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List of works by Ursula Sonnewald

2,4-13Cβ-hydroxybutyrate Metabolism in Astrocytes and C6 Glioblastoma Cells ⬇️

scientific article published on May 3, 2011

A comprehensive metabolic profile of cultured astrocytes using isotopic transient metabolic flux analysis and C-labeled glucose

scientific article

A subconvulsive dose of kainate selectively compromises astrocytic metabolism in the mouse brain in vivo

scientific article

Acute changes in intermediary metabolism in cerebellum and contralateral hemisphere following middle cerebral artery occlusion in rat.

scientific article published in May 2009

Alteration of glial-neuronal metabolic interactions in a mouse model of Alexander disease

scientific article (publication date: August 2010)

Alterations in brain metabolism, CNS morphology and CSF dynamics in adult rats with kaolin-induced hydrocephalus

scientific article published in February 2002

Altered 13C glucose metabolism in the cortico-striato-thalamo-cortical loop in the MK-801 rat model of schizophrenia

scientific article published on 17 November 2010

Altered astrocyte-neuronal interactions after hypoxia-ischemia in the neonatal brain in female and male rats

scientific article published on 22 July 2014

Altered neurochemical profile in the McGill‐R‐Thy1‐APP rat model of Alzheimer's disease: a longitudinal in vivo1H MRS study ⬇️

scientific article published on October 1, 2012

Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood.

scientific article published in January 2016

Astrocyte metabolism is disturbed in the early development of experimental hydrocephalus

scientific article published in April 2003

Astrocyte modulation of neurotoxic injury.

scientific article

Astrocyte-neuronal interactions in epileptogenesis.

scientific article

Astrocytes may play a role in the etiology of absence epilepsy: a comparison between immature GAERS not yet expressing seizures and adults

scientific article published on 17 July 2007

Astrocytes, Metabolism, Signaling and Brain Drains: Introduction to the Special Issue in Honor of Gerald Dienel

scientific article published on 27 November 2015

Astrocytic pyruvate carboxylation: Status after 35 years

scientific article published on 23 February 2019

Availability of neurotransmitter glutamate is diminished when beta-hydroxybutyrate replaces glucose in cultured neurons.

scientific article

Brain [U-13 C]glucose metabolism in mice with decreased α-ketoglutarate dehydrogenase complex activity

scientific article published on 03 March 2011

Brain metabolism in adult chronic hydrocephalus

scientific article

Brain mitochondrial metabolic dysfunction and glutamate level reduction in the pilocarpine model of temporal lobe epilepsy in mice

scientific article published on 24 April 2013

Carbon monoxide improves neuronal differentiation and yield by increasing the functioning and number of mitochondria.

scientific article published on 29 April 2016

Cerebrospinal fluid from patients with dementia contains increased amounts of an unknown factor

scientific article published in October 2004

Changes of glial-neuronal interaction and metabolism after a subconvulsive dose of pentylenetetrazole

scientific article published in October 2004

Characterization of brain metastases using high-resolution magic angle spinning MRS.

scientific article published in February 2008

Characterization of glucose-related metabolic pathways in differentiated rat oligodendrocyte lineage cells

scientific article published on 9 September 2015

Chronic acetyl-L-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice

scientific article

Citrate, beneficial or deleterious in the CNS?

scientific article

Compartmentation of Glutamine, Glutamate, and GABA Metabolism in Neurons and Astrocytes: Functional Implications ⬇️

scientific article published on October 1, 2003

Complex glutamate labeling from [U-13C]glucose or [U-13C]lactate in co-cultures of cerebellar neurons and astrocytes

scientific article published on 5 October 2006

Cortical glutamate metabolism is enhanced in a genetic model of absence epilepsy

scientific article published on 15 March 2006

Deletion of Neuronal GLT-1 in Mice Reveals Its Role in Synaptic Glutamate Homeostasis and Mitochondrial Function

scientific article published on 29 March 2019

Demonstration of extensive GABA synthesis in the small population of GAD positive neurons in cerebellar cultures by the use of pharmacological tools

scientific article published on 3 March 2006

Demonstration of pyruvate recycling in primary cultures of neocortical astrocytes but not in neurons

scientific article

Detoxification of ammonia in mouse cortical GABAergic cell cultures increases neuronal oxidative metabolism and reveals an emerging role for release of glucose-derived alanine

scientific article published on 18 May 2010

Dietary supplementation with acetyl-l-carnitine in seizure treatment of pentylenetetrazole kindled mice

scientific article

Differential roles of alanine in GABAergic and glutamatergic neurons.

scientific article

Direct measurement of backflux between oxaloacetate and fumarate following pyruvate carboxylation.

scientific article

Distinct changes in neuronal and astrocytic amino acid neurotransmitter metabolism in mice with reduced numbers of synaptic vesicles

scientific article

Effect of methylmercury on glutamate metabolism in cerebellar astrocytes in culture ⬇️

scientific article published on September 1, 2003

Effects of methylmercury on primary brain cells in mono- and co-culture

scientific article published on 15 June 2005

Effects of pentylenetetrazole and glutamate on metabolism of [U-(13)C]glucose in cultured cerebellar granule neurons

scientific article published in February 2002

Energy substrates to support glutamatergic and GABAergic synaptic function: role of glycogen, glucose and lactate

scientific article published on December 2007

Estimation of intracellular fluxes in cerebellar neurons after hypoglycemia: Importance of the pyruvate recycling pathway and glutamine oxidation

scientific article published on 17 February 2011

Expression of glutamine synthetase and glutamate dehydrogenase in the latent phase and chronic phase in the kainate model of temporal lobe epilepsy

scientific article published in June 2008

First direct demonstration of extensive GABA synthesis in mouse cerebellar neuronal cultures.

scientific article published in November 2004

Functional and phenotypic differences of pure populations of stem cell-derived astrocytes and neuronal precursor cells

scientific article published on 22 December 2015

Functional metabolic interactions of human neuron-astrocyte 3D in vitro networks

scientific article (publication date: 2016)

GABA alters the metabolic fate of [U-13C]glutamate in cultured cortical astrocytes

scientific article published in January 2005

GAD65 is essential for synthesis of GABA destined for tonic inhibition regulating epileptiform activity

scientific article published on 4 November 2010

Glial-neuronal interactions are impaired in the schizophrenia model of repeated MK801 exposure.

scientific article published on 14 December 2005

Glial-neuronal interactions following kainate injection in rats

scientific article published in January 2003

Glucose and Intermediary Metabolism and Astrocyte-Neuron Interactions Following Neonatal Hypoxia-Ischemia in Rat.

scientific article

Glucose is necessary to maintain neurotransmitter homeostasis during synaptic activity in cultured glutamatergic neurons

scientific article published in February 2006

Glucose metabolism and astrocyte-neuron interactions in the neonatal brain

scientific article

Glutamate is preferred over glutamine for intermediary metabolism in cultured cerebellar neurons

scientific article published on 11 October 2006

Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation

scientific article published on 23 January 2013

Glutamate neurotransmission is affected in prenatally stressed offspring

scientific article

Glutamate oxidation in astrocytes: Roles of glutamate dehydrogenase and aminotransferases

scientific article published on 15 September 2016

Glutamate: Where does it come from and where does it go?

scientific article published on 20 November 2014

Glutamine in the central nervous system: function and dysfunction.

scientific article

Glutamine uptake and expression of mRNA's of glutamine transporting proteins in mouse cerebellar and cerebral cortical astrocytes and neurons.

scientific article published in January 2004

High-resolution magic angle spinning MRS of breast cancer tissue

High-resolution magic angle spinning and 1H magnetic resonance spectroscopy reveal significantly altered neuronal metabolite profiles in CLN1 but not in CLN3.

scientific article published in September 2004

Homeostasis of neuroactive amino acids in cultured cerebellar and neocortical neurons is influenced by environmental cues

scientific article published in January 2005

How do glial-neuronal interactions fit into current neurotransmitter hypotheses of schizophrenia?

scientific article published on 7 November 2006

Hypoglutamatergic activity in the STOP knockout mouse: a potential model for chronic untreated schizophrenia

scientific article published in November 2007

Immobilization of Primary Astrocytes and Neurons for On-Line Monitoring of Biochemical Processes by NMR

Impaired glutamine metabolism in NMDA receptor hypofunction induced by MK801.

scientific article published on 25 July 2005

Improvement of neuronal differentiation by carbon monoxide: Role of pentose phosphate pathway.

scientific article published on 15 May 2018

In vitro uptake of glutamate in GLAST- and GLT-1-transfected mutant CHO-K1 cells is inhibited by the ethylmercury-containing preservative thimerosal

scientific article published on January 2005

In vivo mapping of temporospatial changes in manganese enhancement in rat brain during epileptogenesis

scientific article published on 07 August 2007

Inhibitors of the alpha-ketoglutarate dehydrogenase complex alter [1-13C]glucose and [U-13C]glutamate metabolism in cerebellar granule neurons

scientific article published in February 2006

Intracellular metabolic compartmentation assessed by 13C magnetic resonance spectroscopy

scientific article

Introduction to the Glutamate-Glutamine Cycle

scientific article published in January 2016

Knockout of GAD65 has major impact on synaptic GABA synthesized from astrocyte-derived glutamine

scientific article

Limbic structures show altered glial-neuronal metabolism in the chronic phase of kainate induced epilepsy

scientific article published on 21 August 2007

Long-term kainic acid exposure reveals compartmentation of glutamate and glutamine metabolism in cultured cerebellar neurons

scientific article published on 29 December 2006

Manganese, copper, and zinc in cerebrospinal fluid from patients with multiple sclerosis

scientific article published in January 2003

Mercuric chloride inhibits the in vitro uptake of glutamate in GLAST- and GLT-1-transfected mutant CHO-K1 cells

scientific article published on March 2006

Metabolic aspects of neuron-oligodendrocyte-astrocyte interactions

scientific article published on 13 May 2013

Metabolic changes in the cerebrospinal fluid of patients with lumbar disc herniation or spinal stenosis

scientific article

Metabolic compartmentation in cortical synaptosomes: influence of glucose and preferential incorporation of endogenous glutamate into GABA.

scientific article

Metabolic profiling of human brain metastases using in vivo proton MR spectroscopy at 3T.

scientific article

Metabolism is normal in astrocytes in chronically epileptic rats: a (13)C NMR study of neuronal-glial interactions in a model of temporal lobe epilepsy

scientific article published in October 2005

Mild reduction in the activity of the alpha-ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis

scientific article published on May 2009

Mislocalization of AQP4 precedes chronic seizures in the kainate model of temporal lobe epilepsy

scientific article published on 26 January 2013

Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: Triheptanoin and Acetyl-L-Carnitine

scientific article published on 03 October 2015

Neuronal and astrocytic metabolism in a transgenic rat model of Alzheimer's disease

scientific article

Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools

scientific article

Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+ levels.

scientific article published in May 2009

Neuronal hyperexcitability and seizures are associated with changes in glial-neuronal interactions in the hippocampus of a mouse model of epilepsy with mental retardation

scientific article published on 19 November 2010

Neuronal-glial interactions in rats fed a ketogenic diet

scientific article published on 20 March 2006

Neuron–Astrocyte Interactions, Pyruvate Carboxylation and the Pentose Phosphate Pathway in the Neonatal Rat Brain ⬇️

scientific article published on March 16, 2013

No improvement of neuronal metabolism in the reperfusion phase with melatonin treatment after hypoxic-ischemic brain injury in the neonatal rat.

scientific article published on 3 November 2015

Oligodendrocytes Do Not Export NAA-Derived Aspartate In Vitro.

scientific article published on 9 July 2016

Oligodendrocytes: Development, Physiology and Glucose Metabolism

scientific article published on January 2016

Pentylenetetrazole affects metabolism of astrocytes in culture.

scientific article published in January 2005

Pentylenetetrazole decreases metabolic glutamate turnover in rat brain

scientific article published in June 2003

Pharmacology and toxicology of astrocyte-neuron glutamate transport and cycling

scientific article

Pyruvate carboxylation in different model systems studied by (13)C MRS.

scientific article

Pyruvate recycling in cultured neurons from cerebellum

scientific article published in November 2007

Quantification of Metabolic Rearrangements During Neural Stem Cells Differentiation into Astrocytes by Metabolic Flux Analysis

scientific article published on 12 April 2016

Quantification of amounts and (13)C content of metabolites in brain tissue using high- resolution magic angle spinning (13)C NMR spectroscopy

scientific article

Quantitative importance of the pentose phosphate pathway determined by incorporation of 13C from [2-13C]- and [3-13C]glucose into TCA cycle intermediates and neurotransmitter amino acids in functionally intact neurons

scientific article

Reduced Astrocytic Contribution to the Turnover of Glutamate, Glutamine, and GABA Characterizes the Latent Phase in the Kainate Model of Temporal Lobe Epilepsy ⬇️

scientific article published on April 27, 2011

Region- and age-dependent alterations of glial-neuronal metabolic interactions correlate with CNS pathology in a mouse model of globoid cell leukodystrophy.

scientific article published on 24 April 2013

Repeated injection of MK801: an animal model of schizophrenia?

scientific article

Role of glutamine and neuronal glutamate uptake in glutamate homeostasis and synthesis during vesicular release in cultured glutamatergic neurons

scientific article published in July 2005

Stirred vessel cultures of rat brain cells aggregates: characterization of major metabolic pathways and cell population dynamics

scientific article

System N transporters are critical for glutamine release and modulate metabolic fluxes of glucose and acetate in cultured cortical astrocytes: changes induced by ammonia.

scientific article published on 7 October 2015

The GLT-1 (EAAT2; slc1a2) glutamate transporter is essential for glutamate homeostasis in the neocortex of the mouse.

scientific article

The Neuron-Glia Unit in Neuropathology: Is it a Double-Edged Sword?

scientific article published on 01 January 2003

The anticonvulsant actions of carisbamate associate with alterations in astrocyte glutamine metabolism in the lithium-pilocarpine epilepsy model

scientific article published on 26 October 2014

The glutamine-glutamate/GABA cycle: function, regional differences in glutamate and GABA production and effects of interference with GABA metabolism.

scientific article

The ketogenic diet and brain metabolism of amino acids: relationship to the anticonvulsant effect

scientific article published on January 2007

The pentose phosphate pathway and pyruvate carboxylation after neonatal hypoxic-ischemic brain injury

scientific article published on 05 February 2014

The pentylenetetrazole-kindling model of epilepsy in SAMP8 mice: behavior and metabolism.

scientific article published in April 2002

The pentylenetetrazole-kindling model of epilepsy in SAMP8 mice: glial-neuronal metabolic interactions

scientific article published in December 2003

The role of glia in neuronal recovery following anoxia: In vitro evidence of neuronal adaptation

scientific article

The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex

scientific article published on 01 November 2007

Tricarboxylic acid cycle activity measured by 13C magnetic resonance spectroscopy in rats subjected to the kaolin model of obstructed hydrocephalus.

scientific article

Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epilepsy

scientific article published on 2 December 2013

Triheptanoin—A medium chain triglyceride with odd chain fatty acids: A new anaplerotic anticonvulsant treatment? ⬇️

scientific article published on August 19, 2011

Which clinical and experimental data link temporal lobe epilepsy with depression?

scientific article

β-Hydroxybutyrate is the preferred substrate for GABA and glutamate synthesis while glucose is indispensable during depolarization in cultured GABAergic neurons

scientific article published on 13 June 2011

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