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List of works by Bruce R Ksander

A Murine Model for Metastatic Conjunctival Melanoma

scientific article

A Novel Model of Metastatic Conjunctival Melanoma in Immune-Competent Mice

scientific article published in September 2015

A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors.

scientific article published on 21 November 2012

A novel treatment for ocular tumors using membrane FasL vesicles to activate innate immunity and terminate immune privilege

scientific article published on 01 July 2005

ABCB5 is a limbal stem cell gene required for corneal development and repair

scientific article (publication date: 17 July 2014)

Activation of tumor-specific CD4(+) T lymphocytes by major histocompatibility complex class II tumor cell vaccines: a novel cell-based immunotherapy.

scientific article published in March 2004

By altering ocular immune privilege, bone marrow-derived cells pathogenically contribute to DBA/2J pigmentary glaucoma

scientific article

Control of ocular tumor growth and metastatic spread by soluble and membrane Fas ligand

scientific article published in December 2007

Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions.

scientific article

Epigenetic silencing of the CIITA gene and posttranscriptional regulation of class II MHC genes in ocular melanoma cells

scientific article

Expression of MAGE Genes in Ocular Melanoma Cell Lines ⬇️

scientific article published on 01 July 1997

Expression of Multidrug Resistance Transporter ABCB5 in a Murine Model of Human Conjunctival Melanoma

scientific article published on April 2015

Expression of angiogenic factors Cyr61 and tissue factor in uveal melanoma

scientific article published on December 2002

Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development

scientific article published in September 2003

HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status

scientific article published in February 2018

Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.

scientific article

Immunity causing blindness: five different paths to herpes stromal keratitis ⬇️

scientific article published on September 1, 1997

In vivo gene delivery and visualization of corneal stromal cells using an adenoviral vector and keratocyte-specific promoter

scientific article published in July 2004

Increased Resistance to Staphylococcus aureus Endophthalmitis in BALB/c Mice: Fas Ligand Is Required for Resolution of Inflammation but Not for Bacterial Clearance ⬇️

scientific article published on April 8, 2013

Influence of immune surveillance and immune privilege on formation of intraocular tumors

scientific article published on January 2007

Integrin-linked kinase regulates senescence in an Rb-dependent manner in cancer cell lines

scientific article published on 15 July 2015

Investigation of factors associated with ABCB5-positive limbal stem cell isolation yields from human donors

scientific article published on 24 October 2019

Limbal stem cells: identity, developmental origin, and therapeutic potential.

scientific article published on 3 November 2017

Local treatment with alpha-melanocyte stimulating hormone reduces corneal allorejection.

scientific article published on July 2009

Lung cancer patients' CD4(+) T cells are activated in vitro by MHC II cell-based vaccines despite the presence of myeloid-derived suppressor cells

scientific article published on 6 March 2008

MHC class II-transduced tumor cells originating in the immune-privileged eye prime and boost CD4(+) T lymphocytes that cross-react with primary and metastatic uveal melanoma cells

scientific article published on May 2007

Membrane Fas ligand activates innate immunity and terminates ocular immune privilege

scientific article published on 01 September 2002

Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment

scientific article published on 18 June 2018

Modeling of human uveal melanoma in zebrafish xenograft embryos

scientific article

NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration

scientific article published on 7 January 2013

Opposing roles for membrane bound and soluble Fas ligand in glaucoma-associated retinal ganglion cell death.

scientific article

Overexpression of Soluble Fas Ligand following Adeno-Associated Virus Gene Therapy Prevents Retinal Ganglion Cell Death in Chronic and Acute Murine Models of Glaucoma.

scientific article published on 14 November 2016

Proceedings of the Association for Research in Vision and Ophthalmology and Champalimaud Foundation Ocular Oncogenesis and Oncology Conference

scientific article published on 09 January 2018

RB116: an RB1+ retinoblastoma cell line expressing primitive markers.

scientific article

Recovery of activated cytotoxic T cells from minor H incompatible tumor graft rejection sites. 1989.

scientific article published in May 2007

Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma

scientific article

Repairing the corneal epithelium using limbal stem cells or alternative cell-based therapies.

scientific article published on 23 February 2018

Reprogramming to recover youthful epigenetic information and restore vision

scientific article published on 02 December 2020

Requirement of CD80+ costimulation for rejection of ocular tumors and termination of immune privilege

scientific article published on 27 April 2006

Retinal microglia initiate neuroinflammation in ocular autoimmunity

scientific article published on 25 April 2019

Retinoblastoma cells are inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase.

scientific article

Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming

scientific article published on 31 July 2019

Soluble Fas ligand blocks destructive corneal inflammation in mouse models of corneal epithelial debridement and LPS induced keratitis

scientific article published on 23 October 2018

Soluble Guanylate Cyclase a1-Deficient Mice: a novel murine model for Primary Open Angle Glaucoma

scientific article

Soluble guanylate cyclase α1-deficient mice: a novel murine model for primary open angle glaucoma

scientific article

Spontaneous bacterial keratitis in CD36 knockout mice.

scientific article

Termination of systemic immunity in the presence of intraocular tumors: influence of ocular immune privilege on tumor vaccines

scientific article published on January 2006

The absence of invariant chain in MHC II cancer vaccines enhances the activation of tumor-reactive type 1 CD4+ T lymphocytes.

scientific article published on 28 August 2007

Tumor Cell Programmed Death Ligand 1-Mediated T Cell Suppression Is Overcome by Coexpression of CD80 ⬇️

scientific article published on May 9, 2011

Tumor cells transduced with the MHC class II Transactivator and CD80 activate tumor-specific CD4+ T cells whether or not they are silenced for invariant chain

scientific article published on 01 January 2006

Tumor escape mutants develop within an immune-privileged environment in the absence of T cell selection

scientific article published on July 2006

Uveal Melanoma Cell Lines: Where do they come from? (An American Ophthalmological Society Thesis).

scientific article published on August 2016

Uveal melanoma cell growth is inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase

scientific article

Uveal melanoma cell-based vaccines express MHC II molecules that traffic via the endocytic and secretory pathways and activate CD8+ cytotoxic, tumor-specific T cells.

scientific article

alphaB-crystallin protects retinal tissue during Staphylococcus aureus-induced endophthalmitis

scientific article published on 28 January 2008

sGCα1-deficient mice: a novel murine model of spontaneous primary open angle glaucoma.

scientific article published in August 2011

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