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List of works by Roland Schüle

4-Acyl pyrroles: mimicking acetylated lysines in histone code reading

scientific article

4-Biphenylalanine- and 3-Phenyltyrosine-Derived Hydroxamic Acids as Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A.

scientific article published on 9 August 2016

A Chemical Probe For Tudor Domain Protein Spindlin1 to Investigate Chromatin Functions

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function

scientific article published on 15 October 2019

A novel arginine methyltransferase inhibitor with cellular activity

scientific article

A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer

scientific article

A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.

scientific article published on 9 January 2012

Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1.

scientific article published on 27 February 2011

Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence

scientific article

Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation

scientific article

Cell type specific gene expression analysis of prostate needle biopsies resolves tumor tissue heterogeneity.

scientific article published in January 2015

Cell type-specific functions of the lysosomal protease cathepsin L in the heart

scientific article published on 17 October 2007

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

scientific article

Correction: LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML

scientific article published on 01 June 2019

CtBP and associated LSD1 are required for transcriptional activation by NeuroD1 in gastrointestinal endocrine cells

scientific article published on 14 April 2014

Deficiency in the LIM-only protein Fhl2 impairs skin wound healing

scientific article

Depletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death

scientific article published on 17 February 2020

Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1)

scientific article published on 24 July 2019

Enhanced FHL2 and TGF-β1 Expression Is Associated With Invasive Growth and Poor Survival in Malignant Melanomas

scientific article published on February 2015

Epigenetic regulation of cancer growth by histone demethylases

scientific article

Epigenetics meets GPCR: inhibition of histone H3 methyltransferase (G9a) and histamine H3 receptor for Prader-Willi Syndrome

scientific article published on 11 August 2020

Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes

scientific article

FHL2 expression in peritumoural fibroblasts correlates with lymphatic metastasis in sporadic but not in HNPCC-associated colon cancer

scientific article

FHL2 mediates dexamethasone-induced mesenchymal cell differentiation into osteoblasts by activating Wnt/beta-catenin signaling-dependent Runx2 expression.

scientific article

FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo

scientific article

Fat or bone? A non-canonical decision

scientific article published on 01 November 2007

Fhl2 deficiency results in osteopenia due to decreased activity of osteoblasts

scientific article

Focal adhesion kinase interacts with the transcriptional coactivator FHL2 and both are overexpressed in epithelial ovarian cancer.

scientific article

Four-and-a-half LIM domains protein 2 (FHL2) is associated with the development of craniofacial musculature in the teleost fish Sparus aurata

scientific article published on 08 July 2011

Generation and characterization of an Nse-CreERT2 transgenic line suitable for inducible gene manipulation in cerebellar granule cells.

scientific article

Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate

scientific article published on 31 March 2014

Histone demethylation and androgen-dependent transcription

scientific article published on 17 August 2006

Identification and Structure-Activity Relationship Studies of Small-Molecule Inhibitors of the Methyllysine Reader Protein Spindlin1.

scientific article

Identification of Highly Potent Protein Kinase C-Related Kinase 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and in vitro Testing

scientific article

Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform.

scientific article published on 17 February 2016

Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor

scientific article

Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4.

scientific article published on 23 February 2017

KDM4 inhibition targets breast cancer stem-like cells

scientific article

KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells

scientific article published on 06 May 2019

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

scientific article

LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML

scientific article published on 24 January 2019

LSD1 promotes oxidative metabolism of white adipose tissue

scientific article published on 10 June 2014

Lestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cells

scientific article

Long-range upstream and downstream enhancers control distinct subsets of the complex spatiotemporal Sox9 expression pattern

scientific article published on 3 February 2006

Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue

scientific article

Lsd1 prevents age-programed loss of beige adipocytes

scientific article published on May 2017

Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells

scientific article published on 25 January 2018

Lsd1, a metabolic sensor of environment requirements that prevents adipose tissue from aging

scientific article published on 26 June 2017

Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology

scientific article

Lysine-specific demethylase 1 has dual functions as a major regulator of androgen receptor transcriptional activity.

scientific article

Lysine-specific demethylase 1 is highly expressed in solitary fibrous tumors, synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumors, and malignant peripheral nerve sheath tumors

scientific article published on 29 April 2011

Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy

scientific article (publication date: March 2009)

Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells

scientific article published in Nature Communications

Molecular cloning of the Matrix Gla Protein gene from Xenopus laevis. Functional analysis of the promoter identifies a calcium sensitive region required for basal activity

scientific article published on April 2002

Molecular cloning of the Matrix Gla Protein gene from Xenopus laevis. Functional analysis of the promoter identifies a calcium sensitive region required for basal activity

article

NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.

scientific article

NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle

scientific article

Next-generation sequencing reveals a novel role of lysine-specific demethylase 1 in adhesion of rhabdomyosarcoma cells

scientific article published on 21 November 2019

Nitroreductase-Mediated Release of Inhibitors of Lysine-Specific Demethylase 1 (LSD1) from Prodrugs in Transfected Acute Myeloid Leukaemia Cells

article published in 2019

Nitroreductase-mediated release of inhibitors of Lysine-Specific Demethylase 1 (LSD1) from prodrugs in transfected acute myeloid leukaemia cells

scientific article published on 30 March 2020

Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity

scientific article published on 5 September 2013

Overexpression of histone demethylase Fbxl10 leads to enhanced migration in mouse embryonic fibroblasts

scientific article published on 16 September 2016

PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity

scientific article

PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells

scientific article published on December 2014

Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation

scientific article

Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4

scientific article

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes.

scientific article

Proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor enhances androgen receptor functions through LIM-only coactivator, four-and-a-half LIM-only protein 2

scientific article

SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer

scientific article published on 16 September 2014

Screening assays for epigenetic targets using native histones as substrates

scientific article published on 30 September 2011

Selective targeting of epigenetic reader domains

scientific article published on 6 March 2017

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

scientific article published on 13 November 2015

Structure-activity studies on N-Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation

scientific article published on 6 December 2017

Studies of intestinal morphology and cathepsin B expression in a transgenic mouse aiming at intestine-specific expression of Cath B-EGFP.

scientific article published on 28 August 2011

Substituted 2-(2-aminopyrimidin-4-yl)pyridine-4-carboxylates as potent inhibitors of JumonjiC domain-containing histone demethylases

scientific article

TGF-β1-dependent induction and nuclear translocation of FHL2 promotes keratin expression in pilomatricoma.

scientific article published on 5 December 2014

Target-based approach to inhibitors of histone arginine methyltransferases

scientific article published on 14 April 2007

Tetrazolylhydrazides as Selective Fragment-Like Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A.

scientific article

The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases

scientific article published on 19 July 2019

The Clinically Used Iron Chelator Deferasirox is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases

scientific article published on 9 July 2019

The LIM-only coactivator FHL2 modulates WT1 transcriptional activity during gonadal differentiation

scientific journal article

The expanding world of histone lysine demethylases

scientific article published in April 2007

The histone acetyltransferase inhibitor Nir regulates epidermis development.

scientific article published on 28 February 2018

The histone code reader SPIN1 controls RET signaling in liposarcoma

scientific article published on March 2015

The histone code reader Spin1 controls skeletal muscle development.

scientific article published on 23 November 2017

The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles.

scientific article published in December 2004

The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus

scientific article published on February 2002

Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1).

scientific article

Transcriptional repressor NIR interacts with the p53-inhibiting ubiquitin ligase MDM2.

scientific article published on 10 January 2014

Tumoral expression of nuclear cofactor FHL2 is associated with lymphatic metastasis in sporadic but not in HNPCC-associated colorectal cancer.

scientific article published on 11 December 2014

Virtual screening of PRK1 inhibitors: ensemble docking, rescoring using binding free energy calculation and QSAR model development

scientific article

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