List of works by Darragh Duffy

A Call for Blood-In Human Immunology

scientific article published on 01 June 2019

A Comprehensive Assessment of Demographic, Environmental and Host Genetic Associations with Gut Microbiome Diversity in Healthy Individuals

A child with severe juvenile dermatomyositis treated with ruxolitinib

scientific article published on 01 November 2018

A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals

scientific article published on 13 September 2019

Absence of neuronal autoantibodies in neuropsychiatric systemic lupus erythematosus

scientific article published on 19 September 2020

An in vitro diagnostic certified point of care single nucleotide test for IL28B polymorphisms

scientific article published on 6 September 2017

Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients

scientific article published on 27 May 2020

Anti-MDA5 juvenile idiopathic inflammatory myopathy: a specific subgroup defined by differentially enhanced interferon-α signalling

scientific article published on 22 November 2019

Antibody-coated microbiota in nasopharynx of healthy individuals and IVIg-treated patients with hypogammaglobulinemia

scientific article published on 16 January 2020

Apolipoprotein H expression is associated with IL28B genotype and viral clearance in hepatitis C virus infection

scientific article published on 4 June 2014

Associations between consumption of dietary fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort

scientific article published on 05 May 2020

Associations between untargeted plasma metabolomic signatures and gut microbiota composition in the <i>Milieu Intérieur</i> population of healthy adults

scientific article published on 10 December 2020

Associations between usual diet and gut microbiota composition: results from the Milieu Intérieur cross-sectional study

scientific article published on 01 May 2019

Auto-antibodies against type I IFNs in patients with life-threatening COVID-19

scientific article published on 24 September 2020

Automated flow cytometric analysis across large numbers of samples and cell types

scientific article published on 7 January 2015

Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS

scientific article published on 01 April 2019

Brief Report: Blockade of TANK-Binding Kinase 1/IKKɛ Inhibits Mutant Stimulator of Interferon Genes (STING)-Mediated Inflammatory Responses in Human Peripheral Blood Mononuclear Cells

scientific article published on 20 April 2017

Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients

scientific article published on 14 November 2015

CXCL10 antagonism and plasma sDPPIV correlate with increasing liver disease in chronic HCV genotype 4 infected patients

scientific article

Cardiac valve involvement in ADAR-related type I interferonopathy

scientific article published on 26 November 2019

Catatonia in a patient with Aicardi-Goutières syndrome efficiently treated with immunoadsorption

scientific article published on 19 June 2020

Circulating Interferon-α Measured With a Highly Sensitive Assay as a Biomarker for Juvenile Inflammatory Myositis Activity: Comment on the Article by Mathian et al

scientific article published on 23 November 2019

Comment on: 'Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors' by Giannelou et al: mutations in TRNT1 result in a constitutive activation of type I interferon signalling

scientific article published on 01 June 2018

Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement-A new target for lupus treatment

scientific article published on 10 July 2019

Deconvolution of the Response to Bacillus Calmette-Guérin Reveals NF-κB-Induced Cytokines As Autocrine Mediators of Innate Immunity

scientific article

Decreased Type I Interferon Production by Plasmacytoid Dendritic Cells Contributes to Severe Dengue

scientific article published on 17 December 2020

Detection of interferon alpha protein reveals differential levels and cellular sources in disease.

scientific article published on 18 April 2017

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

scientific article published on 14 June 2018

Development and clinical validation of the Genedrive point-of-care test for qualitative detection of hepatitis C virus

article

Development of a Bead-Based Multiplex Assay for the Analysis of the Serological Response against the Six Pathogens HAV, HBV, HCV, CMV, T. gondii, and H. pylori

scientific article published on 30 October 2017

Differential Expression of Interferon-Alpha Protein Provides Clues to Tissue Specificity Across Type I Interferonopathies

scientific article published on 07 January 2021

Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection

scientific article published on 01 September 2021

Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges

scientific article published on 27 December 2017

Diversity in immunogenomics: the value and the challenge

scientific article

Dynamic Changes of Post-Translationally Modified Forms of CXCL10 and Soluble DPP4 in HCV Subjects Receiving Interferon-Free Therapy

scientific article published on 16 July 2015

Dysregulation of tryptophan catabolism at the host-skin microbiota interface in Hidradenitis Suppurativa

scientific article published on 24 September 2020

Efficacy of JAK1/2 inhibition in the treatment of chilblain lupus due to TREX1 deficiency

scientific article published on 03 October 2018

Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children.

scientific article published on 20 August 2016

Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli

scientific article published on March 2014

Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations

scientific article

Genetic factors and age are the strongest predictors of humoral immune responses to common pathogens and vaccines

article

Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers

scientific article published on 01 January 2021

Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines

article

Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus

scientific article published on 01 September 2018

Identifying the etiology and pathophysiology underlying stunting and environmental enteropathy: study protocol of the AFRIBIOTA project

Immune profiling enables stratification of patients with active TB disease or M. tuberculosis infection

scientific article published on 16 October 2020

Immune response biomarkers in human and veterinary research

scientific article published on 01 August 2018

Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo

scientific article published on 02 December 2020

Impact of IL28B, APOH and ITPA Polymorphisms on Efficacy and Safety of TVR- or BOC-Based Triple Therapy in Treatment-Experienced HCV-1 Patients with Compensated Cirrhosis from the ANRS CO20-CUPIC Study

scientific article published on 15 December 2015

Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients

scientific article published on 23 April 2020

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

scientific article published on 13 July 2020

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

scientific article published on 24 September 2020

Inhibition of DPP4 activity in humans establishes its in vivo role in CXCL10 post-translational modification: prospective placebo-controlled clinical studies

scientific article published on 09 April 2016

Inhibition of IFNα secretion in cells from patients with juvenile dermatomyositis under TBK1 inhibitor treatment revealed by single-molecular assay technology

scientific article published on 30 October 2019

Inhibition of IFNα secretion in cells from patients with juvenile dermatomyositis under TBK1 inhibitor treatment revealed by single-molecular assay technology

scientific article published on 23 January 2020

Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth

scientific article published on 18 February 2019

Innate immune stimulation of whole blood reveals IFN-1 hyper-responsiveness in type 1 diabetes

scientific article published on 05 June 2020

Interleukin-7/Interferon axis drives T-cell and salivary gland epithelial cell interactions in Sjögren's syndrome

scientific article published on 15 October 2020

JAK Inhibition in the Aicardi-Goutières Syndrome

scientific article published on 01 November 2020

JAK inhibitor improves type I interferon induced damage: proof of concept in dermatomyositis

scientific article published on 01 June 2018

Milieu intérieur: Defining the boundaries of a healthy immune response for improved vaccination strategies

scientific article published on 24 July 2018

Mitochondrial double-stranded RNA triggers antiviral signalling in humans

scientific article published in Nature

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling

scientific article published on 01 November 2020

Myogenic Progenitor Cells Exhibit Type I Interferon-Driven Proangiogenic Properties and Molecular Signature During Juvenile Dermatomyositis

scientific article published on 21 September 2017

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

scientific article published on 23 February 2018

Neuromyelitis optica in patients with increased interferon alpha concentrations

scientific article published on 01 January 2020

Overview of STING-associated vasculopathy with onset in infancy (SAVI) among 21 patients

scientific article published on 17 November 2020

PSMB10, the last immunoproteasome gene missing for PRAAS

scientific article published on 26 November 2019

Plasma Type I IFN Protein Concentrations in Human Tuberculosis

scientific article published on 22 August 2019

Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses.

scientific article published on 19 June 2018

Potential utility of the Genedrive point-of-care test for HCV RNA detection

scientific article published on 22 September 2018

Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part one

article

Protein biomarkers discriminate Leishmania major-infected and non-infected individuals in areas endemic for cutaneous leishmaniasis

scientific article

Publisher Correction: Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

scientific article published on 01 June 2018

Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome

scientific article published on 01 December 2018

Semi-automated and standardized cytometric procedures for multi-panel and multi-parametric whole blood immunophenotyping

scientific article published on 06 January 2015

Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2

scientific article published on 01 December 2019

Sex differences in IL-17 contribute to chronicity in male versus female urinary tract infection

scientific article published on 30 May 2019

Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses.

scientific article published on 24 August 2016

Standardized whole blood stimulation improves immunomonitoring of induced immune responses in multi-center study

scientific article

Study of the Humoral Immune Response towards HCV Genotype 4 Using a Bead-Based Multiplex Serological Assay

Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC+ CD4+ cell levels: a surrogate marker candidate of HIV-induced intestinal damage.

scientific article published in July 2018

Systems Biology Methods Applied to Blood and Tissue for a Comprehensive Analysis of Immune Response to Hepatitis B Vaccine in Adults

scientific article published on 04 November 2020

T-cell biomarkers for diagnosis of tuberculosis: candidate evaluation by a simple whole blood assay for clinical translation.

scientific article published on 22 March 2018

The ABCs of viral hepatitis that define biomarker signatures of acute viral hepatitis

scientific article

The Milieu Intérieur study - an integrative approach for study of human immunological variance

scientific article published on 3 January 2015

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

scientific article published on 16 May 2022

Three Copies of Four Interferon Receptor Genes Underlie a Mild Type I Interferonopathy in Down Syndrome

scientific article published on 22 June 2020

Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles

scientific article published on 14 June 2019

Type I interferon-mediated autoinflammation due to DNase II deficiency

scientific article published on 19 December 2017

Ultrasensitive HIV-1 p24 Assay Detects Single Infected Cells and Differences in Reservoir Induction by Latency Reversal Agents

scientific article published on 11 January 2017

Use of ruxolitinib in COPA syndrome manifesting as life-threatening alveolar haemorrhage

scientific article published on 30 October 2019

[Milieu Interieur: defining a healthy immune response for a better understanding of diseases]

scientific article published on 30 April 2019

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