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List of works by Margaret Spitz

A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma

scientific article published on 10 June 2011

A case-control analysis of lymphocytic chromosome 9 aberrations in lung cancer

scientific article published on December 2002

A case-control study of a sex-specific association between a 15q25 variant and lung cancer risk

scientific article published on 25 October 2011

A genetic variant near the PMAIP1/Noxa gene is associated with increased bleomycin sensitivity

scientific article

A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma

scientific article

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

scientific article

A recurrent mutation in PARK2 is associated with familial lung cancer

scientific article

A review of the application of inflammatory biomarkers in epidemiologic cancer research

scientific article

A risk model for prediction of lung cancer

scientific article published on 01 May 2007

A second genetic variant on chromosome 15q24-25.1 associates with lung cancer

scientific article

Admixture mapping of lung cancer in 1812 African-Americans

scientific article

Aggregation of cancer among relatives of never-smoking lung cancer patients

scientific article

An analysis of DNA repair as a determinant of survival in patients with non-small-cell lung cancer

scientific article

An analysis of single nucleotide polymorphisms of 125 DNA repair genes in the Texas genome-wide association study of lung cancer with a replication for the XRCC4 SNPs

scientific article

An evolutionary perspective on single-nucleotide polymorphism screening in molecular cancer epidemiology

scientific article published on March 2004

An expanded risk prediction model for lung cancer

scientific article

Association between hypothyroidism and hepatocellular carcinoma: a case-control study in the United States

scientific article published on May 2009

Association of a novel functional promoter variant (rs2075533 C>T) in the apoptosis gene TNFSF8 with risk of lung cancer--a finding from Texas lung cancer genome-wide association study

scientific article

Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of squamous cell carcinoma of the head and neck

scientific article

Association of smoking with tumor size at diagnosis in non-small cell lung cancer ⬇️

scientific article published on June 8, 2011

Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans.

scientific article

BRCA2-branching out too?

scientific article published on 02 April 2015

Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes.

scientific article

CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis--a meta-analysis

scientific article published in May 2015

Characterization of large structural genetic mosaicism in human autosome

journal article published in 2015

Characterizing the cancer genome in lung adenocarcinoma

scientific article

Chipping away at the genetics of smoking behavior.

scientific article published in May 2010

Common 5p15.33 and 6p21.33 variants influence lung cancer risk

scientific article

Comparison of pathway analysis approaches using lung cancer GWAS data sets

scientific article

Complex segregation analysis reveals a multigene model for lung cancer

scientific article published on 16 November 2004

Cotinine Conundrum--A Step Forward but Questions Remain ⬇️

scientific article published on April 25, 2012

Cross Cancer Genomic Investigation of Inflammation Pathway for Five Common Cancers: Lung, Ovary, Prostate, Breast, and Colorectal Cancer

scientific article

DNA Repair Capacity in Peripheral Lymphocytes Predicts Survival of Patients With Non–Small-Cell Lung Cancer Treated With First-Line Platinum-Based Chemotherapy ⬇️

scientific article published on September 26, 2011

DNA repair capacity and lung cancer risk in never smokers

scientific article

Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study

scientific article

Derived SNP alleles are used more frequently than ancestral alleles as risk-associated variants in common human diseases ⬇️

scientific article published on April 1, 2012

Detectable clonal mosaicism and its relationship to aging and cancer

journal article published in 2012

Dietary folate intake and lung cancer risk in former smokers: a case-control analysis ⬇️

scientific article published on October 1, 2003

Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking

scientific article

Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women: case-control study

scientific article published on October 2008

Erratum to: Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls

scientific article

Erratum: Corrigendum: Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

scholarly article published in Nature Genetics

Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies

scientific article

Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer

scientific article published on 9 September 2008

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

journal article published in 2016

Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 Regions Identifies Functional and Histology-Specific Lung Cancer Susceptibility Loci in African-Americans ⬇️

scientific article published on December 5, 2012

Focused Analysis of Exome Sequencing Data for Rare Germline Mutations in Familial and Sporadic Lung Cancer

scientific article

GPC5 rs2352028 variant and risk of lung cancer in never smokers

scientific article published in August 2010

Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans

scientific article published on 11 January 2016

Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes - A Meta-Analysis

scientific article published on 10 August 2016

Genetic Variants on 15q25.1, Smoking, and Lung Cancer: An Assessment of Mediation and Interaction ⬇️

scientific article published on February 3, 2012

Genetic susceptibility to lung cancer: the role of DNA damage and repair.

scientific article

Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: risk and prognosis prediction

scientific article published on 15 June 2013

Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population

scientific article

Genome-wide gene–environment interaction analysis for asbestos exposure in lung cancer susceptibility ⬇️

scientific article published on May 27, 2012

Genome-wide scan of 29,141 African Americans finds no evidence of directional selection since admixture

scientific article

Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls

scientific article published on February 2013

IARC monographs: 40 years of evaluating carcinogenic hazards to humans

journal article published in 2015

Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia

scientific article

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

journal article published in 2014

In vitro sensitivity to ultraviolet B light and skin cancer risk: a case-control analysis

scientific article published on December 2005

Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers

scientific article

Increased risk of lung cancer in individuals with a family history of the disease: a pooled analysis from the International Lung Cancer Consortium

scientific article

Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls

scientific article

Informed genome-wide association analysis with family history as a secondary phenotype identifies novel loci of lung cancer

scientific article

Inherited variation at chromosome 12p13.33, including RAD52, influences the risk of squamous cell lung carcinoma

scientific article

International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants

scientific article

International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways

scientific article

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

scientific article published on 12 June 2017

Mediating effects of smoking and chronic obstructive pulmonary disease on the relation between the CHRNA5-A3 genetic locus and lung cancer risk

scientific article

Method for evaluating multiple mediators: mediating effects of smoking and COPD on the association between the CHRNA5-A3 variant and lung cancer risk

scientific article

Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma

scientific article published on 29 July 2008

Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.

scientific article

Multistage Analysis of Variants in the Inflammation Pathway and Lung Cancer Risk in Smokers ⬇️

scientific article published on May 9, 2012

Mutagen sensitivity and genetic variants in nucleotide excision repair pathway: genotype-phenotype correlation.

scientific article

Mutagen sensitivity has high heritability: evidence from a twin study

scientific article published on 01 June 2006

Never smokers and lung cancer risk: a case-control study of epidemiological factors.

scientific article

Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study

scientific article

Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk.

scientific article

Pilot study of CYP2B6 genetic variation to explore the contribution of nitrosamine activation to lung carcinogenesis.

scientific article published on 16 April 2013

Polymorphisms of FAS and FAS ligand genes involved in the death pathway and risk and progression of squamous cell carcinoma of the head and neck

scientific article published on September 2006

Projecting individualized probabilities of developing bladder cancer in white individuals

scientific article published on 01 November 2007

Rare variants in known susceptibility loci and their contribution to risk of lung cancer

journal article published in 2018

Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

scientific journal article

Reduced DNA repair capacity for removing tobacco carcinogen-induced DNA adducts contributes to risk of head and neck cancer but not tumor characteristics

scientific article

Relationship Between Plasma Carotenoids and Prostate Cancer

scientific article published on 01 January 2005

Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk

scientific article published on 11 July 2011

Repair of UV light-induced DNA damage and risk of cutaneous malignant melanoma

scientific article published on 01 February 2003

Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium

scientific article

Risk for smoking-related cancer among relatives of lung cancer patients

scientific article published in December 2003

Role of Selected Genetic Variants in Lung Cancer Risk in African Americans ⬇️

scientific article published on April 1, 2013

Seizure 6-like (SEZ6L) gene and risk for lung cancer

scientific article

Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms

scientific article

Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25.

scientific article

Smoking, DNA repair capacity and risk of nonsmall cell lung cancer

scientific article published in October 2003

Smoking-related genomic signatures in non-small cell lung cancer

scientific article published on 05 September 2008

Somatic mutations affect key pathways in lung adenocarcinoma

scientific article

Telomere dysfunction: a potential cancer predisposition factor.

scientific article

The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer

scientific article published on 28 October 2008

The landscape of recombination in African Americans

scientific article

Trends in prevalence of prognostic factors and survival in lung cancer patients from 1985 to 2004 at a tertiary care center.

scientific article

Variants in Inflammation Genes Are Implicated in Risk of Lung Cancer in Never Smokers Exposed to Second-hand Smoke ⬇️

scientific article published on August 25, 2011

XPA polymorphism associated with reduced lung cancer risk and a modulating effect on nucleotide excision repair capacity

scientific article

XRCC3 genetic polymorphism, smoking, and lung carcinoma risk in minority populations ⬇️

scientific article published on October 15, 2003

p53 Genotypes and Haplotypes Associated With Lung Cancer Susceptibility and Ethnicity

scientific article published in May 2002

p73 G4C14-to-A4T14 gene polymorphism and interaction with p53 exon 4 Arg72Pro on cancer susceptibility: a meta-analysis of the literature

scientific article

p73 G4C14-to-A4T14 polymorphism and risk of lung cancer

scientific article published on 01 October 2004

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