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List of works by Kevin M Haigis

A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity

scientific article published on 25 November 2002

A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells

scientific article published on July 2017

Abstract 4922:KRASandBRAFmutations influence correlation structure of locus-specific CpG island methylation and CIMP in colorectal cancer

Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner

scientific article published on June 2015

An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background

scientific article

Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review

scientific article

BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner

scientific article

Brother's Keeper: Wild-Type Mutant K-Ras Dimers Limit Oncogenesis

scientific article published in February 2018

Cancers of the Colon and Rectum: Identical or Fraternal Twins? ⬇️

scientific article published on February 1, 2012

Comparative analysis of radiosensitizers for K-RAS mutant rectal cancers

scientific article

Computational translation of genomic responses from experimental model systems to humans

article

Cross-species transcriptomic signatures predict response to MK2 inhibition in mouse models of chronic inflammation

scientific article published on 07 November 2021

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

scientific article published on 30 March 2008

Discovery of a selective inhibitor of doublecortin like kinase 1

scientific article published on 06 April 2020

Dominant Role of Oncogene Dosage and Absence of Tumor Suppressor Activity in Nras-Driven Hematopoietic Transformation ⬇️

scientific article published on June 3, 2013

E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8

scientific article

Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice

scientific article published on 27 March 2020

HDAC6 and SIRT2 Regulate the Acetylation State and Oncogenic Activity of Mutant K-RAS ⬇️

scientific article published on May 30, 2013

Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus ⬇️

scientific article published on December 16, 2010

High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down

scientific article published on 29 May 2020

Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin-Independent Targets by Proteomics

scientific article published on 03 June 2019

Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening

scientific article

In vivo delivery of lenti-Cre or adeno-Cre into mice using intranasal instillation

scientific article

In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α-induced apoptosis and proliferation by MAPKs

scientific article published on 22 March 2011

Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras

scientific article published on 5 December 2011

Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis.

scientific article published on 27 February 2018

Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation

scientific article published on 08 March 2010

Intestinal adenomas can develop with a stable karyotype and stable microsatellites

scientific article

Intra-pancreatic Distal Bile Duct Carcinoma is Morphologically, Genetically, and Clinically Distinct from Pancreatic Ductal Adenocarcinoma

scientific article published on 8 March 2016

Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D

scientific article published on 01 August 2019

K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif

scientific article

KRAS Alleles: The Devil Is in the Detail

scientific article published on 12 September 2017

Lrig1 Marks a Distinct Population of Proliferative and Quiescent Intestinal Stem Cells and Acts as a Tumor Suppressor

scholarly article published in May 2011

Lung premalignancy induced by mutant B-Raf, what is thy fate? To senesce or not to senesce, that is the question

scientific article published on 01 February 2007

MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis

scientific article published on 16 April 2018

MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression

scientific article published on 16 December 2020

Microfluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-β on microglial accumulation

scientific article

Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice

scientific article published on 20 May 2013

Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-α-induced apoptosis in the intestinal epithelium

scientific article

Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression

scientific article published on 28 December 2012

Mutational analysis and clinical correlation of metastatic colorectal cancer

scientific article

Mutational and clinical predictors of pathologic complete response in the treatment of locally advanced rectal cancer

scientific article

NRAS mutations are rare in colorectal cancer

scientific article

Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α.

scientific article published on 02 October 2013

Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium

scientific article

No back seat for a progression event-K-RAS as a therapeutic target in CRC.

scientific article published on February 2017

Non-redundancy within the RAS oncogene family: insights into mutational disparities in cancer

scientific article published on 30 September 2009

Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer

scientific article

Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells

scientific article

Preclinical efficacy of MEK inhibition in Nras-mutant AML.

scientific article

Proapoptotic function of the retinoblastoma tumor suppressor protein

scientific article

Producing and concentrating lenti-Cre for mouse infections

scientific article published on March 2014

Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation

scientific article published on 11 September 2019

Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation

scientific article

RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects

scientific article

ROS1 signaling regulates epithelial differentiation in the epididymis

scientific article

Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma

scientific article published on 27 August 2007

RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth

scientific article

Regulating the regulator: post-translational modification of RAS ⬇️

scientific article published on December 22, 2011

Regulation of RAS oncogenicity by acetylation

scientific article

Regulation of homeostasis and oncogenesis in the intestinal epithelium by Ras.

scientific article published on 17 June 2011

Requirement for Rac1 in a K-ras induced lung cancer in the mouse

scientific article published in September 2007

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

scientific article

Specific mutations in KRAS codons 12 and 13, and patient prognosis in 1075 BRAF wild-type colorectal cancers

scientific article published on 2 July 2012

Substrate-based kinase activity inference identifies MK2 as driver of colitis

scientific article published on 01 November 2019

The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile.

scientific article published on 29 March 2018

The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor

scientific article

The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium

scientific article published on 28 October 2005

Tissue-Specific Oncogenic Activity of KRASA146T

scientific article published on 05 April 2019

Tissue-specificity in cancer: The rule, not the exception

scientific article

Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice.

scientific article published on 3 August 2009

Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer

scientific article published on January 2007

Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function

scholarly article

Whole-mount X-Gal staining of mouse tissues

scientific article published on April 2014

p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis

scientific article

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