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List of works by Christopher P Austin

'IRDiRC Recognized Resources': a new mechanism to support scientists to conduct efficient, high-quality research for rare diseases

scientific article published on 26 October 2016

155. High Throughput screen for identifying small molecule modulators of alpha-glucosidase for the potential treatment of Pompe disease

A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase

scientific article published on August 2008

A Cell-based beta-Lactamase Reporter Gene Assay for the CREB Signaling Pathway

scientific article

A Global Approach to Rare Diseases Research and Orphan Products Development: The International Rare Diseases Research Consortium (IRDiRC).

scientific article published in January 2017

A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution

scientific article

A bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker

scientific article

A cell-based PDE4 assay in 1536-well plate format for high-throughput screening

scientific article published on 30 June 2008

A cell-based assay for IkappaBalpha stabilization using a two-color dual luciferase-based sensor

scientific article published on February 2007

A class of tricyclic compounds blocking malaria parasite oocyst development and transmission

scientific article

A dual-fluorescence high-throughput cell line system for probing multidrug resistance

scientific article

A dynamic map for learning, communicating, navigating and improving therapeutic development

scientific article published on 22 December 2017

A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction

scientific article

A high-throughput approach for identification of novel general anesthetics

scientific article

A high-throughput screen for aggregation-based inhibition in a large compound library

scientific article published on 21 April 2007

A high-throughput screening assay for determining cellular levels of total tau protein

scientific article

A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics

scientific article

A miniaturized glucocorticoid receptor translocation assay using enzymatic fragment complementation evaluated with qHTS.

scientific article published on August 2008

A multiplex calcium assay for identification of GPCR agonists and antagonists

scientific article

A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel

scientific article

A new resorufin-based alpha-glucosidase assay for high-throughput screening

scientific article published on 14 April 2009

A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats

scientific journal article

A novel chordoma xenograft allows in vivo drug testing and reveals the importance of NF-κB signaling in chordoma biology

scientific article (publication date: 2013)

A quantitative high-throughput screen for modulators of IL-6 signaling: a model for interrogating biological networks using chemical libraries

scientific article

A quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor beta with a peptide of steroid receptor coactivator 2

scientific article

A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression

scientific article

A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases

scientific article published on 14 August 2009

A robotic platform for quantitative high-throughput screening

scientific article

An AlphaScreen-based high-throughput screen to identify inhibitors of Hsp90-cochaperone interaction

scientific article

Application of a Dynamic Map for Learning, Communicating, Navigating, and Improving Therapeutic Development

scientific article published on 22 December 2017

Application of a homogenous membrane potential assay to assess mitochondrial function ⬇️

scientific article published on March 20, 2012

Are hERG channel blockers also phospholipidosis inducers?

scientific article published on 20 June 2013

Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery

scholarly article by Nathan P Coussens et al published 1 September 2018 in Clinical and Translational Science

Assay, Preclinical, and Clinical Brick Walls and Opportunities for System Change Through GRANDRx

scientific article published on 16 March 2010

Assay, preclinical, and clinical brick walls and opportunities for system change through GRANDRx

scientific article

Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia

scientific article

Automated high-content screening for compounds that disassemble the perinucleolar compartment

scientific article

Basic science: Bedrock of progress

scientific article published on March 2016

Bisphenol A affects androgen receptor function via multiple mechanisms ⬇️

scientific article published on 04 April 2013

Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition

scientific article

Characterization of chemical libraries for luciferase inhibitory activity

scientific article

Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening

scientific article published on 19 February 2008

Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines

scientific article published on 27 April 2011

Collaborative development of 2-hydroxypropyl-β-cyclodextrin for the treatment of Niemann-Pick type C1 disease

scientific article

Comparison on functional assays for Gq-coupled GPCRs by measuring inositol monophospate-1 and intracellular calcium in 1536-well plate format

scientific article published on 11 July 2008

Compound Management for Quantitative High-Throughput Screening

scientific article

Compound cytotoxicity profiling using quantitative high-throughput screening

scientific article

Comprehensive Mechanistic Analysis of Hits from High-Throughput and Docking Screens against β-Lactamase

scientific article

Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries

scientific article

Deconstructing the Translational Tower of Babel

scientific article published on 09 November 2018

Defining clinical outcome pathways

scientific article published in June 2022

Detection of phospholipidosis induction: a cell-based assay in high-throughput and high-content format.

scientific article

Development of a scintillation proximity assay for analysis of Na+/Cl- -dependent neurotransmitter transporter activity

scientific article published on October 2003

Differentiating Alzheimer disease-associated aggregates with small molecules

scientific article

Discovery, synthesis, and biological evaluation of novel SMN protein modulators

scientific article

Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction

scientific article

Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

article

Evaluation of 2-thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one analogues as GAA activators

scientific article

Evaluation of Cholesterol Reduction Activity of Methyl-β-cyclodextrin Using Differentiated Human Neurons and Astrocytes ⬇️

scientific article published on August 24, 2012

Evaluation of micro-parallel liquid chromatography as a method for HTS-coupled actives verification

scientific article published in December 2007

Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity

scientific article

Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk).

scientific article

Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

scientific article

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

scientific article

Expanding biological space coverage enhances the prediction of drug adverse effects in human using in vitro activity profiles

scientific article published on 28 February 2018

Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors

scientific article

Fluorescence spectroscopic profiling of compound libraries

scientific article

Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format

scientific article published in January 2006

Fostering collaborative research for rare genetic disease: the example of niemann-pick type C disease

scientific article

Four clinically utilized drugs were identified and validated for treatment of adrenocortical cancer using quantitative high-throughput screening ⬇️

scientific article published on September 21, 2012

Future of Rare Diseases Research 2017-2027: an IRDiRC Perspective

scientific article

Gene Therapy: The View from NCATS.

scientific article published on January 2016

High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase

scientific article

High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington's Disease Model

scientific article

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells

scientific article

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.

scientific article published on 19 March 2012

High-throughput screening assays for the identification of chemical probes

scientific article published on August 2007

Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatB

scientific article

Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1

scientific article

Identification of Clinically Used Drugs That Activate Pregnane X Receptors ⬇️

scientific article published on October 21, 2010

Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation

scientific article

Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors

scientific article published on January 2013

Identification of a potent new chemotype for the selective inhibition of PDE4

scientific article

Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening

scientific article published on August 2009

Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction

scientific article

Identification of chemical compounds that induce HIF-1alpha activity

scientific article

Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memory

scholarly article

Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action

scientific article

Identification of oxadiazoles as new drug leads for the control of schistosomiasis

scientific article

Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay

scientific article

Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening

scientific article

Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels

scientific article

Identification of repurposed small molecule drugs for chordoma therapy.

scientific article

Identification of small molecule compounds that inhibit the HIF-1 signaling pathway

scientific article

Identification of small molecule modulators of gene transcription with anticancer activity

scientific article

Identification of therapeutic candidates for chronic lymphocytic leukemia from a library of approved drugs

scientific article

Improved Diagnosis and Care for Rare Diseases through Implementation of Precision Public Health Framework

scientific article published in January 2017

Improving the human hazard characterization of chemicals: a Tox21 update

scientific article published on 19 April 2013

Inhibition of morphine-induced cAMP overshoot: a cell-based assay model in a high-throughput format

scientific article

Innovation in therapeutics development at the NCATS.

scientific article published on January 2014

International collaborative actions and transparency to understand, diagnose, and develop therapies for rare diseases

scientific article published on 01 May 2019

Intrathecal 2-hydroxypropyl-β-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1-2 trial

scientific article published on 10 August 2017

Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research

scientific article

ML238: An Antimalarial Small Molecule of a Unique Structural Class

ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in mice

scientific article

Measure, mine, model, and manipulate: the future for HTS and chemoinformatics?

scientific article published on 07 September 2006

Medical research: Next decade's goals for rare diseases

scientific article published in August 2017

Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK.

scientific article

Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone.

scientific article

Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization

scientific article published on 26 January 2016

Monitoring compound integrity with cytochrome P450 assays and qHTS.

scientific article

Multi-gram scale synthesis of FR180204.

scientific article

N4-phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease

scientific article

Niemann-Pick Disease Type C: Induced Pluripotent Stem Cell-Derived Neuronal Cells for Modeling Neural Disease and Evaluating Drug Efficacy

scientific article

Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays

scientific article

Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening

scientific article published in December 2008

Paradigm shift in toxicity testing and modeling

scientific article

Perspectives on validation of high-throughput assays supporting 21st century toxicity testing

scientific article (publication date: 2013)

Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents

scientific article

Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study

scientific article

Prediction of Cytochrome P450 Profiles of Environmental Chemicals with QSAR Models Built from Drug‐Like Molecules ⬇️

scientific article published on October 11, 2012

Predictive models for cytochrome p450 isozymes based on quantitative high throughput screening data

scientific article

Prepublication data sharing

scientific article

Profiling Environmental Chemicals for Activity in the Antioxidant Response Element Signaling Pathway Using a High Throughput Screening Approach ⬇️

scientific article published on May 2, 2012

Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential

scientific article

Progress in Rare Diseases Research 2010-2016: An IRDiRC Perspective

scientific article published on 10 August 2017

Putting translational science on to a global stage

scientific article published on April 2016

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

scientific article

Quantitative High-Throughput Screening for Chemical Toxicity in a Population-Based In Vitro Model ⬇️

scientific article published on January 19, 2012

Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease

scientific article

Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade

scientific article

Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death

scientific article

Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor

scientific article

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

scientific article published on 24 July 2006

Reply to Kojo: Mechanisms of antioxidant-induced DNA damage.

scientific article published on 13 June 2012

Repurposing Approved and Abandoned Drugs for the Treatment and Prevention of Cancer through Public–Private Partnership ⬇️

scientific article published on January 13, 2012

Research resource: modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay

scientific article

Selective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines as antagonists of the Neuropeptide S Receptor

scientific article

Structure Based Model for the Prediction of Phospholipidosis Induction Potential of Small Molecules ⬇️

scientific article published on July 5, 2012

Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis

scientific article published on October 2009

Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor

scientific article (publication date: 27 November 2013)

Synergistic combination of flavopiridol and carfilzomib targets commonly dysregulated pathways in adrenocortical carcinoma and has biomarkers of response

article published in 2018

Synthesis and characterization of a new fluorogenic substrate for alpha-galactosidase

scientific article published on 13 June 2009

Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors ⬇️

scientific article published on July 21, 2011

Systematic Study of Mitochondrial Toxicity of Environmental Chemicals Using Quantitative High Throughput Screening ⬇️

scientific article published on August 15, 2013

The International Rare Diseases Research Consortium: Policies and Guidelines to maximize impact.

scientific article published on 20 November 2017

The NCATS BioPlanet - An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics

The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics

scientific article

The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists

scientific article published on October 2011

The Tox21 robotic platform for the assessment of environmental chemicals – from vision to reality ⬇️

scientific article published on May 31, 2013

The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform ⬇️

scientific article

The pilot phase of the NIH Chemical Genomics Center

scientific article

Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease

scientific article

Toxicity testing in the 21st century: implications for human health risk assessment

scientific article

Two High Throughput Screen Assays for Measurement of TNF-α in THP-1 Cells ⬇️

scientific article

Two high-throughput screening assays for aberrant RNA-protein interactions in myotonic dystrophy type 1.

scientific article

Weighted feature significance: a simple, interpretable model of compound toxicity based on the statistical enrichment of structural features

scientific article published on 04 October 2009

δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders

scientific article

δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders

scientific article published in Journal of Biological Chemistry

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