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List of works by Vijay Kuchroo

A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells

scientific article published on September 2016

A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells

scientific article published in November 2017

A Model for How Signal Duration Can Determine Distinct Outcomes of Gene Transcription Programs ⬇️

scientific article published on March 13, 2012

A T cell extrinsic mechanism by which IL-2 dampens Th17 differentiation

scientific article published on 26 February 2015

A chimeric T cell receptor with super-signaling properties

scientific article published on 17 May 2004

A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells.

scientific article

A transgenic model of central nervous system autoimmunity mediated by CD4+ and CD8+ T and B cells

scientific article published on 25 January 2012

Aberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17 cells

scientific article published on 17 November 2020

Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease

scientific article published on April 2004

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

scientific article

Age-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung

scientific article published on 19 November 2019

Aiolos promotes TH17 differentiation by directly silencing Il2 expression ⬇️

scientific article published on July 1, 2012

Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs

scientific article

Amelioration of proteolipid protein 139-151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms

scholarly article

An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets

scientific article published on 01 November 2020

An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction

scientific article

An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells

scientific journal article

An autoimmune disease-associated CTLA4 splice variant lacking the B7 binding domain signals negatively in T cells

scientific article published in January 2005

An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells

scientific article published on 10 September 2018

Anti-Ro52 monoclonal antibodies specific for amino acid 200-239, but not other Ro52 epitopes, induce congenital heart block in a rat model

scientific article published on 14 November 2011

Augmented Th17 differentiation in Trim21 deficiency promotes a stable phenotype of atherosclerotic plaques with high collagen content

scientific article published on 4 September 2017

Author Correction: Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia

scientific article published on 01 October 2018

Author Correction: The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity

scientific article published on 01 April 2020

Autoimmunity

scientific article published on 30 October 2009

Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.

scientific article

Beneficial effect of galectin 9 on rheumatoid arthritis by induction of apoptosis of synovial fibroblasts

scientific article published on 01 December 2007

Blockade of Tim-3 binding to phosphatidylserine and CEACAM1 is a shared feature of anti-Tim-3 antibodies that have functional efficacy.

scientific article published on 9 November 2017

Brief report: increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice

scientific article published on March 2013

CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis

scientific article published on 01 October 2007

CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions

scientific article published on August 2005

CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity

scientific article

CD8+ T Cells Specific for Tumor Antigens Can Be Rendered Dysfunctional by the Tumor Microenvironment through Upregulation of the Inhibitory Receptors BTLA and PD-1 ⬇️

scientific article published on December 28, 2011

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

scientific journal article

Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses

scientific article published on 08 October 2019

Characterization of MHC- and TCR-binding residues of the myelin oligodendrocyte glycoprotein 38-51 peptide

scientific article published in January 2004

Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1-CD8+ Tumor-Infiltrating T Cells

scientific article published on 08 January 2019

Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation

scientific article published on 01 July 2020

Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis.

scientific article published on 27 August 2013

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

scientific article

Coinhibitory receptors and CD8 T cell exhaustion in chronic infections

scientific article published on September 2014

Combinatorial prediction of marker panels from single-cell transcriptomic data

scientific article published on 01 October 2019

Comment on "Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection".

scientific article published in July 2014

Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells ⬇️

scientific article published on June 7, 2012

Control of TH17 cells occurs in the small intestine.

scientific article

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

scientific article

Copolymer effects on microglia and T cells in the central nervous system of humanized mice

scientific article published in December 2005

Correction

Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

scientific article published on 16 March 2016

Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation.

scientific article published on 6 February 2017

Cross-reactive TCR responses to self antigens presented by different MHC class II molecules

scientific article published on August 2004

Cutting edge: CD4+CD25+ regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis

scientific article published in November 2005

Cutting edge: CD94/NKG2 is expressed on Th1 but not Th2 cells and costimulates Th1 effector functions

scientific article published on November 2002

Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice

scientific article

Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells

scientific article published on May 2009

Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells

scientific article

Cutting edge: TIGIT has T cell-intrinsic inhibitory functions

scientific journal article

Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation

scientific article

Cutting edge: the Idd3 genetic interval determines regulatory T cell function through CD11b+CD11c- APC.

scientific article published on December 2008

Cytokines and transcription factors in the differentiation of CD4+ T helper cell subsets and induction of tissue inflammation and autoimmunity

scientific article published on 08 October 2020

Cytosolic Phospholipase A2α Blockade Abrogates Disease during the Tissue-Damage Effector Phase of Experimental Autoimmune Encephalomyelitis by Its Action on APCs ⬇️

scientific article published on July 11, 2011

DUBA-UBR5 axis: other than transactivation

scientific article

Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells

scientific article

Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice.

scientific article

Defining the functional states of Th17 cells

scientific article

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.

scientific article

Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function.

scientific article published on 12 March 2018

Detection of autoreactive myelin proteolipid protein 139-151-specific T cells by using MHC II (IAs) tetramers

scientific article published on January 2003

Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice.

scientific article

Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function

scientific article

Differentiation and Characterization of Tr1 Cells.

scientific article published in April 2016

Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis

scientific article published in July 2004

Dissimilar background genes control susceptibility to autoimmune disease in the context of different MHC haplotypes: NOD.H-2(s) congenic mice are relatively resistant to both experimental autoimmune encephalomyelitis and type I diabetes

scientific article published on July 2004

Distinct functions of autoreactive memory and effector CD4+ T cells in experimental autoimmune encephalomyelitis

scientific article published on 26 June 2008

Dynamic regulatory network controlling TH17 cell differentiation

scientific article published on 6 March 2013

Dysregulated T cell expression of TIM3 in multiple sclerosis

scientific article (published 2006-06-12)

Dysregulation of immune homeostasis in autoimmune diseases

scientific article published on 06 January 2012

Editorial: Th17 cells

Effector T cell differentiation: are master regulators of effector T cells still the masters?

scientific article published on 26 August 2015

Emerging Tim-3 functions in antimicrobial and tumor immunity

scientific article published on 21 June 2011

Emerging new roles of Th17 cells

scientific article published on September 2012

Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment

scientific article published on 01 September 2020

Epigenetic and transcriptional mechanisms for the regulation of IL-10

scientific article published on 01 August 2019

Erratum: Corrigendum: An IL-27/NFIL3 signalling axis drives Tim-3 and IL–10 expression and T-cell dysfunction

scientific article published in Nature Communications

Erratum: IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ Foxp3− effector T cells

scholarly article published in Nature Immunology

Erratum: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

scientific article published on 15 November 2017

Experimental autoimmune encephalomyelitis can be prevented and cured by infection with Trypanosoma cruzi

Expression of self-antigen in the thymus: a little goes a long way.

scientific article published on December 2003

Expression of the immune regulator tripartite-motif 21 is controlled by IFN regulatory factors

scientific article published on 23 August 2013

Ezh2 lines up the chromatin in T regulatory cells.

scientific article published in February 2015

Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1

scientific article published on 01 March 2018

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses

scientific article published on 02 September 2019

Fragile TIM-4-expressing tissue resident macrophages are migratory and immunoregulatory.

scientific article

Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity.

scientific article published on 2 March 2018

Functional Th1 cells are required for surgical adhesion formation in a murine model

scientific article published on May 2008

Galectin-1 Triggers an Immunoregulatory Signature in Th Cells Functionally Defined by IL-10 Expression ⬇️

scientific article published on February 17, 2012

Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions.

scientific article published in December 2008

Galectin-9 signaling through TIM-3 is involved in neutrophil-mediated Gram-negative bacterial killing: an effect abrogated within the cystic fibrosis lung

scientific article published on 29 January 2014

Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis

scientific article published on 20 February 2008

Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells

scientific journal article

Gene-environment interaction in induction of autoimmunity

article

Genetic and epigenetic fine mapping of causal autoimmune disease variants

scientific article

Genetic background determines the requirement for B7 costimulation in induction of autoimmunity

scientific article published in September 2002

Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.

scientific article

Good guys gone bad: exTreg cells promote autoimmune arthritis

scientific article published on 01 January 2014

Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense

scientific article published on 05 December 2019

H1N1 vaccination in Sjögren's syndrome triggers polyclonal B cell activation and promotes autoantibody production

scientific article published on 31 July 2017

High Incidence of Spontaneous Disease in an HLA-DR15 and TCR Transgenic Multiple Sclerosis Model

article

High Ro52 Expression in Spontaneous and UV-Induced Cutaneous Inflammation

scientific article published on 05 February 2009

High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3

scientific article published in Scientific Reports

How Cytokine networks fuel inflammation: Interleukin-17 and a tale of two autoimmune diseases

scientific article published on July 2013

Human disease mutations highlight the inhibitory function of TIM-3

scientific article published on 01 December 2018

I kappa B kinase 2/beta deficiency controls expansion of autoreactive T cells and suppresses experimental autoimmune encephalomyelitis

scientific article published in July 2007

IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells

scientific article published on 01 February 2004

IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice

scientific article published in July 2004

IL-10, a key effector regulatory cytokine in experimental autoimmune encephalomyelitis

scientific article

IL-12 family cytokines: immunological playmakers

scientific article

IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together

scientific article published on January 2005

IL-17 Blockade in Psoriasis

scientific article published in December 2016

IL-17 and Th17 Cells

scientific article published on 2009

IL-17-producing human peripheral regulatory T cells retain suppressive function

scientific article published on 26 January 2009

IL-17A directly inhibits TH1 cells and thereby suppresses development of intestinal inflammation

scientific article published in June 2009

IL-18: throwing off the shackles to boost anti-tumor immunity

scientific article published on 18 August 2020

IL-1β promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation

scientific article published on 13 March 2013

IL-21 Promotes CD8+ CTL Activity via the Transcription Factor T-bet ⬇️

scientific article published on March 11, 2013

IL-21 and TGF-beta are required for differentiation of human T(H)17 cells

scientific article published on 11 May 2008

IL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis

scientific article

IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization

scientific article published on 22 August 2016

IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections

scientific article

IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling

scientific article

IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.

scientific article published on September 2013

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

scientific journal article

IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells

scholarly article

IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells

scholarly article

Immune checkpoints in central nervous system autoimmunity.

scientific article published on July 2012

Immunological basis for the development of tissue inflammation and organ-specific autoimmunity in animal models of multiple sclerosis

scientific article published on January 2010

Immunological unresponsiveness characterized by increased expression of CD5 on peripheral T cells induced by dendritic cells in vivo

scientific article published on June 2004

Immunology of neuromyelitis optica: a T cell-B cell collaboration

scientific article

Immunology. The yin and yang of follicular helper T cells

scientific article published on 01 August 2009

Immunology: Fast and feel good?

scientific article published in March 2003

Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice

scientific article

Induction and effector functions of T(H)17 cells.

scientific article published on June 2008

Induction and molecular signature of pathogenic TH17 cells

scientific article

Induction and transcriptional regulation of the co-inhibitory gene module in T cells

scientific article published in Nature

Induction of a colitogenic phenotype in Th1-like cells depends on interleukin-23 receptor signaling

scientific article published in 2022

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

scientific journal article

Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27.

scientific article published on 3 September 2011

Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A

scientific article (publication date: 15 May 2002)

Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance

scientific journal article

Interferon-alpha induces up-regulation and nuclear translocation of the Ro52 autoantigen as detected by a panel of novel Ro52-specific monoclonal antibodies

scientific article published on May 2008

Interleukin-17 and type 17 helper T cells

scientific article

Interplay between effector Th17 and regulatory T cells

scientific article published on 23 September 2008

KIM-1 Mediated Tubular Fatty Acid Uptake Leads to Progressive Diabetic Kidney Disease

scientific article

KIM-1-mediated phagocytosis reduces acute injury to the kidney

scientific article

Killers come to the rescue

scientific article published on 01 December 2002

Lab management: insights for the new investigator

scientific article published on 01 September 2006

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.

scientific article published on May 2016

Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis

scientific article published on June 2008

Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread.

scientific article

Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis

scientific article

Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway

scientific article published on 27 July 2009

Maternal MHC regulates generation of pathogenic antibodies and fetal MHC-encoded genes determine susceptibility in congenital heart block

scientific article published on 9 August 2010

Mechanisms of TIGIT-driven immune suppression in cancer

Melanoma progression is associated with NK cell exhaustion.

scientific article published on 6 November 2014

Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses

scientific article

Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation.

scientific article published on 29 April 2013

Modeling tumor immunity of mouse glioblastoma by exhausted CD8+ T cells

scientific article published on 9 January 2018

Modified amino acid copolymers suppress myelin basic protein 85-99-induced encephalomyelitis in humanized mice through different effects on T cells

scholarly article

Modulation of CD4 co-receptor limits spontaneous autoimmunity when high-affinity transgenic TCR specific for self-antigen is expressed on a genetically resistant background

scientific article published on 05 September 2007

Molecular pathways in the induction of interleukin-27-driven regulatory type 1 cells.

scientific article

Monoclonal antibodies to distinct regions of human myelin proteolipid protein simultaneously recognize central nervous system myelin and neurons of many vertebrate species

scientific article published in February 2006

Multilayer regulation of CD4 T cell subset differentiation in the era of single cell genomics

scientific article published on 03 January 2019

MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling ⬇️

scientific article published on January 22, 2013

Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice

scientific article

Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis.

scientific article

Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis

scholarly article

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.

scientific article

Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells

scientific article published on 08 July 2009

New pieces in the puzzle: how does interferon-beta really work in multiple sclerosis?

scientific article published in May 2009

New roles for TIM family members in immune regulation

scientific article

Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia.

scientific article published on 5 March 2018

OR.56. The Sjögren's Syndrome Associated Autoantigen Ro52 Is a Ring-Dependent E3 Ligase That Regulates Cell Death

Oct1 and OCA-B are selectively required for CD4 memory T cell function

scientific article

Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity

scientific article published on 28 November 2011

PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8⁺ T cells induced by melanoma vaccines

scientific article published on 16 December 2013

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

scientific article published on 14 December 2009

PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells

scholarly article

Pathogenic Transdifferentiation of Th17 Cells Contribute to Perpetuation of Rheumatoid Arthritis during Anti-TNF Treatment

scientific article

Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis

scientific article

Peripheral deletion of antigen-reactive T cells in oral tolerance

scientific article published in Nature

Phagocytosis imprints heterogeneity in tissue-resident macrophages.

scientific article published on 21 April 2017

Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways.

scientific article published on August 2011

Physical attraction of Th9 cells is skin deep

scientific article published on April 2015

Podoplanin is a negative regulator of Th17 inflammation

scientific article published on 7 September 2017

Podoplanin negatively regulates CD4+ effector T cell responses

scientific article

Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2.

scientific article published on 9 August 2012

Polyamine metabolism is a central determinant of helper T cell lineage fidelity

scientific article published in 2021

Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity

scientific article

Proinflammatory T helper type 17 cells are effective B-cell helpers

scientific article

Promotion of proinflammatory Th1 and Th17 responses by Tim‐1 expressed on dendritic cells ⬇️

scholarly article

Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells

scientific journal article

Protect the killer: CTLs need defenses against the tumor

scientific article published on 01 August 2002

Protein C receptor (PROCR) is a negative regulator of Th17 pathogenicity.

scientific article published on 26 September 2016

Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis

article

Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice

scientific article

Publisher Correction: An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells

scientific article published on 01 January 2019

RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression

scientific article published on 22 June 2016

Recipient T cell TIM-3 and hepatocyte galectin-9 signalling protects mouse liver transplants against ischemia-reperfusion injury.

scientific article

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

scientific article (publication date: 11 May 2006)

Recovery from EAE is associated with decreased survival of encephalitogenic T cells in the CNS of B7-1/B7-2-deficient mice

scientific article published on 01 July 2003

Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells.

scientific article

Reduced self-reactivity of an autoreactive T cell after activation with cross-reactive non-self-ligand

scientific article

Regulation of T-cell immunity by T-cell immunoglobulin and mucin domain proteins

scientific article published on July 2007

Regulatory T cells: recommendations to simplify the nomenclature.

scientific article published in April 2013

Repurposing a novel anti-cancer RXR agonist to attenuate acute GVHD and maintain graft-versus-leukemia responses

scientific article published on 24 September 2020

Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression

scientific article published on August 2008

Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockade

scientific article

Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block

scientific article

Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells

scientific article

Role of Co-stimulatory Molecules in T Helper Cell Differentiation

scientific article published on 01 January 2019

Role of Th1 and Th17 cells in organ-specific autoimmunity.

scientific article published on 27 May 2008

Role of the B7-CD28/CTLA-4 pathway in autoimmune disease

scientific article (publication date: 2002)

SGK1 Governs the Reciprocal Development of Th17 and Regulatory T Cells.

scientific article published in January 2018

Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein

scientific article

Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.

scientific article published on 25 June 2015

Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity

scientific article

Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms

scientific article

Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells.

scientific article

Specific T regulatory cells display broad suppressive functions against experimental allergic encephalomyelitis upon activation with cognate antigen

article

Specific targeting of the IL-23 receptor, using a novel small peptide noncompetitive antagonist, decreases the inflammatory response

scientific article published on 20 August 2014

Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium

scientific article published on 19 March 2021

Structural organization and Zn2+-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52

scientific article

Suppression by TFR cells leads to durable and selective inhibition of B cell effector function

scientific article published on 3 October 2016

Systems-based approaches to study immunometabolism

scientific article published in 2022

T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis

scientific article

T Cell-Independent Mechanisms Associated with Neutrophil Extracellular Trap Formation and Selective Autophagy in IL-17A-Mediated Epidermal Hyperplasia.

scientific article published on 24 October 2016

T Follicular Regulatory Cell-Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity

scientific article published on 09 November 2020

T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

scientific article published on 01 November 2018

T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice

scientific article

T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses.

scientific article published on 3 November 2011

T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire

scientific article

T cell tolerance induced by cross-reactive TCR ligands can be broken by superagonist resulting in anti-inflammatory T cell cytokine production

scientific article published on 01 August 2005

T cell-derived interleukin (IL)-21 promotes brain injury following stroke in mice

scientific article

T cell–derived inducible nitric oxide synthase switches off Th17 cell differentiation

scientific article published on July 2013

T(H)-17 cells in the circle of immunity and autoimmunity

scientific article published on April 2007

T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

scientific journal article

T-bet, a Th1 transcription factor regulates the expression of Tim-3.

scientific article

T-cell immunoglobulin and mucin domain 4 (TIM-4) signaling in innate immune-mediated liver ischemia-reperfusion injury

scientific article

TGF-beta induces IL-9 production from human Th17 cells.

scientific article

TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis

scientific article

TGF-β signaling initiated in dendritic cells instructs suppressive effects on Th17 differentiation at the site of neuroinflammation

scientific article

TIGIT predominantly regulates the immune response via regulatory T cells.

scientific article

TIM Family Proteins Promote the Lysosomal Degradation of the Nuclear Receptor NUR77 ⬇️

scientific article published on December 11, 2012

TIM family of genes in immunity and tolerance

scientific article published on January 2006

TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity

scientific article

TIM-3 and its regulatory role in immune responses

scientific article

TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines

scientific article

TIM-3 restrains anti-tumour immunity by regulating inflammasome activation

scientific article published on 09 June 2021

TIM-4 Identifies IFN-γ-Expressing Proinflammatory B Effector 1 Cells That Promote Tumor and Allograft Rejection

scientific article published on 28 August 2017

TIM-4 expressed on APCs induces T cell expansion and survival

scientific article

TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation

scientific article published on 27 March 2005

TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection

scientific article

TIM3 comes of age as an inhibitory receptor

scientific article published on 01 November 2019

TIM3(+)FOXP3(+) regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer

scientific article published on April 2013

TIMs: central regulators of immune responses

scientific article published on 17 November 2008

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

scientific article

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

scientific article published on 30 May 2011

Targeting latency-associated peptide promotes antitumor immunity.

scientific article published on May 2017

Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes

scientific article

Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

scientific article

Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions

scientific article published on December 2015

Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation

scientific article

Th17 cells: effector T cells with inflammatory properties

scientific article

Th17 cells: from precursors to players in inflammation and infection

scientific article published on 04 March 2009

Th17: the third member of the effector T cell trilogy

scientific article published on 4 September 2007

Th3 cells in peripheral tolerance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells derived from TGF-beta T cell-transgenic mice

scientific article published on 01 January 2007

Th3 cells in peripheral tolerance. II. TGF-beta-transgenic Th3 cells rescue IL-2-deficient mice from autoimmunity

scientific article published on 01 January 2007

The CD226/CD155 interaction regulates the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance in humans.

scientific article published on 26 August 2013

The ICOS molecule plays a crucial role in the development of mucosal tolerance

scientific article published on 01 December 2005

The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death

scientific article published on May 2006

The TIGIT/CD226 Axis Regulates Human T Cell Function ⬇️

scientific article published on March 16, 2012

The TIM gene family regulates autoimmune and allergic diseases

scientific article

The TIM gene family: emerging roles in immunity and disease

scientific article

The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

scientific article

The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27.

scientific article

The autoimmune diabetes locus Idd9 regulates development of type 1 diabetes by affecting the homing of islet-specific T cells

scientific article published on 01 May 2006

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

scientific article

The costimulatory role of TIM molecules

scientific article published on May 2009

The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis

scientific article published in July 2004

The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation

scientific article

The many faces of Th17 cells ⬇️

scientific article published on September 6, 2011

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation.

scientific article published on 13 September 2017

The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90.

scientific article published on 2 December 2012

The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon gamma production.

scientific article published in October 2002

The transcription factor musculin promotes the unidirectional development of peripheral Treg cells by suppressing the TH2 transcriptional program

scientific article published on 23 January 2017

The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity

scientific article published on 23 January 2020

Tim protein structures reveal a unique face for ligand binding

scientific article published on 01 March 2007

Tim-1 is essential for induction and maintenance of IL-10 in regulatory B cells and their regulation of tissue inflammation

scientific article

Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation

scientific article published on February 2009

Tim-1 stimulation of dendritic cells regulates the balance between effector and regulatory T cells

scientific article

Tim-2 regulates T helper type 2 responses and autoimmunity

scientific article published on 25 July 2005

Tim-3 and its role in regulating anti-tumor immunity

scientific article

Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance.

scientific article

Tim-3, Lag-3, and TIGIT.

scientific article published on 13 September 2017

Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells.

scientific article

Tim-3: A co-receptor with diverse roles in T cell exhaustion and tolerance

scientific article published on 01 April 2019

Tim3 binding to galectin-9 stimulates antimicrobial immunity

scientific journal article

Toxicity and Efficacy of a Novel GADD34-expressing Oncolytic HSV-1 for the Treatment of Experimental Glioblastoma.

scientific article published on 6 March 2018

Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses

scientific article published on 01 October 2019

Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis

scientific article published on 17 November 2017

Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses

scientific article

Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis

scientific article published on 25 April 2022

Type 1 regulatory T cells (Tr1) in autoimmunity

scientific article

Type 2 innate lymphoid cells in the induction and resolution of tissue inflammation

scientific article published on 01 November 2018

Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells

scientific article published on 31 October 2020

Unexpected targets and triggers of autoimmunity

scientific article published on May 2014

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patients ⬇️

scientific article published on September 6, 2010

Using EAE to better understand principles of immune function and autoimmune pathology

scientific article published on 09 July 2013

Value added: neural progenitor cells suppress inflammation and autoimmunity ⬇️

scientific article published on August 26, 2011

WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis.

scientific article

γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism.

scientific article

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