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List of works by Guillaume Lessene

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

scientific article published on 07 October 2019

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.

scientific article published in February 2018

BCL-XL exerts a protective role against anemia caused by radiation-induced kidney damage

scientific article published on 25 November 2020

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.

scientific article

Crystallization and preliminary X-ray characterization of Epstein-Barr virus BHRF1 in complex with a benzoylurea peptidomimetic

scientific article

Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms

scientific article published on 19 April 2022

Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1.

scientific article

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

scientific article published on 22 November 2021

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

scientific article published on 23 August 2018

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

scientific article published on 19 June 2020

Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2

scientific article published on 26 August 2020

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors

scientific article published on 12 March 2021

Strategies, Setbacks, and Successes in the Synthesis of (-)-Spiroleucettadine

scientific article published on 26 July 2018

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations

scientific article published on 03 June 2019

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer

scientific article published in August 2017

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