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List of works by Philip D Kiser

A functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase 1

scientific article

A therapeutic combination of GPCR modulators that protects photoreceptors from degeneration

scientific article published on 21 November 2017

Abnormal Cannabidiol Modulates Vitamin A Metabolism by Acting as a Competitive Inhibitor of CRBP1

scientific article published on 18 February 2019

Analysis of Carotenoid Isomerase Activity in a Prototypical Carotenoid Cleavage Enzyme, Apocarotenoid Oxygenase (ACO)

scientific article

Biochemistry. As good as chocolate

scientific article published on May 2013

Catalytic mechanism of a retinoid isomerase essential for vertebrate vision

scientific article

Chemistry of the retinoid (visual) cycle

scientific article

Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones

scientific article published on 15 January 2019

Crystal structure of native RPE65, the retinoid isomerase of the visual cycle

scientific article

Enzyme That Makes You Cry-Crystal Structure of Lachrymatory Factor Synthase from Allium cepa.

scientific article published on 14 July 2017

Evidence for distinct rate-limiting steps in the cleavage of alkenes by carotenoid cleavage dioxygenases

scientific article published on 28 May 2019

Eyes on systems pharmacology

scientific article published on 05 October 2016

Function of mammalian M-cones depends on the level of CRALBP in Müller cells

scientific article published on 01 January 2021

Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase

scientific article

Impact of retinal disease-associated RPE65 mutations on retinoid isomerization

scientific article published on 23 August 2008

Importance of Membrane Structural Integrity for RPE65 Retinoid Isomerization Activity

scientific article

Insights into Substrate Specificity and Metal Activation of Mammalian Tetrahedral Aspartyl Aminopeptidase

scientific article

Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65.

scientific article published on 12 April 2018

Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase

scientific article published on 24 July 2016

Key enzymes of the retinoid (visual) cycle in vertebrate retina

scientific article

LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3

scientific article

Membrane-binding and enzymatic properties of RPE65

scientific article

Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina

scientific journal article

Molecular pharmacodynamics of emixustat in protection against retinal degeneration

scientific article

Pathways and disease-causing alterations in visual chromophore production for vertebrate vision

scientific article published on 13 November 2020

Photic generation of 11-cis-retinal in bovine retinal pigment epithelium

scientific article published on 06 November 2019

Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism.

scientific article published on 13 March 2017

Publisher Correction: Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing

scientific article published on 29 October 2020

Purification, crystallization and structure determination of native GroEL fromEscherichia colilacking bound potassium ions

scientific article

Rational Tuning of Visual Cycle Modulator Pharmacodynamics

scientific article

Reappraisal of dioxygen binding in NOV1 crystal structures

scientific article

Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing

scientific article published on 19 October 2020

Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function.

scientific article published on 2 March 2018

Retinoids and Retinal Diseases

scientific article published on 18 July 2016

Shedding new light on the generation of the visual chromophore

scientific article published on 05 August 2020

Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids

scientific article published on 8 January 2008

Structural Basis for the Acyltransferase Activity of Lecithin:Retinol Acyltransferase-like Proteins

scientific article

Structural basis for carotenoid cleavage by an archaeal carotenoid dioxygenase

scientific article published on 03 August 2020

Structural biology of 11-retinaldehyde production in the classical visual cycle

article

Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center

scientific article published on 11 May 2017

Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis

scientific article

Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration

scientific article published on 26 July 2016

Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor.

scientific article

The Biochemical Basis of Vitamin A Production from the Asymmetric Carotenoid β-Cryptoxanthin

scientific article published on 15 June 2018

The Biochemical Basis of Vitamin A3 Production in Arthropod Vision

scientific article published on 26 January 2016

The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision

scientific article

The human mitochondrial enzyme BCO2 exhibits catalytic activity towards carotenoids and apocarotenoids

scientific article published on 01 September 2020

Use of thallium to identify monovalent cation binding sites in GroEL

scientific article

Utilization of Dioxygen by Carotenoid Cleavage Oxygenases

scientific article

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