properties of ovarian clear cell carcinoma in vitro.

scientific article published on 23 February 2017

The Emerging Role of FOXL2 in Regulating the Transcriptional Activation Function of Estrogen Receptor β: An Insight Into Ovarian Folliculogenesis.

scientific article published in June 2016

The Expression of MAS1, an Angiotensin (1-7) Receptor, in the Eutopic Proliferative Endometria of Endometriosis Patients

scientific article published on 06 July 2018

The anti-malarial chloroquine suppresses proliferation and overcomes cisplatin resistance of endometrial cancer cells via autophagy inhibition.

scientific article

The concept of platinum sensitivity could be applied to recurrent cervical cancer: a multi-institutional retrospective study from the Japanese Gynecologic Oncology Group

scientific article published on 7 August 2017

The influence of infertility treatment on the prognosis of endometrial cancer and atypical complex endometrial hyperplasia

scientific article published in February 2013

The oncogene KRAS promotes cancer cell dissemination by stabilizing spheroid formation via the MEK pathway

The prevalence of cervical regulatory T cells in HPV-related cervical intraepithelial neoplasia (CIN) correlates inversely with spontaneous regression of CIN.

scientific article

Therapeutic Human Papillomavirus (HPV) Vaccines: A Novel Approach ⬇️

scientific article published on December 28, 2012

Therapeutic significance of targeting survivin in cervical cancer and possibility of combination therapy with TRAIL.

scientific article published on 5 February 2018

Tokishakuyakusan, a traditional Japanese medicine (Kampo) mitigates iNKT cell-mediated pregnancy loss in mice

scientific article published on 12 July 2018

Treatment with paclitaxel plus carboplatin, alone or with irradiation, of advanced or recurrent endometrial carcinoma

scientific article published on 22 September 2006

Undetected human papillomavirus DNA and uterine cervical carcinoma: Association with cancer recurrence

scientific article published on 20 October 2015

Use of Cap Analysis Gene Expression to detect human papillomavirus promoter activity patterns at different disease stages

scientific article published on 22 October 2020

Vaginal cancer possibly caused by pessary and immunocompromised condition: Multiple risk factors may influence vaginal cancer development.

scientific article

Xanthogranulomatous inflammation of the perimetrium with infiltration into the uterine myometrium in a postmenopausal woman: a case report

scientific article

[Development of new therapies targeting human papillomavirus molecules]

scientific article published on 01 January 2014

[HPV vaccine for cervical cancer prevention]

scientific article published on 01 June 2010

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