List of works - Chrislaine Withers-Martinez

A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1.

scientific article published on 01 January 2020

A multifunctional serine protease primes the malaria parasite for red blood cell invasion

scientific article (publication date: 18 March 2009)

An inhibitory antibody blocks interactions between components of the malarial invasion machinery

scientific article

Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor.

scientific article

Ca

scientific article

Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity identifies differences in amino acid preferences between peptide-based substrates and covalent inhibitors

scientific article published on 24 June 2019

Correction: Juxtamembrane Shedding of Plasmodium falciparum AMA1 Is Sequence Independent and Essential, and Helps Evade Invasion-Inhibitory Antibodies

scientific article published on 29 February 2012

Corrigendum: The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin

scientific article published on 28 May 2014

Crystal structure of the malaria vaccine candidate apical membrane antigen 1.

scientific article published on 24 February 2005

Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery

scientific article published on 10 May 2019

Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens

scientific article published in September 2005

Essentiality of Plasmodium falciparum plasmepsin V

scientific article published in PLoS ONE

Expression of recombinant Plasmodium falciparum subtilisin-like protease-1 in insect cells. Characterization, comparison with the parasite protease, and homology modeling

scientific article

Fine mapping of an epitope recognized by an invasion-inhibitory monoclonal antibody on the malaria vaccine candidate apical membrane antigen 1.

scientific article published on 27 December 2006

Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease

scientific article

High-Level Expression of the Malaria Blood-Stage Vaccine Candidate Plasmodium falciparum Apical Membrane Antigen 1 and Induction of Antibodies That Inhibit Erythrocyte Invasion.

scientific article published in October 2002

High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasion ⬇️

scientific article

Identification of a Plasmodium falciparum phospholipid transfer protein

scientific article (publication date: November 2013)

Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite

scientific article (publication date: 25 September 2006)

Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies ⬇️

scientific article

Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress

scientific article (publication date: May 2013)

Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface

scientific article

Molecular determinants for subcellular trafficking of the malarial sheddase PfSUB2.

scientific article published on 30 July 2013

Molecular determinants of binding to the Plasmodium subtilisin-like protease 1.

scientific article published on 4 March 2013

Molecular identification of a malaria merozoite surface sheddase

scientific article

Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum.

scientific article published in December 2007

Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1.

scholarly article

Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D

scientific article published on 29 November 2018

Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle

scientific article (publication date: April 2015)

Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target.

scientific article

Processing of Plasmodium falciparum Merozoite Surface Protein MSP1 Activates a Spectrin-Binding Function Enabling Parasite Egress from RBCs

scientific article (publication date: 14 October 2015)

Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte

scientific article

Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG function

scientific article published on 16 March 2020

Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes

scientific article (publication date: 14 December 2007)

Subtilisin-like proteases of the malaria parasite.

scientific article published in July 2004

Targeted Deletion of a Plasmodium Site-2 Protease Impairs Life Cycle Progression in the Mammalian Host

scientific article

The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin

scientific article

Unique insertions within Plasmodium falciparum subtilisin-like protease-1 are crucial for enzyme maturation and activity

scientific article published on 8 September 2005

List of works by Chrislaine Withers-Martinez

A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1.

A multifunctional serine protease primes the malaria parasite for red blood cell invasion

An inhibitory antibody blocks interactions between components of the malarial invasion machinery

Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor.

Ca

Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity identifies differences in amino acid preferences between peptide-based substrates and covalent inhibitors

Correction: Juxtamembrane Shedding of Plasmodium falciparum AMA1 Is Sequence Independent and Essential, and Helps Evade Invasion-Inhibitory Antibodies

Corrigendum: The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin

Crystal structure of the malaria vaccine candidate apical membrane antigen 1.

Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery

Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens

Essentiality of Plasmodium falciparum plasmepsin V

Expression of recombinant Plasmodium falciparum subtilisin-like protease-1 in insect cells. Characterization, comparison with the parasite protease, and homology modeling

Fine mapping of an epitope recognized by an invasion-inhibitory monoclonal antibody on the malaria vaccine candidate apical membrane antigen 1.

Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease

High-Level Expression of the Malaria Blood-Stage Vaccine Candidate Plasmodium falciparum Apical Membrane Antigen 1 and Induction of Antibodies That Inhibit Erythrocyte Invasion.

High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasion ⬇️

Identification of a Plasmodium falciparum phospholipid transfer protein

Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite

Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies ⬇️

Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress

Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface

Molecular determinants for subcellular trafficking of the malarial sheddase PfSUB2.

Molecular determinants of binding to the Plasmodium subtilisin-like protease 1.

Molecular identification of a malaria merozoite surface sheddase

Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum.

Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1.

Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D

Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle

Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target.

Processing of Plasmodium falciparum Merozoite Surface Protein MSP1 Activates a Spectrin-Binding Function Enabling Parasite Egress from RBCs

Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte

Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG function

Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes

Subtilisin-like proteases of the malaria parasite.

Targeted Deletion of a Plasmodium Site-2 Protease Impairs Life Cycle Progression in the Mammalian Host

The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin

Unique insertions within Plasmodium falciparum subtilisin-like protease-1 are crucial for enzyme maturation and activity