List of works - Mark K. Louder

A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope.

scientific article published on 7 March 2018

A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase I clinical trial

scientific article published on 26 September 2008

A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention

publication published on 01 January 2021

Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individuals

scientific article

Analysis of the neutralizing antibody response elicited in rabbits by repeated inoculation with trimeric HIV-1 envelope glycoproteins.

scientific article published in January 2005

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization

scientific article published on 01 July 2019

Broad HIV-1 neutralization mediated by CD4-binding site antibodies

scientific article published on 26 August 2007

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

scientific article

Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge

scientific article published on September 2017

CD4-binding-Site Recognition by VH1-46 Germline-derived HIV-1 Neutralizers.

scientific article published in October 2014

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

scientific article

Correction for Acharya et al., Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

article

Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibodies Identified from a Patient with 2F5-Like Antibodies

Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies

scientific article

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

scientific article

Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.

scientific article

Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization

scientific article

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

scientific article

Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells

scientific article

Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations

scientific article published on 01 July 2019

Early short-term antiretroviral therapy is associated with a reduced prevalence of CD8(+)FoxP3(+) T cells in simian immunodeficiency virus-infected controller rhesus macaques

scientific article

Enhanced exposure of the CD4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain

scientific article published on 04 March 2009

Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo

scientific article

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

scientific article published on 04 June 2018

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

scientific article published on 28 July 2020

Expanded breadth of virus neutralization after immunization with a multiclade envelope HIV vaccine candidate

scientific article

Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces

scientific article published on 09 November 2021

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

scientific article

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

scientific article

HIV-1 envelope pseudotyped viral vectors and infectious molecular clones expressing the same envelope glycoprotein have a similar neutralization phenotype, but culture in peripheral blood mononuclear cells is associated with decreased neutralization

scientific article published in September 2005

HIV-1 neutralization coverage is improved by combining monoclonal antibodies that target independent epitopes

scientific article published on 18 January 2012

HIV-1 neutralizing antibodies display dual recognition of the primary and coreceptor binding sites and preferential binding to fully cleaved envelope glycoproteins

scientific article

Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

scientific article

Human immunodeficiency virus type 1 neutralization measured by flow cytometric quantitation of single-round infection of primary human T cells

scientific article

Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.

scientific article published on November 2016

Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV.

scientific article published on 18 December 2013

Improvement of antibody functionality by structure-guided paratope engraftment

scientific article published in Nature Communications

Improving neutralization potency and breadth by combining broadly reactive HIV-1 antibodies targeting major neutralization epitopes

scientific article

Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations ⬇️

scientific article published on 23 November 2017

Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry

scientific article published in Nature Communications

Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual

scientific article published on 12 March 2019

Lysis of human immunodeficiency virus type 1 by a specific secreted human phospholipase A2

scientific article published on 8 November 2006

Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting

scientific article

Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

scientific article

Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection

scientific article

Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01.

scientific article

Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.

scientific article published on March 2017

Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains

scientific article published on 27 March 2013

Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies

scientific article

Multiple Antibody Lineages in One Donor Target the Glycan-V3 Supersite of the HIV-1 Envelope Glycoprotein and Display a Preference for Quaternary Binding

scientific article published on 21 September 2016

Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody

scholarly article

N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function

scientific article

Neutralizing antibodies elicited by immunization of monkeys with DNA plasmids and recombinant adenoviral vectors expressing human immunodeficiency virus type 1 proteins

scientific article published on January 2005

New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency

scientific article

Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection

scientific article

Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design

scientific article

Potent and broad HIV-neutralizing antibodies in memory B cells and plasma

scientific article published on January 2017

Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection

scientific article

Preparation of clinical-grade recombinant canarypox-human immunodeficiency virus vaccine-loaded human dendritic cells

scientific article published on 7 October 2002

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

scientific article published on April 2017

Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity.

scientific article published on 28 February 2018

Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

scientific article (publication date: 13 August 2010)

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth

scientific article published on 19 November 2020

Removal of variable domain N-linked glycosylation as a means to improve the homogeneity of HIV-1 broadly neutralizing antibodies

scientific article published on 01 January 2020

Residue-level prediction of HIV-1 antibody epitopes based on neutralization of diverse viral strains

scientific article published on 10 July 2013

SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

scientific article published on 11 June 2020

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

scientific article published on 05 August 2020

Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.

scientific article published on March 2017

Structural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 Å Cocrystal Structure of gp120 and M48U1

scientific article

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

scientific article

Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition

article

Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16

scientific article

Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies

scientific article published on 01 November 2021

Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

scientific article

Structure of BMS-806, a Small-molecule HIV-1 Entry Inhibitor, Bound to BG505 SOSIP.664 HIV-1 Env Trimer.

scientific article published in October 2014

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

scientific article

Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition

scientific article published on 01 April 2020

Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding Site

scientific article published on 31 August 2016

Structure-based identification and neutralization mechanism of tyrosine sulfate mimetics that inhibit HIV-1 entry

scientific article

Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

scientific article

Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody

scientific article published in February 2018

The development of CD4 binding site antibodies during HIV-1 infection

scientific article

The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes

scientific article

The v3 loop is accessible on the surface of most human immunodeficiency virus type 1 primary isolates and serves as a neutralization epitope.

scientific article published on March 2004

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

scientific article

VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage

scientific article published on 03 March 2020

Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability

scientific article published on 12 November 2019

Variable Dependence on Glycan Recognition within a Lineage of V1V2-directed HIV Neutralizing Antibodies.

scientific article published in October 2014

Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop

scientific article published on May 2017

List of works by Mark K. Louder

A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope.

A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase I clinical trial

A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention

Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individuals

Analysis of the neutralizing antibody response elicited in rabbits by repeated inoculation with trimeric HIV-1 envelope glycoproteins.

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization

Broad HIV-1 neutralization mediated by CD4-binding site antibodies

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge

CD4-binding-Site Recognition by VH1-46 Germline-derived HIV-1 Neutralizers.

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

Correction for Acharya et al., Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibodies Identified from a Patient with 2F5-Like Antibodies

Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.

Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells

Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations

Early short-term antiretroviral therapy is associated with a reduced prevalence of CD8(+)FoxP3(+) T cells in simian immunodeficiency virus-infected controller rhesus macaques

Enhanced exposure of the CD4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain

Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

Expanded breadth of virus neutralization after immunization with a multiclade envelope HIV vaccine candidate

Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

HIV-1 envelope pseudotyped viral vectors and infectious molecular clones expressing the same envelope glycoprotein have a similar neutralization phenotype, but culture in peripheral blood mononuclear cells is associated with decreased neutralization

HIV-1 neutralization coverage is improved by combining monoclonal antibodies that target independent epitopes

HIV-1 neutralizing antibodies display dual recognition of the primary and coreceptor binding sites and preferential binding to fully cleaved envelope glycoproteins

Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

Human immunodeficiency virus type 1 neutralization measured by flow cytometric quantitation of single-round infection of primary human T cells

Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.

Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV.

Improvement of antibody functionality by structure-guided paratope engraftment

Improving neutralization potency and breadth by combining broadly reactive HIV-1 antibodies targeting major neutralization epitopes

Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations ⬇️

Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry

Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual

Lysis of human immunodeficiency virus type 1 by a specific secreted human phospholipase A2

Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting

Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection

Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01.

Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.

Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains

Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies

Multiple Antibody Lineages in One Donor Target the Glycan-V3 Supersite of the HIV-1 Envelope Glycoprotein and Display a Preference for Quaternary Binding

Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody

N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function

Neutralizing antibodies elicited by immunization of monkeys with DNA plasmids and recombinant adenoviral vectors expressing human immunodeficiency virus type 1 proteins

New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency

Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection

Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design

Potent and broad HIV-neutralizing antibodies in memory B cells and plasma

Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection

Preparation of clinical-grade recombinant canarypox-human immunodeficiency virus vaccine-loaded human dendritic cells

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity.

Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth

Removal of variable domain N-linked glycosylation as a means to improve the homogeneity of HIV-1 broadly neutralizing antibodies

Residue-level prediction of HIV-1 antibody epitopes based on neutralization of diverse viral strains

SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.

Structural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 Å Cocrystal Structure of gp120 and M48U1

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition

Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16

Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies

Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

Structure of BMS-806, a Small-molecule HIV-1 Entry Inhibitor, Bound to BG505 SOSIP.664 HIV-1 Env Trimer.

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition

Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding Site

Structure-based identification and neutralization mechanism of tyrosine sulfate mimetics that inhibit HIV-1 entry