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List of works by Hugh C Hemmings

2013 BJA/PGA Special Issue: a selection of nine educational reviews

scientific article published in December 2013

2015 BJA/PGA Special Issue: a selection of nine educational reviews

scientific article

A comparison: the efficacy of sevoflurane-nitrous oxide or propofol-nitrous oxide for the induction and maintenance of general anesthesia

scientific article

A global vision for the British Journal of Anaesthesia

scientific article published in January 2017

A special issue on respiration and the airway: critical topics at a challenging time

scientific article published on 28 April 2020

AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release

scientific article

ARPP-21, a cAMP-regulated phosphoprotein enriched in dopamine-innervated brain regions: tissue distribution and regulation of phosphorylation in rat brain

scientific article published in January 1990

ARPP-21, a cyclic AMP-regulated phosphoprotein (Mr = 21,000) enriched in dopamine-innervated brain regions. Amino acid sequence of the site phosphorylated by cyclic AMP in intact cells and kinetic studies of its phosphorylation in vitro

scientific article published in May 1989

ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Amino acid sequence of ARPP-21B from bovine caudate nucleus

scientific article published on 01 October 1989

ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Purification and characterization of the protein from bovine caudate nucleus

scientific article published on 01 March 1989

ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Immunocytochemical localization in rat brain

scientific article published on 01 March 1989

Activation of brain protein phosphatase-1(I) following cardiac arrest and resuscitation involving an interaction with 14-3-3 gamma

scientific article published on 14 February 2008

Activation of endogenous protein kinase C by halothane in synaptosomes

scientific article

Activity-dependent depression of neuronal sodium channels by the general anaesthetic isoflurane

scientific article published on July 2015

Anaesthesia awareness: 3 years of progress ⬇️

scientific article published on February 1, 2012

Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar

scientific article

Anesthetic effects on glutamatergic neurotransmission: lessons learned from a large synapse.

scientific article published in March 2004

Anesthetic properties of 4-iodopropofol: implications for mechanisms of anesthesia.

scientific article

Are anaesthetics toxic to the brain?

scientific article

Between Clotho and Lachesis: how isoflurane seals neuronal fate

scientific article published in April 2009

Bidirectional modulation of isoflurane potency by intrathecal tetrodotoxin and veratridine in rats

scientific article

Bioblasts, anaesthesia, and power failure: rein in the excitement

scientific article published on 27 March 2018

Biochemical characterization of the stimulatory effects of halothane and propofol on purified brain protein kinase C.

scientific article published in December 1995

CHEB, a convulsant barbiturate, evokes calcium-dependent spontaneous glutamate release from rat cerebrocortical synaptosomes

scientific article published in June 1996

Case scenario: postoperative delirium in elderly surgical patients

scientific article published on January 2010

Change management: the British Journal of Anaesthesia in 2018

scientific article published on 01 January 2019

Characterization in mammalian brain of a DARPP-32 serine kinase identical to casein kinase II.

scientific article

Chronic pain diagnosis in refugee torture survivors: A prospective, blinded diagnostic accuracy study

scientific article published on 05 June 2020

Clinical concentrations of chemically diverse general anesthetics minimally affect lipid bilayer properties

scientific article published on 6 March 2017

Comparative effects of halogenated inhaled anesthetics on voltage-gated Na+ channel function

scientific article published on March 2009

Consensus statement from the BJA Workshop on Cancer and Anaesthesia

scientific article published on 7 August 2014

D1 receptor modulation of memory retrieval performance is associated with changes in pCREB and pDARPP-32 in rat prefrontal cortex

scientific article

DARPP-32 (dopamine and cAMP-regulated phosphoprotein, M(r) 32,000) is a membrane protein in the bovine parathyroid

scientific article published on 01 May 1995

DARPP-32 and phosphatase inhibitor-1, two structurally related inhibitors of protein phosphatase-1, are both present in striatonigral neurons

scientific article

DARPP-32 as a marker for D-1 dopaminoceptive cells in the rat brain: prenatal development and presence in glial elements (tanycytes) in the basal hypothalamus

scientific article

DARPP-32 in the ciliary epithelium of the eye: a neurotransmitter-regulated phosphoprotein of brain localizes to secretory cells

scientific article published in November 1986

DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated neuronal phosphoprotein. I. Amino acid sequence around the phosphorylated threonine

scientific journal article

DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated neuronal phosphoprotein. II. Comparison of the kinetics of phosphorylation of DARPP-32 and phosphatase inhibitor 1

scientific article

DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Purification and characterization of the phosphoprotein from bovine caudate nucleus

scientific article published in January 1984

DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization.

scientific article published in January 1984

DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein: regional, tissue, and phylogenetic distribution

scientific article

DARPP-32, a dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Primary structure and homology with protein phosphatase inhibitor-1.

scientific article published in February 1986

DARPP-32, a dopamine- and cyclic AMP-regulated phosphoprotein in tanycytes of the mediobasal hypothalamus: distribution and relation to dopamine and luteinizing hormone-releasing hormone neurons and other glial elements

scientific article published on 01 November 1988

DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1 ⬇️

scientific article published on August 9, 1984

DARPP-32, a dopamine-regulated phosphoprotein.

scientific article

Depression by isoflurane of the action potential and underlying voltage-gated ion currents in isolated rat neurohypophysial nerve terminals

scientific article published on 16 September 2004

Development of a dopamine- and cyclic adenosine 3':5'-monophosphate-regulated phosphoprotein (DARPP-32) in the prenatal rat central nervous system, and its relationship to the arrival of presumptive dopaminergic innervation

scientific article published on 01 July 1987

Differential Inhibition of Neuronal Sodium Channel Subtypes by the General Anesthetic Isoflurane

scientific article published on 21 February 2019

Differential effects of anesthetic and nonanesthetic cyclobutanes on neuronal voltage-gated sodium channels

scientific article published in February 2000

Differential interaction of anaesthetics and antiepileptic drugs with neuronal Na+ channels, Ca2+ channels, and GABA(A) receptors

scientific article published in February 2003

Differential regulation of protein phosphatase-1(I) by neurabin

scientific article published on 19 April 2007

Distinct rat neurohypophysial nerve terminal populations identified by size, electrophysiological properties and neuropeptide content

scientific article published in October 2004

Distribution of protein phosphatase inhibitor-1 in brain and peripheral tissues of various species: comparison with DARPP-32.

scientific article published on September 1992

Divergent effects of anesthetics on lipid bilayer properties and sodium channel function.

scientific article

Do general anesthetics add up?

scientific article published in June 2006

Dopamine- and adenosine-3′,5′-monophosphate (cAMP)-regulated phosphoprotein of 32 kDa (DARRP-32) in the adrenal gland: immunohistochemical localization ⬇️

scientific article published on October 1, 1991

Dopamine- and adenosine-3′:5′-monophosphate (cAMP)-regulated phosphoprotein of Mr 32,000 (DARPP-32) in the retina of cat, monkey and human ⬇️

scientific article published on September 30, 1991

Dopamine- and cAMP-regulated phosphoprotein (DARPP-32) and dopamine DA1 agonist-sensitive Na+,K+-ATPase in renal tubule cells

scientific article

Dopamine-regulated protein phosphorylation in the basal ganglia

scientific article published on January 1988

Drugs of abuse modulate the phosphorylation of ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in the basal ganglia

scientific article published on July 2000

Effect of halothane on conventional protein kinase C translocation and down-regulation in rat cerebrocortical synaptosomes

scientific article published in February 1997

Effects of Isoflurane on Intracellular Calcium in Boutons of Hippocampal Neurons

Effects of anticonvulsants on veratridine- and KCl-evoked glutamate release from rat cortical synaptosomes

scientific article published on 01 December 1999

Effects of general anesthetics on synaptic transmission and plasticity

article published in 2021

Effects of halothane and propofol on purified brain protein kinase C activation.

scientific article

Effects of intravenous general anesthetics on [3H]GABA release from rat cortical synaptosomes

scientific article published in October 1998

Effects of isoflurane and propofol on glutamate and GABA transporters in isolated cortical nerve terminals

scientific article

Effects of propofol on sodium channel-dependent sodium influx and glutamate release in rat cerebrocortical synaptosomes

scientific article published in February 1997

Emerging molecular mechanisms of general anesthetic action.

scientific article

Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia

scientific article (publication date: August 2002)

Excellence in editorials: fulfilling their critical role in the medical literature

scientific article published on 19 August 2020

Functional dopamine-1 receptors and DARPP-32 are expressed in human ovary and granulosa luteal cells in vitro

scientific article

Further retractions of articles by Joachim Boldt

scientific article published on 01 September 2020

Galloping in full pursuit of the mechanism of anesthetic immobility

scientific article published in June 2008

General anesthetic actions on norepinephrine, dopamine, and gamma-aminobutyric acid transporters in stably transfected cells

scientific article published on October 2002

General anesthetic effects on protein kinase C.

scientific article

General anesthetics do not affect release of the neuropeptide cholecystokinin from isolated rat cortical nerve terminals

scientific article published on December 2002

General anesthetics selectively modulate glutamatergic and dopaminergic signaling via site-specific phosphorylation in vivo

scientific article published on 24 July 2007

HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.

scientific article published on 2 April 2013

Identification of a dopamine- and 3'5'-cyclic adenosine monophosphate-regulated phosphoprotein of 32 kD (DARPP-32) in parathyroid hormone-producing cells of the human parathyroid gland

scientific article (publication date: September 1991)

Identification of the phosphorylation site for cAMP-dependent protein kinase on Na+,K(+)-ATPase and effects of site-directed mutagenesis

scientific article published in Journal of Biological Chemistry

Immunocytochemical localization of phosphatase inhibitor-1 in rat brain

scientific article published on August 1991

Immunohistochemical evidence for the existence of a dopamine- and cyclic AMP-regulated phosphoprotein (DARPP-32) in brown adipose tissue of pigs

scientific article

Increased risk of awareness under anesthesia: an issue of consciousness or of memory?

scientific article published in December 2013

Information technology innovation: the power and perils of big data.

scientific article published in June 2015

Inhibition by propofol of [3H]-batrachotoxinin-A 20-alpha-benzoate binding to voltage-dependent sodium channels in rat cortical synaptosomes

scientific article

Inhibition by volatile anesthetics of endogenous glutamate release from synaptosomes by a presynaptic mechanism

scientific article published on June 1995

Inhibition of Presynaptic Sodium Channels by Halothane ⬇️

scientific article published on April 1, 1998

Inhibitors of protein phosphatase-1. Inhibitor-1 of bovine adipose tissue and a dopamine- and cAMP-regulated phosphoprotein of bovine brain are identical

scientific article published on 01 March 1989

Intrathecal veratridine administration increases minimum alveolar concentration in rats

scientific article published on September 2008

Introduction: 2009 BJA/PGA Supplement: a selection of eight reviews

scientific article published on 01 December 2009

Is a new paradigm needed to explain how inhaled anesthetics produce immobility?

scientific article published on September 2008

Isoflurane Inhibits Dopaminergic Synaptic Vesicle Exocytosis Coupled to Ca2.1 and Ca2.2 in Rat Midbrain Neurons

scientific article published on 24 January 2019

Isoflurane Modulates Hippocampal Cornu Ammonis Pyramidal Neuron Excitability by Inhibition of Both Transient and Persistent Sodium Currents in Mice

scientific article published on 01 July 2019

Isoflurane and propofol inhibit voltage-gated sodium channels in isolated rat neurohypophysial nerve terminals

scientific article published in August 2003

Isoflurane inhibits NaChBac, a prokaryotic voltage-gated sodium channel

scientific article

Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca2+ influx, not Ca2+-exocytosis coupling

scientific article

Isoflurane inhibits the tetrodotoxin-resistant voltage-gated sodium channel Nav1.8.

scientific article published on September 2009

Isoflurane modulates activation and inactivation gating of the prokaryotic Na+ channel NaChBac.

scientific article published on 17 April 2017

Isoflurane reversibly destabilizes hippocampal dendritic spines by an actin-dependent mechanism

scientific article

Isoform-selective effects of isoflurane on voltage-gated Na+ channels

scientific article published in July 2007

Landmarks in UK anaesthesia

scientific article published in December 2017

Localization of dopamine D1 receptors and dopaminoceptive neurons in the chick forebrain ⬇️

scientific article published on November 10, 1997

Localization of dopamine- and cAMP-regulated phosphoprotein-32 and inhibitor-1 in area 9 of Macaca mulatta prefrontal cortex

scientific article

Mammalian brain phosphoproteins as substrates for calcineurin

scientific journal article

Memory and awareness in anaesthesia.

scientific article published on July 2015

Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons

scientific article published on 01 February 1995

Molecular Targets of General Anesthetics in the Nervous System

Morphometrical evidence for a complex organization of tyrosine hydroxylase-, enkephalin- and DARPP-32-like immunoreactive patches and their codistribution at three rostrocaudal levels in the rat neostriatum

scientific article published on 01 December 1988

NAP5: intraoperative awareness detected, and undetected.

scientific article published in October 2014

Neuroprotection by Na+ channel blockade

scientific article published on January 2004

Neurotoxicity of general anesthetics: cause for concern?

scientific article published on December 2009

Nicotinic receptor-evoked hippocampal norepinephrine release is highly sensitive to inhibition by isoflurane

scientific article published on 02 February 2009

Noble meets nouveau: a shared anesthetic binding site for xenon and isoflurane on a glutamate receptor

scientific article published in November 2007

Ontogeny of the dopamine and cyclic adenosine-3':5'-monophosphate-regulated phosphoprotein (DARPP-32) in the pre- and postnatal mouse central nervous system

scientific article

Opposing changes in phosphorylation of specific sites in synapsin I during Ca2+-dependent glutamate release in isolated nerve terminals.

scientific article

Phosphorylated Mr 32,000 dopamine- and cAMP-regulated phosphoprotein inhibits Na+,K(+)-ATPase activity in renal tubule cells ⬇️

scientific article published on April 1, 1991

Phosphorylation of CREB and DARPP-32 during late LTP at hippocampal to prefrontal cortex synapses in vivo

scientific article published in January 2007

Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

scientific article

Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II

scientific article

Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5).

scientific article

Phytochemicals perturb membranes and promiscuously alter protein function.

scientific article

Positively active: how local anesthetics work

scientific article published in July 2010

Presynaptic inhibition of the release of multiple major central nervous system neurotransmitter types by the inhaled anaesthetic isoflurane

scientific article published on 4 December 2012

Protein kinases and phosphoproteins in the nervous system

scientific article

Protein kinases in the brain

scientific article published on January 1985

Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation

scientific article published on 16 January 2008

Rapamycin causes activation of protein phosphatase-2A1 and nuclear translocation of PCNA in CD4+ T cells

scientific article published on October 2004

Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K+ channel, TREK-1.

scientific article

Regional differences in nerve terminal Na+ channel subtype expression and Na+ channel-dependent glutamate and GABA release in rat CNS.

scientific article

Regional differences in the effects of isoflurane on neurotransmitter release ⬇️

scientific article published on May 30, 2011

Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation

scientific article (publication date: 28 September 1999)

Regulation of protein phosphatase 1I by Cdc25C-associated kinase 1 (C-TAK1) and PFTAIRE protein kinase

scientific article

Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 5.

scientific article

Relevance of Clinical Relevance

scientific article published on 01 October 2016

Role of protein phosphorylation in neuronal signal transduction

scientific article

Role of specific presynaptic calcium channel subtypes in isoflurane inhibition of synaptic vesicle exocytosis in rat hippocampal neurones

scientific article published on 02 May 2019

Selective depression by general anesthetics of glutamate versus GABA release from isolated cortical nerve terminals

scientific article published in March 2003

Sleep and anesthesia: the histamine connection

scientific article published in July 2011

Sociosexual investigation in sexually experienced, hormonally manipulated male leopard geckos: relation with phosphorylated DARPP-32 in dopaminergic pathways

scientific article published on 28 October 2014

Sodium Channels as Targets for Volatile Anesthetics ⬇️

scientific article published on March 30, 2012

Sodium channel subtypes are differentially localized to pre- and post-synaptic sites in rat hippocampus.

scientific article published on 31 July 2017

Sodium channels and the synaptic mechanisms of inhaled anaesthetics

scientific article published on 09 June 2009

Special issue on anaesthesia and cancer

scientific article

Special issue on anaesthetic neurotoxicity and neuroplasticity

scientific article published in June 2013

Specificity of protein kinase inhibitor peptides and induction of long-term potentiation

scientific article

Stimulus-dependent phosphorylation of MacMARCKS, a protein kinase C substrate, in nerve termini and PC12 cells

scientific article

Synthetic peptide analogs of DARPP-32 (Mr 32,000 dopamine- and cAMP-regulated phosphoprotein), an inhibitor of protein phosphatase-1. Phosphorylation, dephosphorylation, and inhibitory activity

scientific article published on November 1990

The 2010 BJA/PGA supplement: a selection of 10 educational reviews ⬇️

scientific article published on 01 December 2010

The 2011 BJA/PGA supplement: a selection of nine educational reviews ⬇️

scientific article published on 01 December 2011

The 2012 BJA/PGA supplement: a selection of seven educational reviews

scientific article published on 01 December 2012

The 2014 BJA/PGA special issue: a selection of six educational reviews

scientific article published in December 2014

The 2016 BJA/PGA special issue: a selection of six educational reviews

scientific article published in December 2016

The anxiety-like phenotype of 5-HT receptor null mice is associated with genetic background-specific perturbations in the prefrontal cortex GABA-glutamate system.

scientific article published on 21 August 2006

The effects of general anesthetics on norepinephrine release from isolated rat cortical nerve terminals

scientific article

The general anesthetic isoflurane depresses synaptic vesicle exocytosis.

scientific article

The good, the bad, and the ugly: the many faces of opioids

scientific article published on 18 April 2019

The many contributions of WW Mapleson to the British Journal of Anaesthesia

scientific article published on 19 December 2018

The rivers of Lethe and Mnemosyne converge: propofol and memory consolidation

scientific article published in June 2011

Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery ⬇️

scientific article published on August 1, 2011

Thinking, fast and slow: highlights from the 2016 BJA seminar on anaesthetic neurotoxicity and neuroplasticity

scientific article published in September 2017

Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery

scientific article published on 27 May 2019

Volatile anaesthetic effects on phospholipid binding to synaptotagmin 1, a presynaptic Ca2+ sensor

scientific article published on 27 May 2005

Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: 4-aminopyridine-evoked release

scientific article published on 20 September 2005

Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: basal release

scientific article published on 20 September 2005

Volatile anesthetics inhibit sodium channels without altering bulk lipid bilayer properties

scientific article

Widespread inhibition of sodium channel-dependent glutamate release from isolated nerve terminals by isoflurane and propofol

scientific article published in December 2001

Women in anaesthesia, a special issue of the British Journal of Anaesthesia

scientific article published on 20 January 2020

Xenon and the pharmacology of fear

scientific article published in December 2008

α2-Adrenergic Receptor and Isoflurane Modulation of Presynaptic Ca2+ Influx and Exocytosis in Hippocampal Neurons

scientific article published on 23 June 2016

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