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List of works by Manuel Portero-Otin

A Stress-Resistant Lipidomic Signature Confers Extreme Longevity to Humans.

scientific article published on 24 March 2016

A prospective pilot study using metabolomics discloses specific fatty acid, catecholamine and tryptophan metabolic pathways as possible predictors for a negative outcome after severe trauma

scientific article published on 22 May 2019

Aberrant regulation of the GSK-3β/NRF2 axis unveils a novel therapy for adrenoleukodystrophy

scientific article published on 01 August 2018

Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy.

scientific article

Adipocyte lipopolysaccharide binding protein (LBP) is linked to a specific lipidomic signature

scientific article

Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence

scientific article published on 16 November 2018

Adipose Tissue Mitochondrial Factors Profile after Dietary Bioactive Compound Weight Reduction Treatments in a Mice Obesity Model

scientific article published on 22 November 2019

Adipose Tissue Protein Glycoxidation is Associated with Weight-Loss Potential

scientific article published on 21 May 2019

Age-Related Changes in Lipidome of Rat Frontal Cortex and Cerebellum Are Partially Reversed by Methionine Restriction Applied in Old Age

scientific article published in 2021

Altered Dynein Axonemal Assembly Factor 1 Expression in C-Boutons in Bulbar and Spinal Cord Motor-Neurons in Sporadic Amyotrophic Lateral Sclerosis

scientific article published on 01 May 2019

Amyloid generation and dysfunctional immunoproteasome activation with disease progression in animal model of familial Alzheimer's disease

scientific article published on 13 January 2012

Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy.

scientific article

Biofluid quantification of TWEAK/Fn14 axis in combination with a selected biomarker panel improves assessment of prostate cancer aggressiveness

scientific article published on 09 September 2019

Biofortification of crops with nutrients: factors affecting utilization and storage

scientific article published on 6 January 2017

Biomarker Identification, Safety, and Efficacy of High-Dose Antioxidants for Adrenomyeloneuropathy: a Phase II Pilot Study

scientific article published on 01 October 2019

Brain iron overload, insulin resistance, and cognitive performance in obese subjects: a preliminary MRI case-control study

scientific article published on 14 August 2014

Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice

scientific article

Carotenoid-enriched transgenic corn delivers bioavailable carotenoids to poultry and protects them against coccidiosis

scientific article published on 2 April 2015

Characterization of the post-prandial insulinemic response and low glycaemic index of a soy beverage

scientific article

Cryptic exon splicing function of TARDBP interacts with autophagy in nervous tissue

scientific article published on 28 July 2018

Depletion of oxidative and endoplasmic reticulum stress regulators in Pick disease

scientific article

Deregulation of purine metabolism in Alzheimer's disease

scientific article published on 8 August 2014

Dietary Lipid Unsaturation Influences Survival and Oxidative Modifications of an Amyotrophic Lateral Sclerosis Model in a Gender-Specific Manner

scientific article published on 01 July 2014

Differential metabolic profiles associated to movement behaviour of stream-resident brown trout (Salmo trutta).

scientific article published on 27 July 2017

Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS

scientific article published on 13 January 2016

Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy

scientific article

Erratum: Obesity changes the human gut mycobiome

scientific article published on 24 February 2016

Estudio de la vulnerabilidad neuronal selectiva en el sistema nervioso central humano

scientific article published on 05 September 2013

Evidence of oxidative stress in the neocortex in incidental Lewy body disease

scientific article

Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia

scientific article published in Scientific Reports

Gender-Specific Beneficial Effects of Docosahexaenoic Acid Dietary Supplementation in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice

scientific article published on 01 January 2020

Gut Microbiota Interacts With Brain Microstructure and Function

scientific article published on 7 October 2015

Human omental and subcutaneous adipose tissue exhibit specific lipidomic signatures

scientific article published on 21 November 2013

Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy

scientific article published on 20 April 2013

Impairment of Mitochondrial Redox Status in Peripheral Lymphocytes of Multiple Sclerosis Patients

scientific article published on 04 September 2019

Increased oxidation, glycoxidation, and lipoxidation of brain proteins in prion disease

scientific article published on 23 July 2008

Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis

scientific article published on 12 January 2016

Lipid alterations in human frontal cortex in ALS-FTLD-TDP43 proteinopathy spectrum are partly related to peroxisome impairment

scientific article published on 17 December 2020

Lipidomic profiling identifies signatures of metabolic risk

scientific article published on 24 December 2019

Lipidomics of human brain aging and Alzheimer's disease pathology.

scientific article published on 19 June 2015

Location-dependent effects of trauma on oxidative stress in humans

scientific article published in PLoS ONE

Maillard reaction versus other nonenzymatic modifications in neurodegenerative processes

scientific article published on 13 December 2007

Metabolomics Predicts Neuroimaging Characteristics of Transient Ischemic Attack Patients

scientific article

Metabolomics of human brain aging and age-related neurodegenerative diseases

scientific article

Metabolomics uncovers the role of adipose tissue PDXK in adipogenesis and systemic insulin sensitivity

scientific article published on 2 February 2016

Metabotyping human endometrioid endometrial adenocarcinoma reveals an implication of endocannabinoid metabolism.

scientific article published on 13 July 2016

Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity

scientific article

Mitochondrial dysfunction and oxidative and endoplasmic reticulum stress in argyrophilic grain disease.

scientific article published in April 2011

Modification of brain lipids but not phenotype in alpha-synucleinopathy transgenic mice by long-term dietary n-3 fatty acids

scientific article published on 12 November 2009

Neuroinflammatory Gene Regulation, Mitochondrial Function, Oxidative Stress, and Brain Lipid Modifications With Disease Progression in Tau P301S Transgenic Mice as a Model of Frontotemporal Lobar Degeneration-Tau

scientific article published on 10 September 2015

Neuroinflammatory signals in Alzheimer disease and APP/PS1 transgenic mice: correlations with plaques, tangles, and oligomeric species

scientific article published in April 2015

Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis

scientific article published on 23 August 2007

Oxidative damage compromises energy metabolism in the axonal degeneration mouse model of X-adrenoleukodystrophy

scientific article

Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: a paradigm for multifactorial neurodegenerative diseases?

scientific article published on 12 February 2012

Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophy

scientific article

Plant-Derived Phenolics Inhibit the Accrual of Structurally Characterised Protein and Lipid Oxidative Modifications ⬇️

scientific article published on August 29, 2012

Plurality of opinion, scientific discourse and pseudoscience: an in depth analysis of the Séralini et al. study claiming that Roundup™ Ready corn or the herbicide Roundup™ cause cancer in rats

scientific article

Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation. Effects of Alzheimer disease and identification of lipoxidation targets.

scientific article published on 29 March 2005

Region-specific vulnerability to lipid peroxidation and evidence of neuronal mechanisms for polyunsaturated fatty acid biosynthesis in the healthy adult human central nervous system.

scientific article published on 6 February 2017

Selected cryptic exons accumulate in hippocampal cell nuclei in Alzheimer's disease with and without associated TDP-43 proteinopathy

scientific article published on 01 March 2020

Sixty years old is the breakpoint of human frontal cortex aging

scientific article published on 12 December 2016

Skin Autofluorescence Measurement in Subclinical Atheromatous Disease: Results from the ILERVAS Project

scientific article published on 06 March 2019

Specific Metabolomics Adaptations Define a Differential Regional Vulnerability in the Adult Human Cerebral Cortex

scientific article published on 08 December 2016

TSHB mRNA is linked to cholesterol metabolism in adipose tissue.

scientific article published on 23 June 2017

The Gut Metagenome Changes in Parallel to Waist Circumference, Brain Iron Deposition, and Cognitive Function

scientific article published on 7 June 2017

The distribution of carotenoids in hens fed on biofortified maize is influenced by feed composition, absorption, resource allocation and storage

scientific article published on 14 October 2016

Type-dependent oxidative damage in frontotemporal lobar degeneration: cortical astrocytes are targets of oxidative damage

scientific article published in December 2008

Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy

scientific article published on 23 February 2010

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