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List of works by Charles F Zorumski

"What Were You Before the War?" Repurposing Psychiatry During the COVID-19 Pandemic

scientific article published on 07 April 2020

11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors.

scientific article

2-Amino-3-phosphonopropionate blocks the induction and maintenance of long-term potentiation in rat hippocampal slices ⬇️

scientific article published on January 28, 1991

24(S)-Hydroxycholesterol as a Modulator of Neuronal Signaling and Survival

scientific article published on 27 January 2015

24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure.

scientific article published on 22 September 2016

24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation

scientific article

3beta -hydroxypregnane steroids are pregnenolone sulfate-like GABA(A) receptor antagonists.

scientific article published in May 2002

5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo

scientific article

A Clickable Analogue of Ketamine Retains NMDA Receptor Activity, Psychoactivity, and Accumulates in Neurons.

scientific article

A Clickable Oxysterol Photolabel Retains NMDA Receptor Activity and Accumulates in Neurons

scientific article published on 06 December 2018

A benzodiazepine recognition site associated with the non-NMDA glutamate receptor

scientific article published in January 1993

A clickable neurosteroid photolabel reveals selective Golgi compartmentalization with preferential impact on proximal inhibition

scientific article

A neuroactive steroid with a therapeutically interesting constellation of actions at GABAA and NMDA receptors

scientific article published on 23 October 2020

A single day of ethanol exposure during development has persistent effects on bi-directional plasticity, N-methyl-D-aspartate receptor function and ethanol sensitivity

scientific article published on 21 September 2005

A spontaneous tonic chloride conductance in solitary glutamatergic hippocampal neurons

scientific article published on 20 September 2006

A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors

scientific article

A tribute to Lee Nelken Robins: from colleagues and friends

AMPA, kainate, and quisqualate activate a common receptor-channel complex on embryonic chick motoneurons

scientific article

Academic Psychiatry Department Names: Reflections on Research, Practice, and Education

scientific article published on 07 July 2020

Activation-dependent properties of pregnenolone sulfate inhibition of GABAA receptor-mediated current

scientific article published in August 2003

Acute and chronic effects of ethanol on learning-related synaptic plasticity.

scientific article published on 16 December 2013

Acute effects of antidepressants on hippocampal seizures

scientific article published in December 1985

Acute effects of ethanol on hippocampal long-term potentiation and long-term depression are mediated by different mechanisms

scientific article

Acute effects of lithium on hippocampal kindled seizures

scientific article published in November 1985

Acute vigabatrin retinotoxicity in albino rats depends on light but not GABA.

scientific article

Additive neuroprotective effects of 24(S)-hydroxycholesterol and allopregnanolone in an ex vivo rat glaucoma model

scientific article published in Scientific Reports

Age dependent sensitivity of the rat retina to the excitotoxic action of N-methyl-D-aspartate

scientific article published in June 1995

Alpha-substituted thiobutyrolactones potentiate GABA currents in voltage-clamped chick spinal cord neurons

scientific article (publication date: 22 April 1988)

Ammonia inhibits long-term potentiation via neurosteroid synthesis in hippocampal pyramidal neurons ⬇️

scientific article published on December 29, 2012

Ammonia-mediated LTP inhibition: effects of NMDA receptor antagonists and L-carnitine

scientific article published in June 2005

An Integrative Model of Personality Disorder: Part 3: Mechanism-Based Approach to the Pharmacotherapy of Personality Disorder: An Emerging Concept

scientific article published on 01 September 2019

An ex vivo rat retinal preparation for excitotoxicity studies

scientific article published in August 1995

Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light.

scientific article published on 25 February 2007

Arachidonic acid rescues hippocampal long-term potentiation blocked by group I metabotropic glutamate receptor antagonists

scientific article published on 01 January 2000

Assessment of Synaptic Effects of Nitric Oxide in Hippocampal Neurons

Astrocytes exert a pro-apoptotic effect on neurons in postnatal hippocampal cultures

scientific article published on January 2005

Asystole in ECT

scientific article published on 01 July 1994

Basal levels of adenosine modulate mGluR5 on rat hippocampal astrocytes.

scientific article

Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor

scientific article

Blockade of desensitization augments quisqualate excitotoxicity in hippocampal neurons

scientific article published in July 1990

Blockade of ionotropic quisqualate receptor desensitization by wheat germ agglutinin in cultured postnatal rat hippocampal neurons ⬇️

scientific article published on December 1, 1992

Blockade of ionotropic quisqualate receptor desensitization in rat hippocampal neurons by wheatgerm agglutinin and other lectins ⬇️

scientific article published on January 1, 1993

Brain stimulation & the treatment of refractory psychiatric disorders.

scientific article published in January 2008

Ca(v)3.2 channel is a molecular substrate for inhibition of T-type calcium currents in rat sensory neurons by nitrous oxide

scientific article

Calcium influx through N-methyl-D-aspartate channels activates a potassium current in postnatal rat hippocampal neurons

scientific article published on 01 May 1989

Calcium-dependent, slow desensitization distinguishes different types of glutamate receptors.

scientific article

Cardiac safety of ECT

scientific article published on 01 December 1993

Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes

scientific article

Characterization of quisqualate receptor desensitization in cultured postnatal rat hippocampal neurons

scientific article published on November 1991

Chemogenetic Isolation Reveals Synaptic Contribution of δ GABA Receptors in Mouse Dentate Granule Neurons

scientific article published on 03 August 2018

Choreoathetosis associated with lithium: case report and literature review

scientific article published on December 1983

Chronic Pain and Tricyclic Antidepressants

scientific article published on 01 March 1981

Chronic pain. A pharmacologic review and behavior modification approach

scientific article published on May 1983

Clinical and neurobiologic implications of antipsychotic-induced movement disorders

scientific article published on 01 October 1986

Combined use of labetalol and nifedipine in controlling the cardiovascular response from ECT

scientific article published on 01 January 1993

Comparison of rat retinal fixation techniques: chemical fixation and microwave irradiation

scientific article published on 01 February 2000

Complex responses activated by ibotenate in postnatal rat hippocampal neurons

scientific article

Components of glial responses to exogenous and synaptic glutamate in rat hippocampal microcultures

scientific article published on 01 January 1996

Computer automated versus visually determined electroencephalographic and electromyographic seizure duration.

scientific article published in June 1994

Concanavalin a enhances excitatory synaptic transmission in cultured rat hippocampal neurons ⬇️

scientific article published on January 1, 1993

Concurrent and Close Temporal Administration of Lithium and ECT.

scientific article

Contribution of presynaptic Na(+) channel inactivation to paired-pulse synaptic depression in cultured hippocampal neurons

scientific article

Contributions of space-clamp errors to apparent time-dependent loss of Mg2+ block induced by NMDA.

scientific article published on 29 March 2017

Convulsant gamma-butyrolactones block GABA currents in cultured chick spinal cord neurons

scientific article published on 01 April 1989

Corticosterone enhances the potency of ethanol against hippocampal long-term potentiation via local neurosteroid synthesis

scientific article published on 3 July 2015

Cross talk between synaptic receptors mediates NMDA-induced suppression of inhibition.

scientific article

Cyclodextrins sequester neuroactive steroids and differentiate mechanisms that rate limit steroid actions

scientific article

Developmental changes in long-term potentiation in CA1 of rat hippocampal slices

scientific article published in May 1995

Developmental changes in the effects of metabotropic glutamate receptor antagonists on CA1 long-term potentiation in rat hippocampal slices

scientific article published in July 1994

Different actions of a short-acting barbiturate on sodium and potassium conductances in invertebrate and vertebrate neurons

scientific article published in February 1989

Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.

scientific article

Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system

scientific article

Direct cortical inputs erase long-term potentiation at Schaffer collateral synapses

scientific article published on September 2008

Dissection method affects electrophysiological properties of hippocampal slices

scientific article published on 01 December 2017

Diverse voltage-sensitive dyes modulate GABAA receptor function

scientific article

Domoic acid: a dementia-inducing excitotoxic food poison with kainic acid receptor specificity

scientific article published in October 1990

Dopamine deficiency underlies learning deficits in neurofibromatosis‐1 mice ⬇️

scientific article published on December 7, 2012

Downregulation of glutamine synthetase via GLAST suppression induces retinal axonal swelling in a rat ex vivo hydrostatic pressure model

scientific article

ECT in primary and secondary depression

scientific article published in June 1986

ECT-induced delirium in depressed patients with Parkinson's disease ⬇️

scientific article published on 01 January 1991

ECT-induced interictal delirium in patients with a history of a CVA

scientific article published on July 1, 1992

ECT: Clinical Variables, Seizure Duration, and Outcome

scientific article published on 01 January 1986

Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits

scientific article

Effect of electrical parameters on ECT convulsive threshold and duration

scientific article

Effect of nitrous oxide on excitatory and inhibitory synaptic transmission in hippocampal cultures

scientific article

Effects of CYP46A1 Inhibition on Long-Term-Depression in Hippocampal Slices ex vivo and 24S-Hydroxycholesterol Levels in Mice in vivo

scientific article published on 29 October 2020

Effects of Isoflurane on N-Methyl-D-Aspartate Gated Ion Channels in Cultured Rat Hippocampal Neurons ⬇️

scientific article published on January 1, 1991

Effects of a benz[e]indene on gamma-aminobutyric acid-gated chloride currents in cultured postnatal rat hippocampal neurons ⬇️

scientific article published on December 1, 1992

Effects of acutely elevated hydrostatic pressure in a rat ex vivo retinal preparation ⬇️

scientific article

Effects of ascorbic acid on UV light-mediated photoreceptor damage in isolated rat retina

scientific article published on 12 January 2007

Effects of bromowillardiine and willardiine on non-N-methyl-D-aspartate receptors in postnatal rat hippocampal neurons ⬇️

scientific article published on July 1, 1991

Effects of fructose-1,6-bisphosphate on morphological and functional neuronal integrity in rat hippocampal slices during energy deprivation

scientific article

Effects of insulin on long-term potentiation in hippocampal slices from diabetic rats

scientific article

Effects of lactate and pyruvate on glucose deprivation in rat hippocampal slices.

scientific article

Effects of medazepam on voltage-gated ion currents of cultured chick sensory neurons

scientific article published on 01 November 1987

Effects of neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one on ethanol-mediated paired-pulse depression of population spikes in the CA1 region of rat hippocampal slices

scientific article published on 27 December 2005

Effects of neurosteroid and benz[e]indene enantiomers on GABAA receptors in cultured hippocampal neurons and transfected HEK-293 cells

scientific article

Effects on gamma-aminobutyric acid (GABA)(A) receptors of a neuroactive steroid that negatively modulates glutamate neurotransmission and augments GABA neurotransmission

scientific article published in October 2001

Effects on membrane capacitance of steroids with antagonist properties at GABAA receptors

scientific article published on 13 March 2008

Electroconvulsive Therapy in Patients with Cerebral Palsy

scientific article published on 01 January 1993

Electroconvulsive therapy and the elderly

scientific article published in September 1985

Electroconvulsive therapy for the elderly: a review

scientific article published on June 1988

Electroconvulsive therapy in patients taking theophylline

scientific article published on 01 November 1993

Electroconvulsive therapy in patients with late-onset psychoses and structural brain changes

scientific article published in January 1991

Electrophysiological properties of identified postnatal rat hippocampal pyramidal neurons in primary culture

scientific article published in January 1993

Elevated potassium shortens action potential duration by altering outward currents in chick dorsal root ganglia neurons

scientific article published in June 1990

Enantioselective Blockade of T-type Ca2+ Current in Adult Rat Sensory Neurons by a Steroid That Lacks γ-Aminobutyric Acid-Modulatory Activity ⬇️

scientific article published on November 1, 1998

Enantioselective modulation of GABAergic synaptic transmission by steroids and benz[e]indenes in hippocampal microcultures

scientific article published in June 1998

Enantioselectivity of pregnanolone-induced gamma-aminobutyric acid(A) receptor modulation and anesthesia

scientific article published in June 2000

Enantioselectivity of steroid-induced gamma-aminobutyric acidA receptor modulation and anesthesia.

scientific article

Endogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices

scientific article published on 23 December 2015

Endogenous Monocarboxylates Sustain Hippocampal Synaptic Function and Morphological Integrity during Energy Deprivation ⬇️

scientific article published on December 15, 1997

Endogenous subunits can cause ambiguities in the pharmacology of exogenous gamma-aminobutyric acidA receptors expressed in human embryonic kidney 293 cells

scientific article published on October 1996

Enhancement of hippocampal excitatory synaptic transmission by platelet-activating factor

scientific article published on December 1, 1992

Ethanol Enhances Neurosteroidogenesis in Hippocampal Pyramidal Neurons by Paradoxical NMDA Receptor Activation ⬇️

scientific article published on July 6, 2011

Ethanol-induced death of postnatal hippocampal neurons

scientific article published in August 2002

Excitotoxic neuronal damage and neuropsychiatric disorders

scientific article

Excitotoxicity of L-dopa and 6-OH-dopa: implications for Parkinson's and Huntington's diseases

scientific article published in June 1990

Excitotoxicity triggered by Neurobasal culture medium

scientific article

Experimentally Induced Mammalian Models of Glaucoma

scientific article

Exploring Nitrous Oxide as Treatment of Mood Disorders: Basic Concepts

scientific article published on 23 January 2018

Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function

scientific article published on April 2014

Expression of fructose sensitive glucose transporter in the brains of fructose-fed rats

scientific article published on 3 April 2006

Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial

scientific article published on 12 November 2020

Functional mapping of limbic seizures originating in the hippocampus: a combined 2-deoxyglucose and electrophysiologic study

scientific article published in December 1985

Functional network dysfunction in anxiety and anxiety disorders

scientific article (publication date: September 2012)

Functional reduction of SK3-mediated currents precedes AMPA-receptor-mediated excitotoxicity in dopaminergic neurons.

scientific article

GABA and Endocannabinoids Mediate Depotentiation of Schaffer Collateral Synapses Induced by Stimulation of Temperoammonic Inputs

scientific article published on 10 February 2016

GABAergic neurosteroids mediate the effects of ethanol on long-term potentiation in rat hippocampal slices

scientific article published on 20 September 2007

Glial contributions to excitatory neurotransmission in cultured hippocampal cells

scientific article

Glial-neuronal interactions underlying fructose utilization in rat hippocampal slices

scientific article published on 09 April 2009

Glutamate transporters and retinal excitotoxicity

scientific article

Glycine antagonists block the induction of long-term potentiation in CA1 of rat hippocampal slices

scientific article published on May 1990

High-sensitivity Cardiac Troponin Elevation after Electroconvulsive Therapy: A Prospective, Observational Cohort Study.

scientific article published on 6 February 2017

Hippocampal slice preparation in rats acutely suppresses immunoreactivity of microtubule-associated protein (Map2) and glycogen levels without affecting numbers of glia or levels of the glutamate transporter VGlut1

scientific article

Homeostatic effects of depolarization on Ca2+ influx, synaptic signaling, and survival.

scientific article published on March 2003

Hydrophobic anions potently and uncompetitively antagonize GABAA receptor function in the absence of a conventional binding site ⬇️

scientific article published on September 1, 2011

Indistinguishable synaptic pharmacodynamics of the N-methyl-D-aspartate receptor channel blockers memantine and ketamine

scientific article published on 07 October 2013

Inhibition of long-term potentiation by NMDA-mediated nitric oxide release

scientific article published on August 28, 1992

Inhibitors of cellular stress overcome acute effects of ethanol on hippocampal plasticity and learning

scientific article published on 22 April 2020

Insights into the structure and function of GABA-benzodiazepine receptors: ion channels and psychiatry ⬇️

scientific article published on February 1, 1991

Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel.

scientific article

Intracellular mGluR5 can mediate synaptic plasticity in the hippocampus

scientific article published on March 2014

Involvement of glutamate in ischemic neurodegeneration in isolated retina

scientific article published in March 2003

Involvement of illumination in indocyanine green toxicity after its washout in the ex vivo rat retina

scientific article published on March 2009

Involvement of nitric oxide in low glucose-mediated inhibition of hippocampal long-term potentiation

scientific article published in March 1997

JAMA Psychiatry: Best of 2019

scientific article published on 02 January 2020

Ketamine and MK-801 prevent degeneration of thalamic neurons induced by focal cortical seizures

scientific article published in September 1989

Ketamine and nitrous oxide: The evolution of NMDA receptor antagonists as antidepressant agents

scientific article published on 19 March 2020

Ketamine anesthesia in electroconvulsive therapy

scientific article

Ketamine, phencyclidine, and MK-801 protect against kainic acid-induced seizure-related brain damage

scientific article published in July 1990

Ketamine: NMDA Receptors and Beyond.

scientific article

Kindling with rapidly recurring hippocampal seizures

scientific article published on December 1985

Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids.

scientific article

L-cysteine, a bicarbonate-sensitive endogenous excitotoxin

scientific article published in May 1990

LTP in CA1 of the adult rat hippocampus and voltage-activated calcium channels

scientific article published in November 1998

Lack of Neurosteroid Selectivity at δ vs. γ2-Containing GABAA Receptors in Dentate Granule Neurons

scientific article published on 23 January 2020

Lactate dehydrogenase release is facilitated by brief sonication of rat hippocampal slices and isolated retinas following acute neuronal damage

scientific article published in July 2001

Limbic seizures, kindling, and psychosis: a link between neurobiology and clinical psychiatry

scientific article published in July 1985

Lithium enhances neuronal muscarinic excitation by presynaptic facilitation

scientific article published on 01 January 1990

Locally-generated Acetaldehyde Contributes to the Effects of Ethanol on Neurosteroids and LTP in the Hippocampus

scientific article published on July 2013

Locally-generated acetaldehyde is involved in ethanol-mediated LTP inhibition in the hippocampus

scientific article published on 24 January 2013

Long-term potentiation during whole-cell recording in rat hippocampal slices

scientific article published in March 1993

Long-term potentiation inhibition by low-level N-methyl-D-aspartate receptor activation involves calcineurin, nitric oxide, and p38 mitogen-activated protein kinase

scientific article published in January 2008

Long-term potentiation requires activation of calcium-independent phospholipase A2

scientific article published on 01 December 1995

Low concentrations of N-methyl-D-aspartate inhibit the induction of long-term potentiation in rat hippocampal slices

scientific article published on March 30, 1992

Low-dose atropine in electroconvulsive therapy

scientific article published in September 1999

Maintenance Electroconvulsive Therapy and Seizure Duration

scientific article published on 01 January 1993

Maintenance electroconvulsive therapy in schizophrenia

scientific article published on 01 May 1994

Mechanisms of neurosteroid interactions with GABA(A) receptors.

scientific article

Metaplastic LTP inhibition after LTD induction in CA1 hippocampal slices involves NMDA Receptor-mediated Neurosteroidogenesis

scientific article published on 24 October 2013

Metaplastic effects of subanesthetic ketamine on CA1 hippocampal function

scientific article published on 13 August 2014

Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis ⬇️

scientific article published on December 15, 2010

Mild chronic perturbation of inhibition severely alters hippocampal function

scientific article published on 11 November 2019

Modulation of GABAA receptor function by benz[e]indenes and phenanthrenes

scientific article

Modulation of LTP induction by NMDA receptor activation and nitric oxide release.

scientific article

Modulation of excitatory synaptic transmission by low concentrations of glutamate in cultured rat hippocampal neurons

scientific article published in July 1996

Modulation of hippocampal long-term potentiation by slow increases in ethanol concentration

scientific article published on 7 March 2007

Modulation of long-term potentiation induction in the hippocampus by N-methyl-D-aspartate-mediated presynaptic inhibition

scientific article

Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate

scientific article

Monocarboxylates (pyruvate and lactate) as alternative energy substrates for the induction of long-term potentiation in rat hippocampal slices ⬇️

scientific article published on August 22, 1997

Motivational disturbances and effects of L-dopa administration in neurofibromatosis-1 model mice.

scientific article

Multiple sclerosis and ECT: possible value of gadolinium-enhanced magnetic resonance scans for identifying high-risk patients ⬇️

scientific article published on January 1, 1992

Müller cell swelling, glutamate uptake, and excitotoxic neurodegeneration in the isolated rat retina

scientific article published on 01 February 1999

NMDA Receptors, mGluR5, and Endocannabinoids are Involved in a Cascade Leading to Hippocampal Long-Term Depression ⬇️

scientific article published on October 12, 2011

NMDA potentiation by visible light in the presence of a fluorescent neurosteroid analogue.

scientific article published on 29 April 2009

NMDA receptors and metaplasticity: Mechanisms and possible roles in neuropsychiatric disorders ⬇️

scientific article published on January 2, 2012

Naloxone and ECT seizure length

scientific article published on 01 March 1997

Nampt is required for long-term depression and the function of GluN2B subunit-containing NMDA receptors

scientific article

Neural activity and survival in the developing nervous system

scientific article

Neuregulin and Dopamine D4 Receptors Contribute Independently to Depotentiation of Schaffer Collateral LTP by Temperoammonic Path Stimulation

scientific article published on July 2017

Neuroexcitatory actions of Tamiflu and its carboxylate metabolite

scientific article published on September 2007

Neuronal expression of the glutamate transporter GLT-1 in hippocampal microcultures.

scientific article published in June 1998

Neuronal platelet-activating factor receptor signal transduction involves a pertussis toxin-sensitive G-protein

scientific article published on 01 May 2000

Neuroprotective agent riluzole potentiates postsynaptic GABA(A) receptor function

scientific article published in February 2002

Neuroprotective effects of pyruvate following NMDA-mediated excitotoxic insults in hippocampal slices

scientific article

Neurosteroid Analogues. 6. The Synthesis and GABAA Receptor Pharmacology of Enantiomers of Dehydroepiandrosterone Sulfate, Pregnenolone Sulfate, and (3α,5β)-3-Hydroxypregnan-20-one Sulfate ⬇️

scientific article published on July 2, 1998

Neurosteroid access to the GABAA receptor

scientific article

Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one

scientific article published in April 2005

Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes

scientific article published in July 2006

Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens

scientific article published on 12 March 2007

Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes

scientific article published on 15 February 2008

Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues.

scientific article published on 15 September 2010

Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of δ(16)-alphaxalone and identification of a δ(17(20)) analogue with potent anesthetic activity

scientific article published on 6 May 2011

Neurosteroid analogues. 17. Inverted binding orientations of androsterone enantiomers at the steroid potentiation site on γ-aminobutyric acid type A receptors

scientific article published on 18 January 2012

Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone.

scientific article

Neurosteroid analogues. 3. The synthesis and electrophysiological evaluation of benz[e]indene congeners of neuroactive steroids having the 5 beta-configuration

scientific article published in October 1995

Neurosteroid analogues. 4. The effect of methyl substitution at the C-5 and C-10 positions of neurosteroids on electrophysiological activity at GABAA receptors

scientific article published in October 1996

Neurosteroid analogues. 8. Structure-activity studies of N-acylated 17a-aza-D-homosteroid analogues of the anesthetic steroids (3alpha, 5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one

scientific article

Neurosteroid analogues. 9. Conformationally constrained pregnanes: structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one

scientific article published on December 2003

Neurosteroid analogues: structure-activity studies of benz[e]indene modulators of GABAA receptor function. 1. The effect of 6-methyl substitution on the electrophysiological activity of 7-substituted benz[e]indene-3-carbonitriles

scientific article published on 01 November 1993

Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation

scientific article published on 30 August 2007

Neurosteroids and oxysterols as potential therapeutic agents for glaucoma and Alzheimer's disease

scientific article published on 01 January 2018

Neurosteroids are endogenous neuroprotectants in an ex vivo glaucoma model.

scientific article

Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond

scientific article published on 27 September 2019

Neurosteroids as therapeutic leads in psychiatry

scientific article

Neurosteroids, stress and depression: potential therapeutic opportunities.

scientific article published on 17 October 2012

Neurotoxic effects of sodium nitroprusside in rat hippocampal slices

scientific article

New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids

scientific article

Nicotinic acetylcholine currents in cultured postnatal rat hippocampal neurons ⬇️

scientific article published on May 1, 1992

Nitric oxide and hippocampal synaptic plasticity ⬇️

scientific article published on September 1, 1993

Nitric oxide and long-term synaptic depression in the rat hippocampus

scientific article published on 01 September 1993

Nitric oxide inhibitors attenuate N-methyl-D-aspartate excitotoxicity in rat hippocampal slices

scientific article published in February 1992

Nitric oxide inhibitors attenuate ischemic degeneration in the CA1 region of rat hippocampal slices

scientific article published on 01 June 1996

Nitric oxide inhibitors facilitate the induction of hippocampal long-term potentiation by modulating NMDA responses ⬇️

scientific article published on September 1, 1993

Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial

scientific article

Nitrous oxide (laughing gas) facilitates excitability in rat hippocampal slices through gamma-aminobutyric acid A receptor-mediated disinhibition

scientific article published in January 2005

Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin ⬇️

scientific article published on April 1, 1998

Non-competitive inhibition of GABA currents by phenothiazines in cultured chick spinal cord and rat hippocampal neurons.

scientific article

Noncompetitive, voltage-dependent NMDA receptor antagonism by hydrophobic anions

scientific article published on 9 November 2012

Noradrenergic Regulation of Synaptic Plasticity in the Hippocampal CA1 Region ⬇️

scientific article published on June 1, 1997

Norepinephrine promotes long-term potentiation in the adult rat hippocampus in vitro

scientific article published in March 1999

Norepinephrine reverses N-methyl-D-aspartate-mediated inhibition of long-term potentiation in rat hippocampal slices

scientific article published in August 1992

Novel Antidepressants and Maintenance Electroconvulsive Therapy: A Review

article

Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum

scientific article published on 28 February 2019

Overlapping symptoms of geriatric depression and Alzheimer-type dementia

scientific article published on October 1988

Oxygen Deprivation Produces Delayed Inhibition of Long-Term Potentiation by Activation of NMDA Receptors and Nitric Oxide Synthase ⬇️

scientific article published on January 1, 1998

Paired-pulse modulation of fast excitatory synaptic currents in microcultures of rat hippocampal neurons

scientific article published on 01 October 1995

Partial cDNA cloning and NGF regulation of a rat 5-HT3 receptor subunit

scientific article published on 01 November 1993

Passive and synaptic properties of hippocampal neurons grown in microcultures and in mass cultures

scientific article published on 01 January 1995

Perspective: Upcoming paradigm shifts for psychiatry in clinical care, research, and education

scientific article published on March 2012

Pharmacological and physiological properties of a putative ganglionic nicotinic receptor, alpha 3 beta 4, expressed in transfected eucaryotic cells.

scientific article

Phosphatidylinositol 4,5-bisphosphate depletion fails to affect neurosteroid modulation of GABAA receptor function.

scientific article published on 20 February 2014

Photodynamic effects of steroid-conjugated fluorophores on GABAA receptors

scientific article published on 13 July 2009

Platelet-activating factor as a potential retrograde messenger

scientific article

Platelet-activating factor as a potential retrograde messenger in CA1 hippocampal long-term potentiation

scientific article

Positive allosteric modulation as a potential therapeutic strategy in anti-NMDA receptor encephalitis.

scientific article published on 23 February 2018

Possible impact of stimulus duration on seizure threshold in ECT.

scientific article published in June 1994

Postsynaptic modulation of NMDA synaptic currents in rat hippocampal microcultures by paired-pulse stimulation

scientific article published on January 1996

Potential clinical uses of neuroactive steroids

scientific article

Potential clinical uses of neuroactive steroids

scientific article published on 01 September 2000

Pregnenolone sulfate and dehydroepiandrosterone sulfate inhibit GABA-gated chloride currents in Xenopus oocytes expressing picrotoxin-insensitive GABA(A) receptors

scientific article published in February 1999

Pregnenolone sulfate modulates inhibitory synaptic transmission by enhancing GABA(A) receptor desensitization

scientific article published on 01 May 2000

Presynaptic influence on the time course of fast excitatory synaptic currents in cultured hippocampal cells

scientific article published on 01 April 1995

Properties of vertebrate glutamate receptors: calcium mobilization and desensitization

scientific article published on September 1, 1992

Propofol inhibits long-term potentiation but not long-term depression in rat hippocampal slices

scientific article published in August 2005

Prospective uses of ECT in the presence of intracranial tumors ⬇️

scientific article published on 01 January 1991

Psychiatric Education in an Era of Rapidly Occurring Scientific Advances ⬇️

scientific article published on April 1, 2003

Psychiatric correlates of chronic solvent abuse

scientific article published in August 1987

Psychopharmacologic and behavioral approaches to chronic arthritic pain

scientific article published on 01 August 1984

Quantification of bursting and synchrony in cultured hippocampal neurons

scientific article

Rapid desensitization of glutamate receptors in vertebrate central neurons

scientific article

Rapid desensitization of glutamate receptors in vertebrate central neurons

scientific article published on 01 June 1988

Recent developments in structure–activity relationships for steroid modulators of GABAA receptors

article

Redox modulation of T-type calcium channels in rat peripheral nociceptors

scientific article

Removal of extracellular calcium after conditioning stimulation disrupts long-term potentiation in the CA1 region of rat hippocampal slices

scientific article published in February 1997

Rich research tradition drives psychiatry at Wash U

scientific article published on 01 January 2008

Risk architecture of schizophrenia: the role of epigenetics

scientific article

Role of ammonia in reversal of glutamate-mediated Müller cell swelling in the rat retina

scientific article

Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors

scientific article

Sensitivity of N-methyl-D-aspartate receptor-mediated excitatory postsynaptic potentials and synaptic plasticity to TCN 201 and TCN 213 in rat hippocampal slices

scientific article

Sex Differences in the Role of CNIH3 on Spatial Memory and Synaptic Plasticity

article by Hannah E. Frye et al published July 2021 in Biological Psychiatry

Short-term environmental enrichment enhances synaptic plasticity in hippocampal slices from aged rats

scientific article published on 18 May 2016

Simultaneous major depression and panic disorder: treatment with electroconvulsive therapy

scientific article published on 01 January 1992

Slow actions of neuroactive steroids at GABAA receptors.

scientific article

Slow death of postnatal hippocampal neurons by GABA(A) receptor overactivation

scientific article published on 01 May 2000

Steroid inhibition of rat neuronal nicotinic alpha4beta2 receptors expressed in HEK 293 cells.

scientific article published in August 2000

Steroid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats.

scientific article published in December 2001

Structurally diverse amphiphiles exhibit biphasic modulation of GABAA receptors: similarities and differences with neurosteroid actions.

scientific article

Substrate turnover by transporters curtails synaptic glutamate transients

scientific article published in November 1999

Swelling of Müller cells induced by AP3 and glutamate transport substrates in rat retina

scientific article published on 01 August 1996

TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model

scientific article

Temperoammonic Stimulation Depotentiates Schaffer Collateral LTP via p38 MAPK Downstream of Adenosine A1 Receptors

scientific article published on 08 January 2019

The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-D-Aspartate Receptors

scientific article (publication date: 30 October 2013)

The activation of phospholipase A2 and release of arachidonic acid and other lipid mediators at the synapse: the role of platelet-activating factor.

scientific article published in March 1993

The effect of agonist concentration, membrane voltage and calcium on N-methyl-D-aspartate receptor desensitization

scientific article published in January 1990

The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures

scientific article published on December 1987

The immediate early gene early growth response gene 3 mediates adaptation to stress and novelty.

scientific article

The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction

scientific article published on 24 June 2009

The influence of the membrane on neurosteroid actions at GABA(A) receptors.

scientific article published on December 2009

The nature and time course of cognitive side effects during electroconvulsive therapy in the elderly

scientific article published in April 1993

The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABAA receptors in rat glaucoma models

scientific article published on 27 February 2020

The relevance of developmental and genetic studies in animals to the neurobiology of psychiatric disorders.

scientific article published on January 1988

The role of T-type calcium channels in the subiculum: to burst or not to burst?

scientific article

The safety of ECT in geriatric psychiatry

scientific article published on 01 June 1987

The sticky issue of neurosteroids and GABA(A) receptors

scientific article

Treatment choices when options appear plentiful

scientific article published on 01 December 2006

Treatment-Resistant Major Depression: Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy

scientific article

Trial of SAGE-217 in Patients with Major Depressive Disorder

scientific article published on 01 September 2019

Trial of SAGE-217 in Patients with Major Depressive Disorder. Reply

scientific article published on 01 November 2019

Trifluoperazine blocks GABA-gated chloride currents in cultured chick spinal cord neurons.

scientific article published in February 1989

Use of Ketamine in Clinical Practice: A Time for Optimism and Caution

scientific article published in March 2017

Using animal models to evaluate the functional consequences of anesthesia during early neurodevelopment

scientific article published on 14 March 2018

Visualizing pregnenolone sulfate-like modulators of NMDA receptor function reveals intracellular and plasma-membrane localization

scholarly article by Mariangela Chisari et al published January 2019 in Neuropharmacology

Visually determined high-frequency seizure activity.

scientific article published in September 1994

Volatile anesthetics gate a chloride current in postnatal rat hippocampal neurons ⬇️

scientific article published on February 1, 1992

Wheat germ agglutinin enhances EPSCs in cultured postnatal rat hippocampal neurons by blocking ionotropic quisqualate receptor desensitization ⬇️

scientific article published on December 1, 1992

Zinc modulates bidirectional hippocampal plasticity by effects on NMDA receptors.

scientific article published in July 2006

[43] Measurement of glial transport currents in microcultures: Application to excitatory neurotransmission

article

beta-Hydroxybutyrate fuels synaptic function during development. Histological and physiological evidence in rat hippocampal slices ⬇️

scientific article published on March 1, 1998

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