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List of works by J Steven Leeder

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Prediction of CYP2D6 phenotype from genotype across world populations

scientific article published on 07 July 2016
Mechanisms of Idiosyncratic Hypersensitivity Reactions to Antiepileptic Drugs

scientific article published on 01 January 1998
Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping*

scientific article published on May 1, 1998
Age Related Changes in Fractional Elimination Pathways for Drugs: Assessing the Impact of Variable Ontogeny on Metabolic Drug-Drug Interactions

scientific article published on May 30, 2013
A modified generalized Fisher method for combining probabilities from dependent tests

scientific article published on February 20, 2014
Impact of the CYP2C19*17 Allele on the Pharmacokinetics of Omeprazole and Pantoprazole in Children: Evidence for a Differential Effect

scientific article published on March 11, 2010
NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations

scientific article
Identification of Novel CYP2D7-2D6 Hybrids: Non-Functional and Functional Variants

scientific article published on October 4, 2010
Analysis of intracellular methotrexate polyglutamates in patients with juvenile idiopathic arthritis: Effect of route of administration on variability in intracellular methotrexate polyglutamate concentrations

scientific article published on June 1, 2010
Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping*

scientific article published on September 1, 1998
Fluticasone Propionate Pharmacogenetics: CYP3A4*22 Polymorphism and Pediatric Asthma Control

scientific article published on January 3, 2013
Acetaminophen overdose with therapeutic intent

scientific article published on 01 January 1998
Development of Biomarkers to Optimize Pediatric Patient Management: What Makes Children Different?

scientific article published on December 1, 2011
Drug metabolism for the paediatrician

scientific article published on 03 September 2014
Single dose, CYP2D6 genotype‐stratified pharmacokinetic study of atomoxetine in children with ADHD

scientific article published on 11 December 2015
Detection of an Endogenous Urinary Biomarker Associated With Cyp2D6 Activity Using Global Metabolomics

scientific article published on December 1, 2014
Epigenetic Regulation of ADME-Related Genes: Focus on Drug Metabolism and Transport

scientific article published on 09 August 2013
Effects of Valproic Acid on Organic Acid Metabolism in Children: A Metabolic Profiling Study

scientific article published on 04 May 2011
Chiral phase analysis of warfarin enantiomers in patient plasma in relation to CYP2C9 genotype

scientific article published on June 12, 1998
Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation

scientific article published on November 25, 2015
Identifying Genomic and Developmental Causes of Adverse Drug Reactions in Children

scientific article published on November 1, 2010
Design and Testing of an EHR-Integrated, Busulfan Pharmacokinetic Decision Support Tool for the Point-of-Care Clinician

scientific article published on March 30, 2016
Population Pharmacokinetics of Oral Baclofen in Pediatric Patients with Cerebral Palsy

scientific article published on March 5, 2014
Individualizing the Use of Medications in Children: Making Goldilocks Happy

scientific article published on June 13, 2014
Interpreting Pharmacogenetic Data in the Developing Neonate: The Challenge of Hitting a Moving Target

scientific article published on September 5, 2012
Decreased Pregnane X Receptor Expression in Children with Active Crohn’s Disease

scientific article published on March 24, 2016
Genetic determinants of fetal opiate exposure and risk of neonatal abstinence syndrome: Knowledge deficits and prospects for future research

scientific article published on July 22, 2015
Cotinine in Human Placenta Predicts Induction of Gene Expression in Fetal Tissues

scientific article published on December 3, 2012
Comprehensive quantitative measurement of folate polyglutamates in human erythrocytes by ion pairing ultra‐performance liquid chromatography/tandem mass spectrometry

scientific article published on July 30, 2012
Non-monooxygenase cytochromes P450 as potential human autoantigens in anticonvulsant hypersensitivity reactions

scientific article published on June 1, 1998
Effect of CYP3A5 genotype, steroids, and azoles on tacrolimus in a pediatric renal transplant population

scientific article published on May 30, 2014
Folate Depletion and Increased Glutamation in Juvenile Idiopathic Arthritis Patients Treated With Methotrexate

scientific article published on December 1, 2014
CYP2D6 and Pharmacogenomics: Where Does Future Research Need to Focus? Part 2: Clinical Aspects

scientific article published on June 1, 2014
CYP2D7 Sequence Variation Interferes with TaqMan CYP2D6*15 and *35 Genotyping

scientific article published on January 12, 2016
Tissue-Specific Expression and Alternative Splicing of Human Microsomal Epoxide Hydrolase

scientific article published on November 1, 1997
In Vitro Hepatic Oxidative Biotransformation of Trimethoprim

scientific article published on July 2, 2015
Low-Dose Methotrexate Results in the Selective Accumulation of Aminoimidazole Carboxamide Ribotide in an Erythroblastoid Cell Line

scientific article published on July 25, 2013
Trends in Adverse Reactions to Trimethoprim-Sulfamethoxazole

scientific article published on December 3, 2012
Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children

scientific article published on 06 April 2016
UGT2B17 and SULT1A1 gene copy number variation (CNV) detection by LabChip microfluidic technology

scientific article published on May 1, 2010
Over-the-Counter Medications: Update on Cough and Cold Preparations

scientific article published on July 1, 2015
Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers

scientific article published on January 15, 2016
Meaningful Use and Clinical Utility of Preemptive Pharmacogenetic Testing: (Re)View From a CYP2D6 Poor Metabolizer

scientific article published on December 15, 2014
Quantification of pravastatin acid, lactone and isomers in human plasma by UHPLC-MS/MS and its application to a pediatric pharmacokinetic study

scientific article published on January 24, 2016
Who Believes They Are "Just Average": Informing the Treatment of Individual Patients Using Population Data

scientific article published on 11 September 2019
High-Resolution Melt Analysis to Detect Sequence Variations in Highly Homologous Gene Regions: Application to CYP2B6

scientific article published on June 1, 2013
Decreased Expression of Nicotinamide Phosphoribosyltransferase in Patients with Juvenile Idiopathic Arthritis Receiving Methotrexate

scientific article published on May 1, 2013
CYP2D6 and Pharmacogenomics: Where Does Future Research Need to Focus? Part 1: Technical Aspects

scientific article published on March 1, 2014
Conference Scene: Pediatric Pharmacogenomics and Personalized Medicine

scientific article published on December 1, 2010
Development and Application of a High-Throughput Screening Method to Evaluate Antifungal Activity against Trichophyton tonsurans

scientific article published on July 9, 2015

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