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List of works by Monika Brüggemann

A Comparative Analysis Of Next-Generation Sequencing and Real-Time Quantitative PCR For Minimal Residual Disease Detection In Follicular Lymphomas ⬇️

scholarly article

A comprehensive microarray-based DNA methylation study of 367 hematological neoplasms

scientific article

ARResT/Interrogate: an interactive immunoprofiler for IG/TR NGS data

scientific article

Acute Lymphoblastic Leukemia: Monitoring Minimal Residual Disease as a Therapeutic Principle ⬇️

scientific article published on February 1, 2012

Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies

scientific article published on 22 March 2012

Adults with Philadelphia chromosome-like acute lymphoblastic leukemia frequently have IGH-CRLF2 and JAK2 mutations, persistence of minimal residual disease and poor prognosis

scientific article published on 25 August 2016

An alternative CYB5A transcript is expressed in aneuploid ALL and enriched in relapse

scientific article published on 18 April 2022

Blastoid variant of mantle cell lymphoma: late progression from classical mantle cell lymphoma and quantitation of minimal residual disease

scientific article

Blinatumomab for minimal residual disease in adults with B-precursor acute lymphoblastic leukemia

scientific article

Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia

scientific article published on March 2017

Blinatumomab vs historic standard-of-care treatment for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukaemia

scientific article published on 24 January 2020

CD20 Expression and Response to Rituximab Treatment in B-Cell Precursor Lymphoblastic Leukemia - Results of the GMALL 08/2013 Trial ⬇️

scholarly article

CD56 expression in T-cell acute lymphoblastic leukemia is associated with non-thymic phenotype and resistance to induction therapy but no inferior survival after risk-adapted therapy

scientific article published on 23 December 2008

Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia.

scientific article

Comparison of chimerism and minimal residual disease monitoring for relapse prediction after allogeneic stem cell transplantation for adult acute lymphoblastic leukemia

scientific article published on 4 June 2014

Comparison of minimal residual disease levels in bone marrow and peripheral blood in adult acute lymphoblastic leukemia

scientific article published on 22 October 2019

Comprehensive translocation and clonality detection in lymphoproliferative disorders by next-generation sequencing

scientific article published on 20 October 2016

Curative outcomes following blinatumomab in adults with minimal residual disease B-cell precursor acute lymphoblastic leukemia

scientific article published on 03 July 2020

Enhancing natural killer cell-mediated lysis of lymphoma cells by combining therapeutic antibodies with CD20-specific immunoligands engaging NKG2D or NKp30.

scientific article published on 05 June 2015

Epileptic seizures and rhinocerebral mucormycosis during blinatumomab treatment in a patient with biphenotypic acute leukemia.

scientific article published on 3 October 2016

Epstein-Barr virus-negative diffuse large B-cell lymphoma hosts intra- and peritumoral B-cells with activated Epstein-Barr virus

scientific article published on 23 October 2014

Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL).

scientific article

Flow cytometric assay for determination of FcgammaRIIIA-158 V/F polymorphism

scientific article published on 8 September 2005

Genomic CDKN2A/2B deletions in adult Ph+ ALL are adverse despite allogeneic stem cell transplantation

scientific article published on 18 January 2018

Genomic Profiling Reveals Gain of Mutations in Histone Methylation Regulators in Relapsed Adult B Cell Precursor ALL ⬇️

scholarly article

Germline variants in IKZF1, ARID5B, and CEBPE as risk factors for adult-onset acute lymphoblastic leukemia: an analysis from the GMALL study group

scientific article published on February 2014

Graft-versus-leukemia activity may overcome therapeutic resistance of chronic lymphocytic leukemia with unmutated immunoglobulin variable heavy-chain gene status: implications of minimal residual disease measurement with quantitative PCR.

scientific article published on 17 June 2004

Has MRD monitoring superseded other prognostic factors in adult ALL?

scientific article published on 2 October 2012

Hematopoietic stem cell involvement in BCR-ABL1-positive ALL as potential mechanism of resistance to blinatumomab therapy.

scientific article

High-Throughput Immunogenetics for Clinical and Research Applications in Immunohematology: Potential and Challenges

scientific article published on 17 April 2017

High-Throughput, Amplicon-Based Sequencing of the CREBBP Gene as a Tool to Develop a Universal Platform-Independent Assay

scientific article published on 9 June 2015

Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell–engaging CD19/CD3-bispecific BiTE antibody blinatumomab ⬇️

scientific article published on May 16, 2012

Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures

scientific article published on 12 March 2019

Intrathecal large granular lymphocytes as an unusual presentation of a small cell T cell lymphoma ⬇️

scientific article published on March 14, 2012

Is Next-Generation Sequencing the way to go for Residual Disease Monitoring in Acute Lymphoblastic Leukemia?

scientific article published on 27 April 2017

Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia

scholarly article by Alva Rani James et al published 14 January 2019 in Journal of Hematology & Oncology

Long-Term Outcomes after Blinatumomab Treatment: Follow-up of a Phase 2 Study in Patients (Pts) with Minimal Residual Disease (MRD) Positive B-Cell Precursor Acute Lymphoblastic Leukemia (ALL) ⬇️

scholarly article

Long-term relapse-free survival in a phase 2 study of blinatumomab for the treatment of patients with minimal residual disease in B-lineage acute lymphoblastic leukemia

scientific article published on 12 January 2017

Long-term survival and T-cell kinetics in relapsed/refractory ALL patients who achieved MRD response after blinatumomab treatment

scientific article

Loss-of-function but not dominant-negative intragenic IKZF1 deletions are associated with an adverse prognosis in adult BCR-ABL-negative acute lymphoblastic leukemia

scientific article published on 27 July 2017

Lot-to-lot stability of antibody reagents for flow cytometry

scientific article published on 29 March 2017

MRD Kinetics in Adult Transplantation Recipients with Relapsed Acute Lymphoblastic Leukemia Depend on Initial Molecular Response to Front-Line Chemotherapy. ⬇️

scholarly article

MRD detection in B-cell non-Hodgkin lymphomas using Ig gene rearrangements and chromosomal translocations as targets for real-time quantitative PCR.

scientific article

Minimal residual disease diagnostics in acute lymphoblastic leukemia: need for sensitive, fast, and standardized technologies

scientific article

Minimal residual disease in adult ALL: technical aspects and implications for correct clinical interpretation

scientific article published on 28 November 2017

Minimal residual disease in adult ALL: technical aspects and implications for correct clinical interpretation.

scientific article published in December 2017

Molecular relapse in adult standard-risk ALL patients detected by prospective MRD monitoring during and after maintenance treatment: data from the GMALL 06/99 and 07/03 trials

scientific article

Molecular response with blinatumomab in relapsed/refractory B-cell precursor acute lymphoblastic leukemia

scientific article published on 01 October 2019

Multi-Genomics of Relapsed B-Cell Precursor Acute Lymphoblastic Leukemia Reveals Three Distinct Genetic Clusters Characterized By Different Alterations ⬇️

scholarly article

Multidrug resistance-associated protein 4 (MRP4) gene polymorphisms and treatment response in adult acute lymphoblastic leukemia

scientific article

Mutational spectrum of adult T-ALL

scientific article published on February 2015

Next-Generation Sequencing and Real-Time Quantitative PCR For Quantification Of Low-Level Minimal Residual Disease In Acute Lymphoblastic Leukemia Of Adults ⬇️

scholarly article

PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia

scientific article published on 06 March 2019

Partial versus productive immunoglobulin heavy locus rearrangements in chronic lymphocytic leukemia: implications for B-cell receptor stereotypy

scientific article published on 10 February 2012

Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia

scientific article published on 10 November 2014

Prognostic value of MRD in CLL patients with comorbidities receiving chlorambucil plus obinutuzumab or rituximab

scientific article published on 19 November 2018

Quantitative assessment of molecular remission after high-dose therapy with autologous stem cell transplantation predicts long-term remission in mantle cell lymphoma.

scientific article

Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study

scientific article

Significance of minimal residual disease in lymphoid malignancies

scientific article published on January 2004

Standardized flow cytometry for highly sensitive MRD measurements in B-cell acute lymphoblastic leukemia

scientific article

Subclonal IKZF1 Deletions Indicate a Multiclonal Evolution In BCR-ABL1-Positive B-Cell Precursor ALL ⬇️

scholarly article

Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival.

scientific article published on 16 May 2011

The predictive strength of next-generation sequencing MRD detection for relapse compared with current methods in childhood ALL.

scientific article published on August 2015

Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations

scientific article published on 19 April 2013

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