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List of works by Gordon C. Weir

A dominant role for glucose in beta cell compensation of insulin resistance

scientific article published in January 2007

A model for diabetic nephropathy: advantages of the inducible cAMP early repressor transgenic mouse over the streptozotocin-induced diabetic mouse.

scientific article

A preexistent hypoxic gene signature predicts impaired islet graft function and glucose homeostasis

scientific article

A stirred microchamber for oxygen consumption rate measurements with pancreatic islets

scientific article

Adult Progenitor Cells as a Potential Treatment for Diabetes

Adult Progenitor Cells as a Potential Treatment for Diabetes

Adult Progenitor Cells as a Potential Treatment for Diabetes

Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cells

scientific article published on 23 January 2009

Alpha-1 antitrypsin treatment of new-onset type 1 diabetes: An open-label, phase I clinical trial (RETAIN) to assess safety and pharmacokinetics.

scientific article

Beta cell identity changes with mild hyperglycemia: Implications for function, growth, and vulnerability

scientific article published on 14 February 2020

Beta cell replication and mass in islet transplantation

Beta-cell growth and regeneration: replication is only part of the story

scientific article published on October 2010

Beta-cell precursors--a work in progress

scientific article published in September 2004

Birth and death of human β-cells in pancreases from cadaver donors, autopsies, surgical specimens, and islets transplanted into mice

scientific article published on 02 January 2013

Bone marrow or foetal liver cells fail to induce islet regeneration in diabetic Akita mice

scientific article published in October 2008

COMPARISON OF LOCAL VS. SYSTEMIC CTLA4Ig IN THE PROLONGATION OF ISLET XENOGRAFT SURVIVAL

Characterization of Islet Preparations

Corrigendum: Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells

scientific article published on 01 August 2015

Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes

scientific article

Current status of islet cell replacement and regeneration therapy

scientific article

Development and retroviral transduction of porcine neonatal pancreatic islet cells in monolayer culture

scientific article published in February 2003

Differentiation of Affinity-Purified Human Pancreatic Duct Cells to -Cells

scientific article published on 01 May 2007

Direct Reprogramming for Pancreatic Beta-Cells Using Key Developmental Genes

scientific article published on 30 January 2015

Direct lineage conversion of pancreatic exocrine to endocrine Beta cells in vivo with defined factors

scientific article published on January 2014

Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes

scientific article published on 14 March 2007

Dreams for type 1 diabetes: shutting off autoimmunity and stimulating beta-cell regeneration

scientific article published on July 2010

Ductal Origin Hypothesis of Pancreatic Regeneration under Attack

Ductal origin hypothesis of pancreatic regeneration under attack

scientific article published on January 2010

Dynamic development of the pancreas from birth to adulthood

scientific article published on 21 March 2016

Enumeration of islets by nuclei counting and light microscopic analysis

scientific article

Establishment of a diabetic mouse model with progressive diabetic nephropathy

scientific article

Evidence for a Role of the Ubiquitin-Proteasome Pathway in Pancreatic Islets

article

Evidence of stress in β cells obtained with laser capture microdissection from pancreases of brain dead donors

scientific article

Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function

scientific article published on 4 November 2005

Exercise induces hypoglycemia in rats with islet transplantation

scientific article published in February 2004

Experimental islet transplantation

Finally! A human pancreatic β cell line

scientific article

Five stages of evolving beta-cell dysfunction during progression to diabetes

scientific article

GABA Signaling Stimulates β Cell Regeneration in Diabetic Mice

scientific article published on 12 January 2017

GLP-1/exendin-4 facilitates β-cell neogenesis in rat and human pancreatic ducts

scientific article published on 06 January 2006

Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection

scientific article

Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes

scientific article

Genetic disruption of SOD1 gene causes glucose intolerance and impairs β-cell function

scientific article published on 05 September 2013

Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia

scientific article

Glucolipotoxicity, β-Cells, and Diabetes: The Emperor Has No Clothes

scientific article published on 13 September 2019

Glucose Driven Changes in Beta Cell Identity Are Important for Function and Possibly Autoimmune Vulnerability during the Progression of Type 1 Diabetes

scientific article published on 24 January 2017

Human Islet Morphology Revisited: Human and Rodent Islets Are Not So Different After All

scientific article

Hyperglycaemia attenuates in vivo reprogramming of pancreatic exocrine cells to beta cells in mice

scientific article published on 23 December 2015

Importance of hyperglycemia on the primary function of allogeneic islet transplants

scientific article published in August 2003

In vivo imaging of autologous islet grafts in the liver and under the kidney capsule in non-human primates

scientific article published on June 2009

Inadequate β-cell mass is essential for the pathogenesis of type 2 diabetes

scientific article published on 29 January 2020

Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia

scientific article published in February 2002

Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

scientific article published on 29 July 2008

Induced ICER Igamma down-regulates cyclin A expression and cell proliferation in insulin-producing beta cells.

scientific article published on April 2005

Induction of Mad expression leads to augmentation of insulin gene transcription

scientific article published on April 2003

Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation

scientific journal article

Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells

scientific journal article

Insulin-Producing Cells Derived from Embryonic Stem Cells: A Potential Treatment for Diabetes

Insulin-producing Cells Derived from Stem Cells

Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas

scientific article published on February 1987

Involvement of Protein Kinase C β2 in c-mycInduction by High Glucose in Pancreatic β-Cells ⬇️

scientific article published on November 19, 2001

Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression

scientific journal article

Islet Oxygen Consumption Rate (OCR) Dose Predicts Insulin Independence in Clinical Islet Autotransplantation

scientific article published on 10 August 2015

Islet neogenesis: a possible pathway for beta-cell replenishment

scientific article published on 28 December 2012

Islet β cell mass in diabetes and how it relates to function, birth, and death

scientific article published on 30 January 2013

Lack of evidence for recipient precursor cells replenishing β-cells in transplanted islets

scientific article published on 17 August 2010

Laser capture microdissection of human pancreatic beta-cells and RNA preparation for gene expression profiling

scientific article

Long-term normoglycemia in rats receiving transplants with encapsulated islets

scientific article published in January 2005

Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells.

scientific article

MAFA and T3 Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC

scientific article

Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats

scientific article published in May 2003

Making β cells from adult cells within the pancreas

scientific article published on October 2013

Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes

scientific article

Mechanisms of Postnatal β-Cell Mass Regulation

article published in 2001

Myths about the structure and function of porcine islets

NeuroD and reaggregation induce β-cell specific gene expression in cultured hepatocytes

article

New sources of pancreatic beta-cells

scientific article

Normal relationship of beta- and non-beta-cells not needed for successful islet transplantation

scientific article

Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes

scientific article published in June 2002

PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells

scientific article published in July 2003

PDX1 in Ducts Is Not Required for Postnatal Formation of β-Cells but Is Necessary for Their Subsequent Maturation ⬇️

scientific article published on June 17, 2013

PROLONGED XENOGRAFT SURVIVAL OF ISLETS INFECTED WITH SMALL DOSES OF ADENOVIRUS EXPRESSING CTLA4Ig1

Pancreatic duct ligation after almost complete β-cell loss: exocrine regeneration but no evidence of β-cell regeneration

scientific article published on 12 September 2013

Pancreatic somatostatin

scientific article

Pig islet xenograft rejection in a mouse model with an established human immune system

scientific article published in March 2008

Prediction of marginal mass required for successful islet transplantation

scientific article published on February 2010

Protective unfolded protein response in human pancreatic beta cells transplanted into mice

scientific article

Quantitative analysis of cell composition and purity of human pancreatic islet preparations

scientific article published on 9 August 2010

Quantitative assessment of islets of Langerhans encapsulated in alginate

scientific article

Reduced Ki67 Staining in the Postmortem State Calls Into Question Past Conclusions About the Lack of Turnover of Adult Human β-Cells

scientific article published on 8 December 2014

Regulation of Insulin Secretion and Islet Cell Function

Reprogramming Mouse Cells With a Pancreatic Duct Phenotype to Insulin-Producing β-Like Cells

scientific article published on 2 April 2015

SUN-LB059 A Rare Case Of Hypoglycemia Secondary To Proinsulin-Intermediate Secreting Tumor

Sleeping islets and the relationship between β-cell mass and function

scientific article published on August 2011

Stem cell approaches for diabetes: towards beta cell replacement

scientific article published on 27 September 2011

Strategies for β-cell replacement in diabetes: obtaining and protecting islet tissue

article published in 2001

Subpopulations of GFP-marked mouse pancreatic β-cells differ in size, granularity, and insulin secretion

scientific article

Suppression of beta cell energy metabolism and insulin release by PGC-1alpha

scientific article published on July 2003

Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice

scientific article

Survival of microencapsulated adult pig islets in mice in spite of an antibody response

scientific article published in December 2004

Sustained NF-κB activation and inhibition in β-cells have minimal effects on function and islet transplant outcomes

scientific article

The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation

scientific article

The Hypoglycemic Phenotype Is Islet Cell-Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase-Deficient Mice

scientific article published on 07 March 2016

The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells

scientific article

Thyroid Hormone Promotes Postnatal Rat Pancreatic β-Cell Development and Glucose-Responsive Insulin Secretion Through MAFA ⬇️

scientific article published on January 10, 2013

Transplantation of islets transduced with CTLA4-Ig and TGFbeta using adenovirus and lentivirus vectors

scientific article published in November 2004

Transplantation of porcine islets in nude mice: Implications for islet replacement therapy in humans

article published in 1995

Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice

scientific article published on 17 March 2016

What Does It Take to Make a Beta Cell?

p38 MAPK is a major regulator of MafA protein stability under oxidative stress

scientific article published on 30 April 2009

β-cell dedifferentiation in diabetes is important, but what is it?

scientific article

β-cell secretory dysfunction: a key cause of type 2 diabetes - Authors' reply

scientific article published on 01 May 2020

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