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List of works by James N. Spencer

An Efficient Computational Assay for β-Lactam Antibiotic Breakdown by Class A β-Lactamases

scientific article published on 07 August 2019

Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases

scientific article published on 16 September 2019

Cyclic boronates as versatile scaffolds for KPC-2 β-lactamase inhibition

scientific article published on 10 January 2020

Discovery of New and Potent InhA Inhibitors as Antituberculosis Agents: Structure-Based Virtual Screening Validated by Biological Assays and X-ray Crystallography

scientific article published on 27 December 2019

Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β-Lactamase-Activated Antibacterial Prodrug

article

Molecular Basis of Class A β-Lactamase Inhibition by Relebactam

scientific article published on 23 September 2019

Multiscale Simulations of Clavulanate Inhibition Identify the Reactive Complex in Class A β-Lactamases and Predict the Efficiency of Inhibition

scientific article published on 07 June 2018

Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl-enzyme conformational dynamics to extend antibiotic resistance

scientific article published on 30 November 2020

Resistance to the "last resort" antibiotic colistin: a single-zinc mechanism for phosphointermediate formation in MCR enzymes

scientific article published on 20 May 2020

Simulations of Shikimate Dehydrogenase from Mycobacterium tuberculosis in Complex with 3-Dehydroshikimate and NADPH Suggest Strategies for MtbSDH Inhibition

scientific article published on 14 March 2019

Structural and Kinetic Studies of the Potent Inhibition of Metallo-β-lactamases by 6-Phosphonomethylpyridine-2-carboxylates.

scientific article

The economic burden of occupational non-melanoma skin cancer due to solar radiation

scientific article published on 25 April 2018

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