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List of works by Wing C Chan

A multiprotein supercomplex controlling oncogenic signalling in lymphoma

scientific article published in Nature

A new biologic prognostic model based on immunohistochemistry predicts survival in patients with diffuse large B-cell lymphoma

scientific article

A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy

scientific article

A novel latent membrane 2 transcript expressed in Epstein-Barr virus-positive NK- and T-cell lymphoproliferative disease encodes a target for cellular immunotherapy

scientific article published on 29 July 2010

A significant diffuse component predicts for inferior survival in grade 3 follicular lymphoma, but cytologic subtypes do not predict survival

scientific article published on 7 November 2002

Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma

scientific article

Accurate classification of diffuse large B-cell lymphoma into germinal center and activated B-cell subtypes using a nuclease protection assay on formalin-fixed, paraffin-embedded tissues

scientific article

Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells

scientific article published on 14 January 2015

Activation of the STAT3 signaling pathway is associated with poor survival in diffuse large B-cell lymphoma treated with R-CHOP

scientific article

Addition of rituximab to standard chemotherapy improves the survival of both the germinal center B-cell-like and non-germinal center B-cell-like subtypes of diffuse large B-cell lymphoma

scientific article published on 28 July 2008

Adult Burkitt lymphoma: advances in diagnosis and treatment.

scientific article

Adult high-grade B-cell lymphoma with Burkitt lymphoma signature: genomic features and potential therapeutic targets

scientific article

Algorithmic fusion of gene expression profiling for diffuse large B-cell lymphoma outcome prediction

scientific article published in June 2004

Allelotyping of gastrointestinal nasal-type NK/T-cell lymphoma.

scientific article

Alternative splicing generates a short BCL6 (BCL6S) isoform encoding a compact repressor

scientific article

An unusual case of composite lymphoma involving chronic lymphocytic leukemia follicular lymphoma and Hodgkin disease

scientific article published on 01 May 2004

Assessment of T-cell receptor repertoire and clonal expansion in peripheral T-cell lymphoma using RNA-seq data

scientific article published on 12 September 2017

Autologous transplantation for aggressive non-Hodgkin's lymphoma: results of a randomized trial evaluating graft source and minimal residual disease

scientific article published in May 2002

BCL2 expression is a prognostic marker for the activated B-cell-like type of diffuse large B-cell lymphoma

scientific article published on 17 January 2006

BCL2 predicts survival in germinal center B-cell-like diffuse large B-cell lymphoma treated with CHOP-like therapy and rituximab

scientific article

BCL2 protein expression parallels its mRNA level in normal and malignant B cells

scientific article

BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma

scientific article

BCL6 promoter interacts with far upstream sequences with greatly enhanced activating histone modifications in germinal center B cells

scientific article

Biological Prognostic Markers in Diffuse Large B-Cell Lymphoma ⬇️

scientific article published on July 1, 2012

Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics

scientific article published on 12 August 2012

B‐cell lymphoma, unclassifiable, with features intermediate between diffuse large B‐cell lymphoma and burkitt lymphoma: study of 39 cases ⬇️

scientific article published on April 18, 2013

CCL3 and CCL4 are biomarkers for B cell receptor pathway activation and prognostic serum markers in diffuse large B cell lymphoma

scientific article

CD43 expression is associated with inferior survival in the non-germinal centre B-cell subgroup of diffuse large B-cell lymphoma

scientific article published on 25 April 2013

CIITA or RFX coding region loss of function mutations occur rarely in diffuse large B-cell lymphoma cases and cell lines with low levels of major histocompatibility complex class II expression

scientific article published on 19 February 2009

CTLA4 Promotes Tyk2-STAT3-Dependent B-cell Oncogenicity

scientific article published on 17 July 2017

Cell of origin fails to predict survival in patients with diffuse large B‐cell lymphoma treated with autologous hematopoietic stem cell transplantation ⬇️

scientific article published on October 18, 2011

Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt's lymphoma

article

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

scientific article

Clinicopathologic Characterization of Aggressive Natural Killer Cell Leukemia Involving Different Tissue Sites

scientific article published on 11 March 2016

Clonal CD8+ lymphocytic proliferation associated with Epstein-Barr virus infection mimicking T-cell leukemia

scientific article

Clonal evolution in t(14;18)-positive follicular lymphoma, evidence for multiple common pathways, and frequent parallel clonal evolution

scientific article

Colorimetric in situ hybridization identifies MYC gene signal clusters correlating with increased copy number, mRNA, and protein in diffuse large B-cell lymphoma

scientific article published on February 2013

Comment on: Frequent CTLA4-CD28 gene fusion in diverse types of T-cell lymphoma, by Yoo et al.

scientific article published on 31 May 2016

Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone

scientific article

Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray

scientific article (publication date: 2004)

Convergent Mutations and Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma

Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma.

scientific article

Cooperative epigenetic modulation by cancer amplicon genes

scientific article

Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling

scientific article published on 25 August 2005

Cytogenetic characterization of diffuse large cell lymphoma using multi-color fluorescence in situ hybridization

scientific article published in January 2002

Cytogenetics and fluorescence in situ hybridization studies of diffuse large B-cell lymphoma in children and young adults

scientific article published in September 2004

Decreased major histocompatibility complex class II expression in diffuse large B-cell lymphoma does not correlate with CpG methylation of class II transactivator promoters III and IV.

scientific article

Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue

scientific article published on 07 January 2014

Diagnostic and Biological Significance of KIR Expression Profile Determined by RNA-Seq in Natural Killer/T-Cell Lymphoma

scientific article published on 06 April 2016

Differences in the cytogenetic alteration profiles of diffuse large B-cell lymphoma among Chinese and American patients ⬇️

scientific article published on May 1, 2013

Diffuse large B-cell lymphoma arising in nodular lymphocyte predominant Hodgkin lymphoma: a report of 21 cases from the Nebraska Lymphoma Study Group

scientific article published on 01 August 2004

Diffuse large B-cell lymphoma arising in nodular lymphocyte predominant hodgkin lymphoma. A report of 21 cases from the Nebraska Lymphoma Study Group

scientific article published on 01 November 2003

Diffuse large B-cell lymphoma in Chinese patients: immunophenotypic and cytogenetic analyses of 124 cases

scientific article published on 01 February 2010

Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction

scientific article published on 26 July 2005

Diffuse large B-cell lymphoma with concordant bone marrow involvement has peculiar genomic profile and poor clinical outcome.

scientific article

Distinct gene expression profiles in different B-cell compartments in human peripheral lymphoid organs

scientific article published on 15 September 2004

Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling

scientific article

EZH2 mutations are frequent and represent an early event in follicular lymphoma

scientific article published on 19 September 2013

EZH2 mutations in follicular lymphoma from different ethnic groups and associated gene expression alterations.

scientific article published on 14 March 2014

Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma.

scientific article

Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms

scientific article published on 03 February 2014

Expression of PKC-beta or cyclin D2 predicts for inferior survival in diffuse large B-cell lymphoma

scientific article published on 01 October 2005

Extranodal marginal zone lymphoma of the dura mater with IgH/MALT1 translocation and review of literature

scientific article published on 18 June 2008

Familial B-cell chronic lymphocytic leukemia: analysis of cytogenetic abnormalities, immunophenotypic profiles, and immunoglobulin heavy chain gene usage

scientific article published on 01 January 2007

Flow cytometric sorting coupled with exon capture sequencing identifies somatic mutations in archival lymphoma tissues

scientific article

Follicular large cleaved cell (centrocytic) lymphoma: An unrecognized variant of follicular lymphoma

scientific article published on 20 November 2017

Frequent occurrence of deletions in primary mediastinal B-cell lymphoma

article

Full clinical recovery after topical acyclovir treatment of Epstein-Barr virus associated cutaneous B-cell lymphoma in patient with mycosis fungoides

scientific article

Gains of MYC locus and outcome in patients with diffuse large B-cell lymphoma treated with R-CHOP

Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas

scientific article

Gene arrays in lymphoma: Where will they fit in?

scientific article published on June 2006

Gene expression profiling in lymphoma diagnosis and management

scientific article published on June 2009

Gene expression profiling in lymphoma diagnosis and research

scientific article published in June 2005

Gene expression profiling in non-Hodgkin lymphomas

scientific article published on January 2015

Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma

scientific article

Generation of variable and fixed length siRNA from a novel siRNA expression vector

scientific article published on 25 April 2006

Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma

scientific article published in April 2018

Genome wide DNA-profiling of HIV-related B-cell lymphomas

scientific article published on 12 October 2009

Genome wide transcriptional analysis of resting and IL2 activated human natural killer cells: gene expression signatures indicative of novel molecular signaling pathways

scientific article published on 10 July 2007

Genome-wide miRNA profiling of mantle cell lymphoma reveals a distinct subgroup with poor prognosis

scientific article

Genomic aberrations affecting the outcome of immunodeficiency-related diffuse large B-cell lymphoma

scientific article published on 28 August 2011

Genomic analysis of lymphoma: potential for clinical application

scientific article published on 01 March 2010

Genomic lesions associated with a different clinical outcome in diffuse large B-Cell lymphoma treated with R-CHOP-21.

scientific article published on 31 August 2010

Genomic signatures in B-cell lymphoma: How can these improve precision in diagnosis and inform prognosis?

scientific article published on 18 August 2015

Genomic signatures in T-cell lymphoma: How can these improve precision in diagnosis and inform prognosis?

scientific article published on 18 August 2015

Global microRNA expression profiling uncovers molecular markers for classification and prognosis in aggressive B-cell lymphoma

scientific article published on 10 December 2014

HACE1 Is a Tumor Suppressor Gene Candidate in Natural Killer Cell Neoplasms ⬇️

scientific article published on November 9, 2012

High microvessel density determines a poor outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus chemotherapy.

scientific article

Hodgkin's disease in the elderly: improved treatment outcome with a doxorubicin-containing regimen

scientific article published in February 2002

IDH2R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma

scientific article

Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations

scientific article

Identification of Primary Mediastinal Large B-cell Lymphoma at Nonmediastinal Sites by Gene Expression Profiling

scientific article

Identification of a 3-gene model as a powerful diagnostic tool for the recognition of ALK-negative anaplastic large-cell lymphoma

scientific article

Immunohistochemical methods for predicting cell of origin and survival in patients with diffuse large B-cell lymphoma treated with rituximab

scientific article

Indolent T-cell lymphoproliferative disease of the gastrointestinal tract

scientific article published on 05 September 2013

Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas

scientific article

Inhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks.

scientific article

Integrated profiling of diffuse large B-cell lymphoma with 7q gain

scientific article published on 21 March 2011

Investigation of theBRAFV600E Mutation by Pyrosequencing in Lymphoproliferative Disorders ⬇️

scientific article published on 01 December 2012

Isolated MYC cytogenetic abnormalities in diffuse large B-cell lymphoma do not predict an adverse clinical outcome

scientific article published in April 2015

Lack of Expression of MTAP in Uncommon T-Cell Lymphomas ⬇️

scientific article published on 01 October 2012

Lack of evidence that HACE1 is not a tumor suppressor gene in NKTCL: to the editor-in-chief.

scientific article published in April 2015

Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis

scientific journal article

Loss of MHC class II gene and protein expression in diffuse large B-cell lymphoma is related to decreased tumor immunosurveillance and poor patient survival regardless of other prognostic factors: a follow-up study from the Leukemia and Lymphoma Mol

scientific article published on 19 February 2004

Loss of major histocompatibility class II expression in non-immune-privileged site diffuse large B-cell lymphoma is highly coordinated and not due to chromosomal deletions.

scientific article published on 20 October 2005

Loss of major histocompatibility class II gene and protein expression in primary mediastinal large B-cell lymphoma is highly coordinated and related to poor patient survival

scientific article published on 16 March 2006

Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma

scientific article

Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells

scientific article published on 26 September 2016

Low levels of monoclonal small B cells in the bone marrow of patients with diffuse large B-cell lymphoma of activated B-cell type but not of germinal center B-cell type

scientific article

Lymphoma diagnosis at an academic centre: rate of revision and impact on patient care

scientific article published on 04 April 2014

MYC and BCL2 protein expression predicts survival in patients with diffuse large B-cell lymphoma treated with rituximab

scientific article published on 08 February 2014

Mantle cell lymphoma with plasma cell differentiation

scientific article published on 01 August 2006

MicroRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma

scientific article published on 25 June 2013

Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component.

scientific article

Molecular diagnosis and outcome prediction in diffuse large B-cell lymphoma and other subtypes of lymphoma

scientific article published in June 2004

Molecular diagnosis of Burkitt's lymphoma

scientific article published in June 2006

Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma

scientific article

Molecular distinctions between pediatric and adult mature B-cell non-Hodgkin lymphomas identified through genomic profiling

scientific article published on 28 February 2012

Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma

scientific article

Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways

scientific article

Multi-kinase inhibitor with anti-p38γ activity in cutaneous T cell lymphoma

scientific article published on 11 May 2018

Mutation and genomic deletion status of ataxia telangiectasia mutated (ATM) and p53 confer specific gene expression profiles in mantle cell lymphoma

scholarly article

Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas

scientific article

Mutations in the DNA-binding codons of TP53, which are associated with decreased expression of TRAILreceptor-2, predict for poor survival in diffuse large B-cell lymphoma

scientific article

NCCN task force report: molecular markers in leukemias and lymphomas

scientific article published on July 2009

New Molecular Assay for the Proliferation Signature in Mantle Cell Lymphoma Applicable to Formalin-Fixed Paraffin-Embedded Biopsies

scientific article published on 14 March 2017

Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphoma ⬇️

scientific article published on April 15, 2003

Oncogenic CARD11 mutations in human diffuse large B cell lymphoma

scientific article

Oncogenically active MYD88 mutations in human lymphoma

scientific article

Outcomes after Allogeneic Stem Cell Transplantation in Patients with Double-Hit and Double-Expressor Lymphoma

scientific article published on 28 November 2017

PCR-based generation of shRNA libraries from cDNAs

scientific article published on 21 June 2006

PRDM1 is a tumor suppressor gene in natural killer cell malignancies ⬇️

scientific article published on December 5, 2011

Peripheral T-cell and NK cell lymphoproliferative disorders: cell of origin, clinical and pathological implications

scientific article

Phase II Trial of 131-Iodine Tositumomab with High-Dose Chemotherapy and Autologous Stem Cell Transplantation for Relapsed Diffuse Large B Cell Lymphoma ⬇️

scientific article published on August 29, 2012

Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival

scientific article published on 13 February 2007

Practical detection of t(14;18)(IgH/BCL2) in follicular lymphoma

scientific article published on August 2008

Prediction of Survival in Follicular Lymphoma Based on Molecular Features of Tumor-Infiltrating Immune Cells

article

Quantitative Proteomics Reveals that miR-155 Regulates the PI3K-AKT Pathway in Diffuse Large B-Cell Lymphoma ⬇️

scientific article published on May 18, 2012

Recent advances in the molecular diagnosis of diffuse large B-cell lymphoma

scientific article

Recurrent chromosomal alterations in molecularly classified AIDS-related lymphomas: an integrated analysis of DNA copy number and gene expression

scientific article published on 01 May 2010

Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation

scientific article published on 13 January 2009

Relapsed or Refractory Double-Expressor and Double-Hit Lymphomas Have Inferior Progression-Free Survival After Autologous Stem-Cell Transplantation

scientific article published on 24 October 2016

Rituximab Improves the Outcome of Patients With Grade 3 Follicular Lymphoma Receiving Anthracycline-Based Therapy

scientific article published on 16 June 2017

STAT3-mediated activation of microRNA cluster 17~92 promotes proliferation and survival of ALK-positive anaplastic large cell lymphoma

scientific article published on 23 August 2013

Single nucleotide polymorphism-arrays provide new insights in the pathogenesis of post-transplant diffuse large B-cell lymphoma

article by Andrea Rinaldi et al published 3 March 2010 in British Journal of Haematology

Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature

scientific article published on 12 February 2007

Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study.

scientific article published on 17 June 2008

Studies of a germinal centre B-cell expressed gene, GCET2, suggest its role as a membrane associated adapter protein.

scientific article

Suitability of stratagene reference RNA for analysis of lymphoid tissues

scientific article

Surface display of recombinant proteins on Bacillus thuringiensis spores.

scientific article published on June 2005

TOSO is overexpressed and correlated with disease progression in Chinese patients with chronic lymphocytic leukemia

scientific article published on 06 December 2010

Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma

scientific journal article

The Stromal Cell Marker SPARC Predicts for Survival in Patients With Diffuse Large B-Cell Lymphoma Treated With Rituximab

article

The addition of rituximab reduces the incidence of secondary central nervous system involvement in patients with diffuse large B-cell lymphoma

scientific article published on 09 January 2012

The miR-17-92 microRNA cluster is regulated by multiple mechanisms in B-cell malignancies

scientific article

The presence of TP53 mutation at diagnosis of follicular lymphoma identifies a high-risk group of patients with shortened time to disease progression and poorer overall survival

scientific article

The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma

article

The t(14;18) and bcl-2 expression are present in a subset of primary cutaneous follicular lymphoma: association with lower grade

scientific article published on 01 November 2002

The t(14;18) defines a unique subset of diffuse large B-cell lymphoma with a germinal center B-cell gene expression profile

scientific article published on 01 April 2002

The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma

scientific article

Transformation of follicular lymphoma to diffuse large B-cell lymphoma proceeds by distinct oncogenic mechanisms

scientific article published on January 2007

Transformation of follicular lymphoma to precursor B-cell lymphoblastic lymphoma with c-myc gene rearrangement as a critical event

scientific article published on 01 January 2008

Tumor-associated macrophages and survival in classic Hodgkin's lymphoma

scientific article

Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome.

scientific article published on 4 September 2013

Two newly characterized germinal center B-cell-associated genes, GCET1 and GCET2, have differential expression in normal and neoplastic B cells

scientific article

UNiquant, a program for quantitative proteomics analysis using stable isotope labeling

scientific article

Validation of tissue microarray immunohistochemistry staining and interpretation in diffuse large B-cell lymphoma

scientific article

Virtual CGH: an integrative approach to predict genetic abnormalities from gene expression microarray data applied in lymphoma ⬇️

scientific article published on April 12, 2011

Whole transcriptome analysis reveals dysregulated oncogenic lncRNAs in natural killer/T-cell lymphoma and establishes MIR155HG as a target of PRDM1.

scientific article

t(14;18)-negative follicular lymphomas are associated with a high frequency of BCL6 rearrangement at the alternative breakpoint region

scientific article published on 22 May 2009

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