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List of works by Satoshi Uematsu

'Toll' gates for future immunotherapy

scientific article published on January 2006

5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival

scientific article

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

scientific article

A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity.

scientific article published on 27 April 2011

Activation and regulation of Toll-like receptors 2 and 1 in human leprosy

scientific article published on 14 April 2003

Activation of cytosolic phospholipase A2alpha in resident peritoneal macrophages by Listeria monocytogenes involves listeriolysin O and TLR2.

scientific article published on 14 December 2007

Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila

scientific article published on 01 November 2007

Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells

scientific journal article

Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders

scientific article published on 01 January 2008

B lymphocyte activation by human papillomavirus-like particles directly induces Ig class switch recombination via TLR4-MyD88

scientific article published on 01 June 2005

Bacterial endotoxin induces the release of high mobility group box 1 via the IFN-beta signaling pathway

scientific article published in February 2009

Bacterial sphingophospholipids containing non-hydroxy fatty acid activate murine macrophages via Toll-like receptor 4 and stimulate bacterial clearance

scientific article published on 29 March 2013

Blocking of the TLR5 activation domain hampers protective potential of flagellin DNA vaccine

scientific article published on 01 July 2007

Cell type-specific involvement of RIG-I in antiviral response

scientific article (publication date: July 2005)

Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity.

scientific article

Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice

scientific article published on 26 November 2009

Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice.

scientific article published on 19 March 2012

Cutting Edge: Overlapping Functions of TLR7 and TLR9 for Innate Defense against a Herpesvirus Infection

Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling

scientific article published on 01 December 2006

Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection

Cutting edge: Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection

scientific article published in April 2007

Deletion of microsomal prostaglandin E synthase-1 protects neuronal cells from cytotoxic effects of β-amyloid peptide fragment 31–35 ⬇️

scientific article published on July 2, 2012

Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives: monoacylated MDP confers TLR2/TLR4 activation

scientific article published in June 2005

Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.

scientific article published on 9 July 2006

Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination

scientific article published in October 2007

Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-β.

scientific article published on 20 June 2013

Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice

scientific article published on 09 May 2007

Eosinophil depletion suppresses radiation-induced small intestinal fibrosis.

scientific article published in February 2018

Erratum: A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA

scholarly article published in Nature Immunology

Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus

scientific article published on 01 July 2008

Human papillomavirus type-16 virus-like particles activate complementary defense responses in key dendritic cell subpopulations

scientific article published in August 2004

IL-6 and IL-10 induction from dendritic cells in response to Mycobacterium tuberculosis is predominantly dependent on TLR2-mediated recognition

scientific article published on 01 September 2004

Identification of a TLR-independent pathway for Borrelia burgdorferi-induced expression of matrix metalloproteinases and inflammatory mediators through binding to integrin alpha 3 beta 1

scientific article published on 01 July 2006

Immune responses of TLR5(+) lamina propria dendritic cells in enterobacterial infection

scientific article published on 24 June 2009

Induction of adaptive immunity by flagellin does not require robust activation of innate immunity

scientific article published on February 2009

Induction of prostaglandin E2 synthesis and microsomal prostaglandin E synthase-1 expression in murine microglia by glioma-derived soluble factors. Laboratory investigation

scientific article published in February 2008

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

Lipopolysaccharide-dependent prostaglandin E(2) production is regulated by the glutathione-dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway

scientific article published in June 2002

Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2

scientific article published on 01 January 2003

Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself

scientific article published on 01 August 2007

Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation

scientific article published on 01 August 2006

Microarray analysis identifies apoptosis regulatory gene expression in HCT116 cells infected with thermostable direct hemolysin-deletion mutant of Vibrio parahaemolyticus.

scientific article

Microglia-specific expression of microsomal prostaglandin E2 synthase-1 contributes to lipopolysaccharide-induced prostaglandin E2 production.

scientific article published on 5 July 2005

Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson's disease

scientific article published on 10 November 2018

Microsomal prostaglandin E synthase-1 is induced in alzheimer's disease and its deletion mitigates alzheimer's disease-like pathology in a mouse model

scientific article published on 29 March 2013

Nonredundant roles of Sema4A in the immune system: defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice

scientific journal article

PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells.

scientific article

Pathogen recognition and innate immunity

scientific article (publication date: 24 February 2006)

Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling

scientific article published on 26 March 2010

Pathological role of Toll-like receptor signaling in cerebral malaria.

scientific article published on 29 November 2006

Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin

scientific article published in June 2009

Rapid CD4+ T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9.

scientific article

Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1.

scientific article

Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta

scientific article

Regulation of cytosolic phospholipase A2 activation and cyclooxygenase 2 expression in macrophages by the beta-glucan receptor

scientific article published on 3 January 2006

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.

scientific article published on 30 May 2008

Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-β

article

Role of lipoteichoic acid in the phagocyte response to group B streptococcus.

scientific article

Selective synergy in anti-inflammatory cytokine production upon cooperated signaling via TLR4 and TLR2 in murine conventional dendritic cells.

scientific article

Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms

article

Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway

scientific article published on 17 July 2005

Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP

scientific journal article

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

scientific article published in Nature

TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses

scientific article published on 01 February 2007

TLR2 engagement on CD8 T cells lowers the thresholdfor optimal antigen-induced T cell activation

scientific article published on 01 July 2006

TLR2-dependent inflammatory response to Porphyromonas gingivalis is MyD88 independent, whereas MyD88 is required to clear infection

scientific article published on 30 December 2009

The role of Toll-like receptors in immune disorders

scientific article

Therapeutic targeting of Toll-like receptors

Toll-Like receptors (TLRs) and their ligands

scientific article published on January 2008

Toll-like receptor 3 enhances late-phase reaction of experimental allergic conjunctivitis

scientific article published on 10 April 2009

Toll-like receptor 6 drives interleukin-17A expression during experimental hypersensitivity pneumonitis.

scientific article published on 11 January 2010

Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice

scientific article published on 2 April 2013

Toll-like receptor and innate immunity

scientific article published in August 2007

Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease

scientific article published on 16 January 2005

Toll-like receptors and Type I interferons

scientific article

VP1686, a Vibrio type III secretion protein, induces toll-like receptor-independent apoptosis in macrophage through NF-kappaB inhibition.

scientific article published on 19 September 2006

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