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List of works by Orietta Spinelli

A novel, highly sensitive and rapid allele-specific loop-mediated amplification assay for the detection of the JAK2V617F mutation in chronic myeloproliferative neoplasms ⬇️

scientific article published on February 7, 2012

A short low-dose imatinib trial allows rapid identification of responsive patients in hypereosinophilic syndromes

scientific article published on 4 September 2009

ASXL1 mutations in primary and secondary myelofibrosis ⬇️

scientific article published on September 19, 2011

Achieving Molecular Remission before Allogeneic Stem Cell Transplantation in Adult Patients with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Impact on Relapse and Long-Term Outcome.

scientific article published in August 2016

Acute promyelocytic leukemia with a cryptic insertion of RARA into PML on chromosome 15 due to uniparental isodisomy: A case report

scientific article

Association of CFHR1 homozygous deletion with acute myelogenous leukemia in the European population

scientific article published on 28 August 2015

CD20 expression has no prognostic role in Philadelphia-negative B-precursor acute lymphoblastic leukemia: new insights from the molecular study of minimal residual disease

scientific article published on 4 November 2011

CEBPA-double-mutated acute myeloid leukemia displays a unique phenotypic profile: a reliable screening method and insight into biological features

scientific article

Chemotherapy-phased imatinib pulses improve long-term outcome of adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia: Northern Italy Leukemia Group protocol 09/00.

scientific article published on 6 July 2010

Clearance of minimal residual disease after allogeneic stem cell transplantation and the prediction of the clinical outcome of adult patients with high-risk acute lymphoblastic leukemia

scientific article published on 01 May 2007

Clinical Effects of Driver Somatic Mutations on the Outcomes of Patients With Myelodysplastic Syndromes Treated With Allogeneic Hematopoietic Stem-Cell Transplantation.

scientific article published on 06 September 2016

Correction: Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1

scientific article published on 14 January 2020

Detection of driver and subclonal mutations in myelofibrosis: clinical impact on pharmacologic and transplant based treatment strategies

scientific article published on 15 May 2017

Durable molecular response despite F317L and E255K mutations: Successful treatment of chronic myeloid leukemia with sequential imatinib, nilotinib and dasatinib

scientific article published on 01 October 2011

EVALUATION OF THE DEVELOPMENTAL TOXICITY OF THE PESTICIDE MCPA AND ITS CONTAMINANTS PHENOL AND CHLOROCRESOL

article

Frequent occurrence of non-malignant genetic alterations in clinical grade mesenchymal stromal cells expanded for cell therapy protocols.

scientific article published on 28 March 2014

Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia

scientific article

Genomic quantitative real-time PCR proves residual disease positivity in more than 30% samples with negative mRNA-based qRT-PCR in Chronic Myeloid Leukemia

scientific article

High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults

scientific article published on 21 November 2016

High Throughput Molecular Characterization of Normal Karyotype Acute Myeloid Leukemia in the Context of the Prospective Trial 02/06 of the Northern Italy Leukemia Group (NILG)

scientific article published on 11 August 2020

Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers

scientific article published on 29 April 2020

Human neutrophils express low levels of FcγRIIIA, which plays a role in PMN activation

scientific article published on 17 January 2019

IDH1-R132 changes vary according to NPM1 and other mutations status in AML.

scientific article published on 8 January 2019

Identification of kit(M541L) somatic mutation in chronic eosinophilic leukemia, not otherwise specified and its implication in low-dose imatinib response

scientific article

Immature Immunoglobulin Gene Rearrangements Are Recurrent in B Precursor Adult Acute Lymphoblastic Leukemia Carrying TP53 Molecular Alterations

scientific article published on 20 August 2020

Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation

scientific article published on 25 March 2019

Improved risk classification for risk-specific therapy based on the molecular study of minimal residual disease (MRD) in adult acute lymphoblastic leukemia (ALL).

scientific article published on 13 January 2009

In Ph+BCR-ABL1P210+ acute lymphoblastic leukemia the e13a2 (B2A2) transcript is prevalent

scientific article published on 08 October 2019

Leukocytosis is a risk factor for thrombosis in essential thrombocythemia: interaction with treatment, standard risk factors, and Jak2 mutation status

scientific article published on 16 November 2006

Minimal Residual Disease Assessment and Risk-based Therapy in Acute Lymphoblastic Leukemia

scientific article published in July 2017

Minimal Residual Disease Monitoring in Adult ALL to Determine Therapy

scientific article published on June 2015

Minimally manipulated whole human umbilical cord is a rich source of clinical-grade human mesenchymal stromal cells expanded in human platelet lysate

scientific article published on 18 March 2011

Molecular Detection of Minimal Residual Disease before Allogeneic Stem Cell Transplantation Predicts a High Incidence of Early Relapse in Adult Patients with NPM1 Positive Acute Myeloid Leukemia

scientific article published on 28 September 2019

Molecular monitoring of residual disease in chronic myeloid leukemia by genomic DNA compared with conventional mRNA analysis

scientific article published on September 2009

Mutations and chromosomal rearrangements of JAK2: not only a myeloid issue

scientific article published on August 2013

Mutations of TP53 gene in adult acute lymphoblastic leukemia at diagnosis do not affect the achievement of hematologic response but correlate with early relapse and very poor survival

scientific article published on 18 March 2016

Myeloblative therapy with autologous haematopoietic stem cell support as consolidation of first remission in acute myeloid leukaemia - very long follow-up

scientific article

Nanopore Targeted Sequencing for Rapid Gene Mutations Detection in Acute Myeloid Leukemia

scientific article published on 09 December 2019

PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia

scientific article published on 14 January 2019

Philadelphia-like acute lymphoblastic leukemia is associated with minimal residual disease persistence and poor outcome. First report of the minimal residual disease-oriented GIMEMA LAL1913

scientific article published on 28 May 2020

Prognostic significance and treatment implications of minimal residual disease studies in Philadelphia-negative adult acute lymphoblastic leukemia

scientific article

Randomized trial comparing standard vs sequential high-dose chemotherapy for inducing early CR in adult AML

scientific article published on 01 April 2019

Randomized trial of radiation-free central nervous system prophylaxis comparing intrathecal triple therapy with liposomal cytarabine in acute lymphoblastic leukemia

scientific article published on 6 March 2015

Repeated infusions of donor-derived cytokine-induced killer cells in patients relapsing after allogeneic stem cell transplantation: a phase I study

scientific article published in July 2007

Results of a lymphoblastic leukemia-like chemotherapy program with risk-adapted mediastinal irradiation and stem cell transplantation for adult patients with lymphoblastic lymphoma.

scientific article published on 11 May 2011

Selective inhibition of Ph-positive ALL cell growth through kinase-dependent and independent effects by CDK6-specific PROTACs

scientific article published on 07 February 2020

Simple, rapid and accurate molecular diagnosis of acute promyelocytic leukemia by loop mediated amplification technology

scientific article published on 27 December 2014

Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1

scientific article published on 11 March 2019

Successful Treatment With Imatinib in a Patient With Chronic Eosinophilic Leukemia Not Otherwise Specified

scientific article published on 21 January 2014

TP53 in adult acute lymphoblastic leukemia

scientific article published on 6 July 2017

Targeting CDK6 and BCL2 exploits the "MYB addiction" of Ph+ acute lymphoblastic leukemia

scientific article published on 12 December 2017

Targeting STAT5 or STAT5-Regulated Pathways Suppresses Leukemogenesis of Ph+ Acute Lymphoblastic Leukemia

scientific article published on 28 August 2018

The sensitivity of acute lymphoblastic leukemia cells carrying the t(12;21) translocation to campath-1H-mediated cell lysis.

scientific article published on March 2006

Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis

scientific article published on 19 September 2017

Updated risk-oriented strategy for acute lymphoblastic leukemia in adult patients 18-65 years: NILG ALL 10/07

scientific article published on 13 November 2020

Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype

scientific article

gDNA qPCR is statistically more reliable than mRNA analysis in detecting leukemic cells to monitor CML.

scientific article

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