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List of works by Kuo-Hsiung Lee

(+)-Arctigenin, a lignan from Wikstroemia indica

scientific article published on 3 January 2008

(-)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata, Induces DNA Double-Strand Breaks

scientific article published on 18 January 2017

1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity

scientific article

2-(1-Hydroxethyl)-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione (BTP-11) enhances the ATRA-induced differentiation in human leukemia HL-60 cells

scientific article published on 21 March 2009

2-(3-Methoxyphenyl)-5-methyl-1,8-naphthyridin-4(1H)-one (HKL-1) induces G2/M arrest and mitotic catastrophe in human leukemia HL-60 cells

scientific article published on 05 January 2012

3,5-Diarylpyrazole Derivatives Obtained by Ammonolysis of the Total Flavonoids from Chrysanthemum indicum Extract Show Potential for the Treatment of Alzheimer's Disease

scientific article

3-O-Glutaryl-dihydrobetulin and related monoacyl derivatives as potent anti-HIV agents

scientific article published in December 2004

5-Hydroxymethyl-2-furfural, a clinical trials agent for sickle cell anemia, and its mono/di-glucosides from classically processed steamed Rehmanniae Radix

scientific article published in November 2007

A New Triterpene Lactone, Maytenfolone, and a New Sesquiterpene Pyridine Alkaloid, Emarginatine H, from the Leaves of Maytenus diversifolia

scientific article published on 17 March 2005

A Novel Plant Sesquiterpene Lactone Derivative, DETD-35, Suppresses BRAFV600E Mutant Melanoma Growth and Overcomes Acquired Vemurafenib Resistance in Mice

scientific article published on 05 April 2016

A new anti-HIV alkaloid, drymaritin, and a new C-glycoside flavonoid, diandraflavone, from Drymaria diandra

scientific article

A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy

scientific article

A sesquiterpene ester from Celastrus hindsii

A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways

scientific article published on March 2011

A-ring modified betulinic acid derivatives as potent cancer preventive agents

scientific article published on 16 December 2013

Abstract B175: A novel plant sesquiterpene lactone derivative DETD suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in mice

scientific article published on 20 May 2016

Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line.

scientific article

Acetophenone Monomers from Acronychia trifoliolata.

scientific article

Acid rearrangment of epoxy-germacranolides and absolute configuration of 1beta,10alpha-epoxy-salonitenolide.

scientific article

Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines

scientific article published on 05 September 2015

Aloperine and Its Derivatives as a New Class of HIV-1 Entry Inhibitors

scientific article published on 9 January 2016

Altaicalarins A-D, cytotoxic bisabolane sesquiterpenes from Ligularia altaica ⬇️

scientific article

Annoquinone-A, an antimicrobial and cytotoxic principle from Annona montana

scientific article published on 25 July 2002

Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid

scientific article

Anti-AIDS agents 54. A potent anti-HIV chalcone and flavonoids from genus Desmos ⬇️

scientific article published on May 19, 2003

Anti-AIDS agents 65: investigation of the in vitro oxidative metabolism of 3',4'-Di-O-(-)-camphanoyl-(+)-cis-khellactone derivatives as potent anti-hiv agents

scientific article published on 8 August 2005

Anti-AIDS agents 66: syntheses and anti-HIV activity of phenolic and aza 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) derivatives

scientific article published on 13 December 2006

Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents

scientific article

Anti-AIDS agents 72. Bioisosteres (7-carbon-DCKs) of the potent anti-HIV lead DCK

scientific article published on 16 May 2007

Anti-AIDS agents 73: structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives

scientific article

Anti-AIDS agents 79. Design, synthesis, molecular modeling and structure-activity relationships of novel dicamphanoyl-2',2'-dimethyldihydropyranochromone (DCP) analogs as potent anti-HIV agents.

scientific article

Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors

scientific article

Anti-AIDS agents 82: synthesis of seco-(3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) derivatives as novel anti-HIV agents

scientific article

Anti-AIDS agents 84. Synthesis and anti-human immunodeficiency virus (HIV) activity of 2'-monomethyl-4-methyl- and 1'-thia-4-methyl-(3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogs

scientific article

Anti-AIDS agents 85. Design, synthesis, and evaluation of 1R,2R-dicamphanoyl-3,3-dimethyldihydropyrano-[2,3-c]xanthen-7(1H)-one (DCX) derivatives as novel anti-HIV agents.

scientific article published on 20 October 2011

Anti-AIDS agents 86. Synthesis and anti-HIV evaluation of 2',3'-seco-3'-nor DCP and DCK analogues

scientific article

Anti-AIDS agents 87. New bio-isosteric dicamphanoyl-dihydropyranochromone (DCP) and dicamphanoyl-khellactone (DCK) analogues with potent anti-HIV activity

scientific article

Anti-AIDS agents 88. Anti-HIV conjugates of betulin and betulinic acid with AZT prepared via click chemistry

scientific article

Anti-AIDS agents 89. Identification of DCX derivatives as anti-HIV and chemosensitizing dual function agents to overcome P-gp-mediated drug resistance for AIDS therapy

scientific article published on 13 March 2012

Anti-AIDS agents 90. novel C-28 modified bevirimat analogues as potent HIV maturation inhibitors.

scientific article

Anti-AIDS agents. 52. Synthesis and anti-HIV activity of hydroxymethyl (3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone derivatives

scientific article published on January 2004

Anti-AIDS agents. 60. Substituted 3'R,4'R-di-O-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP) analogues as potent anti-HIV agents

scientific article published on July 2004

Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents

scientific article published on May 2009

Anti-AIDS agents. Part 56: Synthesis and anti-HIV activity of 7-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (7-thia-DCK) analogs

scientific article

Anti-AIDS agents. Part 57: Actein, an anti-HIV principle from the rhizome of Cimicifuga racemosa (black cohosh), and the anti-HIV activity of related saponins

scientific article published on March 2004

Anti-AIDS agents. Part 58: synthesis and anti-HIV activity of 1-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (1-thia-DCK) analogues

scientific article published on June 2004

Anti-AIDS agents. Part 61: Anti-HIV activity of new podophyllotoxin derivatives

scientific article published on August 2004

Anti-AIDS agents. Part 62: anti-HIV activity of 2'-substituted 4-methyl-3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (4-methyl DCK) analogs

scientific article

Anti-Aids Agents. Part 57. Actein (I), an anti-HIV Principle from the Rhizome of Cimicifuga racemosa (Black Cohosh), and the anti-HIV Activity of Related Saponins.

scientific article published on 28 July 2005

Anti-HBV and cytotoxic activities of pyranocoumarin derivatives

scientific article

Anti-HIV Agents. Part 55: 3′R,4′R-Di-(O)-(−)-camphanoyl-2′,2′-dimethyldihydropyrano[2,3-f]chromone (DCP), a Novel Anti-HIV agent ⬇️

scientific article published on May 5, 2003

Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla

scientific article published on 10 November 2020

Anti-HIV agents derived from the ent-kaurane diterpenoid linearol

scientific article

Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids

scientific article

Anti-HIV tigliane diterpenoids from Reutealis trisperma

scientific article published on 28 March 2020

Anti-inflammatory neolignans from the roots of Magnolia officinalis.

scientific article

Anti-tumor agents 255: novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agents

scientific article

Anti-tumor agents. 136. Cumingianosides A-F, potent antileukemic new triterpene glucosides, and cumindysosides A and B, trisnor- and tetranortriterpene glucosides with a 14,18-cycloapoeuphane-type skeleton from Dysoxylum cumingianum

scientific article published on 12 March 2005

Anticancer principles from medicinal piper ( hú jiāo) plants.

scientific article

Antidiabetic potential of the ethyl acetate extract of Physalis alkekengi and chemical constituents identified by HPLC-ESI-QTOF-MS

scientific article published on 05 July 2018

Antifeedant and Insecticidal Activity of Quassinoids against the Diamondback Moth(Plutella xylostella)and Structure—Activity Relationships

article by Masayuki Daido et al published 14 September 2009 in Bioscience, Biotechnology, and Biochemistry

Antioxidant and Anti-inflammatory Phenylpropanoid Derivatives from Calamus quiquesetinervius ⬇️

scientific article published on September 24, 2010

Antioxidant lignans and chromone glycosides from Eurya japonica

scientific article published on 29 March 2013

Antiplatelet and Anti-HIV Constituents from Euchresta Formosana ⬇️

scientific article published on April 1, 2003

Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species.

scientific article

Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Inhibit Tubulin Polymerization

scientific article published on 31 March 2019

Antitumor Agents 286. Design, Synthesis, and Structure−Activity Relationships of 3′R,4′R-Disubstituted-2′,2′-dimethyldihydropyrano[2,3-f]chromone (DSP) Analogues as Potent Chemosensitizers to Overcome Multidrug Resistance ⬇️

scientific article published on November 17, 2010

Antitumor Agents 291 Expanded B-Ring Modification Study of 6,8,8-Triethyl Desmosdumotin B Analogues as Multidrug-Resistance Selective Agents

scientific article published on December 2011

Antitumor Agents 60. Maytansine, An Antileukemic Principle From Maytenus diversifolia

Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza

scientific article

Antitumor Agents. 280. Multidrug Resistance-Selective Desmosdumotin B Analogues ⬇️

scientific article published on September 23, 2010

Antitumor Agents. 282. 2′-(R)-O-Acetylglaucarubinone, a Quassinoid from Odyendyea gabonensis As a Potential Anti-Breast and Anti-Ovarian Cancer Agent ⬇️

scientific article published on September 24, 2010

Antitumor agents 171. Cytotoxicities of lobatosides B, C, D, and E, cyclic bisdesmosides isolated from Actinostemma lobatum maxim

scientific article published on 25 July 2002

Antitumor agents 216. Synthesis and evaluation of paclitaxel-camptothecin conjugates as novel cytotoxic agents

scientific article published on April 2003

Antitumor agents 220. Antitumor-promoting effects of cimigenol and related compounds on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis

scientific article

Antitumor agents 222. † †For Part 221, see ref 1. Synthesis and anti-androgen activity of new diarylheptanoids ⬇️

scientific article published on November 17, 2003

Antitumor agents 243. Syntheses and cytotoxicity of desmosdumotin C derivatives.

scientific article published on March 2005

Antitumor agents 247. New 4-ethoxycarbonylethyl curcumin analogs as potential antiandrogenic agents

scientific article published on 19 January 2006

Antitumor agents 251: synthesis, cytotoxic evaluation, and structure-activity relationship studies of phenanthrene-based tylophorine derivatives (PBTs) as a new class of antitumor agents

scientific article published on 30 June 2006

Antitumor agents 252. Application of validated QSAR models to database mining: discovery of novel tylophorine derivatives as potential anticancer agents

scientific article published on January 2007

Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents.

scientific article

Antitumor agents 259. Design, syntheses, and structure-activity relationship study of desmosdumotin C analogs

scientific article published on 15 June 2007

Antitumor agents 260. New desmosdumotin B analogues with improved in vitro anticancer activity

scientific article

Antitumor agents 268. Design, synthesis, and mechanistic studies of new 9-substituted phenanthrene-based tylophorine analogues as potent cytotoxic agents

scientific article

Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents.

scientific article published on 29 September 2009

Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents

scientific article

Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents

scientific article

Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents

scientific article

Antitumor agents 279. Structure-activity relationship and in vivo studies of novel 2-(furan-2-yl)naphthalen-1-ol (FNO) analogs as potent and selective anti-breast cancer agents.

scientific article

Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents ⬇️

scientific article published on November 17, 2010

Antitumor agents 283. Further elaboration of desmosdumotin C analogs as potent antitumor agents: activation of spindle assembly checkpoint as possible mode of action

scientific article

Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity

scientific article

Antitumor agents 288: design, synthesis, SAR, and biological studies of novel heteroatom-incorporated antofine and cryptopleurine analogues as potent and selective antitumor agents

scientific article

Antitumor agents 290. Design, synthesis, and biological evaluation of new LNCaP and PC-3 cytotoxic curcumin analogs conjugated with anti-androgens

scientific article

Antitumor agents 292. Design, synthesis and pharmacological study of S- and O-substituted 7-mercapto- or hydroxy-coumarins and chromones as potent cytotoxic agents

scientific article published on 29 December 2011

Antitumor agents 294. Novel E-ring-modified camptothecin-4β-anilino-4'-O-demethyl-epipodophyllotoxin conjugates as DNA topoisomerase I inhibitors and cytotoxic agents

scientific article

Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies

scientific article

Antitumor agents. 213. Modeling of epipodophyllotoxin derivatives using variable selection k nearest neighbor QSAR method

scientific article published on May 2002

Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents

scientific article published in November 2002

Antitumor agents. 221.1 buceracidins A and B, two new flavanones from Bucida buceras

scientific article published on January 2003

Antitumor agents. 228. five new agarofurans, Reissantins A-E, and cytotoxic principles from Reissantia buchananii.

scientific article

Antitumor agents. 233. Lantalucratins A-F, new cytotoxic naphthoquinones from Lantana involucrata

scientific article published on 01 June 2004

Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4beta-[(4' '-benzamido)-amino]-4'-o-demethyl-epipodophyllotoxin derivatives

scientific article published on October 2004

Antitumor agents. 250. design and synthesis of new curcumin analogues as potential anti-prostate cancer agents

scientific article published on June 2006

Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents

scientific article published on September 2006

Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: evaluation of novel conjugates as cytotoxic agents

scientific article

Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant--taxoid conjugates as novel cytotoxic agents

scientific article published on 4 July 2007

Antitumor agents. 261. 20(S)-protopanaxadiol and 20(s)-protopanaxatriol as antiangiogenic agents and total assignment of (1)H NMR spectra

scientific article

Antitumor agents. 266. Design, synthesis, and biological evaluation of novel 2-(furan-2-yl)naphthalen-1-ol derivatives as potent and selective antibreast cancer agents.

scientific article published on June 2009

Antitumor agents. 271: total synthesis and evaluation of brazilein and analogs as anti-inflammatory and cytotoxic agents

scientific article

Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues.

scientific article

Antitumor agents. 274. A new synthetic strategy for E-ring SAR study of antofine and cryptopleurine analogues

scientific article

Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents

scientific article

Antitumor agents. 289. Design, synthesis, and anti-breast cancer activity in vivo of 4-amino-2H-benzo[h]chromen-2-one and 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogues with improved water solubility

scientific article published on 3 February 2012

Antitumor agents. 293. Nontoxic dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs

scientific article

Antitumor agents. Part 209: Pheophorbide-a derivatives as photo-Independent cytotoxic agents

scientific article published in March 2002

Antitumor agents. Part 212. Bucidarasins A-C, three new cytotoxic clerodane diterpenes from Bucida buceras.

scientific article

Antitumor agents. Part 214: synthesis and evaluation of curcumin analogues as cytotoxic agents

scientific article

Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids

scientific article published on October 2002

Antitumor agents. Part 218: Cappamensin A, a new In vitro anticancer principle, from Capparis sikkimensis

scientific article published on July 2003

Antitumor agents. Part 226: synthesis and cytotoxicity of 2-Phenyl-4-quinolone acetic acids and their esters ⬇️

scientific article published on September 1, 2003

Antitumor agents. Part 227: Studies on novel 4'-O-demethyl-epipodophyllotoxins as antitumor agents targeting topoisomerase II.

scientific article published on June 2004

Antitumor agents. Part 230: C4'-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhibitors

scientific article

Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents

scientific article published on March 2004

Antitumor agents. Part 235: Novel 4'-ester etoposide analogues as potent DNA topoisomerase II inhibitors with improved therapeutic potential

scientific article published on June 2004

Antitumor agents. Part 236: Synthesis of water-soluble colchicine derivatives

scientific article

Antitumour triterpenes of Maytenus diversifolia

scientific article published on 25 July 2002

Bauhinin, a New Nitrile Glucoside from Bauhinia championii

scientific article published on 17 March 2005

Benzyl 1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo[3',4':1,2]pyridin[3,4-b]indole-2-substituted acetates: One-pot-preparation, anti-tumor activity, docking toward DNA and 3D QSAR analysis

scientific article

Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors

scientific article published on December 2009

Bioactive chemical constituents from the root bark of Morus australis.

scientific article published on 17 November 2016

Bioactive components from the heartwood of Pterocarpus santalinus

scientific article published on 29 June 2011

Bioactive constituents from the roots of Panax japonicus var. major and development of a LC-MS/MS method for distinguishing between natural and artifactual compounds ⬇️

scientific article

Bioactive constituents of Clausena lansium and a method for discrimination of aldose enantiomers

scientific article

Biologically active constituents from the fruiting body of Taiwanofungus camphoratus ⬇️

scientific article

Biologically active indolizidine alkaloids

scientific article published on 31 October 2020

Biologically active isoquinoline alkaloids covering 2014-2018

scientific article published on 29 July 2020

Biologically active quinoline and quinazoline alkaloids part I.

scientific article published on 13 September 2017

Biologically active quinoline and quinazoline alkaloids part II.

scientific article published on 27 February 2018

Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents.

scientific article published on 12 January 2011

Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents

scientific article

Biyouyanagin A, an anti-HIV Agent from Hypericum chinense L. var. salicifolium. ⬇️

scientific article published on 25 October 2005

Biyouyanagin A, an anti-HIV agent from Hypericum chinense L. var. salicifolium ⬇️

scientific article published on July 2005

CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells

scientific article published on 3 September 2011

CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression.

scientific article published on 8 August 2007

CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation.

scientific article

CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo.

scientific article

Camphoratins A−J, Potent Cytotoxic and Anti-inflammatory Triterpenoids from the Fruiting Body of Taiwanofungus camphoratus ⬇️

scientific article published on October 28, 2010

Cancer preventive agents 10. Prenylated dehydrozingerone analogs as potent chemopreventive agents

scientific article

Cancer preventive agents 11. Novel analogs of dimethyl dicarboxylate biphenyl as potent cancer chemopreventive agents(†).

scientific article published in January 2012

Cancer preventive agents 9. Betulinic acid derivatives as potent cancer chemopreventive agents

scientific article published on 18 May 2009

Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters

scientific article

Cancer preventive agents. Part 1: chemopreventive potential of cimigenol, cimigenol-3,15-dione, and related compounds

scientific article published in February 2005

Cancer preventive agents. Part 8: Chemopreventive effects of stevioside and related compounds

scientific article published on 6 December 2008

Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation

scientific article published on 26 December 2019

Cardiac glycosides from Antiaris toxicaria with potent cardiotonic activity ⬇️

scientific article

Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity

scientific article published on 12 January 2016

Catalytic Hydrogenation of Dehydro Quassinoids and Cytotoxic Antitumor Activity of the Hydrogenation Products

article published in 2006

Cell differentiation enhancement by hydrophilic derivatives of 4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-diones in HL-60 leukemia cells

scientific article published on 22 February 2007

Chemical Structures and Biological Activities of Limonoids from the Genus Swietenia (Meliaceae).

scientific article

Chemopreventive potential of cyclic diarylheptanoids

scientific article published in October 2002

Clerodane diterpenes: sources, structures, and biological activities

scientific article published on 18 July 2016

Computational studies and drug design for HIV-1 reverse transcriptase inhibitors of 3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogs

scientific article

Conjugates of betulin derivatives with AZT as potent anti-HIV agents ⬇️

scientific article published on July 7, 2010

Constituents from the Stems of Hibiscus taiwanensis. ⬇️

scientific article published on 19 July 2005

Constituents from the stems of Hibiscus taiwanensis. ⬇️

scientific article

Correction to first total synthesis of protoapigenone and its analogues as potent cytotoxic agents

scientific article published on 20 July 2012

Correction: A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy

scientific article published on 05 November 2019

Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa

scientific article

Corymbulosins I-W, Cytotoxic Clerodane Diterpenes from the Bark of Laetia corymbulosa.

scientific article published on 29 December 2017

Crotonkinins A and B and related diterpenoids from Croton tonkinensis as anti-inflammatory and antitumor agents

scientific article published on 01 December 2007

Cryptopleurine analogs with modification of e ring exhibit different mechanism to rac-cryptopleurine and tylophorine

scientific article

Cucurbitane-Type Triterpenoids from the Vines of Momordica charantia and Their Anti-inflammatory Activities

scientific article published on 01 May 2020

Cumindysoside A, a novel cytotoxic trisnortriterpene glucoside with a 14, 18-cycloapoeuphane-type skeleton from Dysoxylum cumingianum

scientific article published on 25 July 2002

Cytotoxic Activity of Some Natural and Synthetic Guaianolides

scientific article published on 01 July 2005

Cytotoxic Activity of Some Natural and Syntheticent-Kauranes⊥

scientific article published on 01 March 2007

Cytotoxic Alangium alkaloids from Alangium longiflorum

scientific article published on 13 March 2006

Cytotoxic Isoprenylated Flavonoids from the Roots ofSophora flavescens

Cytotoxic Principles fromSaussurea LappaandCorydalis Turtshaninovii f. Yanhusuo

scientific article published in May 2015

Cytotoxic activity of some natural and synthetic sesquiterpene lactones.

scientific article published on December 2005

Cytotoxic and Antimalarial Constituents from the Roots of Eurycoma longifolia.

scientific article published on 5 May 2004

Cytotoxic and Antimalarial β-Carboline Alkaloids from the Roots of Eurycoma longifolia ⬇️

scientific article published on October 1, 2003

Cytotoxic and anti-HIV Principles from the Rhizomes of Begonia nantoensis. ⬇️

scientific article published on 2 August 2004

Cytotoxic and anti-HIV phenanthroindolizidine alkaloids from Cryptocarya chinensis

scientific article published on June 2012

Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis ⬇️

scientific article published in March 2004

Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia

scientific article published on February 2004

Cytotoxic and potential anticancer constituents from the stems of Schisandra pubescens

scientific article published on 25 July 2013

Cytotoxic aporphinoid alkaloids from thalictrum sessile

scientific article published on 25 July 2002

Cytotoxic calanquinone A from Calanthe arisanensis and its first total synthesis. ⬇️

scientific article published on 3 July 2008

Cytotoxic cardiac glycosides and coumarins from Antiaris toxicaria ⬇️

scientific article

Cytotoxic ent-abietane diterpenes from Gelonium aequoreum.

scientific article published on 21 August 2007

Cytotoxic esterified diterpenoid alkaloid derivatives with increased selectivity against a drug-resistant cancer cell line

scientific article published on 11 November 2011

Cytotoxic geranylflavonoids from Bonannia graeca. ⬇️

scientific article published in April 2011

Cytotoxic phenanthrenequinones and 9,10-dihydrophenanthrenes from Calanthe arisanensis ⬇️

scientific article

Cytotoxic phenylpropanoids and a new triterpene, turformosinic acid, from Turpinia formosana Nakai.

scientific article

Cytotoxic polyisoprenyl benzophenonoids from Garcinia subelliptica ⬇️

scientific article

Cytotoxicity, Hemolytic Toxicity, and Mechanism of Action of Pulsatilla Saponin D and Its Synthetic Derivatives.

scientific article published on 13 November 2017

DYZ-2-90, a novel neo-tanshinlactone ring-opened compound, induces ERK-mediated mitotic arrest and subsequent apoptosis by activating JNK in human colorectal cancer cells.

scientific article published on 3 July 2012

Danazol mediates collateral sensitivity via STAT3/Myc related pathway in multidrug-resistant cancer cells

scientific article published on 12 August 2019

Dantaxusins C and D, two novel taxoids from Taxus yunnanensis.

scientific article published in March 2002

Daphneodorins A-C, Anti-HIV Gnidimacrin Related Macrocyclic Daphnane Orthoesters from Daphne odora

scientific article published on 04 November 2019

Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathways

scientific article

Dehydrozingerone, chalcone, and isoeugenol analogues as in vitro anticancer agents

scientific article published on October 2006

Depletion of 4E-BP1 and regulation of autophagy lead to YXM110-induced anticancer effects

scientific article published on 30 April 2013

Design and Synthesis of Quinolizidine Derivatives as Influenza Virus and HIV-1 Inhibitors

scientific article published on 29 December 2020

Design and one-pot synthesis of new 7-acyl camptothecin derivatives as potent cytotoxic agents

scientific article

Design and synthesis of 2-(3-alkylaminophenyl)-6-(pyrrolidin-1-yl)quinolin-4-ones as potent antitumor agents.

scientific article published on 5 December 2012

Design and synthesis of 2-(3-benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one analogues as potent antitumor agents that inhibit tubulin assembly

scientific article published on August 2009

Design and synthesis of 6,7-methylenedioxy-4-substituted phenylquinolin-2(1H)-one derivatives as novel anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase.

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Design and synthesis of benzylidenecyclohexenones as TrxR inhibitors displaying high anticancer activity and inducing ROS, apoptosis, and autophagy

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Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents

scientific article published on 9 August 2012

Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents

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Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors

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Design and synthesis of new 2-arylnaphthyridin-4-ones as potent antitumor agents targeting tumorigenic cell lines

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Design and synthesis of new 7-(N-substituted-methyl)-camptothecin derivatives as potent cytotoxic agents

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Design and synthesis of novel 7-[(N-substituted-thioureidopiperazinyl)-methyl]-camptothecin derivatives as potential cytotoxic agents

scientific article published on 20 February 2019

Design and synthesis of novel PEG-conjugated 20(S)-camptothecin sulfonylamidine derivatives with potent in vitro antitumor activity via Cu-catalyzed three-component reaction

scientific article published on 6 May 2015

Design and synthesis of novel spin-labeled camptothecin derivatives as potent cytotoxic agents

scientific article

Design, Synthesis and Structure-Activity Relationships of (±)-Isochaihulactone Derivatives

scientific article published on 12 October 2017

Design, Synthesis, and Evaluation of Diarylpyridines and Diarylanilines as Potent Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors ⬇️

scientific article published on November 4, 2010

Design, Synthesis, and Mechanism Study of Benzenesulfonamide-containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities

scientific article published on 16 April 2020

Design, semisynthesis and potent cytotoxic activity of novel 10-fluorocamptothecin derivatives

scientific article published on 8 September 2017

Design, synthesis and antineoplastic activity of novel 20(S)-acylthiourea derivatives of camptothecin

scientific article published on 13 December 2019

Design, synthesis and biological evaluation of novel indolin-2-ones as potent anticancer compounds.

scientific article

Design, synthesis and cytotoxic activity of novel spin-labeled rotenone derivatives

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Design, synthesis and cytotoxic activity of novel sulfonylurea derivatives of podophyllotoxin

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Design, synthesis and evaluation of antiproliferative activity of fluorinated betulinic acid

scientific article published on 11 May 2019

Design, synthesis and experimental validation of novel potential chemopreventive agents using random forest and support vector machine binary classifiers

scientific article

Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives.

scientific article published on 28 February 2017

Design, synthesis and potent cytotoxic activity of novel podophyllotoxin derivatives

scientific article published on 17 February 2013

Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV-1 RNase H inhibitors

scientific article published on 24 January 2019

Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents

scientific article

Design, synthesis, and cytotoxic activity of novel 7-substituted camptothecin derivatives incorporating piperazinyl-sulfonylamidine moieties.

scientific article

Design, synthesis, and evaluation of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase

scientific article published on 10 December 2020

Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead

scientific article published on 04 July 2013

Design, synthesis, and preclinical evaluation of new 5,6- (or 6,7-) disubstituted-2-(fluorophenyl)quinolin-4-one derivatives as potent antitumor agents.

scientific article published on 25 October 2010

Design, synthesis, and preclinical evaluations of novel 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates.

scientific article

Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives

scientific article published on 3 March 2016

Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents

scientific article

Desmosdumotin C, a novel cytotoxic principle from Desmos dumosus

scientific article published on 26 March 2003

Development and preclinical studies of broad-spectrum anti-HIV agent (3'R,4'R)-3-cyanomethyl-4-methyl-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (3-cyanomethyl-4-methyl-DCK).

scientific article published on December 2008

Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring

scientific article

Development of anti-influenza agents from natural products

scientific article published on 16 July 2020

Development of novel amino-quinoline-5,8-dione derivatives as NAD(P)H:quinone oxidoreductase 1 (NQO1) inhibitors with potent antiproliferative activities

scientific article published on 18 May 2018

Diarylaniline derivatives as a distinct class of HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article

Diosgenin Derivatives as Potential Antitumor Agents: Synthesis, Cytotoxicity, and Mechanism of Action

scientific article published on 31 December 2020

Discovery and synthesis of novel beesioside I derivatives with potent anti-HIV activity

scientific article published on 10 January 2019

Discovery of C<sub>20</sub>-Diterpenoid Alkaloid Kobusine Derivatives Exhibiting Sub-G1 Inducing Activity

scientific article published in 2022

Discovery of an Oleanolic Acid/Hederagenin-Nitric Oxide Donor Hybrid as an EGFR Tyrosine Kinase Inhibitor for Non-Small-Cell Lung Cancer

scientific article published on 13 November 2019

Discovery of diarylpyridine derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

scientific article published on 19 July 2009

Discovery of novel 5-fluoro-N(2),N(4)-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9.

scientific article published on March 2015

Discovery of novel andrographolide derivatives as cytotoxic agents

scientific article published on 29 May 2013

Discovery of novel antitumor dibenzocyclooctatetraene derivatives and related biphenyls as potent inhibitors of NF-κB signaling pathway

scientific article published on 18 November 2013

Discovery of potential dual-target prodrugs of HIV-1 reverse transcriptase and nucleocapsid protein 7

scientific article published on 26 May 2020

Diterpenoids from the stems of Tripterygium hypoglaucum (Celastraceae) and cytotoxic evaluation

scientific article published on 5 March 2015

Drug-like property-driven optimization of 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against rilpivirine-resistant mutant virus

scientific article published on 22 April 2017

Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation

scientific article published on 31 May 2013

Dyscusins A-C, three new steroids from the leaves of Dysoxylum cumingianum ⬇️

scientific article published on January 2011

Effect of bis(hydroxymethyl) alkanoate curcuminoid derivative MTH-3 on cell cycle arrest, apoptotic and autophagic pathway in triple-negative breast adenocarcinoma MDA-MB-231 cells: An in vitro study

scientific article published on 14 November 2017

Efficient 1H nuclear magnetic resonance method for improved quality control analyses of Ginkgo constituents

scientific article

Efficient synthesis and biological evaluation of epiceanothic acid and related compounds

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Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor.

scientific article published on 6 February 2018

Eremophilane sesquiterpenes from Ligularia macrophylla

scientific article published on 02 August 2007

Erratum to "Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors" [Bioorg. Med. Chem. 24 (2016) 3083-3092].

scientific article published on 28 March 2017

Euphomilones A and B, ent-Rosane Diterpenoids with 7/5/6 and 5/7/6 Skeletons from Euphorbia milii

scientific article published on 22 November 2016

Evaluation of Aconitum diterpenoid alkaloids as antiproliferative agents

scientific article

Evaluation of in vitro/in vivo anti-diabetic effects and identification of compounds from Physalis alkekengi

scientific article published on 12 February 2018

Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus

scientific article published on 13 July 2007

First total synthesis of protoapigenone and its analogues as potent cytotoxic agents

scientific article published on 10 July 2007

Flavanone and diphenylpropane glycosides and glycosidic acyl esters from Viscum articulatum

scientific article published in February 2010

Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity

scientific article published on 11 November 2015

Four New Triterpenoids from the Bark of Euonymus alatus forma ciliato-dentatus

scientific article published on 06 April 2019

Four new diterpenoid alkaloids from Aconitum japonicum subsp. subcuneatum

scientific article published on 19 October 2017

Glucuronidation of anti-HIV drug candidate bevirimat: identification of human UDP-glucuronosyltransferases and species differences

scientific article published on 06 December 2006

Gnidimacrin, a Potent Anti-HIV Diterpene, Can Eliminate Latent HIV-1 Ex Vivo by Activation of Protein Kinase C β.

scientific article published on 28 October 2015

HIV entry inhibitors and their potential in HIV therapy

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Honokiol dimers and magnolol derivatives with new carbon skeletons from the roots of Magnolia officinalis and their inhibitory effects on superoxide anion generation and elastase release

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Identification and synthesis of quinolizidines with anti-influenza a virus activity

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Identification of Dihydrofuro[3,4-d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties

scientific article published on 9 January 2019

Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries

scientific article published on 14 September 2019

Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui

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In Vivo and Mechanistic Studies on Antitumor Lead 7-Methoxy-4-(2-methylquinazolin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one and Its Modification as a Novel Class of Tubulin-Binding Tumor-Vascular Disrupting Agents.

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In vitro anti-inflammatory effects of diterpenoids and sesquiterpenoids from traditional Chinese medicine Siegesbeckia pubescens

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Incorporation of Privileged Structures into Bevirimat Can Improve Activity against Wild-Type and Bevirimat-Resistant HIV-1.

scientific article published on 22 September 2016

Indole alkaloid glycosides from the aerial parts of Strobilanthes cusia

scientific article published on 26 November 2014

Inhibition of the Epstein-Barr virus lytic cycle by moronic acid

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Intercedensides A-C, three new cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert

scientific article published in August 2003

Intercedensides D-I, cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert

scientific article published on 01 April 2005

Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation

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Isolation and cytotoxicity of rhinacanthin-A and -B, two; naphthoquinones, from Rhinacanthus nasutus

scientific article published on 25 July 2002

Isolation of rhododaurichromanic acid B and the anti-HIV principles rhododaurichromanic acid A and rhododaurichromenic acid from Rhododendron dauricum

article

Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora

scientific article published on 30 September 2020

Isolation, Structure Elucidation, and Antiproliferative Activity of Butanolides and Lignan Glycosides from the Fruit of Hernandia nymphaeifolia

scientific article published on 05 November 2019

Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme.

scientific article published on 23 April 2013

Isolation, structures, and structure - cytotoxic activity relationships of withanolides and physalins from Physalis angulata

scientific article published on 20 June 2007

Kalanchosides A-C, new cytotoxic bufadienolides from the aerial parts of Kalanchoe gracilis

scientific article published on November 2006

Kalanchosides A—C, New Cytotoxic Bufadienolides from the Aerial Parts of Kalanchoe gracilis. ⬇️

scientific article published on 14 February 2007

Kalshinoids A-F, Anti-inflammatory Sesquiterpenes from Kalimeris shimadae

scientific article published on 05 December 2019

Kalshiolin A, new lignan from Kalimeris shimadai

scientific article published on 13 June 2019

Kaurane and abietane diterpenoids from Tripterygium doianum (Celastraceae).

scientific article published on July 2004

Kleinhospitine E and Cycloartane Triterpenoids from Kleinhovia hospita

scientific article published on 16 July 2018

Kuafumine, a Novel Cytotoxic Oxoaporphine Alkaloid from Fissistigma glausescens

scientific article published on 17 February 2009

LC/TIS-MS fingerprint profiling of Cimicifuga species and analysis of 23-Epi-26-deoxyactein in Cimicifuga racemosa commercial products

scientific article published in March 2005

MJ-66 induces malignant glioma cells G2/M phase arrest and mitotic catastrophe through regulation of cyclin B1/Cdk1 complex

scientific article

Maytensifolin-C, a friedelane alcohol fromMaytenus diversifolia

scientific article published on 25 July 2002

Mechanism of action of cytotoxic compounds from the seeds of Euphorbia lathyris.

scientific article published on 2 February 2018

Mechanistic studies on regioselective dephosphorylation of phosphate prodrugs during a facile synthesis of antitumor phosphorylated 2-phenyl-6,7-methylenedioxy-1H-quinolin-4-one

scientific article published on 08 July 2013

Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release

scientific article

Molecular mechanism of the inhibitory effect of KS-5 on bFGF-induced angiogenesis in vitro and in vivo.

scientific article

Molecular modeling, design, synthesis, and biological evaluation of novel 3',4'-dicamphanoyl-(+)-cis-khellactone (DCK) analogs as potent anti-HIV agents

scientific article

Molephantin, a novel cytotoxic germacranolide from Elephantopus mollis. X-Ray crystal structure

scientific article

Montacin and cis-montacin, two new cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona montana.

scientific article

Multidrug resistance-selective antiproliferative activity of Piper amide alkaloids and synthetic analogues

scientific article

Multidrug resistant cancer cells susceptibility to cytotoxic taxane diterpenes from Taxus yunnanensis and Taxus chinensis

scientific article published on October 2002

Multidrug-resistant cancer cell susceptibility to cytotoxic quassinoids, and cancer chemopreventive effects of quassinoids and canthin alkaloids

scientific article published on September 2004

N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines: a novel class of antitumor agents targeting the colchicine site on tubulin

scientific article published on 29 June 2013

NPRL-Z-1, as a new topoisomerase II poison, induces cell apoptosis and ROS generation in human renal carcinoma cells

scientific article

Napalolides A−D, Four New Sesquiterpene Lactones fromCarpesium nepalense

scientific article published on 26 July 2002

Neglschisandrins E-F: two new lignans and related cytotoxic lignans from Schisandra neglecta.

scientific article published on 19 February 2013

Neo-clerodane diterpenoids from Scutellaria barbata with activity against Epstein-Barr virus lytic replication

scientific article published on 3 February 2015

New Dammarane-type Saponins from

scientific article published on 08 April 2019

New Seco-DSP derivatives as potent chemosensitizers

scientific article published on 15 July 2020

New betulinic acid derivatives as potent proteasome inhibitors

scientific article

New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1.

scientific article published on 20 February 2013

New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis

scientific article

New bis(hydroxymethyl) alkanoate curcuminoid derivatives exhibit activity against triple-negative breast cancer in vitro and in vivo.

scientific article published on 8 March 2017

New cembranolide analogues from the formosan soft coral Sinularia flexibilis and their cytotoxicity.

scientific article published in December 2003

New dammarane-type saponins from the galls of Sapindus mukorossi.

scientific article published in June 2005

New developments in natural products-based anti-AIDS research

scientific article published on January 2007

New developments in the chemistry and biology of the bioactive constituents of Tanshen

scientific article

New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama

scientific article

New lignans and cytotoxic constituents from Wikstroemia lanceolata

scientific article published on March 2004

New sesquiterpenes from Capsicum annuum

scientific article published in November 2004

New transformation pathway and cytotoxic derivatives from the acid hydrolysis of timosaponin B III

scientific article published on 20 November 2018

Nine new cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana.

scientific article

Notolutesins A-J, dolabrane-type diterpenoids from the Chinese liverwort Notoscyphus lutescens

scientific article

Novel Betulinic Acid-Nucleoside Hybrids with Potent Anti-HIV Activity

scientific article published on 09 September 2020

Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor Agents: Optimization of Diarylanilines with High Potency against Wild-Type and Rilpivirine-Resistant E138K Mutant Virus

scientific article published on 12 April 2016

Novel N-(3-carboxyl-9-benzyl-beta-carboline-1-yl)ethylamino acids: synthesis, anti-tumor evaluation, intercalating determination, 3D QSAR analysis and docking investigation

scientific article

Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects

scientific article published on 13 February 2015

Novel cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana.

scientific article published on August 2005

Novel lignan derivatives as selective inhibitors of DNA topoisomerase II

scientific article published on 12 May 2003

Novel potent antiplatelet thrombotic agent derived from biguanide for ischemic stroke

scientific article published on 18 May 2020

Novel sesquiterpene lactone analogues as potent anti-breast cancer agents

scientific article published on 25 March 2016

Ochrocephalamine A, a new quinolizidine alkaloid from Oxytropis ochrocephala Bunge

scientific article published on 4 October 2016

Ochrocephalamines B-D, Three Alkaloids from Oxytropis ochrocephala Bunge

scientific article published on 14 June 2019

Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors

scientific article

Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site

scientific article published on 06 February 2014

Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors

scientific article

Optimization of the antiviral potency and lipophilicity of halogenated 2,6-diarylpyridinamines as a novel class of HIV-1 NNRTIS.

scientific article

Paliasanines A-E, 3,4-Methylenedioxyquinoline Alkaloids Fused with a Phenyl-14-oxabicyclo[3.2.1]octane Unit from Melochia umbellata var. deglabrata

scientific article published on 18 September 2020

Perspectives on biologically active camptothecin derivatives

scientific article

Phenanthrene-based tylophorine-1 (PBT-1) inhibits lung cancer cell growth through the Akt and NF-kappaB pathways

scientific article published on April 2009

Phenolic diterpenoid derivatives as anti-influenza a virus agents

scientific article published on 29 January 2015

Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata

scientific article published on 01 July 2006

Physicochemical property-driven optimization of diarylaniline compounds as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.

scientific article

Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib sensitive and resistant melanoma via GPX4 inhibition and metabolic reprogramming

scientific article published on 26 February 2022

Phytoagent Deoxyelephantopin and Its Derivative Inhibit Triple Negative Breast Cancer Cell Activity through ROS-Mediated Exosomal Activity and Protein Functions

scientific article

Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death

scientific article published on 25 May 2017

Phytotoxic cis-clerodane diterpenoids from the Chinese liverwort Scapania stephanii

scientific article

Picomolar dichotomous activity of gnidimacrin against HIV-1.

scientific article

Plant-derived natural product research aimed at new drug discovery

scientific article published on 22 April 2008

Plant-derived terpenoids and analogues as anti-HIV agents

scientific article

Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents

scientific article published on 13 August 2009

Potent Anti-HIV Ingenane Diterpenoids from Euphorbia ebracteolata

scientific article published on 11 June 2019

Prenylated Acetophloroglucinol Dimers from Acronychia trifoliolata: Structure Elucidation and Total Synthesis

scientific article published on 24 September 2019

Prenylated benzophenones and xanthones from Hypericum scabrum.

scientific article published in November 2004

QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cells.

scientific article published on 17 October 2011

Rapid Recognition and Targeted Isolation of Anti-HIV Daphnane Diterpenes from Daphne genkwa Guided by UPLC-MSn ⬇️

scientific article published on 20 December 2019

Rational selection of training and test sets for the development of validated QSAR models

scientific article

Rautandiols A and B, pterocarpans and cytotoxic constituents from Neorautanenia mitis

scientific article

Recent Progress of Research on Herbal Products Used in Traditional Chinese Medicine: the Herbs belonging to The Divine Husbandman's Herbal Foundation Canon ( Shén Nóng Běn Cǎo Jīng).

scientific article published on January 2012

Recent advances in natural anti-HIV triterpenoids and analogs

scientific article published on 14 July 2020

Recent advances in the investigation of curcuminoids

scientific article published on 17 September 2008

Recent discovery of plant-derived anti-diabetic natural products

scientific article published on May 2012

Recent progress in the development of coumarin derivatives as potent anti-HIV agents

scientific article

Recent progress on C-4-modified podophyllotoxin analogs as potent antitumor agents

scientific article

Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora

scientific article published on 01 December 2006

SAR study on N2,N4-disubstituted pyrimidine-2,4-diamines as effective CDK2/CDK9 inhibitors and antiproliferative agents.

scientific article published on 27 March 2018

Salviatalin A and salvitrijudin A, two diterpenes with novel skeletons from roots of Salvia digitaloides and anti-inflammatory evaluation

scientific article published on 17 June 2010

Salvisertin A, a New Hexacyclic Triterpenoid, and Other Bioactive Terpenes from Salvia deserta Root

scientific article published on 16 February 2018

Sapinmusaponins F-J, bioactive tirucallane-type saponins from the galls of Sapindus mukorossi

scientific article published on 01 May 2006

Scaffold Hopping-Driven Optimization of 4-(Quinazolin-4-yl)-3,4-dihydroquinoxalin-2(1H)-ones as Novel Tubulin Inhibitors

scientific article published on 30 December 2019

Seco-4-methyl-DCK derivatives as potent chemosensitizers

scientific article published on 12 November 2018

Secondary Metabolites, Monoterpene-Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata.

scientific article published on 6 April 2018

Secondary metabolites from the Chinese liverwort Cephaloziella kiaeri

scientific article published on 13 September 2013

Selective cytotoxic eremophilane-type sesquiterpenes from Penicillium citreonigrum ⬇️

scientific article published on 14 December 2015

Separation and characterization of active flavonolignans of Silybum marianum by liquid chromatography connected with hybrid ion-trap and time-of-flight mass spectrometry (LC-MS/IT-TOF)

scientific article published on 01 September 2007

Sesquiterpene Lactone Deoxyelephantopin Isolated from Elephantopus scaber and Its Derivative DETD-35 Suppress BRAFV600E Mutant Melanoma Lung Metastasis in Mice

scientific article published on 22 March 2021

Songaricalarins A-E, cytotoxic oplopane sesquiterpenes from Ligularia songarica ⬇️

scientific article published on 8 October 2012

Spiro[3.5]nonenyl Meroterpenoid Lactones, Cryptolaevilactones G-L, an Ionone Derivative, and Total Synthesis of Cryptolaevilactone M from Cryptocarya laevigata

scientific article published on 23 August 2019

Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L ⬇️

scientific article

Stelleralides D-J and Anti-HIV Daphnane Diterpenes from Stellera chamaejasme

scientific article published on 12 November 2015

Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates

scientific article

Structural analogs of tylophora alkaloids may not be functional analogs

scientific article

Structural characterization of anti-HIV drug candidate PA-457 [3-O-(3',3'-dimethylsuccinyl)-betulinic acid] and its acyl glucuronides in rat bile and evaluation of in vitro stability in human and animal liver microsomes and plasma

scientific article published on 02 June 2006

Structure and Stereochemistry of Corytensine, a New Phthalideisoquinoline Alkaloid from Corydalis Ochotensis

scientific article published on 24 February 2009

Structure and Stereochemistry of Emargiatine-A, a Novel Cytotoxic Sesquiterpene Pyridine Alkaloid from Maytenus emarginata: X-Ray Crystal Steructure of Emarginatine-A Monohydrate

scientific article published on 2 March 2009

Structure and Stereochemistry of Pseudolarolide-I, a Novel Cytotoxic Peroxytriterpene Dilactone from Pseudolarix kaempferi

scientific article published on 16 April 2009

Structure and Stereochemistry of Thalicsiline, a New Antiinflammatory C20 — Diterpenoid Alkaloid from Thalictrum sessile

scientific article

Structure and stereochemistry of (−)-odorinol, an antileukemic diamide from Aglaia odorata

Structure and stereochemistry of amorphispironone, a novel cytotoxic spironone type rotenoid from Amorpha fruticosa

scientific article published in April 2004

Structure and stereochemistry of carolenalone, a new sesquiterpene lactone from north carolina L.

scientific article published on 25 July 2002

Structure and stereochemistry of eupaformonin, a novel cytotoxic sesquiterpene lactone from eupatorium formosanum hay.

Structure and stereochemistry of maytensifolin-a, a novel hydroperoxy-nortriterpene from maytenus diversifolia

scientific article published on 25 July 2002

Structure and stereochemistry of microlenin, a novel antitumour dimeric sesquiterpene lactone from Helenium microcephalum; X-ray crystal structure

Structure and stereochemistry of radermasinin, a novel cytotoxic triterpene lactone from Radermachia sinica. X-Ray crystal structure of radermasinin monohydrate

scientific article published on 30 March 2004

Structure and stereochemistry of taxuchin A, a new 11(15 ? 1)abeo-taxane type diterpene from Taxus chinensis

scientific article

Structure and stereochemistry of the epoxide of phantomolin, a novel cytotoxic sesquiterpene lactone from Elephantopus mollis

scientific article published on 25 July 2002

Structure and synthesis of murrapanine, a novel skeletal indole-naphthoquinone alkaloid and cytotoxic principal from Murraya paniculata var. omphalocarpa

scientific article published on 25 July 2002

Structure-activity relationships of chalcone analogs as potential inhibitors of ADP- and collagen-induced platelet aggregation

scientific article published on 06 August 2011

Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents

scientific article published on 20 December 2017

Structure-activity relationships of quassinoids for eukaryotic protein synthesis

scientific article published in March 2005

Structures and stereochemistry of melicophyllone A and hypocholesterolemic melicophyllone B, novel sesquiterpene lactones from Melicope triphylla

scientific article published on 30 March 2004

Synthesis and SAR studies of novel 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives for anticancer activity

scientific article

Synthesis and Structure-Activity Relationship Correlations of Gnidimacrin Derivatives as Potent HIV-1 Inhibitors and HIV Latency Reversing Agents

scientific article published on 25 July 2019

Synthesis and anti-HIV activity of 2'-deoxy-2'-fluoro-4'-C-ethynyl nucleoside analogs

scientific article

Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives

scientific article published on 28 November 2005

Synthesis and antitumor activity of bis(hydroxymethyl)propionate analogs of pterostilbene in cisplatin-resistant human oral cancer cells

scientific article published on 08 June 2018

Synthesis and bioactivity of 4,10-dimethyl-pyridino[2,3-h]quinolin-2(1H)-one-9-carboxylic acid and its esters

scientific article

Synthesis and biological evaluation of N-alkyl-N-(4-methoxyphenyl)pyridin-2-amines as a new class of tubulin polymerization inhibitors

scientific article published on 6 December 2012

Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents

scientific article published on 20 February 2017

Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives

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Synthesis and biological relationships of 3',6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents

scientific article

Synthesis and evaluation of novel podophyllotoxin analogs.

scientific article

Synthesis and in vitro anticancer activity of 6,7-methylenedioxy (or 5-hydroxy-6-methoxy)-2-(substituted selenophenyl)quinolin-4-one analogs

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Synthesis and in vitro anticancer activities of biotinylated derivatives of glaucocalyxin A and oridonin

scientific article published on 22 May 2020

Synthesis and mechanistic studies of novel spin-labeled combretastatin derivatives as potential antineoplastic agents

scientific article published on 9 January 2013

Synthesis and preclinical evaluations of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one monosodium phosphate (CHM-1-P-Na) as a potent antitumor agent

scientific article

Synthesis and proteasome inhibition of glycyrrhetinic acid derivatives

scientific article published on 05 June 2008

Synthesis and proteasome inhibition of lithocholic acid derivatives

scientific article

Synthesis and structure-activity relationship studies of novel 3,9-substituted α-carboline derivatives with high cytotoxic activity against colorectal cancer cells

scientific article published on 7 January 2016

Synthesis of Lithocholic Acid Derivatives as Proteasome Regulators

scientific article published on 15 August 2012

Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants

scientific article

Synthesis of new 2'-deoxy-2'-fluoro-4'-azido nucleoside analogues as potent anti-HIV agents

scientific article

Synthesis of novel spin-labeled derivatives of 5-FU as potential antineoplastic agents

scientific article

Synthesis of novel spin-labeled podophyllotoxin derivatives as potential antineoplastic agents: Part XXV

scientific article

Synthesis of unsymmetrical biphenyls as potent cytotoxic agents

scientific article published on 22 August 2008

Synthesis, Anticancer Activity, and Preliminary Pharmacokinetic Evaluation of 4,4-Disubstituted Curcuminoid 2,2-bis(Hydroxymethyl)Propionate Derivatives

scientific article published on 22 January 2020

Synthesis, DNA intercalation and 3D QSAR analysis of cis-2,4,5-trisubstituted-1,3-dithiolanes as a novel class of antitumor agents.

scientific article published on 13 June 2009

Synthesis, antitumor activity, and mechanism of action of 6-acrylic phenethyl ester-2-pyranone derivatives.

scientific article

Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors

scientific article published on 17 May 2016

Synthesis, in vitro anti-inflammatory and cytotoxic evaluation, and mechanism of action studies of 1-benzoyl-β-carboline and 1-benzoyl-3-carboxy-β-carboline derivatives

scientific article published on 22 January 2011

Synthesis, nano-scale assembly, and in vivo anti-thrombotic activity of novel short peptides containing L-Arg and L-Asp or L-Glu

scientific article published on 29 April 2008

Tabercorymines A and B, Two Vobasinyl-Ibogan-Type Bisindole Alkaloids from Tabernaemontana corymbosa. ⬇️

scientific article published on 6 September 2017

Taburnaemines A-I, Cytotoxic Vobasinyl-Iboga-Type Bisindole Alkaloids from Tabernaemontana corymbosa.

scientific article published on 10 January 2018

Talarolactone A, an Isocoumarin Derivative Fused with Dihydrothiophene with Selective Antimigratory Activity from the Endolichenic Fungus Talaromyces sp

scientific article published on 21 April 2020

Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus.

scientific article published on 23 March 2018

Tenulin and isotenulin inhibit P-glycoprotein function and overcome multidrug resistance in cancer cells

scientific article published on 05 September 2018

Terpenoids from Juniperus polycarpus var. seravschanica

scientific article published on 07 September 2006

The Isolation and Structural Elucidation of Three New Neolignans, Puberulins A, B, and C, as Platelet Activating Factor Receptor Antagonists from Piper puberulum

scientific article

The antitumor agent PBT-1 directly targets HSP90 and hnRNP A2/B1 and inhibits lung adenocarcinoma growth and metastasis.

scientific article published on 31 January 2014

The aqueous extract, not organic extracts, of Terminalia arjuna bark exerts cardiotonic effect on adult ventricular myocytes

scientific article published on 01 February 2011

The cytotoxic principles of Hyptis capitata and the structures of the new triterpenes hyptatic acid-A and -B

scientific article published on 25 July 2002

The cytotoxic properties of natural coumarins isolated from roots of Ferulago campestris (Apiaceae) and of synthetic ester derivatives of aegelinol.

scientific article

The discovery of a class of novel HIV-1 maturation inhibitors and their potential in the therapy of HIV.

scientific article

The newly synthesized 2-(3-hydroxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-one triggers cell apoptosis through induction of oxidative stress and upregulation of the p38 MAPK signaling pathway in HL-60 human leukemia cel

scientific article

The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells

scientific article published on 22 February 2011

The novel synthetic compound 6-acetyl-9-(3,4,5-trimetho-xybenzyl)-9H-pyrido[2,3-b]indole induces mitotic arrest and apoptosis in human COLO 205 cells

scientific article published on 21 August 2013

The structure and stereochemistry of eupahyssopin, a new antitumor germacranolide from eupatorium hyssopifolium

scientific article published on 25 July 2002

Three New Quassinoid Derivatives and Related Compounds as Antitumor Promoters fromBrucea javanica

scientific article published on 24 December 2003

Three new agarofuran sesquiterpenes reissantins F-H from Reissantia buchananii

scientific article published on January 2006

Total Synthesis and in Vitro Anti-Tumor-Promoting Activities of Racemic Acetophenone Monomers from Acronychia trifoliolata.

scientific article

Total Synthesis of (+)-Medicarpin.

scientific article

Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs

scientific article

Total synthesis of cordatanine, structural reassignment of drymaritin, and anti-inflammatory activity of synthetic precursors

scientific article published on 28 July 2015

Total synthesis of phenanthroindolizidine alkaloids (+/-)-antofine, (+/-)-deoxypergularinine, and their dehydro congeners and evaluation of their cytotoxic activity

scientific article published on 18 April 2008

Total synthesis of plagiochin G and derivatives as potential cancer chemopreventive agents

scientific article

Toward synthesis of third-generation spin-labeled podophyllotoxin derivatives using isocyanide multicomponent reactions

scientific article published on 29 January 2014

Triethylated chromones with substituted naphthalenes as tubulin inhibitors.

scientific article published on 25 September 2016

Tripfordines A-C, sesquiterpene pyridine alkaloids from Tripterygium wilfordii, and structure anti-HIV activity relationships of Tripterygium alkaloids.

scientific article

Tripfordines A−C, Sesquiterpene Pyridine Alkaloids from Tripterygium wilfordii, and Structure Anti-HIV Activity Relationships of Tripterygium Alkaloids

scientific article published on 20 December 2006

Triterpenes and a triterpene glucoside from Dysoxylum cumingianum

scientific article

Two New Quassinoids, Ailantinols C and D, fromAilanthus Altissima

Two new cadinane-type sesquiterpenes from the Chinese liverwort Frullania serrata

scientific article published on 27 June 2014

Two new protopines argemexicaines A and B and the anti-HIV alkaloid 6-acetonyldihydrochelerythrine from formosan Argemone mexicana

scientific article published in February 2003

Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides

scientific article published on November 2005

Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication

scientific article published on 30 August 2017

Vitepyrroloids A-D, 2-Cyanopyrrole-Containing Labdane Diterpenoid Alkaloids from the Leaves of Vitex trifolia.

scientific article

Wilforine resensitizes multidrug resistant cancer cells via competitive inhibition of P-glycoprotein

scientific article published on 16 May 2020

Xanthohumol isolated from Humulus lupulus prevents thrombosis without increased bleeding risk by inhibiting platelet activation and mtDNA release

scientific article published on 8 February 2017

eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer

scientific article

ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide

scientific article

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