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List of works by Christopher B Newgard

A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation.

scientific article published on 12 September 2016

A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function.

scientific article published on July 2012

A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

scientific article (publication date: April 2009)

A futile metabolic cycle activated in adipocytes by antidiabetic agents

scientific article published on 23 September 2002

A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion

scientific article

Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy

scientific article

Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease

scientific journal article

Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease

scientific article published on 22 October 2009

Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance

scientific article published on 15 November 2012

Adverse Effects of Fenofibrate in Mice Deficient in the Protein Quality Control Regulator, CHIP

article

Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity

scientific article published in 2022

An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans

scientific article published on September 2004

Analysis of serum metabolic profiles in women with endometrial cancer and controls in a population-based case-control study

scientific article

Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations.

scientific article

Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events

scientific article published on 19 February 2010

Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes.

scientific article published on 16 December 2016

BMI, RQ, diabetes, and sex affect the relationships between amino acids and clamp measures of insulin action in humans

scientific article published on 15 October 2013

Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease

scientific article published in May 2012

Beta-cell specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice

scientific article published on 31 August 2020

Biochemistry. A glucose-to-gene link

scientific article published in May 2009

Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells

scientific article published on 6 May 2003

Biomedicine. Insulin resistance takes a trip through the ER.

scientific article published in October 2004

Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism.

scientific article

Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness

scientific article published on February 2013

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

scientific article (publication date: July 2016)

Branched-chain amino acids alter neurobehavioral function in rats

scientific article published on 18 December 2012

Branched-chain amino acids in disease

scientific article published on 01 February 2019

Branching out for detection of type 2 diabetes

scientific article published on 01 May 2011

CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-α-Gabpa and stress-induced adaptive responses via NF-κB-cMYC

scientific article

Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice.

scientific article published on 18 February 2014

Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial

scientific article

Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction

scientific article published on 29 November 2014

Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling

scientific article

Cardiovascular Metabolomics

scientific article published in April 2018

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure

scientific article published on 08 April 2016

Cell lines derived from pancreatic islets

scientific article

Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis

scientific article published in March 2007

Cholinergic augmentation of insulin release requires ankyrin-B.

scientific article published on 16 March 2010

Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice

scientific article published on 19 September 2013

Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis

scientific article

Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion

scientific article

Contamination with E1A-positive wild-type adenovirus accounts for species-specific stimulation of islet cell proliferation by CCK: a cautionary note.

scientific article

Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion.

scientific article published on 20 June 2013

Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3

scientific journal article

Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1

scientific article

Cord Blood Metabolomics: Association With Newborn Anthropometrics and C-Peptide Across Ancestries

scientific article published on 01 October 2019

Correction: Genetic Networks of Liver Metabolism Revealed by Integration of Metabolic and Transcriptional Profiling

scientific article

Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing

scientific article published on 01 February 2019

Daily Variation of Serum Acylcarnitines and Amino Acids

scientific article

Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival

scientific article

Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse

scientific article published on 12 January 2012

Diabetes: The good in fat.

scientific article published on 19 November 2014

Dietary Patterns among Asian Indians Living in the United States Have Distinct Metabolomic Profiles That Are Associated with Cardiometabolic Risk

scientific article published on 01 July 2018

Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins

scientific article published on 01 October 2019

Dietary branched-chain amino acid restriction alters fuel selection and reduces triglyceride stores in hearts of Zucker fatty rats

scientific article published on 03 December 2019

Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss

scientific article published on April 2011

Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion

scientific article published on 13 June 2013

Discrete and complementary mechanisms of protection of beta-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy

scientific article published in June 2003

Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure.

scientific article published on 3 June 2019

Dissecting the in vivo metabolic potential of two human gut acetogens

scientific article

Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver

article

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling

scientific article published on 3 October 2017

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.

scientific article published in March 2018

Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial.

scientific article published on 24 February 2018

Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism.

scientific article published on 22 April 2013

Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women

scientific article

Effect of heparin administration on metabolomic profiles in samples obtained during cardiac catheterization

scientific article

Effects of HIV infection on the metabolic and hormonal status of children with severe acute malnutrition

scientific article

Effects of a gut pathobiont in a gnotobiotic mouse model of childhood undernutrition

scientific article

Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

scientific article published on 01 July 2019

Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis.

scientific article published on 4 October 2017

Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology

scientific article

Energetics and metabolism in the failing heart: important but poorly understood

scientific article published on July 2010

Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism

scientific article published on 27 September 2016

Erratum. Maternal BMI and Glycemia Impact the Fetal Metabolome. Diabetes Care 2017;40:902-910.

scientific article published on 8 January 2018

Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity. ⬇️

scientific article

Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha

scientific journal article

Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice

scientific article

Fatty acid oxidation and insulin action: when less is more

scientific article published in June 2008

Fenofibrate Induced Cardiac Fibrosis in Mice Deficient in the Protein Quality Control Regulator, CHIP

FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site

scientific article

Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents.

scientific article

Galphaz negatively regulates insulin secretion and glucose clearance

scientific article

Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling

scientific article

Getting biological about the genetics of diabetes

scientific article published on 01 April 2010

Glucose metabolism as a target of histone deacetylase inhibitors.

scientific article published on 23 December 2008

Glycogen-targeting subunits and glucokinase differentially affect pathways of glycogen metabolism and their regulation in hepatocytes

scientific article

Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children

scientific article

Gut microbiota from twins discordant for obesity modulate metabolism in mice

scientific article (publication date: 6 September 2013)

HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism.

scientific article published on 14 May 2015

Hepatic Expression of a Targeting Subunit of Protein Phosphatase-1 in Streptozotocin-diabetic Rats Reverses Hyperglycemia and Hyperphagia Despite Depressed Glucokinase Expression ⬇️

scientific article published on April 15, 2003

Hepatic SRC-1 activity orchestrates transcriptional circuitries of amino acid pathways with potential relevance for human metabolic pathogenesis ⬇️

scientific article

Hepatic acyl-CoA:diacylglcyerol acyltransferase (DGAT) overexpression, diacylglycerol, and insulin sensitivity

scientific article published on August 23, 2011

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

scientific article published on 8 February 2004

Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity

scientific article published on 22 June 2016

Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance

scientific article

High heritability of metabolomic profiles in families burdened with premature cardiovascular disease

scientific article published on 07 April 2009

Human amylin proteotoxicity impairs protein biosynthesis, and alters major cellular signaling pathways in the heart, brain and liver of humanized diabetic rat model in vivo.

scientific article published on 23 April 2016

Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.

scientific article

Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells

scientific article published on 16 March 2020

Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans

scientific article published on 9 August 2015

Improvement in insulin resistance after gastric bypass surgery is correlated with a decline in plasma 2-hydroxybutyric acid

scientific article published on 17 April 2018

Improving human β-cell maturation in vitro

scientific article published on 01 February 2019

Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha

scientific article published on 26 February 2009

Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle

scientific article

Increasing fructose 2,6-bisphosphate overcomes hepatic insulin resistance of type 2 diabetes ⬇️

scientific article published on January 1, 2002

Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells

scientific article

Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77.

scientific article published on 09 September 2009

Integrated metabolomics and genomics: systems approaches to biomarkers and mechanisms of cardiovascular disease

scientific article published on April 2015

Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.

scientific article

Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells

scientific article

Isolation of a mycoplasma-specific binding peptide from an unbiased phage-displayed peptide library

scientific article

John Denis McGarry, PhD: A Remembrance of a Master Metabolic Physiologist

scientific article published on 01 July 2018

Kruppel-like factor 15 is required for the cardiac adaptive response to fasting.

scientific article

Leptin therapy in insulin-deficient type I diabetes

scientific article

Lower brain-derived neurotrophic factor in patients with prader-willi syndrome compared to obese and lean control subjects

scientific article

Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women

scientific article

Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries

scientific article published on 27 November 2018

Mechanical unloading promotes myocardial energy recovery in human heart failure

scientific article

Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes

scientific article

Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes

scientific article

Metabolic Networks and Metabolites Underlie Associations Between Maternal Glucose During Pregnancy and Newborn Size at Birth.

scientific article published on 05 April 2016

Metabolic profiles predict adverse events after coronary artery bypass grafting

scientific article published on 4 February 2012

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

scientific article

Metabolism: A is for adipokine

scientific article published in July 2005

Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure

scientific article published on 29 July 2016

Metabolomic Profiling Reveals a Role for Caspase-2 in Lipoapoptosis ⬇️

scientific article published on April 3, 2013

Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis

scientific article published on 5 November 2015

Metabolomic analysis reveals extended metabolic consequences of marginal vitamin B-6 deficiency in healthy human subjects

scientific article

Metabolomic profile associated with insulin resistance and conversion to diabetes in the Insulin Resistance Atherosclerosis Study

scientific article

Metabolomic profiling for the identification of novel biomarkers and mechanisms related to common cardiovascular diseases: form and function

scientific article

Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion.

scientific article published on 23 March 2009

Metabolomics applied to diabetes research: moving from information to knowledge

scientific article

Metabolomics applied to islet nutrient sensing mechanisms ⬇️

scientific article

Metabolomics reveals broad-scale metabolic perturbations in hyperglycemic mothers during pregnancy

scientific article published on 29 August 2013

Mig-6 plays a critical role in the regulation of cholesterol homeostasis and bile acid synthesis.

scientific article

Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues

scientific article published on 30 January 2002

Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance

scientific article published on January 2008

Mixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data

scientific article

Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women

scientific article published on 21 January 2009

MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet

scientific article published on 5 August 2015

Multi-Omic Profiling Reveals the Opposing Forces of Excess Dietary Sugar and Fat on Liver Mitochondria Protein Acetylation and Succinylation

scholarly article published 10 February 2018

Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet.

scientific article published on 28 July 2015

Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion

scientific article published on 01 November 2020

Near-roadway air pollution exposure and altered fatty acid oxidation among adolescents and young adults - The interplay with obesity

scientific article published on 22 June 2019

Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis

scientific article

Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors

scientific journal article

Non-Targeted Metabolomics Analysis of Golden Retriever Muscular Dystrophy-Affected Muscles Reveals Alterations in Arginine and Proline Metabolism, and Elevations in Glutamic and Oleic Acid In Vivo

scientific article

Non-targeted metabolomics analysis of cardiac Muscle Ring Finger-1 (MuRF1), MuRF2, and MuRF3 in vivo reveals novel and redundant metabolic changes.

scientific article

Non-targeted metabolomics of Brg1/Brm double-mutant cardiomyocytes reveals a novel role for SWI/SNF complexes in metabolic homeostasis

scientific article

OR07-1 Cord Blood Metabolomics: Association with Newborn Anthropometrics and C-Peptide across Ancestries

Obesity and lipid stress inhibit carnitine acetyltransferase activity

scientific article published on 06 January 2014

Obesity-related derangements in metabolic regulation

scientific article

Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function

scientific article published on 09 October 2008

PGC-1beta in the regulation of hepatic glucose and energy metabolism

scientific journal article

Pathogenesis of A⁻β⁺ ketosis-prone diabetes

scientific article published on 16 November 2012

Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2.

scientific article published on 12 August 2013

Peptide-mediated targeting of the islets of Langerhans

scientific article published in July 2005

Perinatal western-type diet and associated gestational weight gain alter postpartum maternal mood.

scientific article published on 14 September 2017

Peripheral blood metabolite profiles associated with new onset atrial fibrillation

scientific article published on 14 February 2019

Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency.

scientific article published on 3 August 2005

Physiological mechanisms of sustained fumagillin-induced weight loss.

scientific article published on 8 March 2018

Plasma acylcarnitines are associated with physical performance in elderly men

scientific article

Plasma acylcarnitines are associated with pulmonary hypertension

scientific article

Postprandial Metabolite Profiles Reveal Differential Nutrient Handling After Bariatric Surgery Compared With Matched Caloric Restriction ⬇️

scientific article published on April 1, 2014

Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions

scientific article published on 22 December 2016

Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines

scientific article published on May 2006

Proteomic Profiling Reveals Adaptive Responses to Surgical Myocardial Ischemia-Reperfusion in Hibernating Arctic Ground Squirrels Compared to Rats

scientific article published on June 2016

Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults

scientific article published on 11 October 2013

Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium.

scientific article

Recommendations for Improving Identification and Quantification in Non-Targeted, GC-MS-Based Metabolomic Profiling of Human Plasma

scientific article published on 25 August 2017

Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion

scientific article published on 08 December 2020

Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation

scientific article published on 15 April 2019

Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability ⬇️

scientific article published on February 16, 2011

Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL.

scientific article

Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women

scientific article published on 05 June 2009

Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition

scientific article published on 01 July 2018

Research Resource: Roles for Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) in Systems Metabolism

scientific article published on 22 March 2016

Research resource: tissue- and pathway-specific metabolomic profiles of the steroid receptor coactivator (SRC) family

scientific article published on 11 January 2013

Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats

scientific article published on 24 October 2008

Reversal of Diet-induced Glucose Intolerance by Hepatic Expression of a Variant Glycogen-targeting Subunit of Protein Phosphatase-1 ⬇️

scientific article published on November 13, 2001

SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome

scientific article

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

scientific article

SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks

scientific journal article

SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart

scientific article (publication date: 2012)

Severe acute malnutrition in childhood: hormonal and metabolic status at presentation, response to treatment, and predictors of mortality

scientific article

Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition.

scientific article published on 17 February 2016

Sildenafil Treatment in Heart Failure With Preserved Ejection Fraction: Targeted Metabolomic Profiling in the RELAX Trial.

scientific article

Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets

scientific article

Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation

scientific article published on 08 July 2013

Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization

scientific article

Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1

scientific article

Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: insights gained from a multidisciplinary approach

scientific article

Suppression of beta cell energy metabolism and insulin release by PGC-1alpha

scientific article published on July 2003

Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor

scientific article

TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism

scientific article

Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose

scientific article published in PLoS ONE

The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.

scientific article

The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells

scientific article

The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis.

scientific article published on September 2017

The Role of Voltage-Gated Potassium Channels Kv2.1 and Kv2.2 in the Regulation of Insulin and Somatostatin Release from Pancreatic Islets ⬇️

scientific article published on November 16, 2012

The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain

scientific article published on February 2009

The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project: Rationale and design

scientific article published on 18 October 2005

The coactivator SRC-1 is an essential coordinator of hepatic glucose production.

scientific article published on December 2010

The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins

scientific article published in October 2011

The liver--a potential new player in islet regeneration?

scientific article published on 01 January 2009

The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion

scientific article

The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion

scientific article published on 25 September 2006

The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance

scientific article published on May 2012

The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions

scientific article published on 14 November 2006

The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells

scientific article published on 7 February 2007

The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination

scientific article published on 25 June 2015

Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy ⬇️

scientific article published on June 11, 2012

Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function

scientific article

Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies

scientific article published in January 2004

Validation of the association between a branched chain amino acid metabolite profile and extremes of coronary artery disease in patients referred for cardiac catheterization

scientific article published on 12 November 2013

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