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List of works by Per Johan Klasse

A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure

scientific article

A cluster of continuous antigenic structures in the transmembrane protein of HIV-1: individual patterns of reactivity in human sera.

scientific article published in June 1991

A comparative immunogenicity study in rabbits of disulfide-stabilized, proteolytically cleaved, soluble trimeric human immunodeficiency virus type 1 gp140, trimeric cleavage-defective gp140 and monomeric gp120.

scientific article published on 28 November 2006

A monoclonal antibody to CD4 domain 2 blocks soluble CD4-induced conformational changes in the envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) and HIV-1 infection of CD4+ cells

scientific article

A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene

scientific article

A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies

scientific article

AIDS/HIV. A STEP into darkness or light?

scientific article published on 01 May 2008

ANTI-STLV-IIImac REACTIVITY IN HIV SEROPOSITIVE INDIVIDUALS IN SWEDEN

scientific article published in The Lancet

Altered CD4 interactions of HIV type 1 LAI variants selected for the capacity to induce membrane fusion in the presence of a monoclonal antibody to domain 2 of CD4.

scientific article published on July 1996

An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability

scientific article

An aberrant subclass pattern of HIV-specific immunoglobulin G in sera from haemophiliacs.

scientific article

An immune-selected point mutation in the transmembrane protein of human immunodeficiency virus type 1 (HXB2-Env:Ala 582(-->Thr)) decreases viral neutralization by monoclonal antibodies to the CD4-binding site

scientific article published on September 1993

Analysis of a highly immunodominant epitope in the human immunodeficiency virus type 1 transmembrane glycoprotein, gp41, defined by a human monoclonal antibody ⬇️

scientific article published on September 1, 1990

Animal Models for Microbicide Studies ⬇️

scientific article published on January 1, 2012

Antibodies to SARS-CoV-2 and their potential for therapeutic passive immunization

scientific article published on 23 June 2020

Antibodies to West Nile virus: a double-edged sword

scientific article

Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike

scientific article

Antibodies to a putative HIV gp41 immunosuppressive peptide, pHIVIS (583-599), do not correlate significantly with outcome in HIV infection.

scientific article published on March 1990

Antibody Responses Elicited by Immunization with BG505 Trimer Immune Complexes

scientific article published on 30 September 2019

Antibody neutralization of HIV-1.

scientific article

Antiretroviral drug-based microbicides to prevent HIV-1 sexual transmission

scientific article published on January 2008

Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

scientific article published on 20 February 2013

Binding of inferred germline precursors of broadly neutralizing HIV-1 antibodies to native-like envelope trimers.

scientific article

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface

scientific article

CD4-Chemokine receptor hybrids in human immunodeficiency virus type 1 infection.

scientific article published on September 1999

Cell surface expression of CCR5 and other host factors influence the inhibition of HIV-1 infection of human lymphocytes by CCR5 ligands

scientific article

Chemokine receptor trafficking and viral replication

scientific article

Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation

scientific article published on 21 October 2013

Clinical adjuvant combinations stimulate potent B-cell responses in vitro by activating dermal dendritic cells

scientific article

Closing and opening holes in the glycan shield of HIV-1 envelope glycoprotein SOSIP trimers can redirect the neutralizing antibody response to the newly unmasked epitopes

article

Collusion between neutralizing antibodies and other immune factions in the destruction of adenoviral vectors

article published in the Proceedings of the National Academy of Sciences of the United States of America

Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer

scientific article

Cross-reactivity with SIVmac in east African HIV-1-positive sera: evidence against double infection with HIV-1 and a SIVmac/HIV-2-like virus

scientific article

Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

scientific article

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

scientific article

Cyclophilins unfold the Gag?

scientific article published in Nature

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.

scientific article published on 28 August 2017

Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens

scientific article

Differential IgG subclass responses to epitopes in transmembrane protein of HIV-1.

scientific article published in January 1990

Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits

scientific article

Differential regulation of CXCR4 and CCR5 endocytosis

scientific article published on September 1998

Differential regulation of the antibody responses to Gag and Env proteins of human immunodeficiency virus type 1

scientific article published in April 1997

Dominant-negative effect of hetero-oligomerization on the function of the human immunodeficiency virus type 1 envelope glycoprotein complex.

scientific article published on 17 April 2006

Effect of a CCR5 inhibitor on viral loads in macaques dual-infected with R5 and X4 primate immunodeficiency viruses

scientific article published in October 2004

Effects of Adjuvants on HIV-1 Envelope Glycoprotein SOSIP Trimers In Vitro.

scientific article

Effects of sequence changes in the HIV-1 gp41 fusion peptide on CCR5 inhibitor resistance ⬇️

scientific article published on April 19, 2012

Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

scientific article published on 19 September 2019

Entry Inhibitors SCH-C, RANTES, and T-20 Block HIV Type 1 Replication in Multiple Cell Types ⬇️

scientific article published on March 1, 2003

Entry inhibitor-based microbicides are active in vitro against HIV-1 isolates from multiple genetic subtypes

scientific article published on 10 April 2007

Env Exceptionalism: Why Are HIV-1 Env Glycoproteins Atypical Immunogens?

scientific article published on 01 April 2020

Env-glycoprotein heterogeneity as a source of apparent synergy and enhanced cooperativity in inhibition of HIV-1 infection by neutralizing antibodies and entry inhibitors ⬇️

scientific article published on October 22, 2011

Enzymatic removal of mannose moieties can increase the immune response to HIV-1 gp120 in vivo

scientific article published on 02 May 2009

Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques.

scientific article published on 23 February 2018

Good CoP, bad CoP? Interrogating the immune responses to primate lentiviral vaccines ⬇️

scientific article published on October 1, 2012

HIV-1 Escape from a Peptidic Anchor Inhibitor through Stabilization of the Envelope Glycoprotein Spike

scientific article

HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers

scientific article

HIV-1 envelope triggers polyclonal Ig class switch recombination through a CD40-independent mechanism involving BAFF and C-type lectin receptors

scientific article

HIV-1 gp120 impairs the induction of B cell responses by TLR9-activated plasmacytoid dendritic cells

scientific article

HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells

scientific article

HIV-1 neutralization directed to epitopes other than linear V3 determinants ⬇️

scientific article published on January 1, 1991

HIV-1 pathogenesis: the complexities of the CCR5-CCL3L1 complex

scientific article

HIV-1-neutralizing antibody induced by simian adenovirus- and poxvirus MVA-vectored BG505 native-like envelope trimers

scientific article published on 9 August 2017

High-Throughput Protein Engineering Improves the Antigenicity and Stability of Soluble HIV-1 Envelope Glycoprotein SOSIP Trimers

scientific article published on 6 September 2017

How can HIV-type-1-Env immunogenicity be improved to facilitate antibody-based vaccine development?

scientific article published on 20 May 2011

How do viral and host factors modulate the sexual transmission of HIV? Can transmission be blocked?

scientific article

How to assess the binding strength of antibodies elicited by vaccination against HIV and other viruses

scientific article

Human T-cell leukemia virus type 1 envelope glycoprotein gp46 interacts with cell surface heparan sulfate proteoglycans

scientific article

Human and murine monoclonal antibodies directed against a conserved sequence from gp41 (aa583-599) of human immunodeficiency virus type 1.

scientific article published on May 1992

Human immunodeficiency virus type 1 attachment, coreceptor, and fusion inhibitors are active against both direct and trans infection of primary cells

scientific article

IgG subclass profiles in infected HIV type 1 controllers and chronic progressors and in uninfected recipients of Env vaccines

scientific article

Immunogenicity in rabbits of SOSIP trimers from clades A, B and C, given individually, sequentially or in combinations

scientific article published on 24 January 2018

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

scientific article

Improving the Expression and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers by Targeted Sequence Changes.

scientific article

Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization

scientific article

Independent evolution of Fc- and Fab-mediated HIV-1-specific antiviral antibody activity following acute infection

scientific article published on 11 August 2014

Inefficient entry of vicriviroc-resistant HIV-1 via the inhibitor-CCR5 complex at low cell surface CCR5 densities

scientific article published on 20 March 2009

Influences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers

scientific article published on 26 August 2015

Influences on trimerization and aggregation of soluble, cleaved HIV-1 SOSIP envelope glycoprotein

scientific article published on 03 July 2013

Inhibition of virus attachment to CD4+ target cells is a major mechanism of T cell line-adapted HIV-1 neutralization

scientific article

Interactions among HIV gp120, CD4, and CXCR4: dependence on CD4 expression level, gp120 viral origin, conservation of the gp120 COOH- and NH2-termini and V1/V2 and V3 loops, and sensitivity to neutralizing antibodies.

scientific article published on September 1998

Is there enough gp120 in the body fluids of HIV-1-infected individuals to have biologically significant effects?

scientific article published on May 2004

Kinetics of the HIV-CD4 interactions and virus-cell fusion

scientific article published on March 1, 1992

Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody ⬇️

scientific article published on June 20, 2011

Macaque studies of vaccine and microbicide combinations for preventing HIV-1 sexual transmission

scientific article

Mechanisms of enveloped virus entry into animal cells

scientific article

Mechanisms of virus neutralization by antibody

scientific article

Modeling how many envelope glycoprotein trimers per virion participate in human immunodeficiency virus infectivity and its neutralization by antibody

scientific article published on 7 September 2007

Molecular determinants of the ratio of inert to infectious virus particles

scientific article

Multiple CCR5 conformations on the cell surface are used differentially by human immunodeficiency viruses resistant or sensitive to CCR5 inhibitors.

scientific article published on 15 June 2011

Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity

scientific article

Mutations in the vpu, env, and nef genes of a syncytium-inducing variant of HIV type 1 JR-CSF that infects a range of T cell lines

scientific article published on March 1996

N-terminal substitutions in HIV-1 gp41 reduce the expression of non-trimeric envelope glycoproteins on the virus

scientific article published on 26 November 2007

Neutralization of Human Immunodeficiency Virus Type 1 by Antibody to gp120 Is Determined Primarily by Occupancy of Sites on the Virion Irrespective of Epitope Specificity ⬇️

scientific article published on May 1, 1998

Neutralization of Virus Infectivity by Antibodies: Old Problems in New Perspectives

scientific article published on 9 September 2014

Neutralizing Antibody Induction by HIV-1 Envelope Glycoprotein SOSIP Trimers on Iron Oxide Nanoparticles May Be Impaired by Mannose Binding Lectin

scientific article published on 28 February 2020

Neutralizing antibody responses induced by HIV-1 envelope glycoprotein SOSIP trimers derived from elite neutralizers

scientific article published on 30 September 2020

Non-aqueous silicone elastomer gels as a vaginal microbicide delivery system for the HIV-1 entry inhibitor maraviroc.

scientific article published on 12 August 2011

Non-cognate ligands of Procrustean paratopes as potential vaccine components

scientific article published on 01 September 2019

Occluding the mannose moieties on human immunodeficiency virus type 1 gp120 with griffithsin improves the antibody responses to both proteins in mice.

scientific article published on 27 July 2011

Occupancy and mechanism in antibody-mediated neutralization of animal viruses

scientific article

Optimizing the production and affinity purification of HIV-1 envelope glycoprotein SOSIP trimers from transiently transfected CHO cells

article

Partial protection against multiple RT-SHIV162P3 vaginal challenge of rhesus macaques by a silicone elastomer vaginal ring releasing the NNRTI MC1220 ⬇️

scientific article published on October 28, 2012

Partial protection against multiple RT-SHIV162P3 vaginal challenge of rhesus macaques by a silicone elastomer vaginal ring releasing the NNRTI MC1220.

scientific article published on 15 March 2013

Pharmacokinetics and efficacy of a vaginally administered maraviroc gel in rhesus macaques ⬇️

scientific article published on October 30, 2012

Pharmacokinetics of a CCR5 inhibitor in rhesus macaques following vaginal, rectal and oral application

scientific article published on 30 December 2013

Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4.

scientific article

Potent Induction of Antibody-Secreting B Cells by Human Dermal-Derived CD14+ Dendritic Cells Triggered by Dual TLR Ligation ⬇️

scientific article published on November 16, 2012

Potent induction of antibody-secreting B-cells by human dermal-derived CD14+ dendritic cells triggered by dual toll-like receptor ligation

scientific article published on 13 September 2012

Predicting first traversal times for virions and nanoparticles in mucus with slowed diffusion

scientific article

Presence of antibodies to a putatively immunosuppressive part of human immunodeficiency virus (HIV) envelope glycoprotein gp41 is strongly associated with health among HIV-positive subjects

scientific article

Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120.

scientific article published on 10 February 2003

Promiscuous use of CC and CXC chemokine receptors in cell-to-cell fusion mediated by a human immunodeficiency virus type 2 envelope protein.

scientific article published in November 1997

Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor

scientific article published on 6 November 2005

Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion

scientific article

Protection of rhesus macaques from vaginal infection by vaginally delivered maraviroc, an inhibitor of HIV-1 entry via the CCR5 co-receptor

scientific article

Quantification of immunoglobulin on electrophoretic immunoblot strips as a tool for human immunodeficiency virus serodiagnosis.

scientific article published on January 1988

Quantitative Correlation between Infectivity and Gp120 Density on HIV-1 Virions Revealed by Optical Trapping Virometry

scientific article published on 25 April 2016

Quantitative correlation between infectivity and Gp120 density on HIV-1 virions revealed by optical trapping virometry

scientific article published on February 2017

Quantitative model of antibody- and soluble CD4-mediated neutralization of primary isolates and T-cell line-adapted strains of human immunodeficiency virus type 1.

scientific article published on June 1996

Rat monoclonal antibodies to nonoverlapping epitopes of human immunodeficiency virus type 1 gp120 block CD4 binding in Vitro ⬇️

scientific article published on November 1, 1991

Recognition of HIV-inactivating peptide triazoles by the recombinant soluble Env trimer, BG505 SOSIP.664.

scientific article published on 05 January 2017

Recombinant gp120, antibodies to the V3 region of gp120, and neural progenitor cells

scientific article published on 01 March 2005

Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers

scientific article

Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41 ⬇️

scientific article published on February 26, 2011

Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41.

scholarly article

SARS-CoV-2 vaccines: 'Warp Speed' needs mind melds not warped minds

scientific article published on 26 June 2020

SHIV-162P3 infection of rhesus macaques given maraviroc gel vaginally does not involve resistant viruses

scientific article (publication date: 2011)

SOS and IP Modifications Predominantly Affect the Yield but Not Other Properties of SOSIP.664 HIV-1 Env Glycoprotein Trimers

scientific article published on 12 December 2019

Seminal analyses of HIV-1 transmission

scientific article published on 07 July 2020

Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C.

scientific article

Short Communication: Virion Aggregation by Neutralizing and Nonneutralizing Antibodies to the HIV-1 Envelope Glycoprotein

scientific article

Soluble CD4 and CD4 immunoglobulin-selected HIV-1 variants: a phenotypic characterization

scientific article published on July 1993

Specific amino acids in the N-terminus of the gp41 ectodomain contribute to the stabilization of a soluble, cleaved gp140 envelope glycoprotein from human immunodeficiency virus type 1.

scientific article published on 7 November 2006

Specificities and sensitivities of three systems for determination of antibodies to human immunodeficiency virus by electrophoretic immunoblotting.

scientific article published on January 1988

Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies

scientific article published on 25 April 2014

Structural and biological mimicry of protein surface recognition by  / -peptide foldamers

scientific article

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

scientific article published on 11 August 2020

Structural biology. A new bundle of prospects for blocking HIV-1 entry

scientific article

Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers

scientific article published on 03 July 2013

Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

scientific article

Sustained release of the CCR5 inhibitors CMPD167 and maraviroc from vaginal rings in rhesus macaques

scientific article

Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens

scientific article published on 04 August 2020

Targeting B-cell germlines and focusing affinity maturation: the next hurdles in HIV-1-vaccine development?

scientific article published on April 2014

Targeting HIV-1 envelope glycoprotein trimers to B cells by using APRIL improves antibody responses

scientific article published on 28 December 2011

Targeting HIV-1 envelope glycoprotein trimers to B cells using APRIL improves antibody responses

scientific article published on 13 September 2012

Testing-on-a-probe biosensors reveal association of early SARS-CoV-2 total antibodies and surrogate neutralizing antibodies with mortality in COVID-19 patients

scientific article published on 22 November 2020

The impact of envelope glycoprotein cleavage on the antigenicity, infectivity, and neutralization sensitivity of Env-pseudotyped human immunodeficiency virus type 1 particles

scientific article published on July 2005

The molecular basis of viral infection. Preface

scientific article published in January 2015

The molecular basis ofHIVentry ⬇️

scientific article published on June 5, 2012

The site of an immune-selected point mutation in the transmembrane protein of human immunodeficiency virus type 1 does not constitute the neutralization epitope

scientific article published on July 1990

Thermodynamic and kinetic analysis of sCD4 binding to HIV-1 virions and of gp120 dissociation

scientific article published on April 1992

Transmitted/founder and chronic HIV-1 envelope proteins are distinguished by differential utilization of CCR5.

scientific article published on 26 December 2012

Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures

scientific article

Tropical spastic paraparesis associated with human T lymphotropic virus type I in an east African naturalised in Sweden

scientific article published on November 1987

Tropism-independent protection of macaques against vaginal transmission of three SHIVs by the HIV-1 fusion inhibitor T-1249.

scholarly article

Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entry

scientific article

Use of G-protein-coupled and -uncoupled CCR5 receptors by CCR5 inhibitor-resistant and -sensitive human immunodeficiency virus type 1 variants.

scientific article published on 6 March 2013

Use of a small molecule CCR5 inhibitor in macaques to treat simian immunodeficiency virus infection or prevent simian-human immunodeficiency virus infection.

scientific article

V3 determinants of HIV-1 escape from the CCR5 inhibitors Maraviroc and Vicriviroc ⬇️

scientific article published on March 16, 2012

V3: HIV's switch-hitter

scientific article

What Do Chaotrope-Based Avidity Assays for Antibodies to HIV-1 Envelope Glycoproteins Measure?

scientific article published on 25 March 2015

Which topical microbicides for blocking HIV-1 transmission will work in the real world?

scientific article published in September 2006

cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV-1 envelope glycoprotein vaccine candidate

scientific article

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