List of works - James A. Wells

An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

scientific article published on 07 June 2018

Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2

scientific article published on 20 October 2020

Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes

scientific article published on 23 March 2020

Competitive SARS-CoV-2 Serology Reveals Most Antibodies Targeting the Spike Receptor-Binding Domain Compete for ACE2 Binding

scientific article published on 16 September 2020

Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators

article published in the Proceedings of the National Academy of Sciences of the United States of America

Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries

scientific article published on 24 September 2020

Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1

scientific article published on 04 January 2021

Engineered ACE2 receptor traps potently neutralize SARS-CoV-2

scientific article published on 22 October 2020

Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies.

scientific article published on 23 February 2018

Multiomics of azacitidine-treated AML cells reveals variable and convergent targets that remodel the cell-surface proteome

scientific article published on 24 December 2018

National Cancer Institute Think-Tank Meeting Report on Proteomic Cartography and Biomarkers at the Single-Cell Level: Interrogation of Premalignant Lesions

scientific article published on 02 April 2020

New routes for PTP1B allosteric inhibition by multitemperature crystallography, fragment screening and covalent tethering

scholarly article published 13 November 2017

Redox priming promotes Aurora A activation during mitosis

scientific article published on 21 July 2020

Redox-based reagents for chemoselective methionine bioconjugation

scientific article published in February 2017

Subtiligase-Catalyzed Peptide Ligation

scientific article published on 30 October 2019

Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation

scientific article published on 02 March 2020

Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins

scientific article

List of works by James A. Wells