Search filters

List of works by Robert Fletterick

6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) Forms an Irreversible Bond To the Active Site of the GluR2 AMPA Receptor †

scientific article

A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver

scientific article published on 11 December 2015

A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding

scientific article published on 27 June 2006

A surface on the androgen receptor that allosterically regulates coactivator binding

scientific article

Advances in our structural understanding of orphan nuclear receptors.

scientific article

An atomic model of the thin filament in the relaxed and Ca2+-activated states.

scientific article published on 13 January 2006

Conformational adaptation of nuclear receptor ligand binding domains to agonists: potential for novel approaches to ligand design

scientific article

Coordination between motor domains in processive kinesins

scientific article published on 18 February 2004

Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite

scientific article published on 07 March 2019

Crystal structure of kinesin regulated by Ca(2+)-calmodulin

scientific article published on 26 February 2004

Design of thyroid hormone receptor antagonists from first principles

scientific article

Development of 5N-Bicalutamide, a High-Affinity Reversible Covalent Antiandrogen

scientific article published on 5 October 2017

Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators

scientific article published on 31 October 2005

Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2)

scientific article

Dlx5 Homeodomain:DNA Complex: Structure, Binding and Effect of Mutations Related to Split Hand and Foot Malformation Syndrome

scientific article

Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism

scientific article

How does ATP hydrolysis control actin's associations?

scientific article

Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships.

scientific article

Interaction between the androgen receptor and a segment of its corepressor SHP

scientific article

LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival

scientific article published in Nature Communications

Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor

scientific article

Molecular basis for dimer formation of TRβ variant D355R ⬇️

scientific article

NR5A2 discovering compounds that block tumor growth in PDAC.

scientific article published on 26 April 2017

Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation

scientific article

Perspectives on designs of antiandrogens for prostate cancer.

scientific article published in October 2007

Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1.

scientific article

Rearrangements in thyroid hormone receptor charge clusters that stabilize bound 3,5',5-triiodo-L-thyronine and inhibit homodimer formation

scientific article

Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs

scientific article

Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.

scientific article published on February 2005

Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D

scientific article

Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1

scientific article

Structural basis of coactivation of liver receptor homolog-1 by  -catenin

scientific article

Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor

scientific article

Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket

scientific article

Structure of SF-1 Bound by Different Phospholipids: Evidence for Regulatory Ligands

scientific article

Structure of a Novel Winged-Helix Like Domain from Human NFRKB Protein

scientific article

Structure of an F-actin trimer disrupted by gelsolin and implications for the mechanism of severing

scientific article

Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells

scientific article

Structure-based discovery of antagonists of nuclear receptor LRH-1.

scientific article published on 10 May 2013

TR surfaces and conformations required to bind nuclear receptor corepressor

scientific article published on February 2002

Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells

scientific article

The FKBP52 Cochaperone Acts in Synergy with β-Catenin to Potentiate Androgen Receptor Signaling.

scientific article published on 24 July 2015

The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable

scientific article (publication date: 2014)

The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor

scientific article

The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.

scientific article

The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1

scientific article

Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain

scientific article

Thyroxine-thyroid hormone receptor interactions

scientific article

Paulina is supported by:

About Paulina

Help