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List of works by Elżbieta Pękala

(+)-Usnic Acid as a Promising Candidate for a Safe and Stable Topical Photoprotective Agent ⬇️

scientific article published on 28 August 2021

3-Aminomethyl Derivatives of 2-Phenylimidazo[1,2-a]-pyridine as Positive Allosteric Modulators of GABAA Receptor with Potential Antipsychotic Activity.

scientific article

A Comparative Survey of Anti-Melanoma and Anti-Inflammatory Potential of Usnic Acid Enantiomers-A Comprehensive In Vitro Approach

scientific article published on 21 September 2021

A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling

scientific article published on 03 June 2020

A dual-acting 5-HT6 receptor inverse agonist/MAO-B inhibitor displays glioprotective and pro-cognitive properties

scientific article published on 22 August 2020

Analgesic and antiallodynic activity of novel anticonvulsant agents derived from 3-benzhydryl-pyrrolidine-2,5-dione in mouse models of nociceptive and neuropathic pain

scientific article published on 23 December 2019

Analgesic, antiallodynic, and anticonvulsant activity of novel hybrid molecules derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide in animal models of pain and epilepsy

scientific article

Anti-Helicobacter pylori activities of selected N-substituted cinnamamide derivatives evaluated on reference and clinical bacterial strains

scientific article published on 13 February 2018

Antiallodynic and antihyperalgesic activity of new 3,3-diphenyl-propionamides with anticonvulsant activity in models of pain in mice.

scientific article published on 17 December 2017

Anticonvulsant activity of some xanthone derivatives.

scientific article published on 25 June 2008

Anticonvulsant activity, crystal structures, and preliminary safety evaluation of N-trans-cinnamoyl derivatives of selected (un)modified aminoalkanols.

scientific article published on 2 November 2015

Anticonvulsant and analgesic in neuropathic pain activity in a group of new aminoalkanol derivatives

scientific article published on 07 June 2020

Antimutagenic compounds and their possible mechanisms of action

scientific article published on 11 March 2014

Application of liquid chromatography–tandem mass spectrometry method for the simultaneous quantitative analysis of propentofylline and its chiral metabolite M1 in rats ⬇️

scientific article published on March 1, 2011

Autophagy modulating agents as chemosensitizers for cisplatin therapy in cancer

scientific article published on 07 November 2020

Biotransformation of 4-fluoro-N-(1-{2-[(propan-2-yl)phenoxy]ethyl}-8-azabicyclo[3.2.1]octan-3-yl)-benzenesulfonamide, a novel potent 5-HT7 receptor antagonist with antidepressant-like and anxiolytic properties: In vitro and in silico approach

scientific article published on 22 February 2018

Carbonyl reduction pathway in hepatic in vitro metabolism of anthracyclines: Impact of structure on biotransformation rate

scientific article published in May 2021

Chemopreventive and Anticancer Activities of Bacopa monnieri Extracted from Artificial Digestive Juices

scientific article published on 01 March 2017

Cinnamic Acid Derivatives as Cardioprotective Agents against Oxidative and Structural Damage Induced by Doxorubicin

scientific article published on 9 June 2021

Cinnamic acid derivatives as chemosensitising agents against DOX-treated lung cancer cells - involvement of carbonyl reductase 1

scientific article published on 12 August 2020

Cinnamic acid derivatives in cosmetics: current use and future prospects

scientific article published on 24 August 2018

Correction to: Fibroblast-to-myofibroblast transition in bronchial asthma

scientific article published on 01 January 2019

Cunninghamella Biotransformation--Similarities to Human Drug Metabolism and Its Relevance for the Drug Discovery Process.

scientific article

Cunninghamella as a microbiological model for metabolism of histamine H(3) receptor antagonist 1-[3-(4-tert-butylphenoxy)propyl]piperidine.

scientific article published on 16 September 2012

Design, Synthesis and Biological Activity of New Amides Derived from 3‐Benzhydryl and 3‐ sec ‐Butyl‐2,5‐dioxo‐pyrrolidin‐1‐yl‐acetic Acid

scientific article published on 2 March 2021

Design, synthesis and anticonvulsant-analgesic activity of new -[(phenoxy)alkyl]- and -[(phenoxy)ethoxyethyl]aminoalkanols

scientific article published on 11 November 2016

Design, synthesis and biological activity of new amides derived from 3-methyl-3-phenyl-2,5-dioxo-pyrrolidin-1-yl-acetic acid

scientific article published on 13 July 2015

Design, synthesis, and anticonvulsant activity of some derivatives of xanthone with aminoalkanol moieties.

scientific article published on 28 September 2016

Design, synthesis, and biological evaluation of fluorinated imidazo[1,2-a]pyridine derivatives with potential antipsychotic activity

scientific article published on 26 August 2016

Dinuclear half-sandwich Ir(III) complexes containing 4,4′-methylenedianiline-based ligands: Synthesis, characterization, cytotoxicity

scientific article published in April 2021

Discovery of Novel UV-Filters with Favorable Safety Profiles in the 5-Arylideneimidazolidine-2,4-dione Derivatives Group

scientific article published on 24 June 2019

Dual 5-HT6 and D3 Receptor Antagonists in a Group of 1H-Pyrrolo[3,2-c]quinolines with Neuroprotective and Procognitive Activity

scientific article published on 02 April 2019

Effect of some newly synthesized xanthone and piperazine derivatives with cardiovascular activity on rheology of human erythrocytes in vitro.

scientific article published on 16 August 2016

Enantioselective biotransformation of pentoxifylline into lisofylline using wine yeast biocatalysis

scientific article published on 01 March 2007

Enantioselective reduction of pentoxifylline to lisofylline using whole-cell Lactobacillus kefiri biotransformation.

scientific article published in April 2007

Estimating the lipophilicity of a number of 2-amino-1-cyclohexanol derivatives exhibiting anticonvulsant activity

scientific article

Evaluation of Two Novel Hydantoin Derivatives Using Reconstructed Human Skin Model Episkin: Perspectives for Application as Potential Sunscreen Agents

scientific article published on 12 March 2022

Evaluation of anticonvulsant and antinociceptive properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and 3-methylpyrrolidine-2,5-dione

scientific article published on 9 December 2015

Evaluation of mutagenic and antimutagenic properties of new derivatives of pyrrolidine-2,5-dione with anti-epileptic activity, by use of the Vibrio harveyi mutagenicity test

scientific article

Fibroblast-to-myofibroblast transition in bronchial asthma

scientific article published on 12 August 2018

Imidazo[2,1-b]thiazepines: synthesis, structure and evaluation of benzodiazepine receptor binding.

scientific article published in March 2004

Imidazopyridine-Based 5-HT 6 Receptor Neutral Antagonists: Impact of N 1 -Benzyl and N 1 -Phenylsulfonyl Fragments on Different Receptor Conformational States

scientific article published on 13 January 2021

Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives

scientific article published on 25 August 2020

Impact of the aryl substituent kind and distance from pyrimido[2,1-f]purindiones on the adenosine receptor selectivity and antagonistic properties.

scientific article published in April 2003

In Vitro Biotransformation, Safety, and Chemopreventive Action of Novel 8-Methoxy-Purine-2,6-Dione Derivatives

scientific article published on 17 June 2017

In vitro effect of pentoxifylline and lisofylline on deformability and aggregation of red blood cells from healthy subjects and patients with chronic venous disease.

scientific article

In vitro mutagenic, antimutagenic, and antioxidant activities evaluation and biotransformation of some bioactive 4-substituted 1-(2-methoxyphenyl)piperazine derivatives.

scientific article published on 24 July 2016

Interconversion and tissue distribution of pentoxifylline and lisofylline in mice

scientific article published in August 2006

Medicinal potential of mycelium and fruiting bodies of an arboreal mushroom Fomitopsis officinalis in therapy of lifestyle diseases

scientific article published on 18 November 2020

Metabolic carbonyl reduction of anthracyclines - role in cardiotoxicity and cancer resistance. Reducing enzymes as putative targets for novel cardioprotective and chemosensitizing agents.

scientific article

Metabolic stability and its role in the discovery of new chemical entities

scientific article published on 01 September 2019

Microbial biotransformation of some novel hydantoin derivatives: Perspectives for bioremediation of potential sunscreen agents

scientific article published on 29 May 2019

Monoclonal antibodies in targeted therapy ⬇️

scientific article published on September 12, 2012

Multidirectional anti-melanoma effect of galactolipids (MGDG-1 and DGDG-1) from Impatiens parviflora DC. and their synergy with doxorubicin

scientific article published on 04 August 2021

N-Alkylated arylsulfonamides of (aryloxy)ethyl piperidines: 5-HT(7) receptor selectivity versus multireceptor profile.

scientific article published on 30 November 2015

Neuropathic pain-alleviating activity of novel 5-HT6 receptor inverse agonists derived from 2-aryl-1H-pyrrole-3-carboxamide

scientific article published in October 2021

New arylpiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and dihydro[1,3]oxazolo[2,3-f]purinedione targeting the serotonin 5-HT1A /5-HT2A /5-HT7 and dopamine D2 receptors

scientific article

Novel multitarget 5-arylidenehydantoins with arylpiperazinealkyl fragment: Pharmacological evaluation and investigation of cytotoxicity and metabolic stability

scientific article published on 30 July 2019

Novel non-sulfonamide 5-HT6 receptor partial inverse agonist in a group of imidazo[4,5-b]pyridines with cognition enhancing properties.

scientific article published on 16 December 2017

Novel phosphodiesterases inhibitors from the group of purine-2,6-dione derivatives as potent modulators of airway smooth muscle cell remodelling

scientific article published on 06 November 2019

PRELIMINARY EVALUATION OF CENTRAL NERVOUS SYSTEM ACTIVITY OF (E)-N-2-METHYL-3-PHENYLPROP-2-ENYL ((E)-N- α-METHYLCINNAMYL) DERIVATIVES OF SELECTED AMINOALKANOLS.

scientific article

Pan-Phosphodiesterase Inhibitors Attenuate TGF-β-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation

scientific article published on 30 March 2022

Pentoxifylline and its active metabolite lisofylline attenuate transforming growth factor β1-induced asthmatic bronchial fibroblast-to-myofibroblast transition

scientific article published on 30 July 2016

Pharmacokinetic modelling of pentoxifylline and lisofylline after oral and intravenous administration in mice

scientific article published on 01 April 2007

Photodegradation of Bexarotene and Its Implication for Cytotoxicity

scientific article published on 7 August 2021

Photostability of Terbinafine Under UVA Irradiation: The Effect of UV Absorbers

scientific article published on 19 February 2019

Piperlongumine (piplartine) as a lead compound for anticancer agents - Synthesis and properties of analogues: A mini-review

scientific article published on 25 June 2018

Preliminary Safety Assessment of New Azinesulfonamide Analogs of Aripiprazole using Prokaryotic Models

scientific article (publication date: September 2016)

Preliminary mutagenicity and genotoxicity evaluation of selected arylsulfonamide derivatives of (aryloxy)alkylamines with potential psychotropic properties.

scientific article published on 6 October 2015

Preparation of enantiopure (R)-hydroxy metabolite of denbufylline using immobilized Lactobacillus kefiri DSM 20587 as a catalyst

scientific article published in August 2009

RNAi in clinical studies.

scientific article published on January 2013

S(+)-(2E)-N-(2-Hydroxypropyl)-3-Phenylprop-2-Enamide (KM-568): A Novel Cinnamamide Derivative with Anticonvulsant Activity in Animal Models of Seizures and Epilepsy

scientific article published on 19 June 2020

STUDIES OF NEW PURINE DERIVATIVES WITH ACETIC ACID MOIETY IN HUMAN KERATINOCYTES.

scientific article published in January 2017

Saponins as chemosensitizing substances that improve effectiveness and selectivity of anticancer drug-Minireview of in vitro studies

scientific article published on 11 July 2019

Search for new tools to combat Gram-negative resistant bacteria among amine derivatives of 5-arylidenehydantoin.

scientific article published on 15 November 2012

Similar Safety Profile of the Enantiomeric N-Aminoalkyl Derivatives of Trans-2-Aminocyclohexan-1-ol Demonstrating Anticonvulsant Activity

scientific article published on 09 July 2019

Simultaneous LC/ESI-MS separation method for the enantioseparation of some new anticonvulsant drugs

scientific article published on 30 January 2014

Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH3 or 2-CH3

scientific article published on 11 November 2016

Synergistic Cytotoxic and Anti-invasive Effects of Mitoxantrone and Triterpene Saponins from Lysimachia ciliata on Human Prostate Cancer Cells

scientific article published on 13 October 2016

Synergistic anticancer activity of doxorubicin and piperlongumine on DU-145 prostate cancer cells - The involvement of carbonyl reductase 1 inhibition

scientific article published on 03 January 2019

Synthesis and Determination of Lipophilicity, Anticonvulsant Activity, and Preliminary Safety of 3-Substituted and 3-Unsubstituted N-[(4-Arylpiperazin-1-yl)alkyl]pyrrolidine-2,5-dione Derivatives.

scientific article

Synthesis and Pharmacological Evaluation of Novel Silodosin-Based Arylsulfonamide Derivatives as α/α-Adrenergic Receptor Antagonist with Potential Uroselective Profile

scientific article published on 29 August 2018

Synthesis and activity of di- or trisubstituted N -(phenoxyalkyl)- or N -{2-[2-(phenoxy)ethoxy]ethyl}piperazine derivatives on the central nervous system

scientific article published on 25 April 2018

Synthesis and anticonvulsant activity of phenoxyacetyl derivatives of amines, including aminoalkanols and amino acids

scientific article published on 19 October 2018

Synthesis and anticonvulsant activity of trans- and cis-2-(2,6-dimethylphenoxy)-N-(2- or 4-hydroxycyclohexyl)acetamides and their amine analogs

scientific article published on 14 September 2011

Synthesis and biological activity of tricyclic aryloimidazo-, pyrimido-, and diazepinopurinediones

scientific article published on 17 July 2006

Synthesis and biological evaluation of 2-fluoro and 3-trifluoromethyl-phenyl-piperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione as potential antidepressant agents.

scientific article published on 29 June 2016

Synthesis and biological properties of new N-Mannich bases derived from 3-methyl-3-phenyl- and 3,3-dimethyl-succinimides. Part V.

scientific article published on 18 May 2013

Synthesis and in vitro evaluation of anti-inflammatory, antioxidant, and anti-fibrotic effects of new 8-aminopurine-2,6-dione-based phosphodiesterase inhibitors as promising anti-asthmatic agents

scientific article published in December 2021

Synthesis of N ‐(phenoxyalkyl)‐, N ‐{2‐[2‐(phenoxy)ethoxy]ethyl}‐ or N ‐(phenoxyacetyl)piperazine Derivatives and Their Activity Within the Central Nervous System

scientific article published on 27 August 2019

Synthesis, Anticonvulsant, and Antinociceptive Activity of New 3-(2-Chlorophenyl)- and 3-(3-Chlorophenyl)-2,5-dioxo-pyrrolidin-1-yl-acetamides

scientific article published on 12 March 2021

Synthesis, anticonvulsant activity and metabolism of 4-chlor-3-methylphenoxyethylamine derivatives of trans-2-aminocyclohexan-1-ol

scientific article published on 01 December 2014

Synthesis, structure and antiarrhythmic properties evaluation of new basic derivatives of 5,5-diphenylhydantoin

scientific article published in June 2003

Synthesis, structure-activity relationship of some new anti-arrhythmic 5-arylidene imidazolidine-2,4-dione derivatives

scientific article

The Involvement of Xanthone and (<i>E</i>)-Cinnamoyl Chromophores for the Design and Synthesis of Novel Sunscreening Agents

scientific article published on 22 December 2020

The evolution of biologics in the context of oncological therapy

scientific article published on 28 February 2020

The impact of ZnO and TiO2 on the stability of clotrimazole under UVA irradiation: Identification of photocatalytic degradation products and in vitro cytotoxicity assessment.

scientific article

The research on biotransformation of praziquantel

scientific article published in December 2004

The study of the lipophilicity of some aminoalkanol derivatives with anticonvulsant activity.

scientific article

Trans-cinnamaldehyde: biological properties and applications in cosmetology

scientific article published on 5 January 2021

Tricyclic oxazolo[2,3-f]purinediones: potency as adenosine receptor ligands and anticonvulsants.

scientific article published in September 2004

Two new triterpenoid saponins from the leaves of Impatiens parviflora DC. and their cytotoxic activity

scientific article published on 22 November 2016

Unnatural D-amino acids as building blocks of new peptidomimetics

scientific article published on 01 September 2006

Usnic acid reactive metabolites formation in human, rat, and mice microsomes. Implication for hepatotoxicity

scientific article published on 04 July 2018

Validation of a high-performance liquid chromatography method for pharmacokinetic evaluation of pentoxifylline and lisofylline in rat serum and tissues.

scientific article published in May 2009

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