Search filters

List of works by Richard W Titball

A 55 kDa hypothetical membrane protein is an iron-regulated virulence factor of Francisella tularensis subsp. novicida U112.

scientific article published on October 2007

A Bayesian Whittaker-Henderson smoother for general-purpose and sample-based spectral baseline estimation and peak extraction

A Bioluminescent Francisella tularensis SCHU S4 Strain Enables Noninvasive Tracking of Bacterial Dissemination and the Evaluation of Antibiotics in an Inhalational Mouse Model of Tularemia

scientific article published on 26 September 2016

A Burkholderia pseudomallei Macrophage Infectivity Potentiator-Like Protein Has Rapamycin-Inhibitable Peptidylprolyl Isomerase Activity and Pleiotropic Effects on Virulence ⬇️

scientific article published on August 22, 2011

A Burkholderia pseudomallei protein microarray reveals serodiagnostic and cross-reactive antigens

scholarly article

A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A

scientific article

A Noise Trimming and Positional Significance of Transposon Insertion System to Identify Essential Genes in Yersinia pestis

scientific article

A Salmonella enterica serovar Typhi vaccine expressing Yersinia pestis F1 antigen on its surface provides protection against plague in mice

scientific article published on June 2004

A Yersinia pestis guaBA mutant is attenuated in virulence and provides protection against plague in a mouse model of infection

scientific article

A bacterial process for selenium nanosphere assembly ⬇️

scientific article published on August 16, 2011

A cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C.

scientific article

A dam mutant of Yersinia pestis is attenuated and induces protection against plague

scientific article published on 15 September 2005

A genetic programming approach for Burkholderia pseudomallei diagnostic pattern discovery

scientific article published on 26 June 2009

A genomic survey of positive selection in Burkholderia pseudomallei provides insights into the evolution of accidental virulence

scientific article

A liquid-based method for the assessment of bacterial pathogenicity using the nematode Caenorhabditis elegans

scientific article published on May 2002

A novel FK-506-binding-like protein that lacks peptidyl-prolyl isomerase activity is involved in intracellular infection and in vivo virulence of Burkholderia pseudomallei ⬇️

scientific article published on June 16, 2011

A plague upon fibrin

scientific article published on 01 March 2007

A recombinant carboxy-terminal domain of the protective antigen of Bacillus anthracis protects mice against anthrax infection

scientific article

A type IV pilin, PilA, Contributes To Adherence of Burkholderia pseudomallei and virulence in vivo.

scientific article

ATP-binding cassette systems in Burkholderia pseudomallei and Burkholderia mallei

scientific article

ATP-binding cassette transporters are targets for the development of antibacterial vaccines and therapies

scientific article

Absence of Yersinia pestis-specific DNA in human teeth from five European excavations of putative plague victims

scientific article published on February 2004

Administration of antibody to the lung protects mice against pneumonic plague.

scientific article

Age influences resistance of Caenorhabditis elegans to killing by pathogenic bacteria

scientific article published on May 2004

An association between ATP binding cassette systems, genome sizes and lifestyles of bacteria

scientific article published on 12 January 2005

An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions

scientific article published on 21 July 2017

Analysis of known bacterial protein vaccine antigens reveals biased physical properties and amino acid composition

scientific article published on January 2003

Analysis of peptide mimotopes of Burkholderia pseudomallei exopolysaccharide.

scientific article

Application of DNA microarrays to study the evolutionary genomics of Yersinia pestis and Yersinia pseudotuberculosis

scientific article

Are bacterial vaccine antigens T-cell epitope depleted?

scientific article published on 5 July 2008

Attenuated Bacterial Vaccines

Attenuated virulence and protective efficacy of a Burkholderia pseudomallei bsa type III secretion mutant in murine models of melioidosis

scientific article published on 01 August 2004

BWC Verification Measures: Technologies for the Identification of Biological Warfare Agents

Bacterial Biothreat Agents

Biosafety and selectable markers

scientific article published on 7 April 2007

Burkholderia mallei and Burkholderia pseudomallei

Burkholderia pseudomallei and Burkholderia mallei vaccines: Are we close to clinical trials?

scientific article published on 20 March 2017

Burkholderia pseudomallei proteins presented by monocyte-derived dendritic cells stimulate human memory T cells in vitro

scientific article

Burkholderia pseudomallei: animal models of infection

scientific article

Characterisation of an acapsular mutant of Burkholderia pseudomallei identified by signature tagged mutagenesis

scientific article published on 01 July 2002

Characterization and deposition of respirable large- and small-particle bioaerosols

scientific article

Characterization of the Burkholderia pseudomallei K96243 Capsular Polysaccharide I Coding Region ⬇️

scientific article published on January 17, 2012

Characterization of the O antigen gene cluster and structural analysis of the O antigen of Francisella tularensis subsp. tularensis

scientific article

Clostridium absonum α-Toxin: New Insights into Clostridial Phospholipase C Substrate Binding and Specificity ⬇️

scientific article published on October 31, 2003

Clostridium perfringens Epsilon Toxin Compromises the Blood-Brain Barrier in a Humanized Zebrafish Model

Clostridium perfringens epsilon toxin mutant Y30A-Y196A as a recombinant vaccine candidate against enterotoxemia

scientific article

Clostridium perfringens epsilon toxin vaccine candidate lacking toxicity to cells expressing myelin and lymphocyte protein

scientific article published on 30 July 2019

Clostridium perfringens epsilon-toxin shows structural similarity to the pore-forming toxin aerolysin

scientific article

Clostridium perfringens vaccines

scientific article

Clostridium perfringensepsilon toxin H149A mutant as a platform for receptor binding studies

scientific article

Combining vaccination and postexposure CpG therapy provides optimal protection against lethal sepsis in a biodefense model of human melioidosis

scientific article

Comparative genomic characterization of Francisella tularensis strains belonging to low and high virulence subspecies

scientific article

Comparative genomics – what do such studies tell us about the emergence and spread of key pathogens?

Concomitant administration of Yersinia pestis specific monoclonal antibodies with plague vaccine has a detrimental effect on vaccine mediated immunity

scientific article published on 31 August 2007

Construction and evaluation of a eukaryotic expression plasmid for stable delivery using attenuated Salmonella

scientific article published in March 2003

Construction of a Yersinia pestis microarray

scientific article published on January 2003

Coxiella burnetii replicates in Galleria mellonella hemocytes and transcriptome mapping reveals in vivo regulated genes

scientific article published on 01 December 2020

CpG oligonucleotides protect against Venezuelan equine encephalitis virus infection in a route-dependent manner

scientific article published in October 2013

CpG-DNA protects against a lethal orthopoxvirus infection in a murine model

scientific article published in February 2005

Cryo-EM structure of lysenin pore elucidates membrane insertion by an aerolysin family protein

scientific article

Crystal structure of the C. perfringens alpha-toxin with the active site closed by a flexible loop region

scientific article

DNA adenine methylation

scientific article published on January 2003

DNA vaccines for biodefence

scientific article

DNA vaccines: improving expression of antigens ⬇️

scientific article published on September 16, 2003

Deletion of the Bacillus anthracis capB homologue in Francisella tularensis subspecies tularensis generates an attenuated strain that protects mice against virulent tularaemia

scientific article published on 22 July 2010

Derivation and validation of a simple, accurate and robust prediction rule for risk of mortality in patients with Clostridium difficile infection

scientific article

Development and application of the active surveillance of pathogens microarray to monitor bacterial gene flux

scientific article

Development of aptamers specific for potential diagnostic targets in Burkholderia pseudomallei

scientific article

Development of reagents and assays for the detection of pathogenic Burkholderia species ⬇️

scientific article published on January 1, 2011

Development of vaccines against burkholderia pseudomallei

scientific article

Differences in carbon source utilisation distinguish Campylobacter jejuni from Campylobacter coli

scientific article

Different pathologies but equal levels of responsiveness to the recombinant F1 and V antigen vaccine and ciprofloxacin in a murine model of plague caused by small- and large-particle aerosols.

scientific article published on 02 February 2009

Direct repeat-mediated deletion of a type IV pilin gene results in major virulence attenuation of Francisella tularensis.

scientific article

Discrimination of human pathogenic subspecies of Francisella tularensis by using restriction fragment length polymorphism

scientific article

Draft Genome Sequence of the Enteropathogenic Bacterium Campylobacter jejuni Strain cj255

scientific article

Effects of Clostridium perfringens phospholipase C in mammalian cells

scientific article published in April 2004

Efficacy of the live attenuated Francisella tularensis vaccine (LVS) in a murine model of disease

scientific article published in April 2005

Evaluation of antibiotic efficacy against infections caused by planktonic or biofilm cultures of Pseudomonas aeruginosa and Klebsiella pneumoniae in Galleria mellonella.

scientific article published on 31 August 2015

Evaluation of lipopolysaccharide and capsular polysaccharide as subunit vaccines against experimental melioidosis

scientific article published on 01 December 2004

Evidence for cytoskeletal changes secondary to plasma membrane functional alterations in the in vitro cell response to Clostridium perfringens epsilon-toxin.

scientific article published on May 2003

Evidence of Clostridium perfringens epsilon toxin associated with multiple sclerosis

article published in 2019

Experimental aerogenic Burkholderia mallei (glanders) infection in the BALB/c mouse

scientific article

Exploiting the Burkholderia pseudomallei acute phase antigen BPSL2765 for structure-based epitope discovery/design in structural vaccinology

scientific article

Extensive genome analysis of Coxiella burnetii reveals limited evolution within genomic groups

scientific article published on 05 June 2019

Fermentation, Purification, and Efficacy of a Recombinant Vaccine Candidate against Botulinum Neurotoxin Type F from Pichia pastoris

Flagellar glycosylation in Burkholderia pseudomallei and Burkholderia thailandensis.

scientific article

Francisella tularensis

Francisella tularensis genomics and proteomics

scientific article published on 13 April 2007

Francisella tularensis vaccines

scientific article published on 22 February 2007

From crystal structure to in silico epitope discovery in the Burkholderia pseudomallei flagellar hook-associated protein FlgK

scientific article

From protein microarrays to diagnostic antigen discovery: a study of the pathogen Francisella tularensis

scientific article

Functional Analysis of the Role of Toxin-Antitoxin (TA) Loci in Bacterial Persistence

scientific article published on January 2016

Functional characterization of OXA-57, a class D beta-lactamase from Burkholderia pseudomallei

scientific article

Galleria mellonella as a model system to test the pharmacokinetics and efficacy of antibiotics against Burkholderia pseudomallei.

scientific article

Galleria mellonella as an alternative infection model for Yersinia pseudotuberculosis

scientific article published on 21 April 2009

Galleria mellonella as an infection model for Campylobacter jejuni virulence

scientific article published on 13 January 2011

Galleria mellonella as an infection model to investigate virulence of Vibrio parahaemolyticus.

scientific article published on 29 September 2017

Galleria mellonella larvae allow the discrimination of toxic and non-toxic chemicals

scientific article published on 6 February 2018

Gas gangrene: an open and closed case

scientific article published on 01 September 2005

Generation of large droplet aerosols within microbiological containment using a novel flow-focussing technique

Genome Resequencing of Laboratory Stocks of Burkholderia pseudomallei K96243

Genome Sequence of Staphylococcus aureus Ex1, Isolated from a Patient with Spinal Osteomyelitis.

scientific article

Genome sequencing shows that European isolates of Francisella tularensis subspecies tularensis are almost identical to US laboratory strain Schu S4.

scientific article

Genome-wide DNA microarray analysis of Francisella tularensis strains demonstrates extensive genetic conservation within the species but identifies regions that are unique to the highly virulent F. tularensis subsp. tularensis

scientific article

Genome-wide analysis reveals loci encoding anti-macrophage factors in the human pathogen Burkholderia pseudomallei K96243

scientific article

Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei

scientific article

Genotyping and phenotyping of beta2-toxigenic Clostridium perfringens fecal isolates associated with gastrointestinal diseases in piglets

scientific article

Global map of growth-regulated gene expression in Burkholderia pseudomallei, the causative agent of melioidosis

scientific article

Glycosylation of DsbA in Francisella tularensis subsp. tularensis ⬇️

scientific article published on July 29, 2011

Grey variants of the live vaccine strain of Francisella tularensis lack lipopolysaccharide O-antigen, show reduced ability to survive in macrophages and do not induce protective immunity in mice

scientific article published on 6 September 2005

Human immune responses to Burkholderia pseudomallei characterized by protein microarray analysis

scientific article

Identification of a LolC homologue in Burkholderia pseudomallei, a novel protective antigen for melioidosis

scientific article

Identification of a key residue for oligomerisation and pore-formation of Clostridium perfringens NetB.

scientific article published on 12 March 2014

Identification of outer membrane proteins of Yersinia pestis through biotinylation

scientific article

Identification of possible virulence marker from Campylobacter jejuni isolates

scientific article

Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei.

scientific article published on 16 November 2012

Immunisation with anthrolysin O or a genetic toxoid protects against challenge with the toxin but not against Bacillus anthracis.

scientific article published on 9 August 2007

Immunisation with proteins expressed during chronic murine melioidosis provides enhanced protection against disease

scientific article

Immunization against anthrax using Bacillus subtilis spores expressing the anthrax protective antigen

scientific article published in 2007

Immunization with the C-Domain of alpha -Toxin prevents lethal infection, localizes tissue injury, and promotes host response to challenge with Clostridium perfringens

scientific article published on 19 July 2004

Immunological characterisation of sub-units of the Yersinia type III secretion apparatus

scientific article published on January 2003

In silico analysis of potential diagnostic targets from Burkholderia pseudomallei

scientific article published on 01 December 2008

Influence of the molybdenum cofactor biosynthesis on anaerobic respiration, biofilm formation and motility in Burkholderia thailandensis

scientific article

Insect infection model for Campylobacter jejuni reveals that O-methyl phosphoramidate has insecticidal activity

scientific article published on March 2010

Interactions Between Immunotoxins and the Plasma Membrane: Implications for CAT-8015 Immunotoxin Therapy

Interactions of the type III secretion pathway proteins LcrV and LcrG from Yersinia pestis are mediated by coiled-coil domains.

scientific article published on 9 July 2002

Investigating the physiology of viable but non-culturable bacteria by microfluidics and time-lapse microscopy

scientific article

Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosis ⬇️

scientific article published on September 15, 2010

Lipoprotein CD0873 is a novel adhesin of Clostridium difficile

scientific article published on 29 January 2014

Low-Dose Exposure of C57BL/6 Mice to Burkholderia pseudomallei Mimics Chronic Human Melioidosis ⬇️

scientific article published on May 5, 2011

Macroautophagy is essential for killing of intracellular Burkholderia pseudomallei in human neutrophils

scientific article published in January 2015

Macrophage and Galleria mellonella infection models reflect the virulence of naturally occurring isolates of B. pseudomallei, B. thailandensis and B. oklahomensis

scientific article

Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection

scientific article published on 3 August 2016

Melioidosis vaccines: a systematic review and appraisal of the potential to exploit biodefense vaccines for public health purposes

scientific article

Membrane-damaging and cytotoxic phospholipases

article published in 2006

Molecular Architecture and Functional Analysis of NetB, a Pore-forming Toxin from Clostridium perfringens

scientific article

Molecular basis of toxicity of Clostridium perfringens epsilon toxin ⬇️

scientific article published on May 19, 2011

N255 is a key residue for recognition by a monoclonal antibody which protects against Yersinia pestis infection

scientific article published on 26 September 2009

Neutrophils are important in early control of lung infection by Yersinia pestis

scientific article published on 28 January 2010

Novel multi-component vaccine approaches for Burkholderia pseudomallei

scientific article published on 08 April 2019

O-linked glycosylation of the PilA pilin protein of Francisella tularensis: identification of the endogenous protein-targeting oligosaccharyltransferase and characterization of the native oligosaccharide.

scientific article published on 29 July 2011

Oral administration of a Salmonella enterica-based vaccine expressing Bacillus anthracis protective antigen confers protection against aerosolized B. anthracis

scientific article published on 4 December 2006

Oral immunisation with live aroA attenuated Salmonella enterica serovar Typhimurium expressing the Yersinia pestis V antigen protects mice against plague

scientific article published on June 2003

Oral immunization with a dam mutant of Yersinia pseudotuberculosis protects against plague

scientific article published on June 2005

Phenotypic and functional characterization of human memory T cell responses to Burkholderia pseudomallei

scientific article

Phenotypic characterization of a virulence-associated protein, VagH, of Yersinia pseudotuberculosis reveals a tight link between VagH and the type III secretion system

scientific article published on May 2007

Progress toward development of vaccines against melioidosis: A review

scientific article published on August 2010

Protection against Experimental Melioidosis with a Synthetic manno-Heptopyranose Hexasaccharide Glycoconjugate

scientific article

Protection against avian necrotic enteritis after immunisation with NetB genetic or formaldehyde toxoids

scientific article published on 29 May 2013

Protection against experimental melioidosis following immunisation with a lipopolysaccharide-protein conjugate

scientific article

Protection against plague afforded by immunisation with DNA vaccines optimised for expression of the Yersinia pestis V antigen

scientific article published on February 2004

Protective efficacy of a recombinant plague vaccine when co-administered with another sub-unit or live attenuated vaccine.

scientific article published on March 2005

Proteins accessible to immune surveillance show significant T-cell epitope depletion: Implications for vaccine design

scientific article published on 27 June 2009

Proteolytic degradation of human antimicrobial peptide LL-37 by Bacillus anthracis may contribute to virulence

scientific article published on July 2006

Reactive oxygen species and the MEK/ERK pathway are involved in the toxicity of clostridium perfringens α-toxin, a prototype bacterial phospholipase C.

scientific article published on 16 August 2012

Recombinant Bacillus subtilis expressing the Clostridium perfringens alpha toxoid is a candidate orally delivered vaccine against necrotic enteritis

scientific article published on 08 September 2008

Red Blood Cell Susceptibility to Pneumolysin: CORRELATION WITH MEMBRANE BIOCHEMICAL AND PHYSICAL PROPERTIES.

scientific article published on 16 March 2016

Rethinking our understanding of the pathogenesis of necrotic enteritis in chickens.

scientific article published on 30 October 2008

Role of RelA and SpoT in Burkholderia pseudomallei virulence and immunity

scientific article

Role of T cells in innate and adaptive immunity against murine Burkholderia pseudomallei infection

scientific article published on 27 December 2005

Role of trehalose biosynthesis in environmental survival and virulence of Salmonella enterica serovar typhimurium

scientific article published in June 2002

Salmonella enterica serovar typhimurium expressing a chromosomally integrated copy of the Bacillus anthracis protective antigen gene protects mice against an anthrax spore challenge

scientific article

Salmonella vaccines for use in humans: present and future perspectives

scientific article

Second and third generation plague vaccines

scientific article

Signature-tagged mutagenesis of Yersinia pestis

scientific article

Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens

scientific article

Standardization of Larvae to Provide Reliable and Reproducible Results in the Study of Fungal Pathogens

scientific article published on 06 September 2018

Structural and functional role of threonine 112 in a superantigen Staphylococcus aureus enterotoxin B

scientific article

Structural characterization of lipo-oligosaccharide (LOS) from Yersinia pestis: regulation of LOS structure by the PhoPQ system

scientific article published on June 2002

Structures of OppA and PstS from Yersinia pestis indicate variability of interactions with transmembrane domains

scientific article

Superoxide dismutase C is required for intracellular survival and virulence of Burkholderia pseudomallei

scientific article

Synergistic protection of mice against plague with monoclonal antibodies specific for the F1 and V antigens of Yersinia pestis

scientific article

The ABC transporter protein OppA provides protection against experimental Yersinia pestis infection

scientific article

The Clostridium perfringensα-toxin

The Culture Environment Influences Both Gene Regulation and Phenotypic Heterogeneity in

article

The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation

scientific article

The Level of Expression of α-toxin by Different Strains ofClostridium perfringensis Dependent on Differences in Promoter Structure and Genetic Background

The Rational Design of Bacterial Toxin Inhibitors

article by Graeme Clark et al published 1 March 2007 in Current computer-aided drug design

The Use of Reverse Vaccinology in the Design and Construction of Nano-glycoconjugate Vaccines against Burkholderia pseudomallei

scientific article published on 13 September 2017

The ability of CpG oligonucleotides to protect mice against Francisella tularensis live vaccine strain but not fully virulent F. tularensis subspecies holarctica is reflected in cell-based assays

scientific article published on 22 May 2013

The cationic peptide magainin II is antimicrobial for Burkholderia cepacia-complex strains

scientific article

The complete genome sequence of Francisella tularensis, the causative agent of tularemia

scientific article

The condition-dependent transcriptional landscape of Burkholderia pseudomallei

scientific article

The development of tolerance to Clostridium perfringens type D epsilon-toxin in MDCK and G-402 cells

scientific article published on November 2003

The effect of recombinant plasmids on in vivo colonisation of Salmonella enterica serovar Typhimurium strains is not reflected by in vitro cellular invasion assays

scientific article published on September 2002

The first strain of Clostridium perfringens isolated from an avian source has an alpha-toxin with divergent structural and kinetic properties

scientific article

The identification and evaluation of ATP binding cassette systems in the intracellular bacterium Francisella tularensis

scientific article

The identification of surface proteins of Burkholderia pseudomallei

article by Sarah V. Harding et al published March 2007 in Vaccine

The immunologically distinct O antigens from Francisella tularensis subspecies tularensis and Francisella novicida are both virulence determinants and protective antigens

scientific article published on 30 October 2006

The interaction of Pseudomonas aeruginosa PAK with human and animal respiratory tract cell lines

scientific article published on September 2004

The nematode Panagrellus redivivus is susceptible to killing by human pathogens at 37 degrees C.

scientific article published on September 2005

The pathogen Pseudomonas aeruginosa negatively affects the attraction response of the nematode Caenorhabditis elegans to bacteria

scientific article published on 6 May 2006

The pore structure of Clostridium perfringens epsilon toxin.

scientific article published on 14 June 2019

The structure of a Burkholderia pseudomallei immunophilin–inhibitor complex reveals new approaches to antimicrobial development

scientific article

The twin arginine translocation system is essential for aerobic growth and full virulence of Burkholderia thailandensis

scientific article published on 8 November 2013

The type IV pilin, PilA, is required for full virulence of Francisella tularensis subspecies tularensis

scientific article

The use of live attenuated bacteria as a delivery system for heterologous antigens

scientific article published on January 2003

Transcriptional profiles of Burkholderia pseudomallei reveal the direct and indirect roles of Sigma E under oxidative stress conditions.

scientific article

Transformation ofBurkholderia pseudomalleiby Electroporation

scientific article published in 1996

Trehalase plays a role in macrophage colonization and virulence of Burkholderia pseudomallei in insect and mammalian hosts

scientific article published on July 2016

Trehalose and bacterial virulence

scientific article published on 01 December 2020

Tularaemia: bioterrorism defence renews interest in Francisella tularensis

scientific article

Tularemia

scientific article

Vaccination against type F botulinum toxin using attenuated Salmonella enterica var Typhimurium strains expressing the BoNT/F H(C) fragment

scientific article

Vaccination strategies for Francisella tularensis

scientific article

Vaccine delivery using nanoparticles.

scientific article published on 25 March 2013

Vaccines against intracellular bacterial pathogens

scientific article published on 07 June 2008

Variable protection against experimental broiler necrotic enteritis after immunization with the C-terminal fragment of Clostridium perfringens alpha-toxin and a non-toxic NetB variant

scientific article

Variation in Salmonella enterica serovar typhi IncHI1 plasmids during the global spread of resistant typhoid fever

scientific article published on 17 November 2008

Will the enigma of Francisella tularensis virulence soon be solved?

scientific article

Yersinia pestis (plague) vaccines

scientific article

Yersinia pseudotuberculosis is resistant to killing by human neutrophils

scientific article published on 24 February 2011

Yersinia pseudotuberculosis mntH functions in intracellular manganese accumulation, which is essential for virulence and survival in cells expressing functional Nramp1 ⬇️

scientific article published on December 23, 2010

Paulina is supported by:

About Paulina

Help